Michelle Routhenstein, MS, RD, CDCES, CDN’s Post

"The study found that people who scored higher on Life’s Essential 8 had lower epigenetic age biomarkers that help protect against cardiovascular disease (CVD). This finding further cements the knowledge that living a healthy lifestyle can impact longevity and heart health." https://lnkd.in/ex7wPC89 #cardiovasculardisease #heartdisease #healthrisk #healthcare #patients #physicians #lifestyle #habits #diet #nutrition #exercise #hearthealth #epigeneticage #cardiologists #earlydetection

Interesting article..!!

Is #exercise reshaping the #obese phenotype through #gut #microbiota manipulation?   Covid 19 apart, which is the other ongoing alarming pandemic? In one word, #Obesity!   Worldwide obesity has tripled since 1975, and more recently, in 2020, 39M children <5y were overweight or obese according to the WHO. What is the risk? Obese people suffer abnormal or excessive fat accumulation that elicits silent-low grade chronic inflammation and impairs systemic health over time.   The good news is that obesity is preventable but cannot be reversed simply by exercising willpower or with drastic dietary intervention. It is not merely a risk factor of non-communicable diseases (#NCDs) such as diabetes, hypertension, stroke, and cardiovascular diseases (CVD), but a disease on its own.   At least we know it’s not transmissible (merely comfortable), am I right? Frankly speaking, I might not be right …   Almost 10y ago, an elegant study showed how obesity could be transferred simply through faecal microbial transplantation from an Ob mice model to a germ-free one (https://lnkd.in/exsstBRX). Indeed, the gut microbiota seems to play a critical role in the progression of obesity, acting as a #metabolic #machinery able to interfere with the host #bodyweight regulation. How? Regular medium-high intensity #physical #activity represents one of the most powerful tools to counteract obesity due to the manipulation in the gut microbial populations. In which way? 👀   ✨ 1. Increased #microbial #diversity and #SCFAs release. #Athletes' gut microbiota shows higher alpha diversity compared to obese patients. ✨ 2. Elevated #cardiorespiratory #fitness (#CRF). Higher CRF (VO2peak or VO2max) correlated with higher microbial diversity and faecal #butyrate (https://lnkd.in/euJk7Bch). ✨ 3. Reduced risk of #insulin #resistance. Rectal administration of SCFAs increases #GLP-1 secretion, confirming that a shortage of SCFA-releasing bacteria may produce glucose intolerance through a reduction in GLP-1 (https://lnkd.in/eMUgzH8D). ✨ 4. High dynamic sports increase the natural abundance of L. acidophilus, B. animalis, F. prausnitzii, and Prevotella intermedia. Professional #cyclists show a higher abundance in Prevotella and Methanobrevibacter smithii (BCAA metabolism), #marathon #runners report higher levels of Veillonella atypica (optimal lactate clearance), while #rugby #players show a higher abundance of Akkermansia (prevention of leaky gut). Differences in abundance across groups can be the consequence of sport-specific characteristics, and the gut response to the skeletal muscle adaptation to training.   Clearly, exercise-induced gut microbiota changes depend on the basal physiological state and the level of training of any individual, either obese people or athletes. The goal? Customise exercise-based therapeutic intervention focusing on the gut microbiota as barycentre of health. 🎯 Link: https://lnkd.in/edEvSW7F  

The microbiome may significantly reduce dementia risk by influencing several modifiable factors identified by The Lancet Commission. These include: 1. Diabetes: Enhances insulin sensitivity and glycemic regulation. 2. Obesity: Improves energy metabolism and body composition. 3. Depression: Modulates neuroinflammation and neurotransmitter synthesis via the gut-brain axis. 4. High LDL Cholesterol: Affects lipid metabolism and cholesterol homeostasis. 5. Physical Inactivity: Influences microbiota composition and metabolic output through exercise. These insights highlight the potential role of the gut microbiome in mitigating dementia risk through various pathways. #GutHealth #Probiotics #GutBrainAxis

Could modulating the microbiome be a key to reducing dementia risk? This post highlights potential connections between gut bacteria and several dementia risk factors. #Microbiome #Biotech #Investment #Healthcare

45% OF DEMENTIA COULD BE PREVENTED BY ACTING ON MODIFIABLE RISK FACTORS. The 2024 update of the Lancet Commission on dementia provides new hopeful evidence about dementia prevention, intervention, and care. As people live longer, the number of people who live with dementia continues to rise, even as the age-specific incidence decreases in high-income countries, emphasising the need to identify and implement prevention approaches. Evidence is increasing and is now stronger than before that tackling the many risk factors for dementia that we modelled previously (ie, less education, hearing loss, hypertension, smoking, obesity, depression, physical inactivity, diabetes, excessive alcohol consumption, traumatic brain injury, air pollution, and social isolation) reduces the risk of developing dementia. In this report have been added new compelling evidence that untreated vision loss and high LDL cholesterol should be considered among the risk factors for dementia. A central role is played by the intestinal microbiota. Of the 14 risk factors described some can be modified by improving the intestinal microbiota, such as: diabetes, obesity, depression, high LDL cholesterol, and physical activity. #dementia #prevention #Lancet https://lnkd.in/dM8VMHiX

