📣 Using cryo-electron tomography, Team Harper found an amorphous aggregate phase exists next to polyQ aggregates in cultured cells in-situ. Autophagosomes preferentially interacted with the amorphous phase, preventing interaction with the polyQ aggregates. Check out Team Harper's publication to read more about their findings. https://lnkd.in/eAu8Mh9F
Aligning Science Across Parkinson’s | ASAP’s Post
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Medicinal Chemistry, Organic Chemistry; CoFounder at SAFF Chemical Reagent, Alkin Kimya, Chaphy Therapeutics
I'm pleased to share the publication of our most recent study. You could read that a few particular cell organelles have been stained by our newly developed ESIPT-based ligand. Through the excited state intramolecular proton transfer (ESIPT) mechanism, the proposed ligand is able to emit fluorescence. The ligand has the ability to label cells using both red and green fluorescence https://lnkd.in/gXnFizCr
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New 3i Investigator Article Alert!! Transforaminal lumbar interbody fusion subsidence: computed tomography analysis of incidence, associated risk factors, and impact on outcomes https://lnkd.in/g2hHj6ht
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Cryo-CLEM users, have you signed up to our webinar yet? https://bit.ly/3vWNR8g Learn how to improve the efficacy of fluorescence guided cryo-FIB with enhanced FM systems! #CryoFIB #CryoCLEM #Microtubules
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Molecular Beacon probes are dual-labelled probes that form a stem-loop (hairpin) structure, bringing the reporter and quencher into proximity. The loop region contains the sequence that hybridises to the target sequence, while the complementary sequences at both ends of the probe form the stem. These probes generate fluorescence under non-hydrolytic conditions via hybridisation to the target. Learn more in the video below: https://hubs.li/Q02q8qPJ0
Try Molecular Beacons for your multiplex assay
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"Protocol for measuring cell cycle Zn2+ dynamics using a FRET-based biosensor" "The exchangeable Zn2+ pool in cells is not static but responds to perturbations as well as fluctuates naturally through the cell cycle." The authors "present a protocol to carry out long-term live-cell imaging of cells expressing a cytosolic Zn2+ sensor." https://lnkd.in/gyjCayrA #livecellimaging
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This Microscopy Monday features anti-Cofilin 1 (red)(https://bit.ly/49dnxoZ), Flash Phalloidin™ Green 488 (green)(https://bit.ly/3QNor4B) staining of HeLa cells captured by a Revvity Operetta CLS™ High Content Analysis System. Explore more: (https://bit.ly/3WevbIC) #Revvity
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Technology Pioneer | Innovative Biotechnology Leader | ~ Translating Innovations to Diagnostic and Therapeuti Solutions
The ability of UL-FVIII to keep activity higher is fantastic news! This suggests that the clots formed may be more stable (resistant to lysis) as suggested by the works of Weisel et al. The next question to be addressed is the one relating to immunogenicity. #clots
The development of an Ultra-Long modified factor VIII, efanesoctocog alfa, extends beyond traditional factor VIII by utilizing advanced techniques like Fc fusion and hydrophilic polypeptides, offering prolonged correction of FVIII levels. This breakthrough allows patients to manage their condition with fewer constraints, marking a new era in hemophilia care. https://lnkd.in/gU_3rGub Cedric HERMANS MD PhD FRCP (Lon,Edin) | Glenn Pierce
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