About
Stanford trained plastic surgeon & regenerative medicine scientist focused on helping…
Contributions
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How do you define and measure the impact of translational research?
Determining how to measure this impact can be challenging. In many ways, the successful application of principles discovered through basic science research to a specific clinical or health problem (i.e. translational research), helps validate the impact of that discovery. Similarly, successful clinical trials that have been designed based on the findings of translational research determine the true impact of that translation.
Activity
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I am honored to announce I have joined the Forum on the Arms Trade as an expert on arms sales; security assistance; export control/transfer policy…
I am honored to announce I have joined the Forum on the Arms Trade as an expert on arms sales; security assistance; export control/transfer policy…
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A #Rohingya man shared a heart-wrenching sentiment with our team. His words reflect the escalating brutality in Myanmar's Rakhine State. Jason…
A #Rohingya man shared a heart-wrenching sentiment with our team. His words reflect the escalating brutality in Myanmar's Rakhine State. Jason…
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🎙 Behind-the-scenes of the HUM2N podcast. In episode 3 I am joined by Dr. Aseem Malhotra and Dr. Mark Menolascino to discuss the most important…
🎙 Behind-the-scenes of the HUM2N podcast. In episode 3 I am joined by Dr. Aseem Malhotra and Dr. Mark Menolascino to discuss the most important…
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Experience
Education
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Stanford University School of Medicine
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Stanford has a long history of educating the best and brightest in plastic surgery. With one of the first integrated training programs in the United States, since 1965 we have been training outstanding clinical surgeons, scientists, and innovators who are shaping the field of plastic surgery.
Our residents have six years of outstanding clinical training at Stanford Hospital and our affiliated training institutions: Lucile Packard Children’s Hospital, Palo Alto Veterans Affairs…Stanford has a long history of educating the best and brightest in plastic surgery. With one of the first integrated training programs in the United States, since 1965 we have been training outstanding clinical surgeons, scientists, and innovators who are shaping the field of plastic surgery.
Our residents have six years of outstanding clinical training at Stanford Hospital and our affiliated training institutions: Lucile Packard Children’s Hospital, Palo Alto Veterans Affairs Hospital, Santa Clara Valley Medical Center, The Buncke Clinic, Kaiser Santa Clara and the Plastic Surgery Center. These institutions provide an unparalleled breadth and depth of exposure to all of plastic surgery. Additionally, each site offers a unique and diverse patient population. -
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Stanford Ignite is a certificate program taught by the Stanford GSB Faculty.
As part of a team, I developed a business model to commercialize a novel biomedical technology:
-identified the needs answered by the benefits of our technology
-assessed the disruptive potential of our technology
-calculated market size and profit potential
-assessed risks and route to market
-outlined potential exit strategies -
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Activities and Societies: Cricket
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Activities and Societies: Speech and Debate
Licenses & Certifications
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Physician And Surgeon (Allopathic - M.D.)
Medical Board Of California
Issued ExpiresCredential ID A150534
Publications
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A single-center blinded randomized clinical trial to evaluate the anti-aging effects of a novel HSF™-based skin care formulation
J Cosm Derm
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Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing
Plastic and Reconstructive Surgery
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Skin Fibrosis. Identification and Isolation of a Dermal Lineage with intrinsic fibrogenic potential
Science
Excess fibrous connective tissue, similar to scarring, forms during the repair of injuries. Fibroblasts are known to be involved, but their role is poorly characterized. Rinkevich et al. identify two lineages of dermal fibroblasts in the dorsal skin of mice (see the Perspective by Sennett and Rendl). A fibrogenic lineage, defined by embryonic expression of Engrailed-1, plays a central role in dermal development, wound healing, radiation-induced fibrosis, and cancer stroma formation. Targeted…
Excess fibrous connective tissue, similar to scarring, forms during the repair of injuries. Fibroblasts are known to be involved, but their role is poorly characterized. Rinkevich et al. identify two lineages of dermal fibroblasts in the dorsal skin of mice (see the Perspective by Sennett and Rendl). A fibrogenic lineage, defined by embryonic expression of Engrailed-1, plays a central role in dermal development, wound healing, radiation-induced fibrosis, and cancer stroma formation. Targeted inhibition of this lineage results in reduced melanoma growth and scar formation, with no effect on the structural integrity of the healed skin, thus indicating therapeutic approaches for treating fibrotic disease.
