Antibody Basics: Hybridoma Sequencing ๐งฌ ๐งช What is it? Hybridoma sequencing is the sequencing of the variable heavy (VH) and variable light (VL) domains of monoclonal antibodies produced from a hybridoma cell line. ๐ก Why does it matter? Hybridoma technology revolutionized the field of antibody drug discovery by enabling the mass production of monoclonal antibodies to an antigen of interest. However, it has its limitationsโcontamination risks, low yield, and storage constraints. Hybridoma sequencing overcomes these challenges and prevents the loss of hybridoma cell lines. Biointron's hybridoma sequencing service offers fast turnaround times (1 week to deliver sequencing results after receiving the hybridoma cell line), and guaranteed 100% sequence accuracy (cross-verified with five independent clones).ย https://lnkd.in/ecs76rrh #Biointron #Antibodies #DrugDiscovery #Education #Hybridoma
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๐๐๐ฐ! ๐๐ฆ๐๐ฅ๐ฅ-๐๐๐๐ฅ๐ ๐๐ง๐ญ๐ข๐๐จ๐๐ฒ ๐๐ฑ๐ฉ๐ซ๐๐ฌ๐ฌ๐ข๐จ๐ง ๐๐๐๐ค๐๐ ๐๐ฌ! Biointron offers a new choice for your small-scale antibody expression rush needs. ๐๐ง๐ญ๐ซ๐จ๐๐ฎ๐๐ข๐ง๐ ๐๐ฎ๐ฌ๐ก๐๐๐ยฎ : ๐ก ๐๐๐ฌ๐ข๐ ๐ง๐๐ ๐ญ๐จ ๐๐ ๐๐จ๐ฌ๐ญ-๐๐๐๐๐๐ญ๐ข๐ฏ๐ ๐๐ง๐ ๐ญ๐ข๐ฆ๐-๐ฌ๐๐ฏ๐ข๐ง๐ โก ๐๐ฌ ๐๐๐ฌ๐ญ ๐๐ฌ ๐ ๐๐๐ฒ๐ฌ ๐งช ๐๐จ๐ซ๐ ๐ญ๐ก๐๐ง ๐,๐๐๐ ๐ฌ๐๐ฆ๐ฉ๐ฅ๐๐ฌ ๐ ๐๐ฑ๐ฉ๐ฅ๐จ๐ซ๐ ๐๐ข๐๐๐๐ซ๐๐ง๐ญ ๐ฌ๐๐๐ฅ๐๐ฌ ๐๐ซ๐จ๐ฆ ๐๐ฎ๐ฉ๐๐ซ, ๐๐ญ๐๐ง๐๐๐ซ๐, ๐๐ง๐ ๐๐ข๐ง๐ข Now adding ๐๐ฎ๐ฌ๐ก๐๐๐ยฎ - ๐๐๐ง๐, with 100 ug transfection grade expression plasmids ready in only 4 days! For more details, visit our website: https://lnkd.in/gbgdjSYe Contact us at [email protected] or +1 (732) 790-8340, or DM our LinkedIn homepage RIGHT NOW! #Biointron #Antibodyexpression #antibodydiscovery #antibodytherapeutics #purifiedantibody #antibodyproduction
Small Scale Antibody Expression in 4 Days - Biointron RushMabยฎ
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Find the antibody for your project, exploreย Biointron's rich antibody product portfolio, and take advantage of our 40% sitewide discount! ๐ Save on your project with Biointron! Click here ๐ https://lnkd.in/eSw3_Qpa โ ๐๐๐ง๐๐ก๐ฆ๐๐ซ๐ค ๐๐จ๐ฌ๐ข๐ญ๐ข๐ฏ๐ ๐๐ง๐ญ๐ข๐๐จ๐๐ฒ ๐ ๐๐ฌ๐จ๐ญ๐ฒ๐ฉ๐ ๐๐๐ ๐๐ญ๐ข๐ฏ๐ ๐๐ง๐ญ๐ข๐๐จ๐๐ฒ ๐ญ ๐๐ง๐ญ๐ข-๐๐จ๐ฎ๐ฌ๐ ๐๐ง๐ญ๐ข๐๐จ๐๐ฒ โ ๐๐ข๐ฌ๐ฉ๐๐๐ข๐๐ข๐ ๐๐ง๐ญ๐ข๐๐จ๐๐ฒ ...and more! #Biointron #Abinvivo #reagents #invivo #antibodies #proteins
Abinvivo - A Biointron Brand Dedicated to Antibodies for In Vivo Research!
