“I have been seriously seeking health for the past 10+ years and I find myself pondering, repeating and sharing Zachary Bush isms over and over and over. I found his practice and his lectures to be helpful, encouraging and profoundly different and innovative. I highly recommend him for his expertise and knowledge and especially for his caring and compassion he is providing true health care. ”
Zach Bush, MD
Charlottesville, Virginia, United States
5K followers
500+ connections
Charlottesville, Virginia, United States
5K followers
500+ connections
About
Zach Bush, MD is a physician specializing in internal medicine, endocrinology and hospice…
Activity
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Every moment, we plant seeds in the garden of our lives. With each thought, each breath, we shape the legacy we will leave behind—for ourselves and…
Every moment, we plant seeds in the garden of our lives. With each thought, each breath, we shape the legacy we will leave behind—for ourselves and…
Liked by Zach Bush, MD
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Every moment, we plant seeds in the garden of our lives. With each thought, each breath, we shape the legacy we will leave behind—for ourselves and…
Every moment, we plant seeds in the garden of our lives. With each thought, each breath, we shape the legacy we will leave behind—for ourselves and…
Shared by Zach Bush, MD
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Giving back and impact at its finest Paka Apparel
Giving back and impact at its finest Paka Apparel
Liked by Zach Bush, MD
Experience
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Education
Licenses & Certifications
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Board Certification Hospice and Palliative Care
American Academy Hospice and Palliative Care
Issued -
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Volunteer Experience
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Physician Leader
US Navy Ship Comfort
- Present 14 years 7 months
Disaster and Humanitarian Relief
Physician leader, US Navy Ship Comfort, Haiti Relief Operation.
Director of pre- and post-surgical care.
February, 2010. Port-au-Prince, Haiti
Publications
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Temozolomide Treatment for Aggressive Pituitary Tumors: Correlation of Clinical Outcomes with DNA Methylation and MGMT Expression.
J Clin Endocrinol Metab.
Bush ZM, Longtine JA, Cunningham T, Schiff D, Jane, Jr. JA, Vance ML, Thorner MO, Laws, Jr. ER, Lopes MB.
Temozolomide Treatment for Aggressive Pituitary Tumors: Correlation of Clinical Outcomes with DNA
Methylation and MGMT Expression.
[Original Research]
J Clin Endocrinol Metab.
2010 Nov;95(11):E280-90
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Immunohistochemistry of COUP-TFI: An adjuvant diagnostic tool for the identification of corticotroph microadenomas.
Bush ZM, Lopes MBS, Hussaini IM, Jane, Jr JA, Laws ER, Vance ML.
Immunohistochemistry of COUP-TFI: An adjuvant diagnostic tool for the identification of corticotroph microadenomas.
[Original Research]
Pituitary.
2010;13:1-7. -
Management of acromegaly: Is there a role for primary medical therapy?
Bush ZM, Vance ML.
Management of acromegaly: Is there a role for primary medical therapy?
[Review]
Rev Endocr Metab Disord.
2008 Mar;9(1):83-94. -
Acute pancreatitis in HIV-infected patients: are etiologies changing since the introduction of protease inhibitor therapy?
Bush ZM, Kosmiski L.
Acute pancreatitis in HIV-infected patients: are etiologies changing since the introduction of protease inhibitor therapy?
[Original Research]
Pancreas. 27(1):E1-5, 2003 Jul. -
Endocrine Complications After Skull Based Endoscopic Surgery.
Thieme Medical Publishers Inc.
Book Publication
Bush ZM, Vance ML, Jane, Jr. JA.
Endocrine Complications After Skull Based Endoscopic Surgery.
Chapter 47. ENDOSCOPIC SKULL BASE AND BRAIN SURGERY: TIPS AND PEARLS by Aldo
Stamm.
Thieme Medical Publishers Inc.
New York, New York.
In press. -
Expert Review of Pharmacoeconomics & Outcomes Research Case Reports in Medicine Virchows Archive
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Invited Reviewer for peer-reviewed journals:
Expert Review of Pharmacoeconomics & Outcomes Research Case Reports in Medicine Virchows Archive -
Gliadin and glyphosate independently, and in combination, induce tight junction injury, and epithelial membrane leak in small bowel and colon epithelial membrane.
J Gastroenterology
Gildea J, Roberts D, Bush ZM (as Senior/corresponding author).
Gliadin and glyphosate independently, and in combination, induce tight junction injury, and epithelial membrane leak in small bowel and colon epithelial membrane.
[Self-Funded Original Research]
(Under Review J Gastroenterology). -
Protection against Gluten-mediated Tight Junction Injury with a Novel Lignite Extract Supplement.
J Nutr Food
Gildea J, Roberts D, Bush ZM (as Senior/corresponding author).
Protection against Gluten-mediated Tight Junction Injury with a Novel Lignite Extract Supplement.
[Self-Funded Original Research]
J Nutr Food
Sci 2016, 6:5 -
Protective Effects of Lignite Extract Supplement on Intestinal Barrier Function in Glyphosate-mediated Tight Junction Injury.
BioMed Central – Public Health
Gildea J, Roberts D, Bush ZM (as Senior/corresponding author).
