Danny Deutsch’s Post

🎉 Exciting news! In case you haven’t heard, we launched our new digital magazine in March: Insights by Servier!   In the first edition, we had the pleasure of chatting about research in rare diseases with Nicolas Levy, physician and researcher in medical genetics, and Chief Scientist Rare Diseases at Servier. ➡️ How can we define rare diseases? ➡️ How are things progressing in terms of new rare disease identification? ➡️ Advances in diagnosis and therapeutic approaches ➡️ Is it possible to cure a rare disease? ➡️ What are the major challenges in this area?   You’ll find all the answers in our interview at 👉 https://lnkd.in/eBTC-jga   #WeAreServier #InsightsByServier #RareDiseases

Hot off the press! Amazing Nature paper on accelerated organ aging and risk of age-related diseases. This was only possible with a technology that can assay large number of proteins on large study population with unmatched sensitivity and consistency. Imagine what our latest SomaLogic Somascan 11k assay will uncover. Proteomics at genomics scale! #agingresearch #plasma #proteomics #highthroughput

🔬📊 Exploring Complexities in Translational Research: Integrating Diet and Disease Models 🌱🧬 We have been into the intricate intersection of cardiovascular complications, uremic models, and cancer. Our work employs diverse diets, including high-fat diets, to simulate various aspects of metabolic syndrome. However, navigating challenges such as accurate diet intake recording, deciphering different animal strains' varied responses to diets, and refining specific procedural methodologies are critical to deriving robust research outcomes. Beyond the technical aspects, we emphasize the pivotal role of the human factor in our research equation. Understanding how individual records influence outcomes is integral to shaping our insights into disease progression and treatment efficacy. Any thoughts on confounding factors? I look forward to sharing more insights from our ongoing studies, which aim to advance medical knowledge and improve patient care. Check out some of our related work in the field. Please feel free to use the following links: Lotfollahzadeh S, et al. Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Mol Metab. 2023 Jul;73:101744. doi: 10.1016/j.molmet.2023.101744. Epub 2023 May 26. Arinze NV, Yin W, Lotfollahzadeh S, et al. Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease. J Clin Invest. 2022 Jan 4;132(1):e142260. doi: 10.1172/JCI142260. #TranslationalResearch #CardiovascularHealth #MetabolicSyndrome #CancerResearch #ScientificInnovation 🌟 The image relates to the GTT during one of the so-called experiments. Elahe Parsafard Arameh Abbasianchavari Ghazal D.

Happy to share our latest research paper published in the PNAS journal. Findings from our study: 🧪🩸Integrated cytokine evaluations of saliva and serum showed that the oral host response was distinct from the systemic response. 🦠🧫The hierarchical classification of COVID-19 status and respiratory severity using multiple modalities separately (i.e., microbiome, salivary cytokines, and systemic cytokines) and simultaneously (i.e., multi-modal perturbation analyses) revealed that the microbiome perturbation analysis was the most informative for predicting COVID-19 status and severity, followed by the multi-modal. 👩🔬🧑🔬🔬Our findings suggest that oral microbiome and salivary cytokines may be predictive of COVID-19 status and severity, whereas atypical local mucosal immune suppression and systemic hyperinflammation provide new cues to understand the pathogenesis in immunologically naïve populations. Huge thanks to my collaborators Marcelo Freire, Khaled Altabtbaei, Saadoun Bin-Hasan, Devarajan Sriraman, and Fahd Al-Mulla. The study was funded by J. Craig Venter Institute, Dasman Diabetes Institute, and L'Oréal

🌟 Day 2 Speakers Spotlight (part 2): Pharmacogenomics and Rare diseases   Hear from esteemed speakers on their research work in Pharmacogenomics and Rare Diseases on 22 Aug at the PRECISE-IHCC Conference themed From Cohorts to Clinics: The New Landscape of Global Healthcare! 💊 Pharmacogenomics  Learn about the relationship between genotype and drug response with insights from Dr Elaine Lo from National University Hospital, Prof Collet Dandara from the University of Cape Town, and Prof Chonlaphat Sukasem, Ramathibodi Hospital, Mahidol University. Speakers in this session will share about how population data and regional implementation practices can shape medication and dosing decisions in patient care. 🧬 Rare Diseases  Overcoming the unique challenges of rare diseases requires collaboration and innovation. Join us in this dialogue between researchers and clinicians – Dr Saumya Jamuar from KK Women's and Children's Hospital, Dr Claudia Gonzaga-Jauregui, International Laboratory for Human Genome Research, Universidad Nacional Autónoma de México, and Dr Gabriela Repetto from Facultad de Medicina Clínica Alemana Universidad del Desarrollo, who will share their knowledge and expertise in rare diseases. 👉🏼 Register for the conference now! https://for.sg/preciseihcc 🗓️ 21-23 August 2024 📍 One Farrer Hotel, Singapore Global Genomics Medicine Collaborative (GGMC) #npm_sg #CohortstoClinics #FromCohortstoClinics #GenomicsConference #PrecisionMedicine #HealthcareInnovation #RareDiseases #Genomics #Pharmacogenomics

