KCR’s Post

ASCP Daily Diagnosis 08/28 CST If given to patients with early and symptomatic COVID-19, treatment with remdesivir can accelerate the rate of viral clearance in oropharyngeal swabs over 1 week. it is possible to determine if a drug is antiviral or not in humans through regular swabbing, quickly and with relatively small numbers of patients. https://lnkd.in/gxHfDazS

Manage Toxicities From ICIs. As use of immune checkpoint inhibitors (ICIs) increases, it's important to answer questions about adverse effects. Check out our latest article in Hospital Pharmacist's Letter to learn more about managing toxicities from ICIs.

Response to direct-acting antiviral therapy was similar between patients with and without HBV coinfection, with most patients completing the planned course of treatment and achieving SVR, even in the case of HBV reactivation. https://lnkd.in/etZi2Rid

HEPCITAJ® #SofosbuvirTablets, Film-coated 400 mg contains the active substance sofosbuvir which is given to treat #hepatitis C virus infection in adults & adolescents from the age of 12 years up to the age of 18 years. Sofosbuvir Tablets, Film-coated 400 mg is always taken with other medicines. Always take this medicine exactly as your health care provider has told you. Check with your health care provider if you are not sure. Ledipasvir and sofosbuvir are both direct-acting antiviral agents. Sofosbuvir is a liver-targeted nucleotide prodrug of the active triphosphate GS-461203, which has been approved for use in HCV genotypes 1–4. It works as an inhibitor of the #HCV NS5B RNA-dependent RNA polymerase, which acts as a chain terminator. It works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. 📝#HepatitisC is a virus that infects the liver. #TajPharma

Two things never cease to amaze me about the Immune System: 1) Its incredible dynamism and plasticity. It senses the world as much as we do (and through us, in a sense, it also interacts with it). 2) How we are nowhere near fully understanding 1). We are just getting started with documenting autoinflammatory syndromes and anti-cytokine antibodies, mechanisms only discovered in the late 90s, early 2000s! #clinicalimmunology #internalmedicine #autoinflammatory #immunodeficiency

One of the particularities for the registration of IVD devices in Brazil is that there are compulsory notification diseases listed in Ordinance 204, of February 17, 2016, issued by the Ministry of Health. Among these diseases we can find Dengue, Chikungunya, Zika and Leptospirosis, which are seasonal. This seasonality can be great business for manufacturers of in vitro diagnostic kits, who must pay attention not only to the commercial scenario, but also to the regulatory one. Discover our impressions of the IVD market for notifiable diseases in our post. Access the link below: https://lnkd.in/dywRHhYg #medicaldevices #ivd #regulatoryaffairs #ANVISA

Closing the Respiratory Tract Infections Diagnostic Gap with PCR-based Testing https://buff.ly/43zgIeT One of the best ways to close this diagnostic “gap” is to improve the clinical understanding and utility of molecular diagnostics, such as PCR testing, says @Christopher J Michaud, PharmD, BCCCP, BCPS, Director of Clinical Treatment, Industry Lab Diagnostic Partners Owner and Principal, Pharmacotherapy Solutions, LLC. Read more in our latest blog.

Response to direct-acting antiviral therapy was similar between patients with and without HBV coinfection, with most patients completing the planned course of treatment and achieving SVR, even in the case of HBV reactivation. https://lnkd.in/etZi2Rid

Study compared the ability of selected hvKp (ST23 and ST86) and MDR hvKp (ST11 and ST147) K. pneumoniae clinical isolates to survive in human blood and serum, and tested phagocytic killing of the microbes by human neutrophils. On average, the hvKp isolates tested had greater survival in blood and serum compared with MDR hvKp isolates. Compared with MDR hvKp isolates, the hvKp isolates had less surface-bound serum complement following culture in normal serum. Consistent with these findings, the percentage of neutrophils with phagocytosed hvKp isolates was limited (<5%), whereas >67% of neutrophils contained ingested MDR hvKp. https://lnkd.in/e5FNxMw9