Other authorsSee publication -
Scarless Wound Healing: Chasing the Holy Grail.
Plastic and Reconstructive Surgery
over 100 million patients acquire scars in the industrialized world each year, primarily as a result of elective operations. although undefined, the global incidence of scarring is even larger, extending to significant numbers of burn and other trauma-related wounds. scars have the potential to exert a profound psychological and physical impact on the individual. beyond aesthetic considerations and potential disfigurement, scarring can result in restriction of movement and reduced quality of…
over 100 million patients acquire scars in the industrialized world each year, primarily as a result of elective operations. although undefined, the global incidence of scarring is even larger, extending to significant numbers of burn and other trauma-related wounds. scars have the potential to exert a profound psychological and physical impact on the individual. beyond aesthetic considerations and potential disfigurement, scarring can result in restriction of movement and reduced quality of life. the formation of a scar following skin injury is a consequence of wound healing occurring through reparative rather than regenerative mechanisms. in this article, the authors review the basic stages of wound healing; differences between adult and fetal wound healing; various mechanical, genetic, and pharmacologic strategies to reduce scarring; and the biology of skin stem/progenitor cells that may hold the key to scarless regeneration.
Other authorsSee publication -
Exercise Induces SDF-1 Mediated Release of Endothelial Progenitor Cells with Increased Vasculogenic Function
Plastic & Reconstructive Surgery
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Understanding Regulatory Pathways of Neovascularization in Diabetes
Expert Review of Endocrinology & Metabolism
Diabetes mellitus results in major comorbidities, including accelerated aging, and therefore represent a significant health burden worldwide. Vascular dysfunction is a major contributory factor, resulting in impaired wound healing, cardiovascular disease and proliferative diabetic retinopathy. While the etiology of abnormal neovascularization in diabetes is complex and paradoxical, the dysregulation of the varied processes contributing to the vascular response are due in large part to the…
Diabetes mellitus results in major comorbidities, including accelerated aging, and therefore represent a significant health burden worldwide. Vascular dysfunction is a major contributory factor, resulting in impaired wound healing, cardiovascular disease and proliferative diabetic retinopathy. While the etiology of abnormal neovascularization in diabetes is complex and paradoxical, the dysregulation of the varied processes contributing to the vascular response are due in large part to the effects of hyperglycemia. In this review, we explore the mechanisms by which hyperglycemia disrupts chemokine expression and function, including the critical hypoxia inducible factor-1 axis, which is also disrupted in aging. We also evaluate potential therapeutic strategies that may one day help alleviate the healthcare burden of diabetes and aging.
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Tissue engineering and regenerative repair in wound healing.
Annals of biomedical engineering
Wound healing is a highly evolved defense mechanism against infection and further injury. It is a complex process involving multiple cell types and biological pathways. Mammalian adult cutaneous wound healing is mediated by a fibroproliferative response leading to scar formation. In contrast, early to mid-gestational fetal cutaneous wound healing is more akin to regeneration and occurs without scar formation. This early observation has led to extensive research seeking to unlock the mechanism…
Wound healing is a highly evolved defense mechanism against infection and further injury. It is a complex process involving multiple cell types and biological pathways. Mammalian adult cutaneous wound healing is mediated by a fibroproliferative response leading to scar formation. In contrast, early to mid-gestational fetal cutaneous wound healing is more akin to regeneration and occurs without scar formation. This early observation has led to extensive research seeking to unlock the mechanism underlying fetal scarless regenerative repair. Building upon recent advances in biomaterials and stem cell applications, tissue engineering approaches are working towards a recapitulation of this phenomenon. In this review, we describe the elements that distinguish fetal scarless and adult scarring wound healing, and discuss current trends in tissue engineering aimed at achieving scarless tissue regeneration.
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Mechanotransduction and Fibrosis.
