CAROLINA BLAGOJEVIC CASTRO’s Post

🌱 Food is truly powerful medicine! A new study published in JAMA Network Open found that eating an anti-inflammatory diet rich in whole grains, fruits, and vegetables can lower the risk of dementia by 31%! 🍎🥦 Even those with cardiometabolic conditions like type 2 diabetes, heart disease, or stroke saw these benefits, according to lead author Abigail Dove. Why does this work? Research suggests that anti-inflammatory nutrients like vitamins, carotenoids, and flavonoids found in fruits and vegetables help neutralize free radicals and reduce stress on the body. By choosing whole, plant-based foods over processed and sugary options, we can take control of our health and protect our minds and bodies for the future. 💪✨ Let’s make every bite count! 🌿🍇 #FoodAsMedicine #HealthyLiving #AntiInflammatory #Sustainability #Nutrition #BrainHealth AgriNovus Indiana Indiana Grown

A recent study showed that diets with higher inflammatory potential, as measured by the dietary inflammatory index, are associated with an increase in NT-proBNP levels—a marker for heart failure risk. This re-emphasizes that making dietary changes may play an important role in managing cardiovascular health. Previous research consistently shows that diets high in inflammation are associated with higher risks of conditions like metabolic syndrome, cancer, coronary heart disease, and heart failure. On the other hand, following an anti-inflammatory diet based on this index has been shown to reduce inflammation in the body, which could help prevent chronic diseases and their complications. What is interesting though is that this dietary inflammatory index which looks at over 6500 pieces of literature shows some foods that increase inflammation, but more of those that help to decrease it. ⭐️ This points to the fact that we need to focus on what we are ADDING to the diet to improve heart health. ❤️ Come join my upcoming 6-week heart optimization group program starting on July 12th. We'll delve into strategies for reducing inflammation through science based nutrition and enhancing your cardiometabolic health with evidence-based approaches. 👉🏼 For further details, click here: https://lnkd.in/e5eigZgA ⭐️ Feel free to reach out via PM if you have any questions! Study reference: https://lnkd.in/e8qGn5pr #heartfailure #heartfailuresurvivor #heartfailureawareness #heartfailuresucks #chf #chfwarrior #aorticstenosis #afib #heartfailurediet #heartattack #lowsodiumdiet #hearthealthydiet #lowerbloodpressure #heartattackprevention #highbloodpressure #highcalciumscore #coronaryarterydisease #heartattacksurvivor #heartfailureprevention #heartdisease #heartdiseaseawareness #heartattackawareness #hearthealth #hearthealthy #hearthealthyfood #hearthealthawareness #hearthealthyeating #hearthealthyliving #cardiovasculardisease #preventivecardiology

Recently published evidence shows that #Fasting-mimicking diet (FMD) significantly ameliorates #aging associated markers in adult trial participants. Biological age, computed using a composite of multiple #biomarkers previously implemented in the CALERIE trial, was decreased by ~2.5 years in participants placed on 3 cycles of FMD (5 day regimen per month: Day 1 ~4600 kJ, 11% protein, 46% fat, 43% carb; Days 2-5 ~3000 kJ, 9% protein, 44% fat, 47% carb). Interestingly, the decrease in aging markers does not correlate with body weight loss (or #BMI), suggesting that biological age reversal by FMD is not driven by weight loss alone. The strongest associations with improved biological age were decreased #HBA1c, decreased CRP, lower systolic blood pressure, and elevated serum albumin. Of note, this diet intervention improved the lymphoid-to-myeloid (L/M) ratio, which has been demonstrated to decrease with aging and contributes to #immunosenescence-related aging #pathologies. Decreased visceral fat, hepatic fat content, and BMI were also observed. It would be fascinating to assess how this diet intervention would compare directly to intermittent fasting interventions, or diet compositions where higher protein % and low carb % are used. #weightloss #diet #bloodpressure #agingresearch #intermittentfasting #metabolichealth #longevitymedicine #antiaging

