The clinical phase 1 study of the T regulatory (Treg) cell product CK0801 in nine patients with bone marrow failure syndromes reported by Kadia et al. in NEJM Evidence fits well into the current immunotherapy era. These cells, brought to the forefront by Shimon Sakaguchi two decades ago, constitute a subpopulation of CD4+ T cells characterized by the surface expression of the alpha chain of the interleukin-2 receptor, CD25, the inhibitory molecule CTLA-4, and the intracellular transcription factor FoxP3. They control, under healthy conditions and through several mechanisms, expansion and function of other immune cells, such as effector T cells and natural killer cells. Defective Treg functions lead to autoimmunity but also contribute to other diseases in which the immune system is involved. In an editorial, Carole Seguin-Devaux, PhD, and Jacques Zimmer, MD, PhD, review the safety and preliminary efficacy results of CK0801. Read the full editorial: https://eviden.cc/4bgUGk8 𝗙𝗨𝗥𝗧𝗛𝗘𝗥 𝗥𝗘𝗔𝗗𝗜𝗡𝗚 Original Article by Tapan Kadia, MD, simrit parmar, MD, MSCI, et al.: Phase 1 Study of CK0801 in Treatment of Bone Marrow Failure Syndromes https://eviden.cc/4bkpyjR #ClincialTrials #MedicalResearch
NEJM Evidence’s Post
More Relevant Posts
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/Grco30sFnjC #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/K2RL30sFpc1 #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/SKns30sFl7c #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/pCAO50Suzhb #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/p1Ey30sFhTC #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/8Plt30sFnAN #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/h9YI30sFyYp #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/giSN30sFmMl #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/UimW30sFkco #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-
-
Transformative advancements in targeted lipid nanoparticles (tLNPs) with DSPE-PEG2000-maleimide! DSPE-PEG2000-maleimide helps researchers achieve the ultimate goal of toxicity-free delivery of nucleic acids, and the broader objective of precision medicine, by enabling the formation of LNPs that will specifically conjugate to antibodies and targeting ligands, delivering lipid-based genes to their intended cellular target. In this latest blog, we zoom in on DSPE-PEG2000-maleimide to explore its utility in improving the specificity and therapeutic potency of tLNPs, and how its effect on nucleic acid delivery unlocks new avenues for developing much-needed therapies for a range of human diseases, from cancer to neurological disorders. Today it’s more about personalized therapies, and DSPE-PEG2000-maleimide stands out as a cutting-edge tool with huge potential for the future of medicine. Keep reading our latest blog for more! https://ow.ly/6GbN30sFiFL #LipidNanoparticles #tLNPs #DSPEPEG2000maleimide #NucleicAcidDelivery #TargetedTherapies #MedicalInnovation #mRNA #HealthcareRevolution #PersonalizedMedicine
To view or add a comment, sign in
-