Intellia Therapeutics, Inc.’s Post

SFBN Feed: Illuminating the dance of the messenger https://lnkd.in/gmGgiVC3 A new method for unlocking the secrets of RNA using ultrabright X-rays has implications for understanding diseases and designing therapeutics. Click here to view original post #BayArea #SanFrancisco #Biotech #Lifescience #News

So amazing how fast antibody production can be! As their catch phrase goes, Biointron can certainly help with accelerating your antibody discovery. https://lnkd.in/gbgdjSYe

EditCo Bio & Saha Lab Collaboration Breakdown: The study demonstrates the efficient production of primary human T cells with simultaneous CRISPR/Cas9-mediated knockout of three genes (B2M, TRAC, PD1) and non-viral transfection of a CAR targeting GD2. The resulting TRAC-B2M-PD1-deficient GD2 CAR T cells show high cytotoxicity against neuroblastoma cells, retain a central memory phenotype, and exhibit low off-target effects and chromosomal alterations. This approach highlights the potential for rapid, safe, and efficient manufacturing of potent allogeneic CAR T-cell products.

Did you miss our Webinar on how to Scale up your CRISPR Screening projects? Watch on-demand where Single Cell Discoveries did a 1M scCRISPR project. Check it out: https://lnkd.in/eyGrj99H

CRISPR-Cas9 is a powerful tool to interrogate gene function in a targeted and systematic manner. Although the technology has been scaled up for large-scale genetic screens in cell culture, similar scale screens in vivo have been extremely challenging due to the cost, labor, and time required to generate and keep track of thousands of mutant animals. We reported the development of Multiplexed Intermixed CRISPR Droplets (MIC-Drop), a platform that makes large-scale reverse genetic screens possible in zebrafish. In this webinar, we will share the details of this technique and discuss best practices for performing MIC-Drop screens in zebrafish. The speakers will discuss: · Steps to successfully perform a large-scale CRISPR screen in zebrafish using the MIC-Drop platform · Possible directions to expand the applicability of MIC-Drop Speaker Saba Parvez Saba Parvez, Ph.D. Postdoctoral fellow, Department of Pharmacology & Toxicology, University of Utah, Salt Lake City, UT

The next big advancement in CITE-seq technology is coming soon.  Expand the power of CITE-seq to beyond the cell surface ! The countdown begins for a complete and validated solution to detect RNA and surface + intracellular proteins !  In the meantime, check out our single cell multiomics solutions at https://lnkd.in/e84Z8cA9. #SingleCellAnalysis #BDBiosciences #SingleCellMultiomics For Research Use Only. Not for use in diagnostic or therapeutic procedures. 

🌟 Missed our recent CellEDIT webinar on #CRISPR Gene Engineering? Don't worry, you can watch the replay now! 📽️Join us as we share key insights from a selection of use cases to explain the uniqueness of CellEDIT and direct intra-nuclear delivery of RNPs in our CRISPR Gene Editing workflow. View the webinar replay here: 🔗 https://bit.ly/48oBj78 🚀 Watch now and take your #research to the next level! #WebinarReplay #geneediting #geneengineering #crisprcas9 #CRISPR

"Regarding vaccine development...and the role my team plays in the development of #cryoEM technology, we see the study and dissemination of virus structures, and the proteins that comprise them, as vital to vaccine design," says my colleague Melanie Adams-Cioaba in a Q&A with Drug Discovery World. Check out the full interview in the spring issue today!