Alumis’ Post

Obicetrapib, our next-generation, oral, once-daily, low-dose #CETP inhibitor, has helped clinical trial participants reduce LDL-C levels by 43-51% and treatment was well-tolerated with a safety profile comparable to placebo. Learn what makes our lead candidate different and potentially promising for the treatment of #ASCVD in this Current Atherosclerosis Reports article: https://bit.ly/3TvO8s1

Here the story of previous CETP inhibitors clinical development and Obicetrapib potentiality. An informative read.

In a significant medical breakthrough, the repurposing of anticancer drugs for Complex Lymphatic Anomalies (CLAs) has shown remarkable improvements in patient outcomes. Our latest our latest blog post featuring a case study that highlights the effectiveness of combination therapy. This pioneering approach provides new hope for managing these rare conditions. Read more about how these developments are reshaping treatment protocols. Read more: bit.ly/4cv3CCJ #RareDiseaseAwareness #ComplexLymphaticAnomalies #HealthInnovation #TreatmentAdvancement #rarediseases

We are evaluating the effectiveness of our investigational oral therapy for #ThyroidEyeDisease (TED) in a Phase 2b/3 clinical trial. Learn more about LIDS: https://lnkd.in/e4xE8anj

Novel microphysiological model for the renal proximal tubule - advantages and limitations for drug transport and toxicity screening. #ToxSpotlight #FreeToRead https://lnkd.in/dU5MTiYY

I've stressed this many times. Dose is critical when treating patients with HBOT. A great example is: At 2.8 to 3 ATA, Hyperbaric Oxygen inhibits neutrophil-endothelial cell adhesion in ischemia reperfusion injury. This works by inhibiting cGMP production and inhibiting the function of Beta-2 Integrin dependent neutrophil adhesion. We only see 50% of this reduction at 2.0 ATA. Dose Matters! #hyperbaricoxygentherapy #hbot #hyperbaricmedicine Undersea and Hyperbaric Medical Society

Intrathecal drug administration is typically used for the treatment of cancer-related chronic pain or muscle spasticity. Explore the challenges associated with repeatable delivery by intrathecal injection. Topics include the impact of anatomical differences of drug delivery, the impact of CSF flow dynamics on drug delivery and potential solutions for variability between subjects in intrathecal drug delivery. https://bit.ly/3yIHQgh

When it comes to drug treatment, clinical signs and symptoms speak volumes. They often correlate with drug and metabolite concentrations in serum, plasma, and whole blood. These specimens are valuable for various scenarios, including patients on dialysis, cases of suspected malabsorption (like post-gastric bypass), and assessing individual pharmacokinetics. Therapeutic and toxic ranges are typically established for serum, plasma, and whole blood specimens, aiding in precise treatment evaluation. But here's an important note: urine isn't suitable for Therapeutic Drug Monitoring (TDM). Trust Clarity Labs for comprehensive insights into drug treatment effectiveness because we know how much your health matters! 💙 #DrugTreatment #TherapeuticMonitoring #ClarityLabs

Precision-guided dosing is empowering data-driven treatment, enhancing drug durability & revolutionizing #IBD care. Register now for our “Empowering Precision in IBD” webinars to learn about the future of #Crohns and #UC treatment: https://lnkd.in/gyBwjbNV

When it comes to drug treatment, clinical signs and symptoms speak volumes. They often correlate with drug and metabolite concentrations in serum, plasma, and whole blood. These specimens are valuable for various scenarios, including patients on dialysis, cases of suspected malabsorption (like post-gastric bypass), and assessing individual pharmacokinetics. Therapeutic and toxic ranges are typically established for serum, plasma, and whole blood specimens, aiding in precise treatment evaluation. But here's an important note: urine isn't suitable for Therapeutic Drug Monitoring (TDM). Trust Clarity Labs for comprehensive insights into drug treatment effectiveness because we know how much your health matters! 💙 #DrugTreatment #TherapeuticMonitoring #ClarityLabs