Society for Biological Engineering (SBE)’s Post

We have successfully completed the project funded by Innovate UK titled: ‘Extending Mironid's PDE4 activator programme: Hyperparathyroidism as a second clinical indication’. Our findings were presented at the project close-out meeting by Caitlin Moore, one of our Biology Research Scientists, with others from our team in attendance. Read our blog to find out more about the project and the next steps: https://lnkd.in/eSgcS-gF #HPT #biopharma #drugdevelopment 

Have you registered for this upcoming live webinar entitled "The Balance of Safety and Efficacy: Understanding Target Antigen Density in Cancer Treatments with the IndEx-2 Inducible Cell Line Platform"?

Great news to share! Following my graduation from Wageningen University, our publication "Type III-B CRISPR-Cas cascade of proteolytic cleavages" was published in Science last week. Congratulations to Jurre Steens, Jack Bravo, Carl Raymund Salazar and the rest of the team! Take a quick look here: https://lnkd.in/eEX8uhyy In our work, we characterize a set of associated genes of a CRISPR-Cas type III-B system from Haliangium ochraceum that contains two caspase-like proteases, SAVED-CHAT and PCaspase (prokaryotic caspase). The activation of the system is signaled by cyclic oligoadenylates (cA3), generated upon target recognition by the type III-B system, which cause the oligomerization/activation of the first protease, and in result, the activation of the second by cleavage. The activated PCaspase then cleaves a multitude of proteins, which results in a strong interference phenotype in vivo in Escherichia coli. I would like as well to thank once again my supervisors and mentors Dr. Raymond Staals and Carl Raymund Salazar, for trusting me a part of this project and for giving me the opportunity to be a part of this great publication. By completing this milestone at WUR, I am looking forward to for a PhD position, so I can continue doing what I feel passionate about, and that is research! #Crispr #Cas10 #Science

Currently, the number of compounds available for human drug development is limited. For this reason (and others), bioprospecting plays a dominant role in the discovery of leads for drug development. In addition, marine resources have become very promising as they are largely undiscovered and can provide chemical novelty and complexity that can be enhanced by scientists. That is where EUREMAP comes in. We aim to harness the existing strengths in marine bioprospecting in Europe and create a new pipeline that aligns and integrates the technical capacities of four major European Research Infrastructures EU-OPENSCREEN, EMBRC - European Marine Biological Resource Centre, EMBL and ELIXIR. Together, we will build a new European transnational service platform for marine natural product discovery and catalyse academic and industrial competitiveness! UiT Norges arktiske universitet | Fundacion MEDINA | Universiteit Gent | Tel Aviv University | Helmholtz Centre for Infection Research | SINTEF | Centre of Marine Sciences (CCMAR) | Consiglio Nazionale delle Ricerche | Sorbonne Université | European Research Executive Agency (REA) | Stazione Zoologica Anton Dohrn | Centre national de la recherche scientifique

Phosphorylation is one of the most important post-translational modifications (PTMs) of proteins, governing critical protein functions. This research delves deeper into the significance of phosphorylation, the most important post-translational modifications (PTMs) of proteins, governing critical protein functions. Di Y, Li W, Salovska B, et al present an optimized Phos-DIA protocol, from sample preparation to bioinformatic analysis, along with practical considerations and experimental configurations for each step. The protocol is designed to be robust and applicable for both small-scale phosphoproteomic analysis and large-scale quantification of hundreds of samples for studies in systems biology and systems medicine. Read the full article 👉https://lnkd.in/egDDPjD2 #Phosphoproteomics #Bioinformatics #ResearchInnovation

The Future is BioMolecular: The Biomolecular Horizons Congress https://lnkd.in/eBbsCpJ8 #FEBSnet #ComBio2024 @IUBMB #FAOBMB @BMH2024Melb https://t.co/pE7D5NXtbz

“The more I learn, the more I realize how little I know – Albert Einstein” Heartfelt gratitude to the organizing committee of the National conference “Antimicrobial Resistance Trends, Environmental Microbiology and Industrial Solutions (ARTEMIS)” Organized by The Department of Biotechnology and Bioengineering, Institute of Advanced Research, Gandhinagar on March 21-22, 2024 (supported by GSBTM, DST and SERB-India) for giving me the opportunity to share a fraction of my scientific knowledge as the youngest invited speaker. Glimpse of the entitled Talk “Molecular imprinting of Staphylococcus aureus in polyacrylamide gel slab for detecting the presence of the bacteria as a contaminant”: 1.      Why Staphylococcus aureus was chosen for detection? 2.      Which are the conventional methods for detecting Staphylococcus aureus? 3.      What is molecular imprinting? 4.      Which are the Factors affecting molecular imprinting? 5.      Detailed discussion on the proposed fabrication method, its miniaturised model and characterization.

I had the privilege of attending American Society for Microbiology and presenting a poster on my project. It was an amazing experience of getting to learn about well-known scientists research, and sharing ideas with other incredible researchers. My project focuses on the effects of gut-microbiome-derived compounds on V. cholerae behavior. I would like to thank the department of Molecular Biosciences at KU, and my advisor, Dr. Caetano Antunes for supporting me in this journey. #ASMicrobe #gut_microbiome #host_pathogen_interactions

At the Frederick National Laboratory we do science that affects us all, the potential is limitless, both yours and ours. We empower our teams to foster discovery, work together, and lead with empathy to solve the scientific challenges of national importance. Let’s have a conversation to discus how we can make that happen… https://bit.ly/3PdKKzB #Bioinformatics

At the Frederick National Laboratory we do science that affects us all, the potential is limitless, both yours and ours. We empower our teams to foster discovery, work together, and lead with empathy to solve the scientific challenges of national importance. Let’s have a conversation to discus how we can make that happen… https://bit.ly/47U2AyL #Bioinformatics