JAMA’s Post

Semaglutide, taken for diabetes or obesity, was associated with non-arteritic anterior ischemic optic neuropathy (NAION). Further study would be needed to clarify if this drug causes NAION associated with visual loss. https://ja.ma/45NOpL5

...here's the link to our paper on how #SNPs (single nucleotide polymorphisms) in the anti-#aging factor #BDNF (brain-derived #neurotrophic factor) can drive obesity. https://lnkd.in/g5ahC8_Q

For patients with minor stroke or transient ischemic attack (TIA) who carry the CYP2C19 loss-of-function allele, those with obesity receive more clinical benefit from ticagrelor-acetylsalicylic acid (ASA) than clopidogrel-ASA. https://fal.cn/3A5mG

When it comes to peripheral neuropathy, do you know what the top risk factors are? They include: -Diabetes -Alcohol misuse -Vitamin deficiencies Other factors like infections, autoimmune diseases, chemotherapy, and disorders of the kidney, liver, or thyroid can also contribute to the condition. Want to find out more about neuropathy and how to help your patients dealing with it? Schedule an appointment to learn about the NeuropaCalm Care Program: https://lnkd.in/g8MCVj_U #NeuropaCalm #peripheralneuropathy #neuropathy #diabetes #pharmacy#pharmacies #pharmacist #pharmacists #clinic#diabeticperipheralneuropathy #medicalprofessional #medicalprofessionals

The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1 Our findings indicate that APS-1, which is caused by AIRE deficiency, is characterized by excessive, multiorgan interferon-γ–mediated responses. JAK inhibition with ruxolitinib in five patients showed promising results. https://lnkd.in/evCDyYTs

Here's why: Constant exposure to low levels of environmental BPA throughout one’s lifetime can increase the risk of developing: • An altered metabolism, which can lead to weight gain and obesity • Insulin resistance, which can lead to Diabetes II • Hypertension, which can lead to heart disease • Certain types of Cancer (including prostate and breast cancer) • Reproductive abnormalities, premature puberty, infertility, and miscarriage The GOOD news is that BPA exposure may be significantly reduced by making certain lifestyle changes, such as by decreasing the use of BPA-containing products!

📌Polycystic ovary syndrome is prevalent among reproductive-aged women and is characterized by irregular cycles, hyperandrogenism, and polycystic ovary morphology. 📌Its uncertain etiology involves genetic and environmental factors, leading to comorbidities like infertility, thyroid diseases, obesity, insulin resistance, and diabetes, necessitating diverse treatment approaches for symptom management. 📌This review aims to understand the underlying causes of the syndrome and to correlate this understanding with symptom management approaches. 📌For more information please check out the review named "POLYCYSTIC OVARY SYNDROME (PCOS) PATHOGENESIS, DIAGNOSIS, AND COMMON TREATMENT OPTIONS: A LITERATURE REVIEW" in our latest issue!

The horseshoe kidney (HSK) is the most common congenital abnormality of the upper urinary tract with an incidence of approximately 1 in 500 in the general population. Ultrasound diagnosis is possible by demonstrating the fusion of the lower poles of both kidneys in front of the descending aorta. HSK is best demonstrated on the coronal scans when renal tissue will be seen crossing the midline. HSK is found in 30% of cases of Turner syndrome and in 20% of trisomy 18. Associated syndromes are found in 15% of cases. The most common is Caudal regression syndrome. An isolated finding of a HSK is generally considered benign. However, there is a higher incidence of Ureteropelvic juction (UPJ) obstructions, nephrolithiasis, and reflux in adult life compared to the general population. Finally horseshoe kidneys also have an increased frequency of some common renal cancers. Here is a 24 weeks Turner Syndrome fetus with HSK. Please note the lower position of the kidneys and the abnormal angle of the renal pelvises.

MK-801, a bimodal drug that successfully cures obesity, hyperglycemia, and dyslipidemia in mouse models of metabolic illness by combining N-methyl-D-aspartate (NMDA) receptor antagonism with glucagon-like peptide-1 (GLP-1) receptor antagonism. https://lnkd.in/g8QUUECF