Mohammad Vaziri’s Post

📢We are thrilled to announce the publication of our latest research in collaboration with our colleagues Angelika Pointner and Alexander G Haslberger from the University of Vienna. 🔍The study sheds light on the role of microRNAs as indicators of individual physiological characteristics and their response to diet and lifestyle. In addition, some lifestyle factors such as exercise, tobacco and alcohol consumption appear to affect miRNA expression patterns differently in men and women. 📝 Read the full paper here: https://lnkd.in/dC7Mrpfh #research #microRNA #nutrigenomics #lifestyle #health #personalizedmedicine #epigenetics #nutrition #prevention #sciencenews

"Detailing the current knowledge of #diet and the #microbiome is timely, given the recent progress in metagenomic sequencing and machine learning. These advancements have deepened our understanding of the microbiome and #humanhealth, facilitating the development of microbiome-targeted therapies and precision #nutrition to combat #diet-related #diseases. The #Mediterranean diet, for instance, has been shown to positively influence the gut microbiota and human health, potentially aiding in the prevention and slowing of disease progression. However, recent studies report that the same diet consumed by two different people can result in differing metabolic health effects and a personalized microbial response. Furthermore, owing to the global rise in the #Western diet and #ultraprocessed food consumption, non-communicable diseases such as #cardiovascular disease, #obesity and type 2 #diabetes have become an epidemic of our time. A healthy microbiome cannot be defined by a single configuration; rather, multiple configurations may be linked to well-being. It is also important to note that certain bacterial phyla, genera or species can be associated with either a healthy or disease state. Therefore, it is important to emphasize that many species have relatively large pangenomes and, as such, #strains within those species can exhibit substantial differences in both #genomes and functionalities. This complexity can pose challenges when associating species with host health. Hence, it is imperative to recognize which foods and dietary patterns promote health or exert adverse effects, to transform this knowledge into practical #dietary recommendations for health promotion and disease #prevention." https://lnkd.in/dVjq2sJf

Anybody interested in keto diets? I certainly use the principles of a ketogenic diet with certain patients who have very poor metabolic health, insulin resistance, obesity and metabolic syndrome. This study suggests that a ketogenic diet in mice increases markers of cellular senescence - sometimes called “zombie cells” in mainstream media! These cells are one of the hallmarks of ageing and is thought to contribute to many of the diseases of ageing. The study shows that this occurs irrespective of the age of the animal, or whether the keto diet was mostly saturated (bad) or unsaturated (healthy) fats. Interestingly however the markers of senescent cells only rose after a continuous keto diet, and that an intermittent keto diet prevented this problem from occurring altogether. If this is in fact true in humans too, this highlights an important point about biology and medicine. It’s that there are rarely perfect solutions, but rather tradeoffs when it comes to us intervening. Particularly when the intervention is particularly unusual or extreme, for example the ketogenic diet could be considered to be a little…extreme. Near zero carbs?? Most people are terrified by the thought! We also can be misled as to what is the best thing to do if we only focus on one biological pathway or marker of health/disease/ageing. The ketogenic diet is as I said, a tool. We have to decide when to use this tool in the right context for the right patient. For example, my metabolically unhealthy patient who may be, say 50 years old, is much closer to facing the consequences of their metabolic health than they are the effects of senescent cells. The overall net effect of the ketogenic diet for such an individual is likely net positive. Certainly when used as a tool in the short term. Understanding the individual balance of risk for a given person and personalised medicine is the way forward. At Agami Health we assess hundreds of biomarkers which help us decide where your balance may lie. This is precision medicine! Love to hear people’s thoughts on this - reply in the comments. #keto #longevity

Just bringing everything together David Allison - I think we all know that there's human bias in food preference - this occurs because of the (stimulant/narcotic) addictive properties in certain foods. These gourmand (high protein x high carbohydrate) foods drive people to want ever more, even as people become progressively more incapacitated with diabesity&associated. The addictive foods happen to be Insulin promoting foods giving rise to the current T2D epidemic. Why so? Nature needed to put in place reward from the drive to eat to ensure organisms eat. A compulsion was required. However once this gourmand path is taken, it's hard to switch back to 'raw vegan low carb organic permaculture-based keto' :-) because this food-set does not supply the same neurochemical hit. We've made food all about addiction and not about nutrition. However, as we know from addiction - change isn't simple. Also - to mention that addictive foodstuff consumption is a gateway drug into other addictive habits (with overcoming the addiction, reversing the process). This connection has not yet been made. Food (or at least the wrong choice of food) as the fundamental gateway drug which fuels the so called 'addictive personality'. Lightbulb moment though.

