Ann Boija, Ph.D.’s Post

🌟 Excited to Share Insights from AACR 2024! 🌟 Attended an enlightening session: "Engineering T cells to eradicate tumors," led by Philip D. Greenberg from Fred Hutchinson Cancer Center. The focus was on revolutionizing T-cell therapy to fight cancer more effectively, tackling the complex challenges and potential breakthroughs. Dr. Greenberg's presentation underscored the power of scientific innovation in overcoming obstacles in cancer treatment. It was a motivational reminder of how far we've come and the promising future that lies ahead in oncology research. Inspired and ready to contribute more to this vital field! Let’s connect if you're passionate about cancer research or have insights on T-cell therapy. The conversation around the future of oncology is one I'm eager to continue. #AACR2024 #CancerResearch #Oncology #Innovation #FredHutch

Check out this insightful article in Happiest Health by Dr. Chandandeep Kaur on the role of aged immune cells in cancer and the potential of clearing them out for effective cancer treatment. The summary is derived from paper published in Cancer Cell (https://lnkd.in/dCETXJam) showing how clearance of senescent macrophages ameliorates tumorigenesis in KRAS-derived lung cancer! https://lnkd.in/dUGXbZ7S

Melittin, a peptide found in bee venom, has shown potential in killing cancer cells through several mechanisms: 1. Membrane Disruption : Melittin integrates into the cell membranes of cancer cells, creating pores or disrupting the lipid bilayer. This leads to cell lysis, where the cell membrane becomes permeable and the cell contents leak out, causing cell death. 2. Induction of Apoptosis : Melittin can trigger programmed cell death (apoptosis) in cancer cells. It activates various signaling pathways that lead to the activation of caspases, enzymes that play a crucial role in the apoptosis process. 3. Inhibition of Cell Proliferation : Melittin can inhibit the proliferation of cancer cells by interfering with cellular signaling pathways that regulate cell growth and division. This can prevent the cancer cells from multiplying. 4. Inhibition of Angiogenesis : Melittin has been shown to inhibit the formation of new blood vessels (angiogenesis) that tumors need for growth and metastasis. By reducing the blood supply to the tumor, melittin can starve the cancer cells of necessary nutrients and oxygen. 5. Disruption of Cellular Signaling: Melittin can interfere with various signaling molecules and pathways within cancer cells, such as the PI3K/Akt pathway, which is often upregulated in cancer. This disruption can lead to reduced cell survival and increased sensitivity to other treatments. Overall, melittin’s ability to target cancer cells selectively while sparing normal cells is a key factor in its potential as an anti-cancer agent. However, further research and clinical trials are necessary to fully understand its mechanisms and to develop safe and effective therapeutic applications.

The research on how removing old, senescent immune cells can help manage the progression of lung cancer. This approach offers promising insights into more effective cancer therapies. Thanks to Sumeet Pandey, PhD, and Samir Morsli #happiesthealth #futureofhealth https://lnkd.in/dG_rAze7

Smoking Cessation services are essential to cancer treatment success and long term survival; essential for cancer prevention and cancer control.

Despite remarkable advances in cancer treatment in recent decades, cancer remains the leading cause of death. At #TeamBayer we are committed to fighting cancer and advancing our research to discover novel therapies. Our goal is to improve current treatments and develop new innovative therapies. In this #SciencePodcast you will learn more about the unsolved challenges facing cancer patients. Discover how genetic testing and artificial intelligence are revolutionizing cancer diagnosis and immunotherapies can transform cancer treatment.

Unlocking the Cancer Code: The Impact of the Human Genome Project Discover how the Human Genome Project decoded our DNA, revolutionizing cancer treatment. Learn about precision medicine and the game-changing breakthroughs in immunotherapy. Stay informed and empowered in the fight against cancer. #CancerResearch #GeneticAdvancements #PrecisionMedicine #ImmunotherapyBreakthroughs #HumanGenomeProject #CancerTreatment #MedicalRevolution #DNAUnraveled #ScienceAndHealth #FightAgainstCancer

A ray of hope in cancer research: A melanoma cancer vaccine with minimal side effects is nearing phase 3 trials. 💉🔬 ◾ This promising development could significantly advance melanoma treatment, offering new hope to patients worldwide. ◾ As we navigate the complex landscape of cancer research, each breakthrough brings us one step closer to a cure. 💡🌐 ◾ Join us as we discuss this significant advancement and its potential impact on cancer treatment. #CancerResearch #MelanomaVaccine #MedicalBreakthrough https://lnkd.in/eXzEFcis

🔬We'd like to share information about a cancer research experiment currently being conducted in our research labs in Wattwil. 🌱Extract of the plant Laminaria is being tested on a breast cancer cell line panel for its impact on cancer development. We would like to know if Laminaria can influence epigenetic mechanisms involved in development of cancer. The general aim of the experiment is to investigate changes in miRNA expression levels using plant extracts. 💡Exosomal miRNAs and exosomes are now one of the most promising approaches for cancer diagnosis and target treatment.

🔬 Highlighting TAR-200: Prof. Andrea Necchi's Perspective on Cancer Treatment Advances Oncology Frontier brings you an insightful overview of the TAR-200 delivery system, a promising development in cancer therapy, through the lens of Professor Andrea Necchi's expertise. As a distinguished figure in oncological research, Professor Necchi's analyses and perspectives are invaluable in understanding the significance of TAR-200 in modern cancer treatment. Dive into our feature to discover how this innovative system could revolutionize oncology. 🔹 What are the unique benefits of TAR-200 in cancer therapy, as explained by Professor Necchi? #OncologyInnovation #TAR200 #CancerResearch #MedicalAdvances #ESMO #HealthcareFuture