Group for Interventional Robotic and Imaging Systems (IRIS)’s Post

The ecstasy of being a neurosurgeon! Science Talk new episode with Dr Easwer, chief neurosurgeon of SCTIMST, on the major advancements in neurosurgery https://lnkd.in/g4X_QKxp

🔬 Exciting Research Update! Our collaboration with Prof Samir Maji's lab(BioSciences and Bio-Engineering, IIT Bombay) explores the mysteries of α-Synuclein fibrils, linked to #Parkinsons neurodegeneration. 🧠 Gratitude to Jaladhar Mahato and SMSD Lab, IIT Bombay for unwavering support! Using polarity-sensitive dye pairs Thioflavin T & Nile red, our study vividly captures surface polarity variations in fibrils, revealing interlaced nanoscale domains. #ResearchHighlight 🌐 🚀 Paving the way for innovative imaging in unresolved systems, our method provides insight into the hydrophobic-hydrophilic tapestry of enigmatic proteins. #FuturePossibilities Read more in ACS Chemical Neuroscience: https://lnkd.in/d68ERRDh #ScienceResearch #Neuroscience #Innovation 📚🔍

This is a big review, and I still haven't read it completely because it went open-access like just yesterday. However, there are still a few things that I want to point out. This is going to be long. ------------------------------------------------------------ Take this statement from the abstract for instance: Statement A : ""Studies in animal models and humans have shown that refractive state is optimized during postnatal development by a closed-loop negative feedback system that uses retinal image defocus as an error signal, a mechanism called emmetropization."" It bears pointing out that 'absence of perceived defocus' rather than being in a emmetropic, 0D state, represents the final endpoint of the closed-loop feedback mechanism (termed emmetropization here). This is an simple consequence of 'reference' for a process dependent on defocus signals. This means, that not just emmetropic eyes, but myopic/hyperopic eyes wearing appropriate refractive compensation, experiencing no change in refraction with time, are also in a similar closed-loop state. Also this statement : Statement B : ""A central question arises: if emmetropization operates as a closed-loop system, why does it not stop myopia development?"" Thinking carefully armed with the insights above about stability of refraction being the primary endpoint, this question is then redundant. This is the same as asking why an eyes undergoes myopic shift at all, when there exists a feedback loop acting in the opposite direction. Both questions are answered by, myopia development/onset/progression is the true/actual open-loop event and not (dioptre/extent of) myopia. ------------------------------------------------------------ And I can already spot them being 'inadvertently' correct in the this statement at the end of the abstract: ""This suggests that it cannot fully trigger the inhibitory arm of the emmetropization feedback loop. As a result, with an open feedback loop, myopia development becomes “open-loop”."" Here, *Myopia development* is nothing but myopia 'onset/progression' and indeed it refers properly to the actual open-loop condition. Similarly, later on, the article talks about inhibitory and stimulatory pathways of the emmetropization arm. Because we have already pointed out that absence of perceived defocus rather than emmetropia itself is the endpoint of the emmetropization loop, these must be two different processes. They can be conveniently termed myopization and hyperopization respectively for the mentioned stimulatory and inhibitory pathways in the text. Myopization, responding to perceived hyperopic defocus predictably causes myopia onset/progression and vice-versa.

Happy Birthday Rosalind Franklin Rosalind Franklin was born on July 25, 1920 in London. She contributed to the discovery of the molecular structure of the DNA. The 1962 Nobel Prize in Physiology or Medicine was awarded to Francis Crick, James Watson and Maurice Wilkins, recognizing their work in discovering the structure of DNA. Not included in the Prize was Rosalind Franklin, a scientist whose research made essential contributions to the Nobel Prize winners understanding of DNA. Franklin’s contributions included key images of DNA, taken with these imaging techniques. X-ray crystallography allows analysis of atomic structures not visible with traditional light microscopy. Through these images, Franklin realized that she was seeing two forms of DNA. #icmr #moleculerbiology #biotech #dnabiology #dnastructure

Dear friends and colleagues, To date very few journals publish video articles in our field, despite this type of article being of paramount importance for sharing techniques and improving their replicability. For this reason, I have opened a Methods Collection with JoVE on “Imaging Vascular Structures and Blood Flow in Ophthalmology”: https://lnkd.in/dKe9gmTM The purpose of this collection is to present innovative methodologies for vascular and blood flow imaging in ophthalmology, highlighting the impact of this technology on enhancing diagnostic capabilities in ocular pathology. The most recent Impact Factor for JoVE (ISSN 1940-087X) is 1.424, according to the 2021 Journal Citation Reports. JoVE articles are indexed in PubMed, Web of Science, SciFinder, EMBASE, and Scopus. Authors submit a traditional text manuscript, after which JoVE handles all the video production. If you are interested in contributing a video article on your methods, either message me or submit an abstract here: https://lnkd.in/dTJikZaW

Hyperelastic Bone (PLG) polymer, first described in a paper published in Science Translational Medicine, has an engineered architecture with nano, micro, and macro-level features designed to promote natural bone regrowth after implantation, without the need for an invasive autograft. #plg #polymerscience #boneregeneration

👀Are you interested in process of emmetropization and myopia development? If so, then probably you will be happy to read our latest publication in Vision Research 👩🏫 #myopia #emmetropization #vision #research #visionscience

🔥A new study led by Victor Borrell's laboratory at Instituto de Neurociencias de Alicante is published on the journal Science Advances 🙌 Researchers have discovered new types of brain stem cells and their involvement of parallel lineages to generate neurons. In this study, in which researchers from Max Planck Institute for Biological Intelligence and Ludwig-Maximilians-Universität München also collaborated, Scientists analysed thousands of cells using informatics tools to determine the genetic trajectory of these cells and their respective lineages. More info 👇 https://lnkd.in/dP9cZSNY You can read the full paper here 👇 https://lnkd.in/dRMPyF2y

Pleased to announce our publication in Environmental Research with an impact factor of 8.4 and Q1 status. The article explores the impact of spinal cord injuries, highlighting recent medical therapy advancements and underscoring challenges in recovery due to SCI's complex pathophysiology. The review delves into the intersection of nanotechnology and tissue engineering for SCI therapy, assessing biomaterials and techniques for cellular regeneration. Check out the article for insights into evolving SCI research and therapeutic strategies. Co-authored by Dr. Amirhossein Sahebkar, a highly regarded medical researcher worldwide. #Research #Nanotechnology #MedicalAdvancements #EnvironmentalResearch

Welcome to read our peer-review entry 📰 Biophysics and Quantum Limitation of Photoreceptive Processes 🖇 https://lnkd.in/gJZNzuGY 📑 This entry paper is an attempt to explain how the discrete nature of light (energy discreteness in the form of photons) constrains the light detection process all along the evolutionary path, in the not-fully-understood photoreceptive systems of unicellular microorganisms (nonimaging systems) and in the complex and well-known visual system of higher organisms (imaging systems). All these systems are perfect examples of the interplay between physics and biology, i.e., they are the perfect topic of research for biophysicists. The paper describes how photoreceptive and visual systems achieve the goal of photon counting, which information is conveyed by a finite number of photons, and which noise factors limit light-detecting processes. ✍ Laura Barsanti, Paolo Gualtieri #rhodopsin #retina #eye #Euglena #gracilis #noise #information