Major Journal article about Direct Biologics product ExoFlo today in the preeminent Pulmonary Journal in the US. https://lnkd.in/gMZTtvBt
Bruce Middleton’s Post
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Rob Vann and Jeff Smith, stand up and be recognized!
Had the opportunity to have breakfast with the person responsible for my entry into leadership almost two decades ago. Bruce Middleton thank you for investing in me back then and again today. It’s great to know all these years later that we were learning from each other then! If you lead people today. Give the person that’s responsible a shout out in the comments or in your own post. Make sure they know you appreciate them taking a chance on you. Because they did! #leadership #gratitude
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This kind of consistent and repeatable achievement of significant milestones is a result of great vision, leadership and extreme dedication to a cause. Thanks to the entire team at Direct Biologics for always digging deep to make it happen.
Excited to announce enrollment of our first patient in our phase 1B/2A, 36 patient, #Crohnsdisease #perianalfistula clinical trial investigating MSC derived #extracellularvesicles for the treatment of this notoriously difficult to treat phenotype. This is the first clinical trial of MSC derived EVs for perianal fistulizing disease, a novel, truly off the shelf cell derived therapy. It takes a great team to move new therapies forward and dedicated patients willing to trust us in advancing the science. A huge thanks to Aline “Ali” BetancourtStephanie CahillLynn WaltzmanAshley AdamsAnita BarnoskiBruce MiddletonChristian GuthCinta BurgosTimothy MoseleyJohn Vacalis #directbiologics
CTG Labs - NCBI
clinicaltrials.gov
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As many as 15% of all ICU admissions are a result of ARDS or ARDS related symptoms. It carries as high as a 50% mortality rate. This kind of result is unparalleled and highlights a therapy that entirely changes the game. We look forward to the results of the Phase 3 trial with great anticipation.
Excited to announce our phase 2 RCT results in #ARDS #extracellularvesicles significantly decreased #mortality ...team effort with our clinical sites across the country, dedicated #physicians and #pulmonologists and #scientists to move #regenerativemedicine forward into the clinic https://lnkd.in/gQt5fKZq
Direct Biologics Announces Publication of Significant Survival Benefit with ExoFlo™ in its Phase 2 Randomized Controlled Clinical Trial in the Journal CHEST
businesswire.com
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Bruce Middleton reposted this
Excited to report our phase 1 results of #pediatrics #perianalfistula #crohnsdisease with MSCs which took a huge #team effort of study coordinators, pediatric gastroenterology, radiology to complete...grateful for this team and looking forward to the next study of extracellular vesicles from MSCs given how well patients responded. Our way to provide point of care, off the shelf product for a devastating phenotype. https://lnkd.in/gnkurSW8
A Phase I Study of Ex Vivo Expanded Allogeneic Bone Marrow–Derived Mesenchymal Stem Cells for the Treatment of Pediatric Perianal Fistulizing Crohn’s Disease
academic.oup.com
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Bruce Middleton reposted this
Direct Biologics Receives FDA Clearance to Initiate Phase 1b/2a Clinical Trial of ExoFlo™ in Patients with Medically Refractory Perianal Fistulizing Crohn’s Disease ExoFlo is the first extracellular vesicle therapeutic candidate to be evaluated in this indication https://lnkd.in/gPySAYiR #regenerativemedicine #extracellularvesicles #biotech #drugdiscovery #ulcerativecolitis #ARDS #crohnsdisease
Accomplished Corporate Development Professional and Early Stage Enthusiast
1yNice work by the team Bruce! Congrats on the publication.