Maintaining a continuous long-term ketogenic diet may lead to the accumulation of aged cells (senescence) in normal tissues, impacting heart and kidney function. However, taking breaks from this restrictive diet could help mitigate these effects. Initially valuable for managing diabetes, the ketogenic diet has gained popularity for weight loss. However, a new study published in Science Advances by researchers at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) suggests that a continuous ketogenic diet may not be as friendly as it seems. The study found that prolonged adherence to a ketogenic diet can induce cellular senescence in tissues, particularly affecting the heart and kidneys. The researchers advocate for an intermittent ketogenic diet, incorporating planned breaks to prevent pro-inflammatory effects linked to senescent cells. "To put this in perspective, 13 million Americans use a ketogenic diet, and we are saying that you need to take breaks from this diet or there could be long-term consequences," said David Gius, MD, PhD, assistant dean of research at UT Health San Antonio. A ketogenic diet, high in fat and low in carbohydrates, leads to the production of ketones. While beneficial for certain health conditions and weight loss, excessive adherence can have adverse effects. The study demonstrated that mice on continuous ketogenic diets exhibited cellular senescence in organs such as the heart and kidneys. However, using a senolytic class of small molecules, which destroy aged cells, and an intermittent ketogenic diet regimen eliminated these effects. "As cellular senescence is linked to organ disease, our results have important clinical implications for understanding the use of a ketogenic diet," Gius said. "As with other nutrient interventions, you need to 'take a keto break.'"https://lnkd.in/dFzhjPwi

This week’s spotlight brings you a selection of studies exploring the diverse benefits and impacts of low-carb and ketogenic dietary interventions on various health conditions, from dementia risk and cardiovascular health to epilepsy management, metabolic balance, and aging. Enjoy the read! 📌   Zhang et al. Associations of sugar intake, high-sugar dietary pattern, and the risk of dementia: a prospective cohort study of 210,832 participants https://lnkd.in/g_P78EjT This study investigated the relationship between high-sugar dietary patterns and dementia in a large-scale general population. Excessive sugar intake was significantly associated with an increased risk of dementia, underscoring the importance of controlling dietary sugar for public health. 📌   Ghasemi et al. Impact of very low carbohydrate ketogenic diets on cardiovascular risk factors among patients with type 2 diabetes; GRADE-assessed systematic review and meta-analysis of clinical trials https://lnkd.in/gFJrZny2 This systematic review and meta-analysis highlights that very low carbohydrate ketogenic diets significantly improve cardiovascular risk factors in patients with type 2 diabetes, including reductions in fasting blood sugar, HbA1c, and blood pressure, as well as increased HDL levels. 📌   He et al. Ketogenic diet therapy leads to antiseizure medication reduction in children and adults with drug-resistant epilepsy https://lnkd.in/gx2YvxsK This study adds to the growing evidence on the potential of ketogenic diet therapy (KDT) in managing drug-resistant epilepsy, showing that KDT can safely lead to the reduction or withdrawal of antiseizure medications in both children and adults. 📌   Schrader et al. Circadian disruption, clock genes, and metabolic health https://lnkd.in/gwMWgpK4 This review highlights the importance of maintaining circadian alignment to prevent adverse metabolic outcomes. This alignment is influenced not only by the timing of sleep but also by factors like light exposure and the timing of food intake. 📌  Kopp. Aging and “Age-Related” Diseases – What Is the Relation? https://lnkd.in/g3WKNVPT By comparing modern societies to hunter-gatherer societies, this review suggests that healthy living practices, including dietary interventions like the ketogenic diet, could play a crucial role in preventing age-related diseases.

