Capstan Therapeutics’ Post

RNA seq data analysis using DESeq2 tutorials on R. one of its plots is Volcano plot which shows the downregulated / lower expressed genes and Upregulated/overexpressed genes according to the case and the data you working with. Here is a volcano plot between Normal Solid tissue (control) samples Vs primary Tumor samples of Bladder cancer patients data. #Bioinformatics #DESSeq2 #RNA_analysis #R_analysis #volcano_plot

Exciting new research published by Wang et al. in Cancer Cell ( IF: 50.3) This study employ single-cell RNA sequencing and machine learning to explore the tumor microenvironment (TME) of gastric adenocarcinoma (GAC). This groundbreaking study uncovers novel immune and stromal cell states across different stages of GAC progression, revealing six distinct TME ecotypes. By pinpointing SDC2 overexpression in cancer-associated fibroblasts (CAFs), this research identifies a new biomarker and potential therapeutic target associated with aggressive GAC phenotypes and poor patient survival. #CancerResearch #Bioinformatics #MachineLearning #GastricCancer #TherapeuticTargets #Biomarkers

Finding out which breast cancer cell line expresses more estrogen receptors is crucial for research and treatment planning. With Bionl.ai's General Search, you get the answer quickly and accurately. Our feature delivers fast insights and relevant resources, helping you stay informed and make data-driven decisions. Try it today and streamline your research: https://www.bionl.ai #Bionlai | #LiteratureSearch | #Bioinformatics | #BreastCancer | #Genomics | #NoCodePlatform | #Pharmacogenomics | #CancerResearch | #CellLine | #EstrogenReceptor

During the 2024 #AACR Annual Meeting this week, the concept of #metastasis has dramatically changed since its last plenary session 14 years ago.... David Lyden's session on "Evolution of the Genome, Microenvironment, and Host through Metastasis" reveals new insights on the importance of tumor-secreted factors and extracellular vesicles (EVPs) which can have downstream effect on different organs and can contribute towards a systemic effect. As Lyden's team discovered, EVPs as a result of a pancreatic tumor can disrupt the liver's function, increase the side effects of chemotherapy and even increase the likelihood of metastases outside the liver. Said differently, “if you have cancer going to the lung, you can’t ignore that you have a fatty liver as well.” The evolving understanding of metastasis emphasizes the need for a more comprehensive approach to cancer research and treatment. To learn more about his work and conference insights, continue reading here: https://lnkd.in/g_XJB3ed #Pharmaceutical #Biotech #Diagnoses #Medicine #Clinical #Healthcare #Lifescience #CancerResearch #CancerTreatment #CancerCells #Oncology #MedicalResearch #Healthcare #CancerAwareness #CancerBiology #InnovationInMedicine #HealthcareIndustry #CancerPrevention #CancerScience #HealthScience #MedicalCommunity #CancerEducation

Some interesting data on non-small cell lung cancer (NSCLC) and biomarker testing in the US. Biomarker testing plays a pivotal role in tailoring treatments. By assessing genetic mutations and protein expressions, clinicians can select optimal therapies, emphasizing the critical importance of understanding the biomarker landscape in NSCLC. These insights are derived from Diaceutics DXRX database of de-identified, real-world patient and lab data. Get in touch to learn more about how our data insights can enhance your precision medicine commercialization strategy. #NSCLC #realworlddata #precisionmedicine

ICYMI: Insights on progesterone receptor testing with Dr Ralph Wirtz Did you read our interview with Dr Wirtz back in December? The discussion focused on a study presented at San Antonio Breast Cancer Symposium (SABCS). This research found that progesterone receptor (PGR) gene expression testing with MammaTyper® could independently identify tumours that are unlikely to be chemotherapy sensitive. Screening out further genomic testing for up to 70% of patients.   It compared Oncotype DX RS with Oncotype DX reported PGR in 4 independent datasets, including 407 cases from the OPTIMA prelim trial. 70.9% of tumours had a high PGR expression. Implementing MammaTyper® into clinical practice could accelerate decision-making and reduce costs by local testing. Next steps include examining survival outcomes over five years, comparing MammaTyper® and Oncotype DX results. We invite more clinicians to join further studies using MammaTyper®. Contact us at [email protected] to get involved Read the full interview via the link in our comments. #BreastCancer #SABCS #Oncology #CancerResearch #HealthcareInnovation #PrecisionMedicine

📝 Case Study: The PD-1 pathway has transformed #immunotherapy development as a means to reawaken the immune system to target #cancer cells. It has been challenging to date, however, to evaluate which individuals will benefit from anti-PD-1 therapies. One way to understand drug response is by evaluating #targetengagement. See how Sapient discovered specific biomarkers in circulation that robustly associate with genetic variants present in the PD-1 pathway and elucidated how these markers map to treatment response: https://bit.ly/44Z3YOA #oncology #PD1biomarker #pharmacodynamics

Immuno-oncology therapies are uniquely complex. Advances in therapeutic platforms and novel trial designs bring opportunities as well as challenges. We are here to help. https://bit.ly/3s17BFE #oncology #immunooncology #clinicalresearch #immunotherapy #biotech #genetherapy #CAGT #celltherapy #clinicaltrials

For #WebinarWednesday, here is an open access one https://lnkd.in/g2ta6e95 This webinar features various cancer research applications: Automated 3D Assays for Cancer & Immuno-Oncology Applications using the Pu·MA System presented by Ekaterina Nikolov Key topics featured: 📌 Immune cell co-cultures with patient-derived tumoroids 📌 Drug treatment of cancer spheroids 📌 Biomarker detection in tumoroids 📌 Metabolite analyses and supernatant sampling #cancerresearch #immunooncology #pumasystem #microfluidics #3dcellassay #organoid #spheroid #flowchips #3dcellculture #tumoroid #immunecoculture #oncologyresearch #biotech #functionalprecisiononcology #functionalprecisionmedicine