Killian Anreise’s Post

📌 New mention of Abyntek Biopharma at Food and Chemical Toxicology journal, entitled “Protective effects of oral administration of lactic acid bacteria strains against methylmercury-induced intestinal toxicity in a murine model”.   The utilization of lactic acid bacteria has been proposed to mitigate the burden of heavy metal exposure through processes probably involving chelation and reduced metal bioaccessibility. Researchers from Universitat Politècnica de València (UPV) have evaluated the effects of daily intake of two strains of lactobacilli (Lactobacillus intestinalis LE1 or Lactobacillus johnsonii LE2) in the reduction of intestinal toxicity due to exposure to heavy metals. One of the positive effects observed is the reduction of the overproduction of mucus produced by methylmercury. The #polyclonal anti-mucina type 2 (MUC2) #antibody from our brand (Abyntek Research Reagents) has been used for this.   👉 Check out the article: https://lnkd.in/dpxqZRax   ⚗ Find out our #bioreagents brand, Abyntek Research Reagents: https://lnkd.in/db2NPwb3 #Antibodies #pAb #Biotech

OAT1 protein plays an important role in the variability of #therapeutic #efficacy & #toxicity of many drugs. Here, the authors exploited the nanoDSF capability of a NanoTemper Technologies Prometheus to understand #OAT1 stability in the presence & absence of ligands. #OATs (organic anion transporters) #proteins are critical to the entry of many #drugs into the renal proximal tubules and, ultimately, for renal excretion. OAT1 is named specifically as a clinically relevant transporter, and it is “recommended” by #regulators to investigate OAT1 inhibitor potential of all new drugs, thus, it is important in #adme, #toxicology & #ddi studies #biophysics #cryoem #structuralbiology

"In mammals, the #Kidney plays an essential role in maintaining blood homeostasis through the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion transporters (OATs) are responsible for the recognition of metabolites and #Toxins in the #Nephron and their eventual urinary excretion. Inhibition of OATs is used therapeutically to improve drug #Efficacy and reduce #Nephrotoxicity!" Simon Newstead and colleagues from the University of Oxford revealed the #CryoEM structures of OAT1 bound to α-KG, the antiviral #Tenofovir and clinical inhibitor #Probenecid, used in the treatment of #Gout: https://lnkd.in/eHx-X8SD #DrugDesign of inhibitors for specific OAT1 family members would substantially expand clinical options for modulating drug #Pharmacokinetics! #CryoEM #Pharmacology #RenalClearance #DrugDiscovery

📌 New mention of Abyntek Biopharma at Food and Chemical Toxicology journal. Researchers at the Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC) publish an article entitled “Oral exposure to inorganic mercury or methylmercury elicits distinct pro-inflammatory and pro-oxidant intestinal responses in a mouse model system”. The article details the effect of chronic exposure to inorganic mercury and its impact on the intestine. As a result, it is detected that the mercury species used caused oxidative stress in the small intestine and inflammation in the colon. Thanks to this research, it has been possible to better understand the effect of mercury on the intestine, and it has been hypothesised that intestinal toxicity is the basis of the pathologies observed at a systemic level due to mercury poisoning. To measure mercury exposure that affects mucus production at the intestinal level, was used the anti-MUC2 #antibody from our own brand of #bioreagents, Abyntek Research Reagents. 👉 Check out the article: https://lnkd.in/dSN3nS4V ⚗ Find our bioreagents brand with more than 45.000 references in antibodies, proteins and ELISA kits https://lnkd.in/db2NPwb3 #Biotech #Proteins #ELISAkit

Accurate and precision of in vitro analysis of kill-rate of antimicrobials requires in-depth method development. This includes assessment of bactericidal or fungicidal impact of new antimicrobial drug candidates and their dynamic relationship between antimicrobial agents and microbial strains. The kill rate studies also play an important role in evaluating the antibiotic component of combination products and to determine synergism or antagonism between drugs (two or more). Aragen has established a dedicated, ultra-modern facility equipped with new technologies for microbiological testing services. We have demonstrated expertise in performing a range of microbiological assessment tests for our clients and partners. Impact of Microbial Kill Rate Studies in the Regulatory Approval Process: ◉ Early Development and Screening ◉ Dose Selection ◉ Comparative Analysis ◉ Resistance Development To know more about our capabilities and to speak with our subject experts write to us at [email protected]. #Microbial #KillRate #invitroAnalysis #antimicrobial #resistance #screening #DoseSelection #regulatory #fungicides #microbiological #Aragen #AragenLifeSciences

