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The original LEAP (Learning Early About Peanut allergy) trial was a randomized controlled trial (RCT) that investigated whether the early introduction of peanut-based foods reduced the development of peanut allergies among high-risk children. The LEAP trial followed children from infancy to 5 years of age.     The LEAP-Trio study, published in NEJM Evidence, builds upon the earlier RCT to explore longer-term outcomes. In the LEAP-Trio study, the authors report on allergy rates in a subset of the original study cohort, now that the children have reached 12 years of age.    In assessing this study statistically, there are three dynamics of importance: the reporting of statistical conclusions, a subtle issue with what “treatment” is being evaluated, and the change in study participants.    Read the editorial "Statistical Considerations When Building upon an Existing Randomized Trial” by Michael Baiocchi, PhD; https://eviden.cc/3UWIzD3    𝗙𝗨𝗥𝗧𝗛𝗘𝗥 𝗥𝗘𝗔𝗗𝗜𝗡𝗚   📄 Original Article by George Du Toit, MB, BCh, Gideon Lack, MB, BCh, et al.: Follow-up to Adolescence after Early Peanut Introduction for Allergy Prevention https://eviden.cc/3V7DWqd  📄 Editorial by Sarita Patil, MD, Stephanie K. Dougan, PhD, and Michael Dougan, MD, PhD: Leaping toward Tolerance https://eviden.cc/3UZFq5L    #Immunology #MedicalResearch 

  • “In assessing this study statistically, there are three dynamics of importance: the reporting of statistical conclusions, a subtle issue with what ‘treatment’ is being evaluated, and the change in study participants.” 

EDITORIAL
Michael Baiocchi, PhD

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