Thousands of molecules screened against thousands of proteins = millions of interactions to find transcription factor inhibitors. 30+ Evosep Biosystems 96-sample tip boxes, which is paired with our Bruker Daltonics timsTOF Ultra for high throughput running at 60 samples a day and 5000 interactions per sample (Daniele Canzani, PhD for scale). What do you think, Shourjo Ghose Ph.D. Daniel Hornburg, PhD ? Of course, we're just getting started for 2024. Another ~36 plates' worth of samples slated to start this upcoming week with our rhabdomyosarcoma screen kickoff. Stay tuned and see you at #ASMS2024! #TeamMassSpec #chemoproteomics #DrugDiscovery #HighThroughputScreens
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This week there's new case-studies for me to share demonstrating the use of the NanoAnalyzer in #LNP characterization and generation of #nanomedicines. The empty particle identification is still a favourite but the new data quantifying the targeting ligands on the surface of LNPs has recently captured a lot of attention. Catch the webinar this Wednesday to learn more https://lnkd.in/gmmzSRT2 #NanoFCM #Nano #Nanoparticle #Liposome #Nanotherapeutic #mRNA #RNA #saRNA #siRNA #mRNAvaccines
Join us for an illuminating webinar on July 10th, 2024! In this GEN webinar, Ben Peacock, PhD, will present the NanoAnalyzer platform and describe how it supports multi-parameter analysis and characterization of biological nanoparticles like LNPs. Key highlights include: - Identify the presence of cargo and surface modifications - Determine the efficacy of nanoparticle loading or functionalization - Identify priority subpopulations within samples using exogenous labeling techniques - Quantify RNA cargo or the surface density of various targeting modalities 🔗 Register Now to secure your spot: https://lnkd.in/gmmzSRT2 #mRNA #LNPs #RNATherapeutics #LipidNanoparticles #RNAEncapsulation #NanoAnalyzer #NanoFCM #GENWebinar
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The interactions between #nanomedicine and the in vivo biological environment largely determine nanomedicine's fate and #therapeutic outcomes after administration. Thus, a better understanding of nano-bio interactions in several scenes is essential for the efficiency of #drugdelivery platforms, as well as the #biosafety of nanomedicine. Check out our new Review paper, discussing the Nano-bio interactions with a special focus on #mRNA nanomedicine. Link: https://lnkd.in/eVWnvTAz
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Introduction to Immunofluorescence. Immunofluorescence (IF) is an immunochemical technique that enables the detection and localization of antigens on tissue or cells using microscopy or flow cytometry. Fluorescent immunostaining allows protein expression patterns and interactions to be characterized. To learn more download the article at https://hubs.li/Q02C-PMt0
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🧬 𝗘𝘅𝗽𝗹𝗼𝗿𝗶𝗻𝗴 𝗣𝗿𝗼𝘁𝗲𝗼𝗺𝗶𝗰𝘀 𝗼𝗻 𝗧𝗶𝘀𝘀𝘂𝗲 𝗦𝗮𝗺𝗽𝗹𝗲𝘀 Due to their complex cellular composition, tissue samples present a unique challenge and opportunity. This complexity allows for detailed monitoring of changes such as inflammation and enables in-depth studies of cell distribution and interactions. Combining proteomics with microscopy techniques like immunohistochemistry offers a powerful approach to studying molecular changes and validating findings. Biogenity utilizes the Thermo Fisher Orbitrap Eclipse for accurate and sensitive proteome analysis. This advanced instrument ensures high sensitivity, which is essential for mapping biological systems and identifying invading cells. We employ TMT for MS3-level quantification to minimize analytical variance, enhancing accuracy for reliable statistical analysis. Discover more about our tissue proteomics services at https://lnkd.in/d3dDFyTp.
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Adjunct Assistant Professor in Electrical and Computer Engineering (ECE) at Georgia Institute of Technology
Membrane-anchored DNA nanojunctions enable closer antigen-presenting cell–T-cell contact in elevated T-cell receptor triggering https://lnkd.in/gAsjGD4P
Researchers have developed a novel approach to investigate the interaction between T-cell receptors and antigen-presenting cells (APCs) during the initiation of intracellular signaling cascades in T cells. They used DNA nanojunctions to manipulate the spacing between antigen-presenting cells and T-cell interfaces. Their study shows that the axial distance of the contact zone is a critical factor in T-cell activation, potentially affecting protein reorganization and mechanical forces. Shortening the intermembrane distance enhances T-cell signaling. Read more: https://lnkd.in/dSTKUBfX #dna #tcell #biomedical #nanotechnology #research
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FITC-Trypsin/Fluorescein Isothiocyanate-Trypsin can be used in fluorescence-based assays, microscopy, flow cytometry, and other imaging techniques. It enables the visualization of Trypsin activity, binding, or localization to specific target sites. This tool provides valuable insights into the proteolytic processes, cellular digestion, and other Trypsin-related functions in biological systems. #FITC-#Trypsin/ #Fluorescein #Isothiocyanate-#Trypsin #microscopy, #flow #cytometry #target https://lnkd.in/gFH6UCxs
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Our Issue 12 front cover features Jigang Wang, Chengchao Xu, Huan Tang et al STEP: profiling cellular-specific targets and pathways of bioactive small molecules in tissues via integrating single-cell transcriptomics and chemoproteomics https://lnkd.in/eXEEP-aW #ChemSciCovers
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We are excited to introduce a new line of Lipid Microparticle products ideal for apoptosis and phagocytosis experiments! PS Lipid Microparticles | PC Lipid Microparticles PS Lipid Microparticles, pHrodoTM Red | PC Lipid Microparticles, pHrodoTM Red https://lnkd.in/gZsRZ8rH Phosphatidylserine (PS) and Phosphatidylcholine (PC) microparticles have phospholipids attached in a unique way allowing headgroups to be exposed and available for the study of biological interactions. Their 3 µm size is ideal for phagocytosis and accommodates analysis with standard flow cytometry and microscopy methods. Learn more: https://lnkd.in/gM7zK9wB
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#MicroscopyMonday Spotlight: Unlocking MEGF10 with #ANR-205! This week, we're exploring the Anti-MEGF10 (extracellular) Antibody (#ANR-205). Highly specific & and applicable in Western blot, IHC & and flow cytometry! Learn more and explore ➡️ https://lnkd.in/eHQPCTxN What microscopy mysteries are you solving? Share below! 👇 #proteinresearch #MEGF10 #researchtools #lifesciences
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