Dr. Houcemeddine Othman, a researcher at the Sidner Brenner Institute for Molecular Bioscience in South Africa, and his team are developing a comprehensive map of genetic variations that may impact the metabolization of drugs for malaria and tuberculosis. Learn how Project Africa GRADIENT, a collaboration between Novartis, GSK & the South African Medical Research Council, is supporting his work and helping to build a network of researchers in this field across Africa. #genetics #malaria #diseaseresearch
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Research, Monitoring, and Evaluation Specialist | Expertise in Health, Reproductive Health, and Family Planning | Rollback Malaria Advocate | Data-Driven Decision Maker
Exciting research news! We have just published a new study that sheds light on the genetic mechanisms of Plasmodium falciparum resistance to sulfadoxine-pyrimethamine, a critical antimalarial drug. The research, conducted in Jos, Nigeria, reveals key insights into mutations in the dihydropteroate synthetase (dhps) gene that confer resistance to this treatment. This study has important implications for the development of effective antimalarial therapies and strategies to combat drug-resistant malaria. Congratulations to my entire research team on this significant contribution to the field of malaria research! Read the full article here: https://lnkd.in/dyRkM3EE #malaria #antimalarial #genetics #resistance #sulfadoxinepyrimethamine #dihydropteroatesynthetase #dhps #Plasmodiumfalciparum #Nigeria #Jos #research #science
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Professor Tastan Bishop, Director of the Research Unit in Bioinformatics, Rhodes University, South Africa, is exploring the unique ways our bodies interact with medications due to genetic differences. By studying how genome variations influence protein levels, she is investigating how our bodies metabolize tuberculosis and malaria drugs. She hopes her research will bring us closer to treating patients according to their genotype – a goal of personalized medicine. Watch the video to discover how Project Africa GRADIENT, a collaboration between Novartis, GSK & the South African Medical Research Council, is supporting researchers across Africa study genetic diversity in the context of malaria and tuberculosis. #personalizedmedicine #geneticsresearch #malaria
Prof Tastan Bishop shares her Project Africa GRADIENT research focus
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🧫 Check out this week's news highlights from AZoLifeSciences - The A to Z of Life Sciences featuring developments from the University of Bath, SLAC National Accelerator Laboratory, Folkhälsan Research Center and the Institute of Molecular Biotechnology of the Austrian Academy of Sciences. #sciencecommunication #scicomm #lifesciences #lifescience #AZoLifeSciences
🚨 What's new in #LifeSciences research? This week's highlights include: 📍 Could A Small Flower Hold The Key to More Stable Peptide Drugs? 📍 Structural Insights Into Coronavirus Spike Proteins 📍 A Novel Technique for Ribonucleotide Quantification 📍 Unraveling Stem Cell Destiny in Intestinal Organoids 💬 To learn more, find our coverage of these developments on our website, AZoLifeSciences.com #LifeScience #Biology #BiologicalResearch #Genetics #GeneticResearch #Genes #Gene #StemCells #BiomedicalResearch #Biomedicine #DrugDevelopment #Proteins #proteinengineering #coronavirus #AZoLifeSciencesNews #LifeSciencesNews #sciencecommunication #scicomm
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Join us for the next Coffee break with TRANSFAC that will be held on February 6th at 6 PM CET. Get the joining link here https://genexplain.com/ask This “Coffee break with TRANSFAC” will be devoted to the following key questions: • How to find a list of tissue-specific TF target genes? • Conserved TF binding sites – how important are they? • PWMs – is that all? What else? Are you interested in other questions and topics? Let us know and vote for the questions to be covered at next Coffee break with TRANSFAC sessions >> https://lnkd.in/etKRbV8R In the upcoming webinar Dr. Alexander Kel, the CEO and CSO of geneXplain GmbH, will address the point of analyzing tissue-specific gene regulation. Dr. Kel will provide his answers to the questions coming from the audience as well as he will answer the following pre-prepared questions: • If you have a list of heart muscle specific genes, how do you find tissue-specific transcription factors regulating those genes? • Position Weight Matrices (PWMs) – why are they important? What else can be used to find TF binding sites? • Does one PWM describe TF binding sites for one transcription factor only (e.g. STAT-1) or for the whole family of factors (STAT-1, STAT-2,….)? • Algorithms for predicting TF binding sites in DNA based on positional weight matrices? • How to define the cutoffs for binding sites scores of PWMs? • In calculating false positives and false negatives you need to know the true binding sites. How are they determined? • Conserved TF binding sites. Are they the only true TF binding sites? How important are they? What is phylogenetic footprinting and how to use it to find TF binding sites regulating your genes? • How to integrate transcriptome (RNA-seq) and epigenome (ATAC-seq) data in one TRANSFAC analysis? You can pre-book your questions at the event page https://genexplain.com/ask and we will handle them to Dr. Kel for addressing them at the online event. The video records of the previous Coffee break with TRANSFAC sessions are also available there. #bioinformatics #SystemsBiology #geneXplain #TRANSFAC #CoffeeBreakWithTRANSFAC #GeneRegulation #Transcription #TranscriptionRegulation #TranscriptionFactors #Genes #research #Biology #PromoterAnalysis #TFBS #TranscriptionFactor #DNA #BindingMotif #TranscriptionFactorBindingSite #freeseminar #QandA #seminar #webinar #freewebinar #Tissue #TissueSpecificity
