NanoString Technologies, Inc.’s Post

What impact could you have on patient healthcare if you were to design a panel for liquid biopsy testing? At The Institute of Cancer Research, scientists designed a pan-cancer sequencing panel for liquid biopsy molecular diagnostics which could be used to profile tumor DNA in the blood of paediatric cancer patients. This opens up the possibility to routinely sample patients, monitoring their response to treatment and following their disease progression to detect relapse as early as possible. Read more in our blog post: https://bit.ly/3R08LK8 What panel would you design? Let us know in the comments. #thefutureisfluid #timematters #precisionmedicine #liquidbiopsy

Two recent papers elucidate particularities of triple negative #breastcancer in patients of African ancestry: a very interesting preprint in bioRxiv (DOI: 10.1101/2024.03.17.585428, PMID: 38562769) presenting results obtained by #spatialbiology technologies (#CyTOF & #spatialtranscriptomics) and an article published in Clinical Cancer Research with results obtained using a custom panel for NanoString Technologies, Inc. #nCounter #geneexpression analysis (DOI: 10.1158/1078-0432.CCR-23-1526, PMID: 38564595). In African-American #tnbc patients the immune "cold"/"desert" tumor tissue status is dominantly orchestrated by the interaction between tumor cells, macrophages and endothelial cells and activation of the #VEGF - #hypoxia pathways whereas in European patients it's the presence of #neutrophils which suppresses otherwise active T-cell responses. A valuable support of research on cancer biology differences between populations on this planet. #EqualButDifferent #cancer #cancerresearch #gotoyourpathologist

Nina Radosevic thanks for sharing it! We are definitely entering a new era of the next generation pathology. High-plex tumor phenotyping for deeper spatial characterization of cancers tissues will give us better understanding of the tumor microenvironment and improve clinical outcome predictions. Recent studies were exploring the biological mechanisms underlying racial disparities in triple-negative breast cancer (#TNBC) outcomes. #Spatial transcriptomics methods were applied to characterize the tumor #microenvironment (TME) of African American (AA) and European American (EA) patients with TNBC. The presence of racially distinct tumor-promoting and immunosuppressive microenvironments in AA and EA patients with TNBC, press the need for more region-specific cancer research! https://lnkd.in/dsbDSC9M https://lnkd.in/dHn5t33j Malak Abedalthagafi ( AlThgafi), Dr. Ammira Al-Shabeeb AKIL, Dr. Saud Abdulsamad (PhD, MSc) , Prof.Humaid Al-Shamsi MB(IRL),FRCP(Lon),FRCP(Ca),FRCP(Glasgow),FACP(US), Abdul Rahman Agha El Kinge, Amal AlRayes, Hitham Aldharee, PhD, Aaron Han 韓中天 ارون هان #tumormicroenvironment, #spatialbiology, #singlecell, #cancer #research #transcriptomics

💡I'm thrilled to share that Scopus' CiteScore 2023 metrics are out, and Technology in Cancer Research & Treatment (TCRT) has advanced from Q3 to Q2 in the oncology discipline! This significant leap reflects our dedication to prioritizing quality in our publications. TCRT is actively seeking further collaborations to continue driving advancements in cancer research. Reach out to us if you wish to be an Author and/or board member of the journal. https://lnkd.in/eFVpWZbV #CiteScore2023 #OncologyResearch #CancerResearch #Oncology #OncoDaily

Thrilled to Share part of my PhD Research in Hepatocellular Carcinoma (HCC). I'm honored to be a co-first author of the recent publication in "Cancers," which delves into the pivotal role of SOCS1 as a tumor suppressor in HCC. This work is a part of my doctoral research journey and represents a significant milestone. This research underscores the importance of SOCS1 in maintaining oxidative stress sensitivity, a vital mechanism for tumor suppression in HCC. I am immensely thankful for the opportunity to work with the brilliant research team led by Subburaj Ilangumaran at the University of Sherbrooke, QC. All the team members' dedication and expertise have been instrumental in bringing this research to fruition. Dive into the full article here for a detailed understanding of our findings and their implications in cancer therapy. https://lnkd.in/e4k57Adv https://lnkd.in/eq4kN-Ne #HepatocellularCarcinoma #CancerResearch #SOCS1 #OxidativeStress #Proteomics

Delighted to announce our next publication titled: "GLUT and HK: Two Primary and Essential Key Players in Tumor Glycolysis" in Seminars in Cancer Biology (Impact factor-15). Our study delves deep into the intricate mechanisms of tumor glycolysis, shedding light on the pivotal roles played by GLUT and HK proteins. Through rigorous investigation, we uncover crucial insights that could revolutionize cancer treatment strategies. For those interested in exploring the complexities of tumor metabolism and its implications for cancer therapy, this article is a must-read. DOI- 10.1016/j.semcancer.2024.03.001 Gratitude and best wishes to all the co-authors and Prof. Vinit Kumar for guiding us. #CancerResearch #TumorGlycolysis #ScientificPublication #GLUT #HK #SeminarsinCancerBiology #ScientificDiscovery

🔬 Unlock Precision in Cancer Research! Dive into the latest advancements with our eBook, "Protocol Guide for KRAS Variant Identification" 🧬, sponsored by Thermo Fisher Scientific. This guide is your key to mastering the complexities of KRAS testing, essential for targeted cancer therapies. 📖 Explore: Step-by-step protocols 🛠️ Cutting-edge techniques 🔍 Real-world applications in oncology 🏥 Perfect for lab professionals and researchers aiming to push the boundaries of genetic testing and personalized medicine. 👉 Read the eBook now: https://bit.ly/4ch9y1N #CancerResearch #GeneticTesting #ThermoFisher #LabLife #PrecisionMedicine

Spatial biology is transforming cancer research, as evidenced by the insightful ONCOLife interview with Dr. Arutha Kulasinghe from The University of Queensland's Clinicalomics Lab. Dr. Kulasinghe emphasizes the significance of spatial biology in distinguishing between responders and non-responders to immunotherapy, ultimately advancing the field of personalized medicine. His groundbreaking research on biomarker discovery and companion diagnostic assays sets the stage for more effective cancer treatments. #oncology #cancerresearch #spatialbiology #immunotherapy #ONCOLife 

Pancreatic ductal adenocarcinoma (PDAC) is a highly resistant and lethal disease. Researchers at the IRCCS Institute in Milan conducted groundbreaking research on PDAC using single-cell technology and Molecular Cartography for spatial genomics. Their study, published in Nature, unveiled an inflammatory loop between tumor cells and specific macrophages driven by a local synergy between prostaglandin E2 (PGE2) and tumor necrosis factor (TNF). Blocking the PGE2–IL-1β axis showed promising results in controlling PDAC in vivo. This breakthrough in research offers new hope for the treatment of pancreatic cancer. https://lnkd.in/gchyj8Kz #PancreaticCancer #Cancerresearch #Singlecell