Medical News Today spoke with five experts to get to the bottom of how much #gut health truly impacts #cardiovascular #health. All the experts we spoke to agreed that the gut #microbiome can have a profound impact on heart health. “The gut microbiome is a complex community of trillions of #microorganisms, including bacteria, viruses, fungi, and protozoa, that reside in the human digestive tract, primarily in the large intestine (colon).” “We know that #inflammation is possibly the main driver these days when it comes to so many health problems, especially with the heart. The microbiome plays a big role in counteracting inflammation.” “There’s a connection between the composition of someone’s gut flora or the microbiome. There’s a connection between the type, distribution, and relative composition of gut bacteria that someone has and an association with their risk factors for heart disease — that includes high blood pressure, high cholesterol, and obesity.” “When gut microbes feed on choline — found in red meat, poultry, eggs, [and] certain fish — they make trimethylamine (TMA), which is absorbed into the body and goes to the liver where it is changed into TMAO,” “#TMAO is bad because it is associated with #cholesterol and artery narrowing #plaque in important arteries in the body, especially the coronary #arteries which supply blood to the heart. So people with high levels of TMAO are at increased risk of heart attacks or stroke,” he noted. “Studies have associated TMAO with aspects of inflammation and blood vessel dysfunction. “It also promotes foam cells in the blood vessels. All of these different things end up promoting different types of heart disease, such as #atherosclerosis, and they can also lead to different aspects of cardiovascular risk factors such as high blood pressure.” “If we eat foods that feed the good bacteria — an alkaline diet high in fruits and veggies — we will be fostering the health of a healthy microbiome. Eating foods that contain too much refined carbohydrates, sugar, and processed foods can have the opposite effect and feed bad bacteria which can trigger inflammation that causes disease — and the arteries and the heart are no exception to this. If there is inflammation in the arteries, as an example, cholesterol will stick to it.” One example includes our gut microbes breaking down compounds into what are called short-chain fatty acids (#SCFAs) like butyrate. “#Butyrate has many known benefits which include being anti-inflammatory and cardio-protective. The better equipped our gut is with benefits to nurture the components of our internal ‘garden,’ the more robust the rest of our systems will be since it is all connected and work together,” https://lnkd.in/dp8Z5_4e

Cellular Senescence. When cells lose the ability to divide because of DNA damage or a shortening of telomeres ,(telomeres are sections of DNA found at the ends of each of our chromosomes) they go through a transformation that results in decline or destruction. The cells either self-destruct (called apoptosis) or go into a period of decline (called senescence). Senescence literally means "the process of growing old." It's defined as the period of gradual decline that follows the development phase in an organism's life. So senescence in humans usually starts sometime in your 20s, at the peak of youth , and continues for the rest of your life. Over time with increasing exposure to environmental assaults your cells experience DNA damage. As this damage increases & accumulates, these damaged cells can enter a state of dysfunction called senescence. Often referred to as “zombie cells,” senescent cells secrete pro-ageing factors that drive healthy cells to age faster and become senescent as well. As more cells become “infected”, the body experiences more inflammation. Science has not yet found a way to interrupt the process of senescence as it relates to humans, and some researchers argue that we never will be able to stop this process. But we can slow it down. Your goal, then, is to slow the process of senescence as much as possible. You can do this by: 1. Eating a Healthy Diet: This provides your body with the nutrients it needs to repair damage and fight off future damage. 2. Reducing Stress: This prevents long-term damage from over-exposure to the stress hormones and the physiological state they create. 3.Avoiding Exposure to Damaging Substances: This helps limit the amount of damage to your body’s tissues. Avoid over-exposure to UV lights, pollution, and toxins. 4.Exercising more: This helps your body to build strength that helps resist damage. 5.Preventing Disease: See your GP for routine checkups and keep your blood pressure, weight and other risk factors under control. Seek advice from a professional nutritional therapist to advise on healthy lifestyle and dietary choices. #lifestyle #lifestylemedicine #cellularhealth #senescence #uv #protect #prevent Frontiers | Cellular Senescence and Ageing: Mechanisms and Interventions

We are just beginning to understand the impact of psychological stress on the gut. This study on mice showed how psychological stress ultimately triggered gut bacteria to increase production of indole-3-acetate (IAA) and a subsequent loss of intestinal secretory cells. Treatment of intestinal diseases such as IBS and IBD requires a multifaceted plan and physicans who understand this approach. Midwest Digestive Health and Nutrition #MDHN https://lnkd.in/gjm6V6xY

🗞️ This week's Metabolic News Weekly offers compelling insights into the intersection of lifestyle, diet, and metabolic health. Discover the latest findings on how #lifestyle changes can significantly improve conditions like #psoriasis and #metabolic syndrome, understand the intricate ways in which paternal diet impacts offspring health, and explore research on immune functions in polycystic ovary syndrome (#PCOS). Each article provides a deeper understanding of metabolic health's key drivers and potential interventions. 🔎 Key Insights: ⏵ Lifestyle interventions significantly alleviate symptoms of psoriasis-associated erectile dysfunction and metabolic syndrome. ⏵ High androgen levels in polycystic ovary syndrome alter immune cell functions. ⏵ Paternal diet before conception influences offspring’s metabolic health through epigenetic mechanisms. ⏵ #Dietary patterns focusing on #cardiometabolic health show substantial benefits. ⏵ #GLP-1 medications are spotlighted for their role in weight management and reducing stroke risk. ☄️Impact: ⏵ Promotes a deeper understanding of lifestyle factors in chronic disease management. ⏵ Highlights the role of immune system in reproductive and metabolic health. ⏵ Stresses the importance of pre-conception health in fathers for offspring well-being. ⏵ Encourages dietary approaches tailored to reduce cardiometabolic risks. Supports the use of GLP-1 medications for broader therapeutic applications. Check out the full articles and more 👇