Kannalife, Inc.’s Post

🔬 New Research Alert! Kannalife Sciences, Inc. Scientists uncover a link between KLS-13019 and the GPR55 receptor, shedding light on its promising role in reducing inflammatory markers associated with chemotherapy-induced peripheral neuropathy (CIPN). In contrast, cannabidiol (CBD) shows low efficacy, highlighting significant differences between the two compounds. Our recent study in the Journal of Molecular Neuroscience investigates the anti-inflammatory actions of KLS-13019 and CBD in CIPN. 💡 Insights from this study pave the way for targeted therapies and innovative approaches to treating inflammation. Stay tuned. 📚 Read the full study here: https://rdcu.be/dFqru Neuropathix, Inc. #Research #Cannabinoids #PeripheralNeuropathy #NeuroPain #Innovation #HealthScience #Neuroscience #MedicalResearch #Inflammation #GPCR #GPR55 #CIPN #Mitochondria

🔬 New Research Alert! Kannalife Sciences, Inc. Scientists uncover a link between KLS-13019 and the GPR55 receptor, shedding light on its promising role in reducing inflammatory markers associated with chemotherapy-induced peripheral neuropathy (CIPN). In contrast, cannabidiol (CBD) shows low efficacy, highlighting significant differences between the two compounds. Our recent study in the Journal of Molecular Neuroscience investigates the anti-inflammatory actions of KLS-13019 and CBD in CIPN. 💡 Insights from this study pave the way for targeted therapies and innovative approaches to treating inflammation. Stay tuned. 📚 Read the full study here: https://rdcu.be/dFqru Neuropathix, Inc. #Research #Cannabinoids #PeripheralNeuropathy #NeuroPain #Innovation #HealthScience #Neuroscience #MedicalResearch #Inflammation #GPCR #GPR55 #CIPN #Mitochondria

🔬 New Research Alert! Kannalife Sciences, Inc., Temple University - Lewis Katz School of Medicine - Scientists Douglas Brenneman, William Kinney, Mark McDonnell, Michael Ippolito, PhD and Sara Jane Ward uncover a link between KLS-13019 and the GPR55 receptor, shedding light on its promising role in reducing inflammatory markers associated with chemotherapy-induced peripheral neuropathy (CIPN). In contrast, cannabidiol (CBD) shows low efficacy, highlighting significant differences between the two compounds. Our recent study in the Journal of Molecular Neuroscience investigates the anti-inflammatory actions of KLS-13019 and CBD in CIPN. 💡 Insights from this study pave the way for targeted therapies and innovative approaches to treating inflammation. Stay tuned. 📚 Read the full study here: https://rdcu.be/dFqru Neuropathix, Inc. Dean Petkanas #KLS13019 #CBD #Research #Cannabinoids #PeripheralNeuropathy #NeuroPain #Innovation #HealthScience #Neuroscience #MedicalResearch #Inflammation #GPCR #GPR55 #CIPN #Mitochondria

☑️ *READ ABSTRACT BELOW:* Keywords: ALS; C9orf72; CP: Neuroscience; GSK2606414; NMO; autophagy; dipeptide repeat proteins; muscle denervation; neural degeneration. Hexanucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Due to the lack of trunk neuromuscular organoids (NMOs) from ALS patients' induced pluripotent stem cells (iPSCs), an organoid system was missing to model the trunk spinal neuromuscular neurodegeneration. With the C9orf72 ALS patient-derived iPSCs and isogenic controls, we used an NMO system containing trunk spinal cord neural and peripheral muscular tissues to show that the ALS NMOs could model peripheral defects in ALS, including contraction weakness, neural denervation, and loss of Schwann cells. The neurons and astrocytes in ALS NMOs manifested the RNA foci and dipeptide repeat proteins. Acute treatment with the unfolded protein response inhibitor GSK2606414 increased the glutamatergic muscular contraction 2-fold and reduced the dipeptide repeat protein aggregation and autophagy. This study provides an organoid system for spinal neuromuscular pathologies in ALS and its application for drug testing. Gao C, Cell Rep. 2024 Mar 26;43(3):113892. doi: 10.1016/j.celrep.2024.113892. Epub 2024 Mar 1. PMID: 38431841. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

3D Model Brains from Multiple Donors: Key Insights 🧠 Innovative Brain Models Researchers have developed 3D brain organoids using cells from multiple donors, with the aim to reveal individual variations in brain development and drug responses. #BrainModels #Organoids 🔬 Chimeroid Technology These "Chimeroids" combine cells from up to five donors, potentially from hundreds in the future, enhancing genetic diversity in brain studies. #Chimeroids #GeneticDiversity 👩🔬 Drug Response Testing This model could predict individual responses to new therapeutics, providing a powerful tool for personalised medicine. #PersonalisedMedicine #DrugTesting 📚 Methodology The approach involves creating single-donor organoids, which are then homogenized and pooled to form composite organoids, enabling detailed neurophysiological and molecular studies. #ResearchMethods #Neuroscience Altogether, it looks very labor intensive and will be great to 'multiplex' starting donor cells so one can backtrack differences in response to treatment. It may also allow one to have different n number replicates in one go! Source: https://lnkd.in/emk7vpVn Image source: Antón-Bolaños et al./Nature