‼️AUTOIMMUNITY: WHY YOU’RE NOT GETTING RESULTS‼️ After working with hundreds of clients and taking thousands of calls, these are the main reasons people trying to overcome autoimmunity naturally hit barriers or fail to get results: 1️⃣Overfocusing on Diet I get it—diet is the first thing you see when researching how to improve autoimmunity online. The advice ranges from eliminating gluten to the carnivore diet. Nutrition is always important, and for a small minority, diet changes alone can be transformative (these tend to be the loudest voices online). However, many people focus solely on diet, even when they see limited or no results. This can lead to stagnation and worse, developing food fears. Constantly signaling danger and restricting your life is counterproductive to health. 2️⃣Underfocusing on Stress Response You cannot separate stress response from immune function. A problematic stress response negatively impacts immunity. When stress increases, the immune system activates. Chronic stress heightens the risk of immune cells making errors that lead to autoimmunity. Stress response issues are ubiquitous in autoimmune conditions and aren’t limited to anxiety or worry. They include nutrient deficiencies, accidents, surgeries, past traumas, toxic loads, and infections. Identifying these is key to addressing the root cause. 3️⃣Majoring in the Minors Online research will show many dysfunctional mechanisms associated with autoimmunity, like stress response, leaky gut, dysbiosis, parasites, methylation issues, estrogen dominance, infection, inflammation, and more. While tests and supplements (like ashwagandha for stress, glutamine for leaky gut, probiotics for gut health, and antimicrobials for infections) can help, they are not the main solution. “I achieved remission as a test said xxxx and I used yyyy supplement” said no one ever! These are minor fixes. It’s like stepping over dollars to pick up pennies. Which of these traps have you fallen into? I’ll go first: all of them! ✅ Follow @summit__health for more tips on improving or reversing chronic symptoms and conditions.

Gut Microbiota and Obesity: The Chicken or the Egg? Although the link between gut microbiota and obesity is increasingly reported, the pathophysiological mechanisms and clinical outcomes are still under debate. This overview of human and animal data addresses several pathophysiologic mechanisms, dietary habits, exercise and probiotic and symbiotic supplementation in the fields of gut microbiota and obesity. Overall, obesity impairs gut microbiota composition due to factors that may be linked to the onset of the disease, such as excessive consumption of high-energy foods, sugars and fats, as well as a low fiber intake and physical inactivity. Conversely, low-energy diets, physical exercise, and probiotic and prebiotic supplementations can enhance gut microbiota in patients with obesity, in addition to improving cardiometabolic markers. As for perspectives, further research is warranted to ascertain proper dietary manipulation, physical exercise protocols and dosing regimens of probiotics. Regarding the latter, the effects on indicators of obesity are clinically modest, and hence skepticism must be exercised. Read the rest of the article here https://buff.ly/3GmGrwj 👈 Visit our website https://buff.ly/3N1bcK8 😄 Watch The Impact of Preventable Disease on Enterprises. https://buff.ly/43DgkdQ 👈 Pre-register here: https://buff.ly/3NzDfAZ 👈 Follow Us on LinkedIn https://buff.ly/3Jy2Wk7 👈 #ImmuneSystem #GutMicrobiota #Thier #HealthisWealth #ImmuneHealth #StayHealthy #GutHealthBenefits

This systematic review identified 13 studies on isocaloric diets and indicated that when energy intakes were matched, isocaloric IF interventions and daily caloric restriction produced relatively similar beneficial effects for weight loss and metabolic risk factors related to chronic diseases in individuals with overweight or obesity. However, very limited evidence suggests that IF may be more effective than daily caloric restriction for fat loss and insulin sensitivity when energy intakes are matched between diet interventions. Despite the accumulating evidence indicating the potential importance of time of eating in alignment with circadian clocks, due to regulation of metabolic functions and autophagY the optimal timing of eating for IF protocols has not been established. A recent relevant shortterm 5-week trial in healthy adults without obesity, showed significant improvements in body mass, fasting glucose, insulin sensitivity, and the pro-inflammatory markers tumor necrosis factor alpha and interleukin 8, in an early-TRE group (eating window: 6:00 AM to 3:00 PM) vs control, but not with mid-day TRE (11:00 AM to 8:00 PM). In this short-term study, energy reductions were similar between TRE groups.52 Fully powered trials comparing early- vs late-TRE are needed to elucidate the role of the time of the eating window. https://lnkd.in/eAgwqHNc