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๐ ๐๐ฎ๐ซ ๐ฅ๐๐ญ๐๐ฌ๐ญ ๐๐ซ๐ญ๐ข๐๐ฅ๐ ๐๐๐ฅ๐ฏ๐๐ฌ ๐ข๐ง๐ญ๐จ ๐ญ๐ก๐ ๐๐ฉ๐ฉ๐ฅ๐ข๐๐๐ญ๐ข๐จ๐ง๐ฌ ๐๐จ๐ซ ๐๐ง๐ญ๐ข๐๐จ๐๐ข๐๐ฌ ๐๐ฌ ๐ญ๐จ๐จ๐ฅ๐ฌ ๐ก At Biointron, we specialize in antibody production and discovery โ dedicating ourselves to advancing human health and promoting sustainability with more than 10 years of experience and over 1500 customers globally. We offer premium solutions at competitive rates, all anchored in our commitment to a brighter and healthier future. Read the article here: https://lnkd.in/dFFXaY6d #Biointron #Antibodies #Abinvivo #DrugDiscovery #Research
Antibodies: Applications as Tools
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๐ ๐๐จ๐ง๐ญ๐ก ๐๐ข๐ฅ๐ฅ ๐๐๐ ๐๐๐ฉ๐๐ง ๐๐๐๐!ย The Biointron team will be waiting for you at Yokohama! ๐ Date: October 9-11, 2024 ๐ Location: Pacifico Yokohama | Yokohama, Japan ๐ฌ Booth #D-28 Schedule a 1-on-1 meeting spot with our expert team. Let's discuss how we can accelerate your projects! ๐ https://lnkd.in/g-miu5-h #Biointron #BioJapan #BIO #biotech #antibody #lifescience
Schedule a meeting with the Biointron team at BIO Japan 2024 in Yokohama!
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โก ๐๐ข๐ ๐ก๐ญ-๐ญ๐ก๐ซ๐จ๐ฎ๐ ๐ก๐ฉ๐ฎ๐ญ ๐ ๐ฎ๐ฅ๐ฅ๐ฒ ๐๐ฎ๐ฆ๐๐ง ๐๐ง๐ญ๐ข๐๐จ๐๐ฒ ๐๐ข๐ฌ๐๐จ๐ฏ๐๐ซ๐ฒ ๐ข๐ง ๐ ๐๐จ๐ง๐ญ๐ก๐ฌ! โณExperience the unparalleled ๐๐๐๐ซ๐จ๐ฉโข timeline from Biointron: Millions of plasma B cells are screened - ๐ ๐ท๐ด๐ NGS sequencing & data analysis - ๐ ๐๐ธ๐ธ๐พ Hundreds of naturally paired heavy & light chains are obtained - ๐ ๐๐ผ๐๐ธ From screening to purified antibodies with validated activity - ๐ ๐๐๐๐๐ป Learn more about this at our website: ๐ https://lnkd.in/gDzW6SrM Or contact us ๐ +1(732)790-8340 | ๐ฉ [email protected] Let's discuss how we can accelerate your antibody discovery! #Biointron #Cyagen #humanantibody #antibodydiscovery #singlebcell
Hight-throughput Fully Human Antibody Discovery in 3 Months!
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A recent review describes practical insights into AI-accelerated therapeutic antibody development ๐ค Recent Artificial Intelligence (AI) breakthroughs have enabled information-richย in silicoย representations of antibodies, accurate prediction of antibody structure from sequence, and the generation of novel antibodies tailored to specific characteristics to optimize for developability properties. The review highlights key AI models like Antibody Language Models (ALMs) and folding models, showing how they improve the efficiency of antibody discovery while emphasizing practical considerations like model licenses for industry application. Despite progress, challenges remain, especially in addressing solubility and viscosity due to limited experimental data. AIโs integration in drug development holds promise for faster, more cost-effective therapeutic innovations. Read the full paper here ๐ https://lnkd.in/eVBUe4W7 #Biointron #Antibodies #AI #DrugDevelopment #DrugDiscovery #Technology Study by Luca Santuari et al.