𝗛𝘂𝗺𝗮𝗻 𝗕𝗿𝗮𝗶𝗻 𝗖𝗵𝗶𝗺𝗲𝗿𝗼𝗶𝗱𝘀 𝗶𝗻 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 - 𝗔𝗻 𝘂𝗽𝗱𝗮𝘁𝗲 𝘁𝗼 𝘁𝗵𝗶𝘀 𝗍𝗁𝖾𝗆𝖾 𝗳𝗿𝗼𝗺 𝗮 𝗉𝗈𝗌𝗍 𝖿𝗋𝗈𝗆 𝗳𝗲𝘄 𝘄𝗲𝗲𝗸𝘀 𝗮𝗴𝗼! A important survey finds that regulatory concerns are a major barrier to the adoption of non-animal testing models in research and development. Despite advances in alternative newer and increasingly more relevant in vitro methods, these models face significant challenges in gaining regulatory acceptance. #NonAnimalTesting #RegulatoryAffairs #R&D Read more here: https://lnkd.in/gxUncYXh 👌 A good work around that should be promoted: A new paper in Nature (https://lnkd.in/e7Dv7QiZ) shows that mixing cells from different individuals can help bypass the need for running different numbers at once.... Human Brain Chimeroids in Disease Research: 🧠 New Adapted Brain Model: Chimeroids, created by co-developing cells from multiple donors, replicate human brain development, allowing for diverse genetic representation. #Neuroscience #Innovation 🧪 Genetic Variation Study: This model investigates how genetic differences affect brain cell response to neurotoxins like ethanol or drugs such as valproic acid, showing variability in susceptibility among the same cells which came from different individuals. #Genetics #Research 🔬 High-Throughput Analysis: Chimeroids are a scalable system for examining individual differences in brain development and disease processes, enhancing our understanding of genetic impacts on health. #Bioinformatics #DiseaseResearch Such newer technologies will fuel research results with wider relevance and takes into account personalised medicine without having to resort to in vivo models.

New study introduces a screening method for identifying drugs that modulate the reactivity of astrocytes, cells implicated in neurodegeneration due to disease, injury, and aging. Histone deacetylase 3 (HDAC3) inhibitors were found to effectively reduce harmful astrocyte responses. The inhibitor RGFP966 specifically prevented the formation of reactive astrocytes and promoted neuroprotection in mouse models, highlighting the therapeutic potential of targeting astrocyte reactivity in neurodegenerative conditions. #Neurodegeneration #AstrocyteModulation #HDAC3Inhibitors #Neuroprotection #BiomedicalResearch #Neuroscience #TherapeuticStrategies https://lnkd.in/ei23Txdx

Small-molecule-induced epigenetic reprograming of lipid metabolism inducing CNS myelin regeneration Published in Cell, this article describes that oligodendrocytes in MS lesions are present but epigenetically silenced, preventing myelin production. Researchers developed a molecule (ESI1) that reverses this silencing, promoting remyelination in animal models and improving cognitive function in aged mice. ESI1 reprograms lipid metabolism in oligodendrocytes to enhance myelin production and potentially offers a new approach to treating demyelinating diseases. https://lnkd.in/edKwZa_C #genetics #genomics #precisionmedicine #genomicmedicine #epigenetics #omics #smallmolecule #brain #neurology #neurodegeneration #neuroscience #ms #multiplesclerosis #biotechnology #therapeutics #aging #longevity #dementia #innovation #research #science #lipids #metabolism #sciencecommunication

🔬 Breaking News: Nanobodies - An Extraordinary Tool in Neuroscience! 🧠 We are nearing the launch of our groundbreaking #nanobody #neuroscience series. Meanwhile, here is a cornerstone paper that has unveiled an exciting discovery in #αsynuclein and nanobody research. The researchers have successfully developed PFFNB2, a nanobody that specifically targets α-syn preformed fibrils. This breakthrough holds immense potential for therapeutic development in α-syn-related diseases such as #LewyBody #Dementia #parkinsonsdisease https://lnkd.in/eTpcZjv4

Publish a new article. Correspondent and study designer: M.Y Zamanian CNS Neuroscience & Therapeutics IF: 7 The results of this study show that Gem has neuroprotective effects through several cellular and molecular mechanisms such as: (1) Gem has the ability to upregulate pro-survival factors (PGC-1α and TFAM), promoting the survival and function of mitochondria in the brain, (2) Gem strongly inhibits the activation of NF-κB, AP-1, and C/EBPβ in cytokine-stimulated astroglial cells, which are known to increase the expression of iNOS and the production of NO in response to proinflammatory cytokines, (3) Gem protects dopamine neurons in the MPTP mouse model of PD by increasing the expression of PPARα, which in turn stimulates the production of GDNF in astrocytes, (4) Gem reduces amyloid plaque pathology, reduces the activity of glial cells, and improves memory, (5) Gem increases myelin genes expression (MBP and CNPase) via PPAR-β, and (6) Gem increases hippocampal BDNF to counteract depression.