Thrilled to announce that our research, "Dietary anthocyanins mitigate high-fat diet-induced hippocampal inflammation in mice," has been accepted for publication in the Journal of Nutrition! This study delves into the potential of anthocyanins to counteract the negative effects of a high-fat diet on brain health.  High-fat diets have been shown to increase the permeability of the intestine, allowing for toxins to enter the bloodstream. This process has been shown to negatively impact the brain. In particular, it has the capacity to impair the function of the hippocampus, the brain region necessary for learning and memory. Our findings reveal that anthocyanins have the capacity to reduce hippocampal microgliosis and inflammation, prevent HPA axis dysregulation, and increase hippocampal BDNF levels. Huge thanks to my incredible PI and collaborators for their support! Excited to continue exploring the benefits of anthocyanins for optimal health. #nutritionresearch #brainhealth #anthocyanins #science #research #publication #journalofnutrition Click the link to read the full paper: https://lnkd.in/gRuqa74m

"Keto diet may cause organ damage, mouse study finds High-fat, low-carb regimen stresses out cells in heart, kidneys, brain, and liver, but effects may be reversible." - So states a new perspective article in Science: https://lnkd.in/gXTmtSDv? "Obesity researcher and statistician David Allison of Indiana University adds that ketogenic diets vary in many ways, including in the sources of fat and protein. The new study finds an effect 'for this [one] diet that happens to be ketogenic,' he says. 'That doesn’t mean it’s true for all ketogenic diets.'" What do you think? Some who may want to comment include: Dr David Ludwig, MD, David L. Katz, MD, MPH, Peter Attia, Kevin Hall, Jeff Volek, Barry Sears, John Speakman, Michael Goran, Christopher Lynch, Dean Ornish, M.D., Arne Astrup, Kevin C. Maki, PhD, Dr. Layne Norton, Donald Layman, Melissa Joy Dobbins MS, RDN, CDCES, Gary Taubes, David A. Sinclair A.O., Ph.D., Matt Kaeberlein, Ted Kyle, Susan Jebb, Susan Roberts, Rafael de Cabo, Steven Austad, Barbara Gower, Kevin Fontaine, Richard Black, Eric Plaisance, PhD, FACSM, ACSM-CEP, CSCS, Tamar Tchkonia, Ed Mannix, Michael Sturek, Bret Rust, Richard Feinman.

What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Disease : #gutmicrobiota, #diversity, #health, #diet, #nutrition, #age, #milkshakefeeding, #necrotizing #enterocolitis, #weaning, #enterotypes, #irritablebowelsyndrome, #inflammation #bowelcancer, #celiacdiseasedisease, #colorectalcancer , #obesity, #type1diabetes #type2diabetes, #Alzheimer’sdisease, #Parkinson’s, #hepaticencephalopathy, #autismspectrumdisorder, #personalizedmedicine

Upcoming hashtag #FDA Seminar/Webinar - December 13, 2023 at 11am edt. Free to attend (with appreciation to the taxpayers!). December 13, 2023 at 11am edt (11am to 12noon edt). The Office of Dietary Supplements within the National Institutes of Health (#ODS #NIH) invites you to attend the virtual #seminar, "Circadian Rhythms and Time-Restricted Eating in Health and Disease". Satchidananda Panda, Ph.D. (Salk Institute for Biological Studies) will begin with an introduction to the role of Circadian rhythm in sustaining health and preventing diseases. Circadian rhythms are cell-autonomous and are present in almost every cell of every organ and brain region. In addition to the genetic and genomic programs that generate and sustain these rhythms, lifestyle factors, including exposure to ambient light and nutrition timing, are dominant modulators of circadian rhythms. As a result, approaches to optimize light exposure and nutrition timing are emerging as powerful and scalable public health approaches for preventing and managing chronic diseases. The presentation will span basic experiments in preclinical models as well as human studies. Having a better understanding of Circadian rhythms may too impact overall health, sleep and sleep quality matters! Recently, Dr Panda discovered that maintaining a daily feeding-fasting cycle—popularly known as time-restricted feeding (#TRF)—can prevent and reverse metabolic diseases. Based on a feasibility study in humans, his lab is currently carrying out a smartphone-based study to assess the extent of circadian disruption among adults. Dr Panda has been focusing his educational outreach on Health and Longevity - Is there a science to living longer and healthier? Flyer: https://lnkd.in/dse5bz5w ZOOM Link: https://lnkd.in/dk-Gwfuf Meeting number: 160 431 4209 Meeting passcode: ODSseminar (63773646 from phones) #ODS #Nutrition #Information #Data #Lifestyle #Habits #Sleep #Alcohol #Exercise #DietaryStyle #HealthStatus #longevity #LE #caloricrestriction #timerestrictedeating #lesscalories #healthburden #lifeextension

