Jakob Wilms’ Post

Imagine a future where leveraging a precision approach – identifying the right patient, for the right treatment, at the right time in their treatment journey – becomes the norm to treat neurodegenerative diseases like Alzheimer’s and Parkinson's. What challenges must we solve to achieve this future?   I had the honor of sitting down with Karen Jagoda, host of the Empowered Patient Podcast, to chat about this very topic – addressing the complexities of developing targeted therapies for these diseases.   Karen and I had a very insightful conversation around the importance of early detection and intervention to identify patients at specific stages and maximize the potential for precision in treating neurodegenerative diseases. With this approach in mind, I shared how #MyCompany is expanding our understanding of the genetics of these disorders, and our commitment to a patient-centric treatment approach.   Want to learn more? Tune in to the full podcast for insights on the future of precision neuroscience and let me know your thoughts in the comments: https://bit.ly/3UhLC92   #PrecisionNeuroscience #AlzheimersDisease #PrecisionMedicine

I can’t say enough good things about @andrewhuberman and #thehubermanlabpodcast. If you’re serious about leveraging neuroscience to optimize your physical and mental health, you likely know about this free resource. The reality is the we need more than free access to quality content. We also need tools that help us cultivate the courage to change. Because without that, we won’t keep showing up with consistency to create lasting change. And DISCIPLINE is a necessary component of behavior modification as well. There are many reasons people struggle to develop discipline like growing up in a family system with a tyrannical authority parent that called the shots and shamed you for making mistakes. There are many reasons people aren’t able to suit up and show up for themselves. It’s not a work ethic problem it’s a self worth problem. Helping people understand what happened to them and how adverse childhood experiences lead to attachment wounds affects more than how we commit and connect in personal relationships. Our family of origin issues shows up in our professional life big time. So if you’re struggling with impostor syndrome or you feel stuck and can’t move forward even with access to the best content like what @thehubermanlabpodcast offers, reach out and let’s connect. Moving forward for many people means it’s time to reflect on how the memos we got growing up and attending to trauma motivated behaviors including addictions of all varieties that numb pain in the short term but in the long run they become another problem to overcome. One addiction that gets rewarded in our society is Workaholism. The reframe is “I’m a super overachiever”. Yup. I see you. I used to engage in those behaviors too. Until my health took a hit. It turns out needing to be busy is a way to avoid being with yourself and your pain. Making money, making lots of money doesn’t make childhood wounds get easier to bare. It just gives you more money to buy more stuff thus creating more ways to distract and avoid pain. I’m all for making profits. Money isn’t evil. But let’s get real about what motivates you. What are you striving for? And why? What happens after you reach a goal? How long can you linger before you have to set another one? Can you sit with yourself? Do you allow spaciousness in your life? How do you attend to your being?

Dr. Hamid Okhravi, the Director of the Neurohealth Institute at EVMS and leading local researcher, is working to find a way to begin to halt Alzheimer’s progression. The groundbreaking research is underway right now at EVMS. It’s called the AHEAD 3-45 study. #AlzheimersAwareness | #AlzheimersAwarenessMonth

🧬 Here is an ultimate database like a GPS for navigating the complex landscape of Alzheimer's Disease (AD) at the cellular level. 🧭 Imagine having the power to zoom in on a single cell and understand its role in AD, just like finding your friend in a crowded concert using your phone's location services. That's what this tool, ssREAD offers with its vast data collection from over 7 million cells! 📱➡️🔬 With ssREAD, researchers can now say goodbye to the days of getting lost in translation (literally) and hello to a new era of precision and clarity in AD research. It's like having a library where the books are cells, and every book tells a story that could lead to unlocking the mysteries of Alzheimer's. 📚🔍 Here is ssREAD, the beacon of hope in Alzheimer's research. It maps, provides better navigation, and is one step closer to finding the insights we've been searching for 🥂🧠 p/b The Ohio State University, The Ohio State University College of Medicine, University of Florida, Cankun Wang, Megan McNutt, Jiang Bian, HONGJUN (Harry) FU, Qin Ma #AlzheimersResearch #Innovation https://lnkd.in/gKx7RY2P

#USask researcher Dr. Tyler Wenzel has developed a “mini-brain” that could revolutionize the way Alzheimer’s and other brain-related diseases are diagnosed and treated. “It gives me something that I think will impact society and have actual relevance and create some change … it has a strong potential to shift the landscape of medicine.” #USaskResearch | #BeWhatTheWorldNeeds Click below for more on this amazing research:

🎉 Thrilled to share my latest publication as a second author - a new paper on Alzheimer's disease biomarkers and risk prediction, focusing on the integration of machine learning, computational modeling, and survival analysis. We developed effective imputation models based on clinical measures to infer Alzheimer's disease neuropathological changes and disease burden. We are proud to build on the foundation laid by our first paper in 2022 (https://lnkd.in/eTT-yz_q), to which I contributed as the third author. A heartfelt thank you to my exceptional co-authors from Emory University School of Medicine and Rush University Medicine Center. Your expertise, commitment, and encouragement have been instrumental in our work's success! This research represents a significant step forward in our understanding and approach to this challenging field, and we hope it will pave the way for early detection, intervention, and effective treatments, enabling more individuals to combat Alzheimer's disease with promising outcomes! #AlzheimersDisease #AlzheimersResearch #Dementia #MachineLearning #Biostatistics #EmoryUniversity #RushUniversity

