Gordon Sanghera’s Post

We are pleased to share our newly published articles entitled: 1. "Exploring recent advancements and future prospects on coordination self-assembly of the regulated lanthanide-doped luminescent supramolecular hydrogels" in #Coordination_Chemistry_Review(IF=20.6), 2. "Bioimaging-guided discrimination of normal/cancer cells using Ag+-mediated red fluorescent carbon dots" in #Chemical_Engineering_Journal(IF=15.1), 3. "Fluorescence switch based on NIR-emitting carbon dots revealing high selectivity in the rapid response and bioimaging of oxytetracycline" in #Journal_of_Materials_Chemistry_B(IF=7.0). The full text of these articles is available at 1. https://lnkd.in/gxnaQZeV 2. https://lnkd.in/ghSfUdrH 3. https://lnkd.in/gEW-cef9

🔉 Promising news in cell therapy! 🤝 PhenomeX, born from Berkeley Lights' acquisition of IsoPlexis, is now set to join forces with Bruker. 🔬With over 400 instruments, PhenomeX specializes in single-cell research, unlocking insights in functional cell biology. 👉 Their advanced platforms will integrate with Bruker's solutions, propelling spatial biology initiatives. 📈 It's a strategic move that promises significant strides in antibody therapeutics and cell therapy. 👀 The $57.8 million all-stock deal is on track to close by year-end, and there are great things to come - this is one to keep an eye on. Read more from the link below Metric Search #celltherapy #cellandgenetherapy #genetherapy #biotechnology #therapeutics #antibodytherapeutics #antibody https://lnkd.in/etuSRZhM

RNA sequencing is routinely used to analyse isoforms as part of biomarker discovery, yet most methods fail to represent the full depth of isoform diversity. Learn how nanopore sequencing overcomes this challenge by capturing entire isoforms in single reads avoiding the need for complex downstream assembly. Learn more: https://bit.ly/3Uphzef

MOFs has attracted everyone’s attention in the recent years. Due to their amazing properties at nanoscale and by strategic adoption of safe-by-design approaches, these class of materials are certainly going to rule the plethora of application area in the future. In this book chapter, we have discussed the use of nanoMOFs as a promising candidate for biomedical applications by drawing a parallel with other nanoscale materials. Please do read for more information.

Spectral Shift technology is already changing how CROs are doing business. Watch this video to see how they decide which screening method gives the most reliable and trustworthy results.

Xiaoxi (Sofie) Wei, Founder & CEO of X-Therma Inc. joined the last CryoChats™ entitled 'Cryopreservation Benefits and Costs of DMSO' on April 17th, 2024. X-Therma Inc. is solving unmet legacy needs in the storage of biological products using convergent biomimetic nanotechnology. This solution can better enable critical biomanufacture processes, safer transport and long-term biobanking for advanced cell therapies, in vitro fertilization, organ transplants, and other rapidly growing regenerative medicine areas. Learn More at https://x-therma.com/ Join us for our next CryoChats™ entitled "Cryopreservation Clinical Risks" on June 12, 2024 at 1PM CDT. Register Here: https://lnkd.in/gUXVHa83 6/12 Cryopreservation Clinical Risks 7/31 Cryopreservation Scaling

Thrilled to announce the publication of our latest paper! 🎉 🎊 🎉 , in which we present for the first time the development of a nanoparticle targeting senescent cells based on the specific enzymatic activity of the senescent secretome. The developed nanodevice is loaded with the senolytic navitoclax and responds to matrix metalloproteinase-3 (MMP-3) associated with the senescent phenotype. Our nanosystem achieves selective release of navitoclax in an MMP-3-dependent manner, while limiting off-target effects on non-senescent cells. This opens the possibility of using nanoparticles able to detect an altered senescent environment and selectively release its contents, thus enhancing the efficacy of senolytic therapies. Many thanks to all authors for their contribution and help during all this time!!!!! #nanomedicine #senescence #navitoclax Read more about our work here: [https://lnkd.in/dwPbGaid].

