Hugo M. Santos’ Post

BREAKTHROUGH: New affordable microscope to improve diagnosis 🧪🔬 A new and affordable microscopy solution, the OpenFlexure Microscope, once an academic project, is now set to change medical diagnostics, especially in remote and low-resource settings. In an article detailing the microscope, scientists and innovators from UK🇬🇧, USA🇺🇸, Tanzania 🇹🇿 and Cameroon🇨🇲 including Ifakara Health Institute, describe its potential impact, particularly in addressing the problem of insufficient access to high-quality lab microscopes in many regions. Introduced in 2016, the microscope provides sufficient image quality to detect diagnostic features such as parasites and cancerous cells and has been successfully tested in real-world settings in Tanzania and the USA. >> https://lnkd.in/e4hj7YZK >>#IFAKARAnews University of Glasgow, Baylor College of Medicine, University of Bath, Mboalab, MD Anderson Cancer Center.

Steroid Hormones and Receptors (SHR) 2024 Abstract Submissions    We are welcoming abstract submission through the deadline of Sunday, September 1: https://bit.ly/3WA6A3O The goal of SHR 2024 is to present and discuss advances in steroid hormone action in biology and medicine, exploring their role in biology, chemistry, pharmacology, oncology, neurology, metabolism, cardiovascular biology and endocrinology. Sessions will cover (but are not limited to) the following topics:  ·        Cancer Biology and Therapeutics  ·        Cardiovascular Biology and Disease  ·        Neurobiology and Aging  ·        Metabolism and Comorbidities  ·        Molecular and Structural Biology of Steroid Receptors  ·        Immune System and Inflammation  ·        Systems Biology and Cell Signaling Networks The conference will feature Plenary and Keynote Lectures, oral presentations and posters by prominent and emerging leaders as well as trainees in the field. Conference proceedings will be published in an international peer-reviewed journal.    #SHR2024 

“How can we apply this advanced AFM-based method that we develop to understand disease progression? If it's cancer, if it's hearing, or if it's inflammation.” Our latest research highlight features Alexander Cartagena-Rivera, Ph.D., the Chief of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) Section on Mechanobiology. In his interview with Melissa Martin, Dr. Cartagena-Rivera discusses the two main divisions of his lab which focus on developing #AFM methods depending on the type of sample and how these methods can help us better understand disease progression and therapeutics. Dr. Cartagena-Rivera is also a member of the NIH Distinguished Scholars program for underrepresented minorities at the National Institute of Health and actively works to analyze the large datasets from AFMs in an unbiased way by considering age, gender, ethnicity, etc. Check it out below to learn more about Dr. Cartagena’s efforts in the lab, ongoing experiments in the clinic, and exciting new opportunities to use AFM technology as a point-of-care tool for people. #cancer #ResearchHighlight

We’re delighted to announce that Dr Arutha Kulasinghe is leading the Lung Cancer METASPATIAL Study that has been awarded nearly $1m by the Australian Government . The project is supported by the Wesley Research Institute and The University of Queensland.   The METASPATIAL Study will be undertaken over the next 4 years at Wesley Research Institute’s new Queensland Spatial Biology Centre (QSBC), with input from a wide range of experts across Australia. Dr Kulasinghe and his team will employ advanced spatial omics technology in their effort to revolutionise lung cancer understanding and treatment.   The Australian Government grant is part of a larger $229.46m initiative, aimed at supporting over 100 life-changing research projects addressing a wide spectrum of health challenges.   This initiative not only highlights the importance of collaborative funding in achieving significant research milestones but also places Wesley Research Institute at the heart of global efforts to combat serious health issues.   We’re grateful for the support from our partners and the Australian Government, reinforcing our dedication to making significant advancements in medical research.   Stay tuned for more updates as we progress with this pioneering venture. Read more - https://lnkd.in/g8Mnv9W7 Medical Research Future Fund - https://lnkd.in/gg78WaYV #WesleyResearchInstitute #LungCancerResearch #SpatialOmics #HealthInnovation #AustralianGovernment #research #Australianresearch

Come and listen to various aspects and case studies of High plex protein profiling with very high reproducibility of protein abundances #proteomics #biomarkers #drugdiscovery #Somalogic

Lab Spotlight: Dr. Lingyan Shi at UC San Diego Dr. Lingyan Shi’s lab focuses on bioorthogonal chemical bond imaging of complex molecular events during aging and disease progression. This work aids in disease detection, diagnosis, and understanding neurodegenerative diseases, cancer, and aging processes. Using the Compresstome Vibratome Dr. Shi’s lab uses our Compresstome vibratome for precise tissue slicing, producing high-quality sections for imaging and analysis. “My students and postdocs have generated impressive results with this instrument,” notes Dr. Shi. Read the full article to learn more about Dr. Shi’s research: https://lnkd.in/edXSmCvF #PrecisionaryInstruments #compresstome #microtomes #vibratingmicrotomes #vibratomes #tissuesectioning #precisioncuttissuesslices #tissueslicing #laboratoryequipment #labsolutions