Visceral fat is an enemy of the liver and a driver of insulin resistance that leads to MASLD/MASH. This paper highlights and defines visceral fat, the impact on our metabolic health and ways to reduce it. “Carrying excess visceral fat is linked to an increased risk of several serious health conditions, including: - MASLD/MASH (we added this). - “Heart disease - Type 2 diabetes - Insulin resistance” “To effectively combat visceral fat and improve your overall health, consider implementing a three-pronged approach that combines a low-carb diet, intermittent fasting, and regular exercise. By reducing your carbohydrate intake, limiting your eating window, and engaging in a mix of resistance and aerobic training, you can create a synergistic effect that targets visceral fat from multiple angles.” “As you begin to shed visceral fat and improve your insulin sensitivity, you’ll likely experience a host of positive changes, including increased energy, better mood, and a reduced risk of chronic diseases. Remember, the journey to better health is a marathon, not a sprint – be patient with yourself and celebrate the small victories along the way.” Obesity Matters, RACHAEL SOOD RN, MSN, NP-C, CDCES, Supriya Joshi, Manal Abdelmalek, Sonal Kumar, European Liver Patients' Association - ELPA Global NASH Council American Association for the Study of Liver Diseases (AASLD) EASL | The Home of Hepatology, Global Liver Institute, Summit Clinical Research, Arizona Liver Health, Houston Liver Institute, American Diabetes Association, Obesity Action Coalition https://lnkd.in/g7x3DgGX

Autoimmune diseases, characterized by the body's immune system attacking its own tissues, have complex and multifactorial origins. Recent research has increasingly focused on how lifestyle factors, including hygiene, habits, community involvement, diet, cooking methods, exercise, and stress, may influence the development and progression of these diseases.
 The hygiene hypothesis suggests that a lack of exposure to infectious agents, symbiotic microorganisms, and parasites in early childhood can lead to an increased risk of autoimmune diseases. This hypothesis is based on the idea that such exposure is crucial for the proper development of the immune system, and its absence can lead to an overactive immune response against the body’s own tissues.ases. Smoking, in particular, has been shown to alter immune function and increase inflammation, potentially triggering autoimmune responses. Meaningful relationships and support play a vital role in overall health. Strong social connections have been linked to lower levels of stress hormones, which can modulate immune function and potentially reduce the risk of autoimmune reactions. Diet is a critical factor in autoimmune diseases. Diets including gluten, dairy and "food-like" products can contribute to inflammation, potentially exacerbating autoimmune responses. The way food is prepared and the materials used in cooking can also impact autoimmune risk. For example, cooking at high temperatures can produce advanced glycation end products (AGEs), which are linked to increased inflammation. Additionally, certain cooking materials, like non-stick coatings, may release chemicals that could potentially affect immune function. Both too little and too much exercise can affect autoimmune diseases. Regular, moderate exercise has been shown to reduce inflammation and support healthy immune function. However, excessive exercise can lead to chronic inflammation and may increase the risk of autoimmune responses. Chronic stress, including the stress from toxic relationships, is a significant factor in autoimmune diseases. Prolonged exposure to stress hormones like cortisol can dysregulate immune function, leading to increased inflammation and a heightened risk of autoimmune reactions. The root mechanisms behind autoimmune diseases are complex and influenced by various lifestyle factors. Understanding the impact of hygiene, habits, community, diet, cooking methods, exercise, and stress is crucial in managing and potentially preventing autoimmune conditions. By addressing these aspects, individuals can take proactive steps towards maintaining a healthy immune system and reducing the risk of autoimmune diseases. #autoimmunedisease #mentalhealth #rheumatoidarthritis #spoonie #lupus #hormonebalance #cortisol #alternativemedicine #immunesystem #chronicillness #toxicrelationships #drlukemartindc #drrogue