I’m really stoked to announce the publication of my very first co-corresponding research article in Molecular Cell. I would like to thank all the authors involved – Naoya Harada, Shuhei Asada, Lige Jiang, Huy Nguyen, Lisa Moreau, Ryan J. Marina, Karen Adelman, and Alan D’Andrea.
Here is the link to our article - https://lnkd.in/eZgA_PUc
Also, check out the article from the Corn group with similar conclusions: https://lnkd.in/ePXum3BY
Here is a brief summary of our findings:
Previous studies had implicated CCAR1 in inter-strand crosslink repair; however, its exact role was unclear. We show that CCAR1 acts a splicing modulator of FANCA pre-mRNA and is needed for FANCA protein expression. CCAR1 acts in concert with the U2AF complex to aid in exclusion of a poison exon from the FANCA transcript, ensuring accurate splicing. Loss of CCAR1 leads to inclusion of the poison exon in the FANCA transcript, leading to loss of FANCA protein expression and thereby causing Fanconi Anemia phenotype.
#FanconiAnemia #Splicing #RNA #poison_exon
Vice President at MWA Consulting, Inc.
2moCongrtulations.