🔊 Weekly round-up!   👩🏻🔬Women in STEM with Leila Jaafar As CEO of NUCLIDIUM AG, Leila Jaafar focuses on shaping, and the execution of, its international strategy towards its primary goal of improving the availability and affordability of radiopharmaceuticals in cancer diagnosis and therapy worldwide. 💊Breakthrough for pancreatic cancer treatment University of California, San Francisco researchers have designed the first small molecule drug targeting K-Ras GD12, which could improve pancreatic cancer outcomes.   🧫Recurrent urinary tract infections: potential cause discovered Duke University School of Medicine researchers find that an overgrowth of nerve cells in the bladder could cause rUTIs, which may offer new approaches to manage symptoms.   🧠Brain organoids: essential ethical investigation Scientists from the Institute for the Advanced Study of Human Biology (ASHBI) have provided important insights for the ethical landscape of brain organoid research, as advances in neuroscience have prompted new considerations.   Click on the links in the comments to read more! 👇   #drugdiscovery #lifescience #drugtargets 

🧬 Changing the History of Medicine—Rosenberg's Unexpected Journey In the early 1960s, Rosenberg and his collaborators at Michigan State University delved into vision research, only to stumble upon a groundbreaking discovery. It was an anti-cancer drug called cisplatin that would change everything. But from the start: Their journey began with a fascination for studying vision and the conductance in proteins. 👁️ Then, however, they pivoted to explore the impact of electric fields on E. coli bacteria, driven by a speculative theory involving a magnetic element in cell division. 🦠 Surprisingly, they discovered that an electric field, produced by platinum foil electrodes, led to abnormal growth in the bacteria but inhibited their division. Recognizing the potential anti-cancer applications, the team embarked on a quest to identify the causative agent, ultimately identifying cisplatin in 1964. Years of follow-up experiments led to remarkable success in treating solid tumors in mice, capturing the attention of the National Cancer Institute (NCI) and securing grant support. ⭐️ Rosenberg's unexpected scientific journey, shaped by serendipity and ambition, not only redefined our understanding of cell division but also paved the way for the revolutionary anti-cancer drug, cisplatin. Stay tuned and follow us for more awesome science! 😉 #science #research #cisplatin #biochemistry

On June 17 at 10:00 AM, Daniëlle Adriaans defended her PhD thesis titled "𝗗𝗶𝗴𝗶𝘁𝗮𝗹 𝗦𝗲𝗹𝗳-𝗠𝗮𝗻𝗮𝗴𝗲𝗺𝗲𝗻𝘁 𝗦𝘂𝗽𝗽𝗼𝗿𝘁 𝗳𝗼𝗿 𝗣𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝘄𝗶𝘁𝗵 𝗘𝘀𝗼𝗽𝗵𝗮𝗴𝗲𝗮𝗹 𝗖𝗮𝗻𝗰𝗲𝗿" at Universiteit Maastricht. 💻 Watch the video of the PhD defence ceremony here: https://lnkd.in/eq5KVH54 📘 Link to thesis: https://lnkd.in/e3D2UJ59 **𝗦𝗨𝗠𝗠𝗔𝗥𝗬** Patients diagnosed with esophageal cancer have to deal with the consequences, such as major impact on their physical status and quality of life. A digital self-management tool could be a solution to support these patients in their self-management during the peri-operative period. This dissertation resulted in a better understanding of patients' needs and desires for (digital) self-management support during pre- (and post-operative) care. In addition, a core set consisting of the most relevant topics for self-management was developed. Differences were found between esophageal cancer patients in their expectations and needs regarding self-management and eHealth for self-management support. It is important to apply a diversity of forms of support given the increased desire to provide person-centered care and the fact that no single approach will meet the needs of all patients at all times. The development of a new (digital) self-management intervention to support these patients can be based on the results of the various studies in this dissertation. Supervisors: Prof. Dr. Joep A.W. Teijink, Prof. Dr. Hanneke W.M. van Laarhoven Co-supervisors: Dr. Angelique T.M. Dierick-van Daele, Dr. Grard A.P. Nieuwenhuijzen #EsophagealCancer #PeriOperativeManagement #SelfManagement #DigitalSelfManagementSupport #CAPHRI #MaastrichtUniversity 

Looking forward to the intersection of advanced technology, engineering and cancer #immunotherapy. These are the kinds of tools we will need to create more advanced and specific modulation of the immune system to fight #cancer! Thanks to SITC for creating this workshop along with the annual #SITC2024 meeting! #AI #engineering #materials