🚀 Advancing Alzheimer's Research! This week, Qairnel was at the kick-off meeting of PREDICTOM, a €21M project dedicated to validating cutting-edge AI technologies for early Alzheimer's detection. 🔬 Our Mission: reinventing clinical trials! Excitingly, Qairnel is leading the clinical evaluation study in France, a pioneering effort with a unique twist – it's a fully decentralized trial led by general practitioners! We're set to recruit 250 participants through our digital clinics at docteurmemo.fr, redefining how we bring innovation to the patients. 🌐 Be Part of the Change! Are you concerned about memory issues and eager to learn more about our innovative study? 👉 https://lnkd.in/eYBcck7D Or perhaps you're a forward-thinking GP interested in shaping the future of healthcare? 👉 email us now at [email protected] Let's shape the future of Alzheimer's detection together! 🌟 with Dag Aarsland Timo Schirmer Spiros Nikolopoulos Holger Fröhlich Lucas Paletta Robert Perneczky Dianne Gove Matthias Müllenborn AnaBea Solana Gaby Marquardt among others. https://lnkd.in/evVRahzf #Qairnel #Predictom #ClinicalInnovation #AlzheimersResearch #DecentralizedTrials #InnovateForHealth

Let’s break it down 👇 ! Now, you know when people say that a talk/vid/whatever, is about a certain type of epilepsy? Well, that doesn’t mean that it isn’t also about YOUR epilepsy/that of the person you love! Because, heaps of what is discovered in research 🧬🧠👨🔬 can contribute to providing answers to potential treatments/solutions for other epilepsies! Today’s Epilepsy Sparks Insights podcast talks about just that! It was focussed on helping people with the #stxbp1 🧬 epilepsy but it just so happens that the results and treatment may also be applicable to helping treat people with other epilepsies like #dravet syndrome 🧬! It’s titled: “Treating Epilepsy By Increasing Neuronal 🧠Excitement!” Yeah, INCREASING excitement! Scientist Jean-François Perrier’s (of the Perrier Lab at Københavns Universitet - University of Copenhagen 🇩🇰) shares with us his wild discovery to hopefully 🤞 be applied in clinical trials at Filadelfia Epilepsihospital og sociale tilbud 🇩🇰 and another in Netherlands 🇳🇱, soon! Check out the chat, here👇👇👇! 📹 YouTube https://shorturl.at/bdkmE 🎧 Podcast (available on any platform under "Epilepsy Sparks Insights" - this is the Podbean link though): https://shorturl.at/auIT3 🔗 More on Jean-François plus Transcription https://shorturl.at/krSW0 #epilepsy #rareepilepsy #STXBP1 #genetics

Welcome to the OM1 Parkinson’s Disease Dataset! With no currently known cure and no interventions that meaningfully reduce the progression of PD, it is tremendously important to find potential patient populations as early as possible since these medications are most effective in the early stages. With the OM1, Inc. Research-Grade, Parkinson’s Disease, Real-World Data (RWD), companies can access longitudinal, multi-source, curated datasets, offering rapid access to deep clinical data, insights, and outcomes. OM1 RWD  offers; ✔ 803,000+ total Parkinson’s Disease patients in the OM1 Real-World Data Cloud.  ✔6,200+ Parkinson’s disease patients with neurologist notes ✔5,308+ Parkinson’s disease patients with deep clinical data With our specialized RWD for PD, customers can leverage data and OM1 expertise to access; ✔Advanced therapies and comorbidities ✔Demographically & geographically diverse population ✔Social Determinants of Health (SDoH) data ✔Clinical notes for additional extraction and curation Meet our expert, Carl D. Marci, M.D. our Chief Clinical Officer and Managing Director of Mental Health and Neuroscience at OM1. Let’s connect to learn more about how OM1 can support necessary insights around current research studies. Check out the links below for more information; 📍Book a meeting: https://lnkd.in/eJcKBAJK 📍Neuro eBook: https://lnkd.in/eKhdanKx 📍PD Smart Link : https://lnkd.in/eF4adVxY #parkinsonsdisease #pd  #neuroscience #patientjourneys

Thank you Cristian Owen for featuring MARAbio's CEO, Michael Paul, PhD, on your recent episode of The Venari Podcast! Michael and the great team at MARAbio share a collective purpose to execute on MARAbio's mission to detect and treat Maternal Autoantibody Related Autism (MARA). Ultimately, we envision testing every woman prior to pregnancy and every child at birth to reduce the care burden of autism and prevent the most severe effects of autism from occurring. #earlydiagnosis #timematters #autismresearch