Actylis’ Post

Having spent years in wet chemistry labs, I've observed that staff tend to stick to familiar protocols, even if they aren't the most efficient. This makes introducing changes challenging, despite their potential to improve operations. It highlights the crucial need to establish and maintain an efficient lab environment. Adopting Continuous Improvement methodologies like Six Sigma, Lean, Kaizen, and others plays a key role in achieving streamlined operations within the lab. If you are curious to know how to implement Lean principles in a pharmaceutical QC lab, I encourage you to look at "Incorporating Lean Principles into Pharmaceutical QC Laboratory Design" published by NOVARTIS, BSM, Flad Architects, Foster Wheeler, JACOBS, and SANDOZ. #PharmaceuticalQAQC #ContinuousImprovement #SixSigma #Lean #Kaizen #LaboratoryOperations #WetChemistryLab

The quality and technology are inherent to our products, and our team is proficient in developing versatile dosage forms for global markets. Our personnel, equipped with comprehensive training, are adept at managing all types of formulations. With over 100 scientists holding master's degrees and PhDs, our team brings a wealth of knowledge and expertise to our research and development endeavors.   Our commitment to excellence is further exemplified by the strategic implementation of Design of Experiments (DOE) and Quality by Design (QbD) principles. Specifically, we have specialized drug delivery domain of Soft Gelatin Capsules with experts & technologists for handling complex product development and manufacturing technology enhancing our capabilities. This meticulous approach, guided by DOE and (QbD) methodologies, not only ensures highest quality in our formulations but also contributes to the establishment of a world-class Research and Development facility at Strides Pharma. #synergICE #ResearchAndDevelopment #DosageForms #RnDExcellence #PharmaIndustry

There are a number of key considerations when a project reaches larger scale production, including compliance, safety, quality, cost and more. In the below blog, we explore the key elements of successful pharmaceutical production and discuss how project teams can work to overcome challenges. #Engineering #Manufacturing #DrugManufacture #CDMO #PDMO #WeAreSterling

Calibration and performance checks of analytical balances are crucial for maintaining accuracy and reliability in pharmaceutical quality control. 📖 Our latest article delves into best practices for adhering to Good Weighing Practice (GWP), ensuring compliance with regulatory standards, and delivering precise results every time. 🔍 Discover how regular calibration helps detect and correct deviations caused by aging, environmental factors, and more. Stay ahead in the industry by implementing these essential practices. 👉 Read the full article and ensure your lab maintains the highest standards of precision and compliance. #GMPInsiders #Pharmaceuticals #QualityControl #AnalyticalBalances #Calibration #GoodWeighingPractice #GWP #LabManagement #Compliance #Precision

📚What is 𝐋𝐀𝐒𝐓 𝐓𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐲? And what are they doing?🤔 🎥Watch this video and learn more about one of our successful business partners, LAST TECHNOLOGY, the leading process equipment designer and manufacturer for the medical, research, and pharmaceutical industries, Engineering, custom automation, and industrial process management. ☑️𝐋𝐀𝐒𝐓 𝐓𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐲 has been in the field of industrial engineering for over a decade, we deal with the development of unique machines and the handling of projects with a high technical level. ☑️𝐋𝐀𝐒𝐓 𝐓𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐲 integrated design takes into account all aspects of the product life cycle, from prototype to product launch and validation, integrating all technological and normative aspects. ☑️Project management strengthened by field experience and solid technical know-how. 📌For more details, visit:‎ www.lasttechnology.it/ 📌Follow us on LinkedIn lnkd.in/drvyxjp #Lasttechnology #Innoxengineering ‎#Pharmaceutical #Pharma #Pharmaceuticals #Pharmaceuticalindustry #Laboratory #containment #pharmaindustry #GMP #autoclaves #sterilizer #RSA #steamautoclave #decontamination #Dryheatsterilizer #Healthcare #LABsterilizer #labequipment #lab #cGLP #dpb #H2O2 #sterilization

Any manufacturing industry that wants to advance in the production process must first digitalize. In order to minimize costs, increase productivity and efficiency, and be adaptable to changes, the digitalization process entails switching from traditional paper-based systems to applications that use automation and computerization. However, the pharmaceutical industry has resisted digitization, mostly because of its lack of experience and the complexity of the development and manufacturing procedures involved.   Here's an example to help you understand: if an event or deviation occurs in the manufacturing process, the investigation should be closed within 30 days. why 30 days because, the investigation process requires the review of extensive documentation, such as log books, BMRs, and BPRs, in order to distinguish between different CPPs and CQAs. Digitizing the processes will reduce the amount of time needed to collect and compile the data, allowing for the identification of differences in minutes as opposed to days.

Obtaining desired particle attributes of drug substances reproducibly in production is technically very demanding. It requires multidisciplinary knowledges and experiences, especially in physical chemistry, chemical engineering, material sciences, process analytics, pharmaceutical regulations, etc. The team of Center for Pharma Crystallization at Porton has been built to address such challenges and delivered countless high standard solutions for obtaining desired particles attributes via controlled crystallization and/or precipitation processes. We strive to provide highly customer focused and efficient R&D services in addressing crystallization/precipitation challenges for drug development programs worldwide. #particleattributes #drugsubstance #crystallization #precipitation #centerforpharmacrystallization #porton #portonpharmasolutions

Technology transfer Series: (Part 4): 3) Comparison Report: During the transfer of pharmaceutical technology, the Receiving Unit must take certain vital actions in order to generate a comparability report. First, a thorough assessment of the machinery, manufacturing procedures, and analytical techniques used by the source unit is carried out. This assessment aids in locating any possible discrepancies or gaps between the receiving and source units. Second, a comprehensive evaluation of the product's critical quality attributes (CQAs) is carried out. This entails examining the drug substance's or product's stability and impurity profiles in addition to its physical, chemical, and biological properties. Any differences or inconsistencies can be found and fixed by contrasting these qualities with the specified requirements. After that, a thorough risk assessment is carried out to determine how any discrepancies or gaps might affect the product's quality, safety, and efficacy. This stage aids in setting priorities and estimating the amount of work needed to close any gaps and guarantee comparability. After the risk assessment, a thorough plan is created to close the gaps found and guarantee comparability. This approach could involve equipment upgrades, process changes, method validations, or even more research to show that the source and receiving units are equivalent. The comparison report, which summarizes all the conclusions, actions done, and supporting information, is then finalized. This report shows the strength of the technology transfer process and is an essential document for regulatory filings.#technologytransfer #productdevelopment #processoptimization #learninganddevelopment Pic Courtesy: https://lnkd.in/dxv--5R6

Manufacturing efficiency can be drastically improved by clear indications of the areas in the process flow. clear labeling of areas are key to process oriented manufacturing. #industrialsigns #processindicatior#processlocationsigns #asktheisignlady #signaramacbd #Thalessg