Recap of the data we presented at this year's ATS. Hopeful for a novel treatment for IPF patients! @GoHealio @HealioPulm https://lnkd.in/dQdTvg95
Cecilia Ganslandt’s Post
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International Medical Director | Physician - Scientist | Science Communication | HBR Advisory Council Member | FRSPH FRSA CMgr FCMI
The use of SCO-101 plus leucovorin, fluorouracil, and irinotecan (FOLFIRI) was found to increase efficacy and maintain safety and tolerability for a small cohort of patients with metastatic #colorectalcancer (CRC), according to results from part 3 of the phase 2a CORIST #clinicaltrial (NCT04247256). In part 3, the median progression-free survival (PFS) was 4.6 months, and after 8 weeks of treatment, the clinical benefit rate (CBR) was 76%. The PFS in part 2 was 2.0 months, and the CBR was 46%. https://lnkd.in/e2fNRT9X
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Today, we shared an update on the SAB-142 trial for #type1diabetes: we have completed dosing the third cohort for SAB-142 with no observation of serum sickness thus far. For further information, please see our press release here: https://lnkd.in/eJbT74hd. Phase 1 of SAB-142 is a randomized, double-blind, placebo-controlled, single-ascending dose, adaptive design clinical study was designed to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous SAB-142 in healthy volunteers and participants with T1D. SAB-142 is a first-in-class human anti-thymocyte immunoglobulin being developed as a disease-modifying treatment to delay the onset and progression of T1D.
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I am proud to share our latest work published by The Laryngoscope about 1-year dupilumab outcomes in CRSwNP patients from the radiological and clinical point of view. https://lnkd.in/dcsMzy_X
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CroiValve yesterday presented favourable 6-month data from the TANDEM I first-in-human study of its novel Duo transcatheter tricuspid coaptation valve system for treating tricuspid regurgitation. The unique Duo system works in tandem with the native valve using a novel anchoring approach across the annulus. Key results showed: 📉 Significant TR reduction in ≥85% of patients 🚀 Improved quality of life 💯 100% survival, no arrhythmias/pacing issues 🎯 Successful device positioning/remodeling ⏱️ With a 43 minute average procedure time, the Duo system demonstrates early promise for treating tricuspid valve disease. 💪 CroiValve will continue evaluating this innovative therapy through additional clinical studies. #TTVR #MedTech #structuralheart #medicaldevices
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(4/9) PI3Kα-Driven Vascular Malformations is the first of two programs in #geneticdisease that we unveiled today. #Vascularmalformations are a series of rare syndromes that occur due to atypical development of lymphatic and/or blood vessels, of which mutant PI3Kα is the most common driver. There are over ~170,000 patients with PI3Kα-driven vascular malformations in the U.S. We believe our mutant-selective PI3Kα inhibitor, RLY-2608, provides the opportunity for greater target coverage, leading to the potential for improved efficacy and better chronic tolerability for these patients. We plan to initiate clinical development in Q1 2025.
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Chief of Radiation Oncology and Radiation Medicine at FHN Leonard Ferguson Cancer Center | Assistant Professor at Loyola University Stritch School of Medicine | Top 1% healthcare profile on LinkedIn | IORBC Board Member
If there was a particular treatment that worked 94% of the time, would you claim that it was placebo? Unlikely. In 2022, Radiation Oncologists from Spain conducted a prospective trial of 100 patients with osteoarthritis of the hands. They were given low dose radiation therapy (LDRT) and followed for 3,6, and 12 months. Here were the results: ❇️ 94% of the patients reported significant pain reduction ❇️ 70% of patients reported improved functional performance ❇️Responses were evaluated with VAS for pain and VPS for joint functionality ❇️ 50% of the patients had a second course of LDRT. Keep in mind that this is a subset of patients that have historically failed all other conservative management 🤯 Reference: https://lnkd.in/gh6fT5Gw
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Medical Doctor, Cardiology Resident presso Fondazione Policlinico Universitario Agostino Gemelli IRCSS
#FORZA trial: 5-year clinical outcomes 📉 For the management of patients with angiographically intermediate coronary stenosis, #OCT and #FFR guidance had a similar risk of MACE at 5 years Thrilled to share our manuscript just published in the European Heart Journal #EHJ
Fractional flow reserve or optical coherence tomography for angiographically intermediate coronary stenoses: 5-year outcomes in the FORZA trial
academic.oup.com
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Positive results in the FYDES study of our subsidiary SYLENTIS 👁️ The clinical trial evaluated the long-term safety of its drug in patients with dry eye disease. With the participation of 301 patients at 26 centers in the United States, FYDES met its primary objective by demonstrating the safety of the ophthalmic solution. 👉 Main findings: 🎯 Primary objective achieved: long-term safety confirmed. 📈 Other results: no clinically relevant changes in other ocular safety parameters, laboratory values, or body temperature were detected. This breakthrough is key to providing new options for the 300 million people affected by dry eye disease. We remain committed to innovation to improve the eye health of our patients. 💙 https://lnkd.in/dkfA3_Zn
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The TIGRIS clinical trial is a Phase 3 follow-on study evaluating the use of Polymyxin B Hemoperfusion #PMX in a randomized controlled trial of adults treated for endotoxemia and septic shock. The trial methods are detailed in “Bayesian methods: a potential path forward for sepsis trials”. https://lnkd.in/g8zcUzub
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Discover clinical trials in Europe for myeloma and AL amyloidosis patients using our Navigator tool. Locate trials matching your criteria, from specific hospitals to disease stages. Explore the MPE Navigator now: https://lnkd.in/dDRHsv2Z #ClinicalTrials #Research #MyelomaAwareness #AmyloidosisAwareness
Myeloma and AL Amyloidosis Trial Navigator
navigator.mpeurope.org
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