Journal of Biomechanics
Scarring and tissue fibrosis represent a significant source of morbidity in the united states. despite considerable research focused on elucidating the mechanisms underlying cutaneous scar formation, effective clinical therapies are still in the early stages of development. a thorough understanding of the various signaling pathways involved is essential to formulate strategies to combat fibrosis and scarring. while initial efforts focused primarily on the biochemical mechanisms involved in scar…
Scarring and tissue fibrosis represent a significant source of morbidity in the united states. despite considerable research focused on elucidating the mechanisms underlying cutaneous scar formation, effective clinical therapies are still in the early stages of development. a thorough understanding of the various signaling pathways involved is essential to formulate strategies to combat fibrosis and scarring. while initial efforts focused primarily on the biochemical mechanisms involved in scar formation, more recent research has revealed a central role for mechanical forces in modulating these pathways. mechanotransduction, which refers to the mechanisms by which mechanical forces are converted to biochemical stimuli, has been closely linked to inflammation and fibrosis and is believed to play a critical role in scarring. this review provides an overview of our current understanding of the mechanisms underlying scar formation, with an emphasis on the relationship between mechanotransduction pathways and their therapeutic implications.
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Clinical Skills Explained
Scion Publishing
**Highly Commended in BMA Book Awards 2013**
Written in a clear and logical style, the book guides the reader through all aspects of clinical skills, from history taking, through key clinical examinations, to essential clinical procedures. Numerous full-colour illustrations help aid student understanding.
Clinical Skills Explained provides comprehensive, clear and easy-to follow coverage of this difficult subject area, not only detailing the core clinical skills techniques, but…**Highly Commended in BMA Book Awards 2013**
Written in a clear and logical style, the book guides the reader through all aspects of clinical skills, from history taking, through key clinical examinations, to essential clinical procedures. Numerous full-colour illustrations help aid student understanding.
Clinical Skills Explained provides comprehensive, clear and easy-to follow coverage of this difficult subject area, not only detailing the core clinical skills techniques, but also explaining why the techniques have to be performed in the particular way described. The book further aids student understanding by integrating clinical skills information with the basic pathology, anatomy and basic sciences that the students will be learning concurrently.Other authors -
Honors & Awards
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Holman Lecture Basic Science Award
Department of Surgery, Stanford Univeristy
Best basic science presentation at the annual Stanford Department of Surgery Holman Lecture.
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Daniel C. Riordan Award
American Society for Surgery of the Hand
The Daniel C. Riordan award recognizes a promising surgical resident or hand fellow with a scholarship to attend the Adrian E. Flatt Residents and Fellows Conference and the ASSH Annual Meeting.
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Troxel Fellowship
Zedplast Alumni Association
The Troxel fellowship was established by the Division of Plastic Surgery and the Zedplast Alumni association in honor of John Troxel, a former Plastic Surgery resident at Stanford who was practicing in Alaska with his wife Sara prior to his untimely death due to a brain aneurysm. He had been very active in healthcare advocacy.
The Troxel Fellow is awarded to a resident who has interest in healthcare policy, advocacy and legislation. The Troxel fellow has the unique opportunity to meet…The Troxel fellowship was established by the Division of Plastic Surgery and the Zedplast Alumni association in honor of John Troxel, a former Plastic Surgery resident at Stanford who was practicing in Alaska with his wife Sara prior to his untimely death due to a brain aneurysm. He had been very active in healthcare advocacy.
The Troxel Fellow is awarded to a resident who has interest in healthcare policy, advocacy and legislation. The Troxel fellow has the unique opportunity to meet with legislators and representatives, and have experienced first-hand the process by which physicians are represented in the government. -
Zedplast Traveling Scholarship
Zedplast Alumni Association
Traveling scholarship to support residents to visit other plastic surgery program for 5-days as an observer to further advance their plastic surgery training and experience.
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Best Oral Presentation
European Plastic Surgery Research Council
Awarded to the best long format oral presentation at the European Plastic Surgery Research Council Meeting.
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Co-Chair for Hand Basic Science Session
European Plastic Surgery Research Council
Selected to co-moderate the Hand Basic Science oral presentation session at the 11th European Plastic Surgery Research Council meeting.
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Clifford C. Snyder, MD: Past Chairman Award
Plastic Surgery Research Council
The Snyder Award is given to the best presentation by a resident/fellow at the Annual Meeting of the Plastic Surgery Research Council.
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PSF Research Fellowship Grant
Plastic Surgery Education Foundation
The purpose of the Research Fellowship Grant is to encourage research and academic career development in plastic surgery. This grant is for salary support ($50,000) for a Resident or Fellow to obtain training and experience in research, under the guidance of an experienced mentor.
Languages
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English
Native or bilingual proficiency
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Urdu / Hindi
Native or bilingual proficiency
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French
Limited working proficiency
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