Andre Murad MD,MSc,PhD,PostDoc Oncogenômica/Oncogenética’s Post

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Diretor Executivo: Personal Oncologia de Precisão e Personalizada

Blood–brain barrier: A physical and biochemical boundary between the bloodstream and the parenchyma of the central nervous system (CNS). Composed of tightly bound vascular endothelial cells, surrounded by a basement membrane, and supported by astrocytes, pericytes, and microglia, the blood–brain barrier shields the CNS from viruses, bacteria, and neurotoxins. It also controls the movement of ions, molecules, and cells between blood and the CNS. The blood–brain barrier prevents 98% of small-molecule drugs and 100% of large-molecule drugs from entering the CNS through the bloodstream. To learn more about this concept, read “Sounding Out the Blood–Brain Barrier” by Kullervo Hynynen, Ph.D., from Sunnybrook Health Sciences Centre and University of Toronto: https://nej.md/41Jxg2V

Sounding Out the Blood–Brain Barrier | NEJM

Sounding Out the Blood–Brain Barrier | NEJM

nejm.org

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