Stasa Stankovic’s Post

Genetic contribution of reproductive traits to risk of uterine leiomyomata: a large-scale, genome-wide, cross-trait analysis - Overall study design of genome-wide, cross-trait analysis We first retrieved summary statistics from large-scale GWAS conducted for age at menarche, age at natural menopause, age at first birth, and uterine leiomyomata, all in European ancestry. Second, we conducted global and local genetic correlation analyses to quantify the shared genetic basis. Third, we performed a cross-trait meta-analysis to identify pleiotropic variants, followed by transcriptome-wide association studies to detect shared expression-trait associations. Finally, we conducted a bidirectional Mendelian randomization analysis to evaluate potential causal relationships. https://ow.ly/SpsF50Rc7eW

We are live from now! 🚀 (Don't miss it!) Today we invite you to an exciting debate on a crucial topic: Genetics and Fertility: Invasive or Non-invasive? 🎙️ Live with: 🔸 Yosu Franco Iriarte - Hospital Ruber Internacional 🔸 Xavier Vendrell, PhD - Sistemas Genómicos | member of SYNLAB 🔸 Eva Gonzalez (Moderator) - Fertypharm 💡 What can you expect? 1. Expert perspectives: Delve into the different genetic techniques applied to fertility. 2. Dynamic discussion: Understand the advantages and disadvantages of invasive and non-invasive methods. 3. Active participation: Ask your questions and get real-time answers from our experts. 🔍 How can you participate? Within the website we have enabled a button that will take you to a form where you can leave your questions to be answered live by the speakers. Invite your colleagues to join the conversation! 👉 Follow us here and ask your questions in real-time: https://lnkd.in/gkg-476G Don't forget to follow us so you don't miss any updates and be part of this fascinating discussion. #WeAreLive #Genetics #Fertility #Debate #4JVF #Fertypharm P.S. What's your opinion on invasive vs. non-invasive methods? Leave us your comments!

Is BMI related to genetics ? A measure commonly used to determine the ideal body size on the basis of an individual's weight and height. Waist circumference is considered a good estimate of your body fat especially your internal fat deposits, and your likelihood of developing weight-related disease. Around 40-70% of inter-individual variability in BMI, commonly used to assess obesity, has been attributed to genetic factors. Genome wide association studies have dramatically changed the pace of detection of common genetic susceptibility variants. #healthyheart #cardiacdietitian #healthyliving #BMI #genetics

New research shows a concerning relationship between DDT and -DDE exposure and the sperm epigenome. The study found that exposure seems to negatively impact future generations' health through epigenetic mechanisms, with a dose-response-like manner. It's important to note that there may be other environmental exposures, genetic diversity, and selection bias contributing factors to consider. Learn more about this study here: https://lnkd.in/d6RchXQf

YES, our webinar will be also available in English 😊 📢 Add Thursday February 29th 2024, 12:15 PM (EST) to your schedule !   Prenato & Genolife - Ma santé génétique invites you to a new webinar on reproductive genetics, presented by Claire Bascunana, genetic counsellor : 🧬HOW GENETIC COUNSELLING CAN IMPACT PRECONCEPTION AND FERTILITY CARE This training is aimed at health professionals interested in the care of patients in preconception situations and reproductive genetics and will be hosted by Laurie Mathieu. Goals : ✔Better guide your patients in preconception or already followed in fertility ✔Understand what genetic counselling is ✔Know the indications for referring a patient to Genetics ✔Know the management of genetic causes of infertility ✔Understand what testing is available and indicated in different contexts 👉 Register via the link below: https://lnkd.in/eB9f6sUA    #preconception #geneticcounselling #fertility #reproductiverisk #genetics #geneticrisk

Delighted for Niche to have been involved in this important initiative showing that in healthy airways, 4wk of corticosteroids reduced gene expression related to innate and adaptive immunity, and markers of type-2 inflammation, implying homeostasis involves tonic signalling in airway mucosa that is exquisitely sensitive to ICS https://shorturl.at/cFGST #asthma

However, there are a number of factors that support the theory that genetics play a part in the onset of Peyronie’s disease. Peyronie’s disease has a far higher occurrence in Caucasian men than in other ethnic groups. Like other diseases found in specific ethnicities for example Cystic Fibrosis, the higher prevalence suggests the presence of a founder mutation. Peyronie’s disease is known as a fibroproliferative disease. With Peyronie’s disease, a fibrous plaque develops in the envelope that stretches the length of the penis. There is a strong correlation with other fibro-pro-lif-Erative diseases such as Dupuytren’s contracture, which is a deformity of the hand, where knots of tissue form under the skin, which develop into thick cords that pull one or more fingers into a bent position. #Mansmatters #GeneticsPeyroniesDisease  #GeneticsDiseaseTreatment #GeneticsDisease

Labcorp’s recently enhanced Reveal® SNP Microarray Pediatric provides a high-resolution, genome-wide analysis to identify copy number and copy neutral abnormalities, giving you deep diagnostic insights.   Learn more about Reveal and other tools that can help you navigate the genetic labyrinth of #autism: #AutismAwareness

However, there are a number of factors that support the theory that genetics play a part in the onset of Peyronie’s disease. Peyronie’s disease has a far higher occurrence in Caucasian men than in other ethnic groups. Like other diseases found in specific ethnicities for example Cystic Fibrosis, the higher prevalence suggests the presence of a founder mutation. Peyronie’s disease is known as a fibroproliferative disease. With Peyronie’s disease, a fibrous plaque develops in the envelope that stretches the length of the penis. There is a strong correlation with other fibro-pro-lif-Erative diseases such as Dupuytren’s contracture, which is a deformity of the hand, where knots of tissue form under the skin, which develop into thick cords that pull one or more fingers into a bent position. #Mansmatters #GeneticsPeyroniesDisease  #GeneticsDiseaseTreatment #GeneticsDisease

Genetic diseases cannot be treated, but their transmission can be prevented. We have the most complete solution on the market, SG Preconception, the comprehensive genetic study of future biological parents that helps to reduce the risk of transmission of hereditary diseases to the next generations. SG Preconception provides accurate genetic answers to make informed decisions in reproductive genetics. More information: [email protected] #SistemasGenomicos #SYNLABEspaña #Genetic #GeneticDiseases #Hereditary #Preconcepcion #Embarazo #Cromosoma #unico #Ginecologia #Obstetricia #Salud #Servicio #Integral #MedicalExcellence #ExcelenciaMedica