Charles River Laboratories’ Post

Bioprocess scale-up can be complex when factoring in changing bioreactor parameters or multiple trial-and-error phases. Consider simplifying & standardizing your approach through Bioreactor scaler tool. https://cytiva.link/2qjkf #biotech #biopharma #biomanufacturing #Upstreambioprocessing #cellculture #Bioreactors

[Join us live] 🗓️ Join us on March 19th at the Bioprocessing summit Europe, where Rok Žigon will discuss the optimization of AAV downstream process development from harvest to final product. ℹ️ This presentation will cover considerations and examples of case studies for various AAV serotypes for all DSP steps. Join us to learn about: ✔️data from initial lysate clarification and pre-capture options to reduce contaminants, ✔️comparison of affinity and ion-exchange capture step ✔️optimization of polishing (full enrichment) step on various monolithic columns, all supported with orthogonal analytics.  ✏️ Register here: https://lnkd.in/dCWrgbdi #AAV #downstream #DSP #biotech #purification

No matter the project size, we want to help you achieve your commercialization. Our custom services are here to build your assay components to the exact specifications you need! Download the handbook with tips and resources on streamlined commercialization! #assaydevelopment #biotech

Do you face issues with leaks or defects in your single-use mixing process causing downtime or lost productivity? You're not alone. Check out this informative article by Arnaud de Boulard, Mustapha hohoud, and myself, which explores the most common causes of leaks in single-use mixers. Gain valuable insights and learn how to overcome these challenges by clicking on the link below. #lifesciences #biotech #biopharma #biotechnology #singleuse https://lnkd.in/dqAgww8d

Quasi-Perfusion Studies for Intensified Lentiviral Vector Production Using a Continuous Stable Producer Cell Line Quasi-perfusion culture was employed to intensify lentiviral vector (LV) manufacturing using a continuous stable producer cell line in an 8-day process. Initial studies aimed to identify a scalable seeding density, with 3, 4, and 5 x 104 cells cm-2 providing similar specific productivities of infectious LV. Seeding at 3 x 104 cells cm-2 was selected, and the quasi-perfusion was modulated to minimize inhibitory metabolite accumulation and vector exposure at 37 °C. Similar specific productivities of infectious and physical LV were achieved at 1, 2, and 3 vessel volumes per day (VVD), with 1 VVD selected to minimize downstream processing volumes. The optimized process was scaled 50-fold to 1,264 cm2 flasks, achieving similar LV titers. https://lnkd.in/g-Z6cQ5W #aspenalert #biotech #bioprocess

Download the white paper to discover Lonza’s modular approach and gain valuable insights into the current mixing landscape. https://lnkd.in/dj7irbyA #biopharma #lifesciences #drugdevelopment

Cytiva Innovations: Know more and see the Xcellerex X-platform bioreactors in action on Oct 31, 2023 at 11 am IST. Book your seat in the link below. #cellculture #upstream #bioreactors

Scale your production of AAV to enable commercial manufacturing. Catch the replay of our recent webinar where Jon Zmuda, R&D Director, discusses upstream and downstream approaches for consistent and scalable production, purification, and characterization of adeno‑associated virus (AAV) at scales ranging from shake flasks to 50 L and 1,000 L single‑use bioreactors.

Download the white paper to discover Lonza’s modular approach and gain valuable insights into the current mixing landscape. https://lnkd.in/eHp-hBVA #biopharma #lifesciences #drugdevelopment