Solu’s Post

New in The Innovation Life! Absolute quantification of the microbiota spatial distribution in the murine large intestine. Jin et al. calculated the number of #bacteria present in the lumen or associated with the mucosal surface of mice gut samples using the bacterial “internal standard method” during sequencing. Read more @InnovationLife https://lnkd.in/e4ZEkUhr #microbiota #microbiology #Genomics #AcademicTwitter

Although certain groups of bacteria dominate the human gut microbiome, the exact composition varies from person to person. For example, bacteria from the Prevotellaceae family and the associated genus Segatella are very common, but not much is known about their biology as they are difficult to isolate and cultivate. They are part of the original microbiome and are found in around 90 percent of people living in non-industrialized regions around the world, such as the Amazon or parts of Africa. In contrast, only 20 to 30 percent of people in Europe and the U.S. carry these bacteria. A research team led by Prof. Till Strowig, who heads the "Microbial Immune Regulation" department at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, recently succeeded in isolating additional representatives of the Segatella bacterial members. With high-resolution and high-throughput genomic analyses, the researchers were able to show that the Segatella group, along with the well-known representative Segatella copri (previously known as Prevotella copri), is a much larger complex than it was previously known, with five species which were never described before," says Strowig. With joint efforts from the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH and the University of Trento (Italy), the research team has comprehensively characterized these species regarding their genomic diversity, biological features, and links with human health. https://lnkd.in/gWbUf-Bi

Exciting research this month from University of Bath on iuc3 plasmids in Klebsiella pneumoniae. Working with MicrobesNG, the team used a combination of short and long reads to characterise iuc3-carrying plasmids from K.pneumoniae isolated from Thailand and Italy 🦠 A key finding was the identification of seven large plasmids that likely emerged through hybridisation of co-circulating plasmids harbouring iuc3 and antimicrobial resistance genes. If you are interested in short or long reads sequencing service for your research project, please get in touch to discuss with our friendly team. #antibioticresistance #sequencing #longreads #research #DNAsequencing #NGS #amr #genomesequencing

🚨 Reminder: March 15th is the last day to register & submit an abstract to the One Health Microbiome Symposium (May 30-31, 2024) This exciting #interdisciplinary event is bringing together #academic, #government, and #industry researchers to explore Microbiome Sciences latest discoveries, approaches, and tools. Join the discussion on May 30-31st! 🌏 🐿 ☘ 🏃♀️ https://lnkd.in/gp2dxvf9 #symposium #onehealth #microbiomeresearch #microbiome #microbiology #genomics #sustainableagriculture #humanhealth #disease #climatechange #climatesolutions #evolution #ecology #microbial #metabolomics #metagenomics #bacteria #fungi #viruses #research #biotechnology

Researchers at the Weizmann Institute of Science have made a groundbreaking discovery – a novel species of yeast that may have the ability to displace its deadly peer, Candida albicans. This strain of yeast is responsible for causing candidiasis, a fungal infection that claims around 200,000 lives annually. The research, led by Prof. Steffen Jung and his team, stemmed from an unexpected observation during their studies on yeast infections. C. albicans, a microscopic yeast commonly found in the body's inner cavities, is typically harmless (except for occasional thrush infections). However, under certain conditions, it can breach the intestinal barrier, leading to invasive candidiasis – a potentially life-threatening condition. This remarkable finding opens up exciting possibilities for developing novel treatments to combat this dangerous fungal infection, potentially saving countless lives worldwide. Read more here! #Yeast #Research #Science #Innovation #ScientificBreakthrough #Health

Very glad to share here my first review article as a first author which has just been published in Virulence (Taylor and Francis) 😊 We have gathered current knowledge on #Shigella sonnei, the pathogen I am studying. S. sonnei is the most prevalent causative agent of #shigellosis (or bacillary dysentery) in high- and middle-income countries. Shigellosis is the leading bacterial cause of diarrhoea and the second cause of diarrhoeal mortality. There is no definitive answer on why the number of shigellosis episodes caused by S. sonnei, in comparison to S. flexneri, increases as a country experiences economic growth. Currently, the global isolation of S. sonnei and its accumulation of antimicrobial resistances are on the rise, a concerning matter that has led the WHO to consider it a priority pathogen. More work is needed on the mechanisms that allow S. sonnei to mount an infection. Interestingly, as more data are collected, discrepancies have come to light in the comparison between S. sonnei and S. flexneri, the primary model to study shigellosis. These include a poorer adaptation to an intracellular lifestyle, mechanisms to outcompete commensal microbiota, and specific virulence factors such as the double layer of O-ag present in the LPS and the capsule. We have collected existing knowledge on Shigella spp. biology, evolution, epidemiology, pathogenesis, virulence, and clinical aspects. In addition, we have highlighted the unique aspects that describe S. sonnei within the context of other Shigella spp. We hope that this review helps pave the way for future research in Shigella and particularly S. sonnei. Full article here 👇 https://lnkd.in/ebQMyCcE #Shigella #sonnei #Shigellosis #BacterialPathogenesis #Enterobacteriaceae #AMR

#Scientists hail #new #antibiotic that can kill #drugresistant #bacteria Zosurabalpin has defeated strains of pneumonia and sepsis in mice, raising hopes for human trials Linda Geddes Science correspondent Wed 3 Jan 2024 11.00 EST Notifications off Scientists have discovered an entirely new class of antibiotic that appears to kill one of three bacteria considered to pose the greatest threat to human health because of their extensive drug-resistance. Zosurabalpin defeated highly drug-resistant strains of Carbapenem-resistant Acinetobacter baumannii (Crab) in mouse models of pneumonia and sepsis, and was being tested in human trials. Crab is classified as a priority 1 critical pathogen by the World Health Organization, alongside two other drug-resistant forms of bacteria – Pseudomonas aeruginosa and Enterobacteriaceae.

We are excited to share our latest paper in Genome Research: "Global compositional and functional states of the human gut microbiome in health and disease." We explored 6014 human gut metagenome samples from 19 countries and 23 diseases, identifying key bacterial markers and distinct functional distributions across westernized and non-westernized populations. Our findings are compiled in the open-access Human Gut Microbiome Atlas: https://lnkd.in/eUPXT4Xt

Potential influence of the gut virome, particularly bacteriophages, on aging and inflammatory processes, with implications for health and longevity. 1. Increase of viral diversity a loss of core-virus abundance was detected. 2. Higher prevalence of viral lytic activity, potentially linked to chronic low-grade inflammation. 3. The centenarian gut virome plays a role in sulfur metabolic pathways, aiding in the conversion of methionine to homocysteine and the release of hydrogen sulfide (H2S), which contributes to resistance against harmful bacteria and supports mucosal integrity. 4. Distinct microbial composition in healthy individuals who reach a century of age. #microbiome #virome #aging #Viromeagainstbacteria