Some more insights in bronchiectasis : The bronchiectasis resistome associates with clinical outcomes, geographic origin, and the underlying host microbiome https://lnkd.in/dg7WTVmN 

At Your Diary Targeting Extracellular Vesicles 2024 "Mitochondria and Microbiota: Crucial Impact"!   The First Conference on Targeting Extracellular Vesicles is set for October 17-18, 2024, at Corinthia Palace in Malta.   Organized by the World Mitochondria Society and the International Society of Microbiota, this event promises to be a pivotal gathering.   🔍 Explore diverse facets of Extracellular Vesicles (EVs) with a focus on mitochondria and microbiota:   Session 1: Introduction to EVs: Current Landscape & Future Prospects Session 2: EVs & Mitochondria: Insights into Biogenesis, Function, and Dynamics Session 3: Microbiota & EVs: Unveiling Roles, Disease Biomarkers, and Therapeutic Strategies Session 4: Exosomes 2024: Advances in Clinical Applications, Engineering, and Therapeutic Interventions   📨 Learn more in our February Press Release: https://lnkd.in/dEXckG8s   🌐 Visit Conference Website : https://lnkd.in/dMm8jZjd   #TargetingExtracellularVesicles #TargetingEVs #extracellularvesicles #evs #exosomes #exosome #microbiome #microbiota #redox #iron #homeostasis #skin #mitochondria #ISM #WMS

🔬 Exciting New Findings on Telomeres and Aging! 🔬 Telomeres, the protective caps at the ends of our chromosomes, shorten as we age, contributing to the aging process and age-related diseases. Our latest study explores the relationship between telomere abnormalities and aging, showing that telomere dysfunctions are influenced by more than just aging—they're also affected by other replication defects. We examined telomere structures and serological markers in a diverse group of individuals aged 26 to 101. The results revealed a strong link between age and telomere damage. Notably, the protein stathmin emerged as a significant marker, correlating with various telomere abnormalities. These findings highlight stathmin’s potential as a simple, yet powerful, biomarker for detecting telomere dysfunction and monitoring the aging process. This discovery opens up exciting prospects for future research and healthcare applications. 🔍 Read the manuscript here: https://rdcu.be/dN5pN #Aging #HealthcareInnovation #Telomeres #Biomarkers #Research #Healthcare #Longevity #Genetics #ScienceNews #Innovation

🌱 Medicinal Mushrooms: Unlocking New Health Possibilities 🍄 Recent advancements in the study of medicinal mushrooms are making waves in the medical community, offering new hope in the fight against chronic diseases. At the 2024 International Mycology Conference IMC12, researchers presented compelling evidence on the therapeutic properties of mushrooms like Reishi, Lion's Mane, and Turkey Tail. ☑ One standout finding: Lion’s Mane has shown potential in promoting nerve growth and improving cognitive function, which could have significant implications for treating neurodegenerative diseases such as Alzheimer’s. Another highlight is the use of Turkey Tail extract in boosting the efficacy of conventional cancer treatments, as detailed in a study from the Journal of Medicinal Fungi [https://lnkd.in/eZkHGQgQ]. ☑ Key Takeaway: Medicinal mushrooms are not just a trend; they are emerging as a critical component in integrative health strategies. Whether in enhancing brain health or supporting cancer therapy, these natural compounds are bridging the gap between traditional remedies and modern medicine. #MedicinalMushrooms #Neurohealth #CancerResearch #IntegrativeMedicine #HealthcareInnovation

#Cancer, #diabetes, #cardiovascular diseases, #COPD: these are the big #PublicHealth enemies in #Denmark and across #Europe. We know #genomics plays a big role in the likelihood of developing #NCDs, and in the way medicines are metabolised by our bodies. Yet, the potential of genomics to #prevent diseases and adverse drug reactions, a.k.a. “predictive genomics”, is under-utilised and not fully understood. Denmark has all the ingredients to run a state-of-the-art predictive genomics programme: -         Top-notch #biobanks -         Widely used electronic health records #ehr -         Excellence in genomics research -         Citizens’ #trust in government and #PersonalisedMedicine. So why isn’t Denmark moving forward more convincingly on polygenic risk scores and pharmacogenomics? Thermo Fisher Scientific and Allelica, Inc will bring together Danish and international experts in #PredictiveGenomics to try to find some answers and suggest solutions at the upcoming interactive workshop on December 7th at the Statens Serum Institut in #Copenhagen. Confirmed speakers include: Andrea Ganna, Ron H.N. van Schaik. Sowmiya Moorthie, Giordano Bottà PhD, Mette Nyegaard, Lasse Folkersen. Iñaki Gutiérrez-Ibarluzea, Paul Franks PhD MPhil MS FTOS, Lars Münter. If you are interested in participating, you can fill in this form. Places are limited! https://lnkd.in/efsJn7h3