L. Fernando Mendoza’s Post

Here, a collaborative research team, including some of my Thermo Fisher Scientific colleagues, reveal the gas-phase structure of β-galactosidase using single-particle #cryoEM down to 2.6-Å resolution, enabled by soft landing of mass-selected protein complexes onto cold TEM grids followed by in situ ice coating. "By providing a direct link between high-resolution imaging and the capability to handle and select protein complexes that behave problematically in conventional sample preparation, the approach has the potential to expand the scope of both native #MassSpectrometry and cryo-EM."

Discover the magnificent potential of porous liquids—the future of solvents that harness the power of porosity. Our latest paper, published open acces in the Processes journal, unveils a groundbreaking molecular dynamics model. This model predicts the formation probabilities of porous liquids for various solvent-porogen pairs. Dive into our research and explore how these models can revolutionize the porous liquids industry. #Porous_liquids #MD_simulation #Molecular_dynamics #Solvents #CO2_Capture

Register for this webinar on December 13 with Thermo Fisher Scientific and University of Utah Professor Peter Shen to learn about considerations for #cryoEM data processing and how scientists are using innovative cryo-EM techniques to expand their 3D structure determination capabilities.

Fluorescence correlation spectroscopy (FCS) techniques provide information about molecular concentrations and diffusion coefficients. These are fundamental for studying for example liquid-liquid phase separation, or biological membranes. Furthermore, cross-correlation reliably reveals binding and colocalization. So far, acquiring good FCS data was not trivial. After getting the data, the next challenge was to select the proper fitting model. Luminosa, PicoQuant`s new single photon counting microscope, facilitates easy and reliable FCS acquisition and analysis. Context-based workflows make acquisition more reproducible. A fast GPU-based algorithm performs online fitting of the data with several models in parallel, and then automatically suggests the best fitting model and parameters. ➡ Click here to watch the full video and to discover more innovative features of Luminosa: https://lnkd.in/enKY6Zgi 🔬 What do you want to use FCS for? #Luminosa #microscopy #fluorescence #FCS

💻 Missed Bruker's webinar on the biophysical characterisation of binary and ternary drug-target complexes using the BRUKER SPR-32 PRO platform? Don't worry! You can still catch up with the research and insights shared by watching the on-demand video: https://bit.ly/3s0gwqZ #Webinar #DrugDiscovery #XRayCrystallography

Fresh out of the oven: our paper in #JASMS describing nano-DESI imaging of N-linked glycans in collaboration with Peggi M. Angel and Richard Drake. https://lnkd.in/gJPbbgnb

🔬 Sometimes, seeing things from a different perspective makes all the difference. That’s why we’re excited to highlight two powerful tools designed to bring precision and versatility to your lab – the Delphi-X Inverso and Oxion Inverso microscopes. https://lnkd.in/dMxaP-M2 Perfect for professionals working with living cell cultures and stained samples, these advanced instruments are equipped with specialized features to meet your research needs. Whether you’re capturing intricate details with phase contrast or exploring molecular interactions with fluorescence, these microscopes provide unparalleled performance and user-friendly features to elevate your research. Discover the clarity and precision you need with Delphi-X Inverso and Oxion Inverso. 🧫🔬 #LabEquipment #Microscopy #ResearchTools #FluorescenceMicroscopy #PhaseContrast #CellCulture #ScientificResearch #GlobeScientific

📢 Don't forget to join us Friday July 4, 2024 @ 11 AM ... for an in-depth exploration into the intricate world of biological tissue structure and hierarchy. Discover the power of multiscale and multimodal correlative microscopy from Prof. Toni Tang in our upcoming webinar titled "Unveiling Biological Tissue Structure & Hierarchy: A Multiscale and Multimodal Correlative Microscopy Approach". This webinar is a must-attend for anyone interested in cutting-edge microscopy techniques and their applications in understanding complex biological systems.  🔬 Don't miss this opportunity to enhance your knowledge and connect with industry experts. Click the link below to register now! 🔗 Register Here: https://bit.ly/bio_webinar #Microscopy #BiologicalTissues #Webinar #ScientificResearch #Multiscale #Multimodal #CorrelativeMicroscopy #TissueEngineering #Biotech #ResearchAndDevelopment Looking forward to seeing you there! 🎉

I'm intrigued about the potential of the NMR frag-lite screen. This screening method, when combined with a soak, could theoretically yield X-ray co-crystals, which could be a game-changer in your research. I hope to use these screening methods to advance my own research! #Science #Research #ScreeningMethods #NMR #Xray #CoCrystals

📢 Exciting Webinar Alert! 🚀 Join us for an in-depth exploration into the intricate world of biological tissue structure and hierarchy. Discover the power of multiscale and multimodal correlative microscopy in our upcoming webinar titled "Unveiling Biological Tissue Structure & Hierarchy: A Multiscale and Multimodal Correlative Microscopy Approach" with expert researcher, Prof. Toni Tand, McMaster University. 🗓️ Date: July 4, 2024 🕒 Time: 11 am Eastern This webinar is a must-attend for anyone interested in cutting-edge microscopy techniques and their applications in understanding complex biological systems. Prof. Tang will guide you through the latest advancements and methodologies, offering valuable insights and practical knowledge. 🔗 Register Here: https://lnkd.in/gYKF-bik #Microscopy #BiologicalTissues #Webinar #ScientificResearch #Multiscale #Multimodal #CorrelativeMicroscopy #TissueEngineering #Biotech #ResearchAndDevelopment Looking forward to seeing you there! 🎉