    🌸🍎 Unveiling Links: Nutrition, Obesity, Inflammation, and Endometrial Cancer Risks 💪🩺 Endometrial cancer poses a significant threat to women's health globally, affecting both pre- and post-menopausal women. A review from a Thrastardottir et al (2023) aims to explore and summarise the findings of recent studies which investigated how poor nutrition, inflammation, and obesity are associated with endometrial cancer across different age groups. Studies suggest that plant-based, Mediterranean, or ketogenic diets are linked to a reduced risk of endometrial cancer. Conversely, higher BMI and obesity-related pro-inflammatory biomarkers are associated with increased risk. In summary, the findings reveal significant roles of nutrition, obesity, and inflammation in endometrial cancer development. Further research is necessary to comprehend these intricate interactions and devise strategies to reduce endometrial cancer prevalence. Reference: Thrastardottir, T. O., Copeland, V.J. and Constantinou, C. (2023). The association between nutrition, obesity, inflammation and endometrial cancer: a Scoping Review. Current Nutrition Reports 12(1):98-121. doi: 10.1007/s13668-022-00447-8. Actions: 1.    Dietary Choices: Consider plant-based, Mediterranean, or ketogenic diets for potential risk reduction. 2.    Weight Monitoring: Keep track of BMI to mitigate endometrial cancer risk. 3.    Healthy Living: Explore strategies to reduce inflammation through healthier lifestyle choices.   #EndometrialCancerAwareness #nutritionmatters #FightObesity #InflammationInsights #WomensHealth #cancerprevention #HealthyDietChoices #empowerwomen #PreventCancerNow          

High Fat Diet 32 (HFD32): A Super-High-Fat Pelleted Diet for Diabetes and Obesity Research in Mice and Rats   Introduction: CLEA Japan introduces HFD32, a revolutionary high-fat diet (32% fat content, 60% energy from fat) for in vivo research on diabetes and obesity. Unlike traditional powdered high-fat diets, HFD32 comes in convenient pellets, enhancing ease of use and animal acceptance.   Features: ・Super-high fat content: Induces obesity and glucose intolerance effectively. ・Pellet form: Improves handling and reduces dust exposure compared to powdered diets. ・Proven efficacy: Triggers significant weight gain, impaired glucose tolerance, and increased visceral fat in mice studies. ・Versatile research tool: Suitable for diabetes and obesity studies, as well as investigating the effects of sugar, light cycles, and sterilization on metabolic syndrome.   Availability and Storage: ・Pre-packaged (3 kg, 6 x 500 g bags) and readily available in both irradiated and non-irradiated variants. ・Frozen storage mandatory; defrosts quickly for feeding (1h at -20°C, 3h at -80°C).   Additional Information: ・HFD32 comes with detailed reference data on mouse studies, ingredients, fatty acid composition, and test results. ・A comprehensive FAQ section addresses common questions regarding delivery, custom diets, storage, and compatibility with other research protocols.   In conclusion, CLEA Japan's HFD32 presents a reliable and convenient solution for inducing diabetes and obesity models in mice and rats, contributing to advancements in metabolic research. For more detailed information, please click here 👉 https://lnkd.in/gz4dJXt3 #experimentalanimal #dietinducedobesity #diabetes #cleajapan