𝟬.𝟮𝟮 𝗺𝗶𝗰𝗿𝗼𝗻 𝗺𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗳𝗶𝗹𝘁𝗲𝗿𝘀 and 𝙋𝙨𝙚𝙪𝙙𝙤𝙢𝙤𝙣𝙖𝙨 𝙙𝙞𝙢𝙞𝙣𝙪𝙩𝙖 𝙋𝙨𝙚𝙪𝙙𝙤𝙢𝙤𝙣𝙖𝙨 𝙙𝙞𝙢𝙞𝙣𝙪𝙩𝙖 is a bacterium often used as a challenge organism in the validation and testing of 0.22 micron membrane filters and other microbial filters. Here's how it relates to the context of membrane filtration: 𝟏. 𝐅𝐢𝐥𝐭𝐞𝐫 𝐕𝐚𝐥𝐢𝐝𝐚𝐭𝐢𝐨𝐧: 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘥𝘪𝘮𝘪𝘯𝘶𝘵𝘢 is a small, nonpathogenic bacterium with a size of approximately 0.22 micron. This makes it an ideal test organism to validate the performance of a 0.22 micron membrane filter. If the filter can effectively retain and remove 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘥𝘪𝘮𝘪𝘯𝘶𝘵𝘢, it is likely to perform well against larger microorganisms. 𝟐. 𝐁𝐚𝐜𝐭𝐞𝐫𝐢𝐚𝐥 𝐑𝐞𝐭𝐞𝐧𝐭𝐢𝐨𝐧 𝐓𝐞𝐬𝐭𝐢𝐧𝐠: In pharmaceutical and biopharmaceutical industries, one of the critical tests for filter validation is the bacterial retention test. In this test, a suspension of 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘥𝘪𝘮𝘪𝘯𝘶𝘵𝘢 is passed through the filter to challenge its retention capabilities. The filter is considered valid if it retains the bacterium, ensuring that it can effectively remove similarly sized or larger microorganisms from the process stream. 𝟑. 𝐑𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐂𝐨𝐦𝐩𝐥𝐢𝐚𝐧𝐜𝐞: Regulatory bodies, such as the U.S. Food and Drug Administration (FDA), require the use of 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘥𝘪𝘮𝘪𝘯𝘶𝘵𝘢 as a challenge organism for validating the performance of 0.22 micron filters and other microbial filters in the pharmaceutical and biotechnology industries. Meeting these requirements is essential for ensuring product safety and quality. 𝟒. 𝐒𝐭𝐞𝐫𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐀𝐬𝐬𝐮𝐫𝐚𝐧𝐜𝐞: Validating that a 0.22 micron filter can effectively retain 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘥𝘪𝘮𝘪𝘯𝘶𝘵𝘢 is crucial for processes that require sterile filtration, such as the manufacturing of injectable drugs and biopharmaceuticals. This testing helps ensure that the filtration process reliably removes potential contaminants. 𝗔𝗱𝗱𝗶𝘁𝗶𝗼𝗻𝗮𝗹 𝗶𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗼𝗻: 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘥𝘪𝘮𝘪𝘯𝘶𝘵𝘢 is generally considered non-pathogenic to humans. It is a bacterium commonly found in various environmental sources, including soil and water. While it is not typically associated with causing diseases in humans, some strains of Pseudomonas species can be opportunistic pathogens in individuals with compromised immune systems. However, Pseudomonas diminuta is not commonly associated with human infections. #filtervalidation #membranefilter #pseudomonasdiminuta #sterileproducts #sterilization #learnwithirudhayam

🔬 Our Latest Research Published in Archives of Toxicology Journal 📚 I am pleased to announce the publication of our recent article titled "A review on immunomodulatory effects of BPA analogues". Given the increasing occurrence of BPA analogues in consumer products and the environment, we sought to assess the toxicological profile of the most common analogues. With bisphenols already recognized as endocrine disruptors, our focus was to provide a review of the existing scientific data concerning the immunomodulatory properties of these compounds. The study delivers valuable insights into their impact on the immune system. Read the full article here: https://lnkd.in/eXATwM-p

#Blood_Culture_Test Market Size, Trends, Growth Rate, Analysis Report Upto 2030 >> https://lnkd.in/dFp7jQha A #blood culture test is a medical #diagnostic procedure which is used to detect the #presence of #bacteria, fungi, or other #microorganisms (pathogens) in a patient's #bloodstream. The test is crucial in diagnosing #bloodstream infections or #sepsis, a severe and potentially life-threatening #condition. BD Dickinson Williams & Company bioMérieux Food Safety & Quality Thermo Fisher Scientific Luminex Corporation - A DiaSorin Company Danaher Corporation Bruker Roche Diagnostics India, Neighbouring Markets T2 Biosystems #technologies #marketgrowth #bloodtesting #biopharmaceuticals #testingsolutions #biotechnology