Protective Effects of Lignite Extract Supplement on Intestinal Barrier Function in Glyphosate-mediated Tight Junction Injury.
[Self-Funded Original Research]
(Under Review - BioMed Central – Public Health).
Projects
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NIH LRP Grant: Neuroimaging, Inflammation, and Endocrine Profiles in Human Subjects with Major Depressive Disorder.
NIH LRP Grant.
Neuroimaging, Inflammation, and Endocrine Profiles in Human Subjects with Major Depressive Disorder.
PI: Bush ZM.
July, 2007 -
Individual Ruth L. Kirschstein National Research Service Award
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Individual Ruth L. Kirschstein National Research Service Award (NRSA) 1-F32-DK082159-01.
Retinoic Acid Receptors: A Novel Therapeutic Target for Cushing’s Disease.
PI: Bush ZM.
Funding period: August, 2008 – July, 2010
$115,560 direct cost -
NIH LRP grant
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NIH LRP grant: PI: Bush ZM.
July, 2008 - June 2010.
$55,508 direct cost -
CTSA Novel Pilot Study Award
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CTSA Novel Pilot Study Award. Retinoid- Mediated Apoptosis: a novel therapeutic approach to the management of Cushing’s disease. Author and lead investigator: Bush ZM.
Faculty Sponsor: Mary Lee Vance.
Funding cycle 3/09-03/10, potential for renewal.
$25,000 direct cost -
ACP Leadership: Associate Physician Delegate, 5th Congressional District, Virginia
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Represented 5th district on Capitol Hill, May, 2008 and May, 2009
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Institutional Ruth L. Kirschstein National Research Service Award
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Institutional Ruth L. Kirschstein National Research Service Award (NRSA) 1-T32-DK07646. PI: Robert Carey.
Funding period: September, 2007- July, 2008.
$47,000 direct cost support -
COUP-TFI and COUP-TFII expression in breast cancer cell lines, opportunities for apoptotic synergy.
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COUP-TFI and COUP-TFII expression in breast cancer cell lines, opportunities for apoptotic synergy. I have demonstrated decreased expression of COUP-TFI and COUP-TFII in two post-menopausal cell lines
(MCF-7 and a Tamoxifen-resistant line), with complete absence noted in pre-menopausal ICI-resistant cells. This finding not only identifies tumor populations that may be vulnerable to retinoic acid therapy, it also opens an avenue to explore pharmaceutical regulation of COUP-TF expression…COUP-TFI and COUP-TFII expression in breast cancer cell lines, opportunities for apoptotic synergy. I have demonstrated decreased expression of COUP-TFI and COUP-TFII in two post-menopausal cell lines
(MCF-7 and a Tamoxifen-resistant line), with complete absence noted in pre-menopausal ICI-resistant cells. This finding not only identifies tumor populations that may be vulnerable to retinoic acid therapy, it also opens an avenue to explore pharmaceutical regulation of COUP-TF expression, which would have the potential to open up a broad array of solid tumors for adjuvant therapy with retinoic acid.
PI: Bush ZM.
Current collaborators: Richard Santen, MD. Ping Fan, PhD. Sarah Aiyar, PhD -
Human Corticotroph Adenomas: Expression of RAR, RXR, COUP-TF, PPAR-gamma and Caspase 3 activity in corticotroph cells.
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IRB#13313 Human Corticotroph Adenomas: Expression of RAR, RXR, COUP-TF, PPAR-gamma and Caspase 3 activity in corticotroph cells.
PI: Bush ZM -
Hyperlipidemic pancreatitis in HIV patients; the effects of protease inhibitor related hypertriglyceridemia.
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Department of Endocrinology, University of Colorado Health Science Center, 2001-2002.
Topic: Hyperlipidemic pancreatitis in HIV patients; the effects of protease inhibitor related hypertriglyceridemia.
Mentors: Lisa Kosmiski, MD and Robert Eckel, MD -
Preoperative Bexarotene Treatment for Cushing’s Disease.
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IRB#13369; GCRC #2335.
Preoperative Bexarotene Treatment for Cushing’s Disease.
Author and lead scientific investigator: Bush ZM.
PI: Vance
ML (faculty PI required for GCRC study). -
Prevalence of Vitamin D deficiency among patients with pituitary tumors.
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IRB-HSR # 3943 Prevalence of Vitamin D deficiency among patients with pituitary tumors.
Co-author and Co-investigator: Bush ZM.
PI: Michael Thorner, MD, DSc -
Retinoic Acid Receptors: A Novel Therapeutic Target for Cushing’s Disease.
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Author and lead investigator: Bush ZM. Mentors and Collaborators: Mary Lee Vance M.D., Beatriz Lopez, M.D., Ph.D., Isa Hussaini Ph.D. John Jane, Jr, M.D., Edward Oldfield,
Salary Support from NIH F32 NRSA grant.
PI: Zachary Bush.
Direct Costs: Umfrid neuroendocrinology
Research Grant. PI: Mary Lee Vance; John Jane, Jr. -
Umfrid Neuroendocrinology Research Fund
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Umfrid Neuroendocrinology Research Fund.