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🚨 What's new in #LifeSciences research? This week's highlights include: 📍 Could A Small Flower Hold The Key to More Stable Peptide Drugs? 📍 Structural Insights Into Coronavirus Spike Proteins 📍 A Novel Technique for Ribonucleotide Quantification 📍 Unraveling Stem Cell Destiny in Intestinal Organoids 💬 To learn more, find our coverage of these developments on our website, AZoLifeSciences.com #LifeScience #Biology #BiologicalResearch #Genetics #GeneticResearch #Genes #Gene #StemCells #BiomedicalResearch #Biomedicine #DrugDevelopment #Proteins #proteinengineering #coronavirus #AZoLifeSciencesNews #LifeSciencesNews #sciencecommunication #scicomm
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Excited to share our latest research collaboration with Genome Institute of Singapore! Our paper, "The variation landscape of CYP2D6 in a multi-ethnic Asian population" has just been published on bioRxiv. We analysed 1,850 whole genomes from the multi-ethnic SG10K cohort using our in-house consensus algorithm, and uncovered unique population-specific trends in CYP2D6 star-allele distribution, showcasing the distinct genetic makeup of Singaporeans. Plus, we identified 14 potential novel CYP2D6 star-alleles. What's more, 46% of individuals in our cohort had actionable CYP2D6 variants, with direct implications for drug dosing and treatment strategies. Read the full paper here: https://lnkd.in/dNwmYZhm Thanks to Yusuf Maulana Rodrigo Toro Jimenez Nicolas Bertin and David Twesigomwe for making this possible! #Pharmacogenomics #PersonalizedMedicine #BioRxiv #CYP2D6 #Genetics #SoutheastAsia #Nalagenetics
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Fast and accurate diagnosis of urea cycle disorders (UCDs) may finally be within reach, thanks to a collaboration between researchers from the Pacific Northwest Research Institute led by Aimée Dudley, Ph.D., and experts with the Urea Cycle Disorders Consortium. The researchers have developed a method using yeast genetics to rapidly measure the effects of thousands of variants of a gene that causes human disease. They aim to shed light on “variants of uncertain significance”—genetic changes that may or may not cause disease—and help the medical community interpret often confusing and unhelpful genetic testing results. Hopes are high that this technique, combined with other advances in genetic testing, could end the diagnostic odysseys and missed diagnoses that are so common in the UCD community. Read more: https://lnkd.in/gk4ppEFd Rare Diseases Clinical Research Network (RDCRN) National Center for Advancing Translational Sciences (NCATS) Children's National Hospital #raredisease #rarediseases #genetics #diagnosis
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CSIR-UGC NET JRF Rank 123 | PhD Bioinformatics at Polish Academy of Sciences | GATE-XL, GATE-BT ' 2021 | GAT-B ' 2020 | TIFR 2022 and 2020| DBT-JRF 2021 | IIT JAM 2019 | JNU ' 2022 | DU ' 2020
Check out my publications! I am thrilled to share the publication of two research papers that explore the varied responses to vitamin D supplementation among different populations. In the first study, we examined the in vivo effects of vitamin D on primary immune cells, revealing significant gene expression changes related to focal adhesion in healthy individuals. Interestingly, the responsiveness varied widely among participants. The second study focused on a Saudi cohort, demonstrating that a significant portion of the population showed low responsiveness to vitamin D supplementation, highlighting the need for tailored approaches similar to those used in Nordic countries. These findings emphasize the importance of personalized vitamin D supplementation strategies across different regions. https://lnkd.in/d-tdt7MP https://lnkd.in/dW924Yuw
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Invivoscribe offers a range of Clonal Controls tailored to specific applications, such as #leukaemia, #lymphoma, and #myeloma. These controls typically consist of DNA or RNA samples with predetermined genetic mutations or rearrangements, providing a standardized reference for laboratories to compare their test results against. To know more - https://lnkd.in/deP5W3c Contact us - [email protected] #DSS #inspiredbytechnology #biotechnology #scienceandtechnology
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I have completed Genes and the Human Condition(from behavior to biotechnology) at coursera. Throughout the program, I've gained valuable insights into -central Dogma -Gene expression -mutation -neurotransmitter and hormones -Human genome -Epigenetics -Genetics of cancer -Transgenic bacteria and plants -Transgenic technologies #coursera #universityofmaryland #genetics #geneandthehumancondition #skillbulding #learninganddevelopment
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