Miltenyi Biotec’s Post

Online!👓 Mitochondrial transfer from Adipose #stemcells to #breastcancer cells drives multi-#drugresistance ------- Breast cancer (BC) is a complex disease, showing heterogeneity in the genetic background, molecular subtype, and treatment algorithm. Historically, treatment strategies have been directed towards cancer cells, but these are not the unique components of the tumor bulk, where a key role is played by the tumor microenvironment (TME), whose better understanding could be crucial to obtain better outcomes. Here Federica Papaccio, Vincenzo Desiderio et al. provide a proof-of-concept of the occurrence of Mitochondrial Transfer (MT) from Adipose Stem Cells (ASCs) to BC models. Blocking MT from ASCs to BCCs could be a new effective therapeutic strategy for BC treatment. For free👇 https://lnkd.in/dEiGH-Y8 #Mitochondrialtransfer #Mitoception #AdiposeStemcells IFO - Istituto Nazionale Tumori Regina Elena - Istituto Dermatologico San Gallicano

Could your daily aspirin also help prevent colorectal cancer (CRC)? It has been long-hypothesized that aspirin possesses anticancer properties, but the pharmacologic evidence has been weak. Researchers in China recently published a new study seeking to explore the effects of aspirin on mice with CRC. The main findings are: 1. Aspirin decreases T-regulatory cell abundance by increasing expression of T-cell immunoglobulin and ITIM domain (TIGIT) 2. Aspirin reduces the abundance of certain bacteria in the microbiome  Both results support the conclusion that aspirin impacts both the immune system and gut microbiome which inhibits CRC in mice. More work is needed to fully understand the behavior of aspirin in humans with CRC, but the study lays exciting groundwork! #MedComms #ColorectalCancer #Research #Oncology

🔬 Celnovte's MSH2 (C2G3) Antibody Achieves Optimal Performance in NordiQC Assessment 🔬 ✅ Key usages of MSH2 marker in IHC: - Identifying DNA mismatch repair proteins. - Diagnosing hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome. - Assessing mismatch repair deficiencies in colorectal and endometrial cancers. - Differentiating between hereditary and sporadic cancers. - Investigating DNA repair mechanisms and cancer susceptibility. - Studying MSH2 expression in normal and malignant tissues in basic and clinical research. Enhance your research and diagnostic precision with the MSH2 marker. #Pathology #IHC #Immunohistochemistry #CancerResearch #LynchSyndrome #msh2 #celnovte #primaryantibody

Sarcoma and Bone Cancer Awareness Month! Let's shed light on these rare and complex diseases! Sarcomas are aggressive tumors requiring innovative therapies and education, while bone cancer is a heterogeneous group of malignancies affecting the skeletal system. Osteosarcoma, Ewing's sarcoma, and chondrosarcoma are just a few subtypes, each with unique genetic landscapes and treatment challenges. By unraveling the genomics of sarcoma and harnessing immunotherapy and targeted therapies, we can improve diagnosis and treatment outcomes. Let's support research, education, and awareness to combat these diseases and provide hope for those affected! #himmel #pharma #sarcoma #bone #awareness

#ACROHighlights [Featured Product] 🔬 Discover the power of Transferrin and Transferrin-R, vital iron transport proteins in the human body, which play a crucial role in various tumors including brain, nasopharyngeal, prostate, breast, ovarian, liver, leukemia, colon, and lung cancers. 💡 Join the forefront of cancer research and leverage the crucial role of Transferrin and Transferrin-R in iron absorption, an essential process for cell production and metabolism, including tumor cells. 🔗 We now offer high-quality TFR Recombinant Proteins, TFR Stable Cell lines, TF Recombinant Proteins, and TF Stable Cell lines!: https://smpl.is/8rjh4 #CancerResearch #Transferrin #TransferrinR #IronTransportProteins #BiotechSolutions #ResearchTools

This study engineers biosensors( bacteria ) to detect specific extracellular DNA sequences related to colorectal cancer (CRC). The biosensors are validated in mice with CRC tumors and show potential for noninvasive detection in the gut. Further development is needed for clinical use, addressing delivery and performance. The approach offers advantages over invasive in vitro diagnostics and holds promise for detecting and treating diseases. https://lnkd.in/gXTDhths https://lnkd.in/gqP92i9e

Chimerix, Inc. #ONC201 #DMG - H3K27M-DMG Patients Treated with ONC201 Demonstrated Median Overall Survival (mOS) of 21.7 Months in the Front-Line Setting, Post Radiation, Versus 12 Months mOS Historical Control - ONC201 Treatment Disrupts Key Metabolic and Epigenetic Pathways Details: https://lnkd.in/eFqGP2Uh

🌟 A team from MIT and ETH Zurich has engineered an AI model capable of distinguishing the stages of Ductal Carcinoma In Situ (DCIS), which is crucial for optimizing treatment strategies. This innovative model, detailed in Nature Communications, utilizes readily available breast tissue images to discern the vital role of cell organization in cancer progression. Promising to enhance diagnostic accuracy and minimize overtreatment, this technology not only revolutionizes breast cancer care but also holds potential for other cancers and neurodegenerative diseases. #HealthTech #CancerResearch #AIInnovation Read more: https://lnkd.in/eiY4EiE7

The age of cancer biomarkers and precision medicine begins with the discovery that HER2 is overexpressed in 20-25% of breast cancers and is associated with adverse outcomes. Herceptin, the first Ab therapeutic for the treatment of solid tumors that blocks the HER2 receptor, is approved in 1998, and ushers in the rise of targeted cancer treatments. What new biomarkers will you discover with spatial biology? Join our panel discussion tomorrow sponsored by Illumina and Life Science Washington to learn how our speakers are using spatial multiomics to advance research on women’s health. 👉https://bit.ly/3VhFfCP #cancertreatment #precisionmedicine #spatialbiology #biomarkerdiscovery #womenshealthwednesdays