PI: Mary Lee Vance and John Jane, Jr.
$107,000
Honors & Awards
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UVA Novel Translational Research Award
Clinical and Translational Science Awards
CTSA Pilot Study award for my proof-of-concept clinical trial: Preoperative Bexarotene treatment for Cushing’s disease.
One faculty awardee each year.
$25,000. -
ENDO 08 Trainee Poster Competition
Endocrine Society
Winner ENDO 08 Trainee Poster Competition
Pituitary Diagnostics and Disease Management Section
Immunohistochemisty of COUP-TFI: an Adjuvant Diagnostic Tool for the Identification of Corticotroph Microadenomas.
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House Staff Resident/Fellow Teaching Award 2005-2006
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I received a House Staff Resident/Fellow teaching award for 2005-2006.
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Nominee: Inpatient Teaching Attending of the Year
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I was nominated for the Inpatient Teaching Attending of the Year for 2005-2006.
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Associates Abstract Contest
Virginia American College of Physicians (ACP)
Awarded in 2004 for Warfarin skin necrosis in a patient with antiphospholipid syndrome, a case report.
Presented at Regional and National ACP meetings spring of 2004. -
Resident/Fellow Teaching Award
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Nominee for 2004-2005.
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Associates Research Poster Competition
Virginia American College of Physicians (ACP)
The prevalence and associated etiologies of acute pancreatitis in the HIV-infected population before and after the introduction of protease inhibitors.
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James Waring Award
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Awarded to the third-year medical student who has demonstrated diligent scholarship and devotion to the field of Internal Medicine”
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The Levitt Prize
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1st place recipient, University of Colorado; a University-wide competition among all literature courses – winning entry argumentative essay
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Basic Science Honors
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Anatomy, Cell Biology, Neurobiology, Embryology, Biochemistry of Nutrition, Immunology, Epidemiology/ Statistics
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Clinical Honors
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Internal Medicine, Internal Medicine Sub-Internship, Family Medicine, Pediatrics, General Surgery, Obstetrics/ Gynecology, Neurology, Psychiatry, Emergency Medicine, Endocrinology, Rheumatology, Hospice, Cardiac Diagnostics
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Deans List
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I was honored to be part of the Dean’s List during every semester of my Undergraduate degree.
Languages
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Spanish
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English
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Organizations
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Medicine Grand Rounds, UVA
Invited Lecturer
-“Glycemic Control in DM2, How Low Should You Go? DISCORD over ADVANCE and ACCORD.” An invitation typically reserved for UVA and visiting faculty
Recommendations received
3 people have recommended Zach
Join now to viewMore activity by Zach
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Join us LIVE this Wednesday, January 17th at 3pmEST / 12pmPST, for the very first Global Health Education Summit of 2024 on the topic of DIABETES.
Join us LIVE this Wednesday, January 17th at 3pmEST / 12pmPST, for the very first Global Health Education Summit of 2024 on the topic of DIABETES.
Shared by Zach Bush, MD
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Here in the Netherlands at the Regenerative Agriculture & Food Systems Summit this week and the conversation so far at the event has been about the…
Here in the Netherlands at the Regenerative Agriculture & Food Systems Summit this week and the conversation so far at the event has been about the…
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Disorder and disease do not define the whole you. No matter what condition you are living with, you are inherently a 99.999% healthy…
Disorder and disease do not define the whole you. No matter what condition you are living with, you are inherently a 99.999% healthy…
Shared by Zach Bush, MD
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Earth Day Panel Webinar l Now Open for Registration There has never been a more critical year to understand how this era of chemical mega-farms has…
Earth Day Panel Webinar l Now Open for Registration There has never been a more critical year to understand how this era of chemical mega-farms has…
Shared by Zach Bush, MD
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F*CK SUSTAINABILITY – THE FUTURE IS REGENERATION Being sustainable is no longer enough - it’s time for regeneration and we need your…
F*CK SUSTAINABILITY – THE FUTURE IS REGENERATION Being sustainable is no longer enough - it’s time for regeneration and we need your…
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“Our own health and the health of the land are inextricably intertwined [but] in the last 70 years, this relationship has been broken,” said the…
“Our own health and the health of the land are inextricably intertwined [but] in the last 70 years, this relationship has been broken,” said the…
Liked by Zach Bush, MD
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This conversation with goop is one I've been excited to share with you and it's officially live: How Soil Health Is Reflected in The Gut
This conversation with goop is one I've been excited to share with you and it's officially live: How Soil Health Is Reflected in The Gut
Shared by Zach Bush, MD
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Los Angeles: I'm honored to moderate an upcoming public discussion with my friend Sanjay Gupta on April 3 as part of LiveTalksLA. It’s going to be…
Los Angeles: I'm honored to moderate an upcoming public discussion with my friend Sanjay Gupta on April 3 as part of LiveTalksLA. It’s going to be…
Liked by Zach Bush, MD
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One of my favorite podcast conversations to date. Thank you for the opportunity and infinite support Rich Roll.
One of my favorite podcast conversations to date. Thank you for the opportunity and infinite support Rich Roll.
Shared by Zach Bush, MD
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