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Our technology enables rapid characterization of biosynthetic gene clusters and their corresponding natural products. In a recent paper out of Christine Beemelmanns' Lab at Saarland University and published in Nature Portfolio Communications Chemistry, the authors surveyed the chemical diversity of macrolactam natural products. To facilitate characterization of these compounds, the researchers turned to our DNAtrap™ cloning method to capture the intact 105-kb cluster from the native host. The captured gene cluster was expressed in a heterologous host confirming that the pathway encodes for production of the ciromicin macrolactam.

DNAtrap™ BGC cloning featured in new Communications Chemistry paper - Terra Bioforge

DNAtrap™ BGC cloning featured in new Communications Chemistry paper - Terra Bioforge

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