Eos reposted this
At Laverock we are continuing to validate the unique features of our technology and now have a complete set of data in human cells demonstrating the ability to silence genes in a programmable, tunable, stable and highly specific manner. We have also demonstrated that the technology can be used to concomitantly silence more than one target gene, further expanding the range of its potential therapeutic applications. The attached data shows simultaneous silencing of two different targets using Laverock’s gene silencing RNAs. GFP-expressing human iPS cells were edited to express RNA of two designs - one targeting GFP the other targeting B2M. This leads to the silencing of both targets with highly correlated efficiencies (GEiGS/WT, GEiGS/GEiGS). The silencing is highly homogenous and the efficiency is also dependent on whether the edit is mono- (GEiGS/WT) or bi-allelic (GEiGS/GEiGS). This shows that Laverock’s approach, can enable the stable and homogenous silencing of multiple targets simultaneously. The silencing efficiency can be tuned through the design of the silencing RNAs and number of alleles edited. We look forward to presenting more detail and further scientific developments at conferences over the rest of the year. Do get in touch if you’d like to discuss our technology and follow us to keep up to date on our news advances. #cellandgenetherapy #genesilencing #advancedtherapies
Great progress.
More progress!
I bake goodies for the homeless women in Cornerstone. at I do volunteer work at St. Matthew's Church.
2wIt is good that more progress is being done.