Frontiers | AI-accelerated therapeutic antibody development: practical insights
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#BiointronWeeklyReports Read our recap of this weekโs news in the antibody industry!ย ย #Biointron #Antibodies #Immunotherapy #PharmaNews #DrugDevelopmentย
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Explore Abinvivo, aย Biointronย brand dedicated to providing antibodies for in vivo research! ๐ฏ Enjoy an ๐๐ฑ๐๐ฅ๐ฎ๐ฌ๐ข๐ฏ๐ ๐๐% ๐๐ข๐ฌ๐๐จ๐ฎ๐ง๐ญ ๐ฌ๐ข๐ญ๐๐ฐ๐ข๐๐ย on all products, valid until December โ perfect for boosting your research project. ๐https://lnkd.in/eSw3_Qpa ๐ Benchmark Positive Antibody ๐ Isotype Negative Antibody ๐ญ Anti-Mouse Antibody โ Bispecific Antibody โฆand much more to elevate your research, with ๐จ๐ง๐ฅ๐ข๐ง๐ ๐๐ก๐๐๐ค๐จ๐ฎ๐ญ ๐๐ง๐ ๐-๐ฐ๐๐๐ค ๐๐๐ฅ๐ข๐ฏ๐๐ซ๐ฒ! #Biointron #Abinvivo #reagents #invivo #antibodies #proteins
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Read on for a recap of the World Bispecifics Summit 2024 ๐ ๐. ๐๐ข๐ฌ๐ฉ๐๐๐ข๐๐ข๐ ๐๐ฅ๐ข๐ง๐ข๐๐๐ฅ ๐๐๐ง๐๐ฌ๐๐๐ฉ๐ โข CLDN18.2 x 4-1BB bispecific:ย anti-4-1BB VHH that targets the membrane proximal region can be further optimized with unidirectional Fc effector function towards TAAs. (Biotheus Inc.)ย โขย ABBV-383: a novel bispecific antibody with enhanced tumor targeting & optimized t-cell engagement in multiple myeloma. (AbbVie)ย โขย Endogenous T cell reactivities as drivers of TCE response & resistance (leveraging TCE immune perturbations to establish predictive biomarkers and novel personalized cell therapies). (Broad Institute of MIT and Harvard Institute) ย ๐. ๐ ๐๐๐ฐ ๐๐๐ง๐๐ซ๐๐ญ๐ข๐จ๐ง ๐จ๐ ๐๐ฆ๐ฆ๐ฎ๐ง๐ ๐๐๐ฅ๐ฅ ๐๐ง๐ ๐๐ ๐๐ซ๐ฌ โขย Solving the combinatorial matrix puzzle and fast-tracking bispecific generation for early-stage functional assessment through multiparametric, high throughput in silico-driven molecular optimization to derisk programs as early as possible. (IPA (ImmunoPrecise Antibodies)) โขย There is growing evidence of T-cell engagers with clinical benefit for solid tumors, not just in hematological malignancies. (Amgen) โขย Selectively activating subsets of T cells present in tumor-infiltrating lymphocytes of solid tumors to promote more potent anti-tumor activity by uncovering associations between Vฮฒ T cell subsets and diseases. (Marengo Therapeutics) ๐. ๐๐๐ญ๐๐ฌ๐ญ ๐๐จ๐ฏ๐๐ฅ ๐ ๐จ๐ซ๐ฆ๐๐ญ๐ฌ โขย XmAb541: 2+1 CLDN6 x CD3 bispecific has two tumor-antigen binding domains and one T-cell binding domain, to treat ovarian cancer & other CLDN6+ solid tumors. (Xencor) โขย Azymetric platform used to optimally format T-cell engagers & bispecific ADCs with a robust Fc heterodimer solution. E.g. Zanidatamab, a bi-paratopic anti-HER2 antibody undergoing clinical studies. (Zymeworks Inc.) โขย FAST-Ig platform used to produce bispecific antibodies and improve antibody pharmacokinetics. E.g. NXT007, a next-gen version of emicizumab for hemophilia A. (Chugai Pharma USA, Inc.) โขย Overcome tolerability challenges with bispecifics targeting CD47 on tumor cells and regulate CD28-mediated T-cell co-stimulation, overcoming tolerability challenges while avoiding systemic toxicities associated with CD47 and CD28 targeting, respectively. (Light Chain Bioscience | Novimmune SA) Read the full recap here: https://lnkd.in/ecNZmcNx #Biointron #Antibodies #Immunotherapy #PharmaNews #DrugDevelopment #Bispecific #ClinicalTrials #Innovation #Networking
15th World Bispecifics Summit 2024 โ Boston: Highlights and Event Recap
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โก ๐ ๐๐๐ฐ ๐๐ฅ๐๐ญ๐๐จ๐ซ๐ฆ ๐๐จ๐ซ ๐ ๐ฎ๐ฅ๐ฅ๐ฒ ๐๐ฎ๐ฆ๐๐ง ๐๐ง๐ญ๐ข๐๐จ๐๐ฒ ๐๐ข๐ฌ๐๐จ๐ฏ๐๐ซ๐ฒ! โณExperience the unparalleled ๐๐๐๐ซ๐จ๐ฉโข timeline from Biointron: Millions of plasma B cells are screened in ๐ ๐ท๐ด๐ NGS sequencing & data analysis in ๐ ๐๐ธ๐ธ๐พ Hundreds of naturally paired heavy & light chains are obtained at ๐ ๐๐ผ๐๐ธ From screening to purified antibodies with validated activity in ๐ ๐๐๐๐๐ป Learn more about this at our website: ๐ https://lnkd.in/gDzW6SrM Or contact us ๐ +1(732)790-8340 | ๐ฉ [email protected] Let's discuss how we can accelerate your antibody discovery! #Biointron #Cyagen #humanantibody #antibodydiscovery #singlebcell
Fully Human Antibody Discovery in 3 Months - Explore AbDropโข Today
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