Talus Bio’s Post

New article from BioDot!!!! Wesley Thio examines the science of single-cell proteomics; a powerful technique that benefits immensely from automation and reduced sample volumes. #biodot #proteomics #automation #liquidhandling #miniaturization #ATSLifeSciences

Best Practices for Single-Cell Proteomics Using Mass Spectrometry 🧪👩🔬👨🔬🥼 In this webinar, Runsheng Zheng and Fernanda Salvato my colleagues from Thermo Fisher Scientific will discuss how to optimally examine single-cell proteomes through label-free, data-independent acquisition (DIA) mass spectrometry. CLICK HERE TO REGISTER👉 https://lnkd.in/ghp84hgb Friday, September 29, 2023  11:00 AM Eastern Time (8:00 AM PT) Researchers use mass spectrometry-based methods for single-cell proteomics, where they can identify and quantify thousands of proteins, proteoforms, and post-translational modifications within each cell. To ensure maximum proteome coverage, scientists employ a label-free, data-independent acquisition (DIA) approach to analyze single-cell proteomes without bias. However, getting started in the single-cell proteomics field is daunting. Topics to be covered  -How to optimize sample preparation, separation, and data analysis when using Thermo Scientific Orbitrap mass spectrometers. -Recent advances in single-cell proteomics. #proteomics #massspectrometry #singlecell #orbitrap #massspec #LCMS #thermo #thermofisherscientific #analyticalchemistry #personalizedmedicine #biomedicalresearch #biology #chemistry

Structural Biology And Molecular Modeling Techniques Market Analysis 2024-2033 The structural biology and molecular modeling techniques market size has grown rapidly in recent years. It will grow from $7.58 billion in 2023 to $9 billion in 2024 at a compound annual growth rate (CAGR) of 18.7%. Read more @ https://lnkd.in/gy7t9DZs #marketresearch #marketintelligence #marketreport #industryanalysis #TheBusinessResearchCompany #TBRC #structuralbiology #molecularmodellingtechniques #drugdevelopment #drugdiscovery #biotechnology #pharmaceuticalindustry

A novel chemical probe, OPA-S-S-alkyne, has been developed to target surface lysines, enabling the Global Analysis of Surface Functionality (GASF) strategy for living cells. This approach identified 2639 surface lysines in Hela cells, with hundreds being highly reactive, providing a significant dataset of surface functional lysine sites. Notably, hyper-reactive lysines on proteins like ROR2 and Endoglin were identified at interaction interfaces, showcasing the strategy's potential for drug discovery by revealing new ligandable sites on cell membrane proteins. Read more Wang, T., Ma, S., Ji, G. et al. A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun 15, 2997 (2024). https://lnkd.in/geuQRKWH

A nice review from Prof. Li's group on labeling methond in mass sectrometry-based proteomics. With the prevent of high resoltuion mass spectromery, more and more labeling methods are introduced, then with the requests for high througput (especially in single cell proteomics), multplex methods, even plexDIA are introduced~

Recent advances in liquid chromatography-tandem mass spectrometry (LC-MS) have enabled scientists and clinicians to analyze thousands of protein markers in a single sample. However, the quality of the LC-MS analysis hinges on the sample preparation stage, a critical juncture that affects the accuracy, reproducibility, and throughput of the results. This is because sample preparation workflows in proteomics are still highly manual and time-consuming, making the process prone to human errors.

📖 WEEKEND READ: Revolutionizing proteomics: unlocking the potential of automation to overcome industry bottlenecks Our Crystal Girod helps untangles the complexities in this News Medical article: https://becls.co/478nSaM #Proteomics #UntangleTheComplexities #LabAutomation

🌟 Exciting Times in the World of Proteomics! 🌟 Thermo Fisher Scientific's remarkable $3.1 billion acquisition of Olink Proteomics is a testament to the incredible #technology that forms the foundation of Olink Proteomics. Olink’s advancements in #proteomics have significant impacts on both ongoing #drugdiscovery and future #precisionmedicine. #Navinci and #Olink Proteomics share the same ancestry, starting as a university spin-out from Ulf Landegren's lab at Uppsala University and the invention of the #ProximityLigationAssay. While Olink Proteomics has developed the #PEA technology and with great knowledge and persistence, accelerating the entire field of proteomics, we've continued to build upon the same technological base of Proximity Ligation Assay. Our focus at Navinci has been on developing #Navenitechnology for #insitu protein analysis in a #spatialbiology context, shedding light on protein function in #spatialproteomics. As former members of the Olink family, we're delighted to witness the remarkable success of Olink Proteomics, big #congratulations to the whole team, that we know has worked very hard to make this happen! Our journey continues in the realm of #illuminating function in spatial proteomics, and we're eager to contribute to this dynamic field. Stay tuned for our upcoming #developments! Read the news here: https://lnkd.in/eG5fvHzu Read more about Ulf Landegren’s innovations here: https://lnkd.in/dYfpf_aY Read more about Proximity Ligation Assay here: https://lnkd.in/dwcGkXfZ #uppsalabiotech #swedishinnovation #LifeScience

Proteomics holds immense promise in unravelling the mysteries of protein expression, interactions, and modifications. However, manual processes in sample preparation pose significant challenges, including time inefficiency, susceptibility to human error, and limitations in scalability. Discover how automation is the key to surmounting these challenges, paving the way for groundbreaking discoveries in protein science! https://ow.ly/2ycm50S6Aj1 #ProteomicsResearch #ProteinExpression #AutomationInScience #SamplePreparation #ResearchAndDiscovery

The future: MS-based proteomics at scale :)