Andras Nagy’s Post

I’m happy to share that our induced Allogenic Cell Tolerance (iACT) project has been published in Nature Biomedical Engineering. This achievement is a testament to the hard work and expertise of the shared first authors, Kristina Vintersten-Nagy, Huijuan Yang, Jeff Harding and all other co-authors. Their efforts, combined with the earlier developed FailSafe technology (PMID: 30429614), provide a promising pathway towards creating a cell source for off-the-shelf available, safe, immune-cloaked and universal therapeutic cells. Such could serve all humans suffering from diseases where cell therapy is an option without the need for immune suppression.The article is open access and available at: <https://lnkd.in/dJpzXdHJ>

We are excited to share our latest scientific publication “𝗖𝗵𝗮𝗺𝗯𝗲𝗿-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗰𝗼𝗻𝘁𝗿𝗮𝗰𝘁𝗶𝗹𝗲 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀 𝗼𝗳 𝗮𝘁𝗿𝗶𝗮𝗹 𝗮𝗻𝗱 𝘃𝗲𝗻𝘁𝗿𝗶𝗰𝘂𝗹𝗮𝗿 𝗵𝗶𝗣𝗦𝗖-𝗰𝗮𝗿𝗱𝗶𝗼𝗺𝘆𝗼𝗰𝘆𝘁𝗲𝘀 𝘁𝗼 𝗚𝗣𝗖𝗥 𝗮𝗻𝗱 𝗶𝗼𝗻 𝗰𝗵𝗮𝗻𝗻𝗲𝗹 𝗰𝗼𝗺𝗽𝗼𝘂𝗻𝗱𝘀: 𝗔 𝗺𝗶𝗰𝗿𝗼𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝘀𝘆𝘀𝘁𝗲𝗺 𝗳𝗼𝗿 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗱𝗿𝘂𝗴 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁” in collaboration with Axol Bioscience Ltd. and Nanion Technologies! Read the article to learn more about axoCells™ human iPSC-derived atrial and ventricular cardiomyocytes and their chamber-specific responses to GPCR and ion channel modulators on contractile level. By focusing on the unique properties of heart chambers, our research underscores the importance of chamber-specific cardiomyocytes for innovative and targeted treatments addressing diseases such as atrial fibrillation and cardiac hypertrophy. Get the paper here: https://lnkd.in/erGjVvaq #atrialfibrillation #cardiachypertrophy #iPS #cardiomyocytes #diseasemodel #publication #contractility #FLEXcyte96

Super proud to support good science by collaborating with innoVitro and Nan]i[on. Really nice WIN for all companies! Read the article to learn more about hiPSC-atrial and ventricular axoCells™ and their chamber-specific responses to GPCR and ion channel modulators on contractile level. By focusing on the unique properties of heart chambers, our research underscores the importance of chamber-specific cardiomyocytes for innovative and targeted treatments addressing diseases such as atrial fibrillation and cardiac hypertrophy. Get the paper here: https://lnkd.in/erGjVvaq #research #biotech #science #cellculture #drugdevelopment #pharma #ipsc #stemcells

CALL FOR PAPERS: https://lnkd.in/greSikwr Dear Colleagues, High-voltage technology and engineering play a fundamental role in the advancement of the life and physical sciences. In 1895, Wilhelm Röntgen generated laboratory X-rays using a high-voltage induction coil. Now, X-rays play a fundamental role in healthcare as both a diagnostic tool and in cancer therapies. Robert J. Van de Graaf and later John Cockroft and Ernest Walton built the first charged particle accelerators in the late 1920s and 1930s, respectively; their unique techniques were the foundation for generating mega-volt potentials. These innovations advanced our collective understanding of the atom. In just a century, high-voltage technology has come to serve as a basis for sterilization and controlling the uptake of drugs, managing pollutants, producing and transmitting energy efficiently, and for continuing research. For this Special Issue, we invite submissions exploring cutting-edge research and recent advances in the field of high-voltage technology and engineering, with an emphasis on scientific and commercial applications. Both theoretical and experimental studies are welcome, as well as comprehensive reviews and survey papers. Specific papers will be selected and highlighted as “invited” and will serve as the foundation for this Special Issue.

Our article in JACC:Basic to Translational Science

My academic poster- our current research: DNA-based Nanomedicine and Nanobiotechnology for the next generation of diagnostic and therapeutic nanodevices for cancer-related and inflammatory diseases 

We will always be surprised while studying and unraveling G-quadruplex diverse topologies. In our latest work published in Wiley Advanced Science, our group designed a DNA sequence that manages to fold into several coexisting quadruplex-duplex hybrids having different conformations governed by loop-loop interactions. To our "surprise", a ligand (Phen-DC3) manages to shift the equilibrium and induces a topological switch/refolding into the preferred topology upon recognizing a certain structural motif. On the bright side: This fact shows another example of G-quadruplexes and their conformational plasticity that can be exploited as a molecular switch / small-molecule aptamer. On the dark side: if ligand-induced refolding of G-quadruplex topology becomes more a common phenomenon, how should we look at the study of drug design for G-quadruplex targeting? Will docking remain a valid technique?

If you are in the southwest and building a flow panel, send me a message! #Flow #flowcytometry #cyto #starbrights #antibodies #spectral #research #immunology #cellbiology #science

We are thrilled to announce the Inaugural Johns Hopkins Research Symposium on Microphysiological Systems! This symposium will highlight the state-of-the-art of human microphysiological systems (e.g., organ chip, organoid, bioprinted tissue) technologies for disease modeling, drug discovery, and precision medicine. Government experts, researchers, and clinicians will gather to explore the latest advancements, share insights, and foster collaborations to drive transformative change in drug development and precision medicine. Highlights of the Symposium:  1) Keynote Address: Dr. Danilo Tagle, Director of the Office of Special Initiatives at the National Center for Advancing Translational Sciences, NIH. 2) Explore groundbreaking MPS research at Johns Hopkins, led by visionary engineers and scientists at the forefront of this rapidly developing field. 3) Engage with distinguished speakers from the NIH, FDA, NIST, and Johns Hopkins as they share insights into their MPS research. (Drs. Marc Ferrer, Nakissa Sadrieh, Mandy B. Esch, Peter Searson, Ramana Sidhaye, Deok-Ho Kim, Annie K., Vasiliki Machairaki, David Gracias, Lena Smirnova, Thomas Hartung, Sumin Lee) 4) Immerse participants in the future of MPS through a poster session, where young researchers showcase and discuss their exciting projects. Event Information ➡  https://lnkd.in/d3sGVD4f #MicrophysiologicalSystems #PrecisionMedicine #DrugDevelopment #MPS #organonachip #bioprinting #organoid

Leaving #sitc2023 today, richer in new insights into tumor microenvironment (TME), including evolving and emerging roles of B cells, CAFs, macrophage and ever elusive neutrophils; with rekindled love for importance of vascular biology, vascular normalization, high endothelial venule (HEV) role in TLS, and newly enhanced power of anti-VEGF approaches by engineering of anti-VEGF CAR-T; and with undying enthusiasm for synthetic biology approaches breaking through toward complex, programmable cell therapies; hoping to be back for more next year!