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Tom Zupancic, our Chief Scientific Office, recently shared his insights at the Ohio House of Representatives, advocating for the transformative potential of House Bill 434. This bill aims to position Ohio as a leader in developing effective therapies for traumatic brain injuries and other neurodegenerative conditions. As a board member of the Brain Injury Research Foundation (BIRF), Tom was one of six expert presenters. He highlighted the urgent need for innovative treatments and the role that comprehensive programs like PRECEPT and SynapFx could play in revolutionizing TBI research and therapy. By fostering statewide collaboration and leveraging multiomics data for combination therapies, we can enhance our approach to these pressing health challenges. #Neuroscience #TraumaticBrainInjury #GeneTherapy

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The Traumatic Brain Injury Accelerator Program, with the Brain Injury Foundation serving as its research Coordinating center, is a unique private public partnership poised to position Ohio as an epicenter of traumatic brain injury research, Much like North Carolina's reputation and vaccine technology, Pennsylvania's expertise in gene therapy, and Maryland's leadership and infectious disease technology, this initiative. Aims to emulate the success stories of all of Ohio. Furthermore, I'd like to illustrate how California promoted positive change statewide by pioneering cell therapy technology. In 2004, California voters overwhelmingly approved a bill authorizing $3 billion in general obligation bonds to establish bonds to establish California Institute of Regenerative Medicine. This nonprofit institute has since generated over 50,000 jobs. Contributing hundreds of millions of dollars in taxes and yielding billions in revenue for the state, we could do the same thing here. Moreover, it is catalyzed numerous organizations to match the states funding commitment, magnifying its impact. Today, it stands as a global leader in stem cell technology, already reaping royalties and interest from its investments. While this funding mechanism represents just one of the strategy states have implemented to enhance their competitiveness in medical research. There is a dwindling interest among large pharmaceutical companies to independently develop therapies for traumatic brain injuries. Instead, these companies have increasingly relied on acquiring or licensing third party biotech products from universities and in startups. How the industry works now. Organizations have conduct conducted by researchers at John Hopkins Bloomberg School of Public Health revealed that the median cost of clinical trials supporting FDA approvals of new drugs is $19 million, constituting only a fraction of the total cost of drug research and development. The bulk of pharmaceutical expenditures is allocated to discovery and preclinical stages, averaging $430 million. Amidst the challenges posed by the traumatic brain injuries, dismal clinical trial. Track record and the hesitancy of small biotech companies entering the market due to lengthy and uncertain drug development timelines. Ohio emerges as a frontier and becoming a central hub of traumatic brain research. We have all of the key essentials here to put this together and make Ohio a hub for this industry. The requirement for matching grants infuses additional capital into Ohio's economy. Research funded by the NIH generates $2.46 and economic activity for every dollar of funding, according to the United Medical Research. Investing in research and development not only saves lives, but fuels job creation and economic growth. Across our communities, Ohio's research universities are a treasure trove of talent and entrepreneurship, precisely the economic inputs the Traumatic Brain Injury Accelerator program aims to expand. Sustaining a constant pipeline of innovative therapies will solidify Ohio's position as a leader in traumatic brain injury drug discovery and retain top research talent within our state, preventing brain drain from Silicon Valley in the East Coast. The Traumatic Brain Injury Accelerated Pilot Program is poised to achieve for traumatic brain injuries what the Manhattan Project and Apollo Project accomplished for physics and space exploration. The convergence of individuals from universities and biotech companies across Ohio uniting to combat I shared affliction for the betterment of humanity is truly extraordinary. Such collaborative efforts on this scale are unprecedented in my experience. Today, I'm advocating for policy reform to enable more efficient and equitable research and development spending to treat a condition that has disabled over 110,000 adults in Ohio.

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