The newest issue of Upward, official magazine of the International Space Station National Laboratory, is live!! Check it out! 🚀⭐ Download the issue here: https://lnkd.in/g9y58tfK Or view the online articles here: https://lnkd.in/gYF7nsgS In this issue’s cover story, see how studying tissue chips in space could lead to new ways to treat immune system aging in patients on Earth. 🌎 Other features highlight how space-based research is helping to improve production of protein-based therapeutics and how researchers are using microgravity to uncover new insights into plant behavior both in space and on the ground. 💊🌱

Biophysical tools are powerful as they provide robust and reliable data, and can be applied to many stages across drug discovery workflows. Watch this on-demand webinar from Eurofins Cerep to learn how they use biophysics to carry out fragment screens and develop targeted protein degraders. You’ll get insight into how they: 💡 Used nanoDSF to confirm that their target protein, PIM3, was well-folded and intact so they could generate reproducible data 💡 Chose Spectral Shift technology over SPR after comparing binding data of a reference compound to the target 💡 Applied the same assay design to measure both low-affinity fragment binding and high-affinity PROTAC binding Watch the webinar: https://ow.ly/5SA150Rz3OE

𝐋𝐮𝐦𝐢𝐧𝐢𝐜𝐞𝐥𝐥 𝐔𝐧𝐯𝐞𝐢𝐥𝐬 𝐑𝐞𝐛𝐫𝐚𝐧𝐝: 𝐂𝐄𝐋𝐋𝐀𝐑𝐈𝐒™ – 𝐘𝐨𝐮𝐫 𝐒𝐭𝐞𝐥𝐥𝐚𝐫 𝐒𝐨𝐥𝐮𝐭𝐢𝐨𝐧 𝐟𝐨𝐫 𝐅𝐥𝐮𝐨𝐫𝐞𝐬𝐜𝐞𝐧𝐜𝐞 𝐂𝐞𝐥𝐥 𝐋𝐚𝐛𝐞𝐥𝐥𝐢𝐧𝐠 Cellaris (formerly known as Luminicell Tracker™), was inspired by a desire to capture the true essence of the technology, as well as the spirit of advancement it represents. The team at Luminicell believe in pushing the boundaries of research discoveries with their stellar performing products. Cellaris reflects not only the product's primary application in cell-related research, but also draws a parallel to the brilliance, high performance and long-lasting nature associated with stars. 𝐊𝐞𝐲 𝐇𝐢𝐠𝐡𝐥𝐢𝐠𝐡𝐭𝐬 𝐨𝐟 𝐂𝐞𝐥𝐥𝐚𝐫𝐢𝐬: 🌟 𝐒𝐭𝐞𝐥𝐥𝐚𝐫 𝐏𝐞𝐫𝐟𝐨𝐫𝐦𝐚𝐧𝐜𝐞 Unprecedented long-lasting and bright signal 🌟 𝐒𝐭𝐚𝐭𝐞-𝐨𝐟-𝐭𝐡𝐞-𝐀𝐫𝐭 𝐓𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐲 Biocompatible fluorescence nanoparticles powered with unique fluorophores that comes with aggregation-induced emission (AIE) characteristics 🌟 𝐄𝐧𝐚𝐛𝐥𝐢𝐧𝐠 𝐁𝐢𝐨𝐦𝐞𝐝𝐢𝐜𝐚𝐥 𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 Designed to address the demanding needs of translational research topics such as cell therapy, drug discovery, 3D model and tissue construct applications. Learn more about Cellaris: https://luminicell.com/ Read the official release here: https://lnkd.in/gd2C5BAD #Luminicell #Cellaris #LiveCell #FluorescenceImaging #Stellar #FluorescenceFriday #FluorescentFriday #LuminicellTracker #Rebranding