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Fascinating chemistry of swapping a C atom with N! It sounds easy but super difficult. Two different ways to achieve the same and led to publication in Nature and Science - double bonanza! One approach, outlined in a paper in Nature led by graduate student Jisoo Woo, works on molecules that already have a nitrogen atom nearby in the structure. The new method cleaves open the ring of atoms using ozone, and then uses the first nitrogen molecule to "guide" the second in. The other approach, described in a paper in Science led by Pearson, works on molecules that don't already have a nitrogen atom. It can simply remove one carbon atom—the right one—and replace it with a nitrogen atom.

There's an interesting ACS-RSC-SCI Symposium on June 11th (12 noon ET / 9 am PT / 5 PM UK / 6 PM CET)  - details below for tuning in. It'll be interesting to hear about the total synthesis of AZD5991 as Hypha made an acyl glucuronide of this compound using microbial biotransformation. The topics are: Total Synthesis of AZD5991 from a Process Chemistry Perspective - Oliver Ring, AstraZeneca Sweden. Necessity is the Mother of Invention: Natural Products and the Chemistry They Inspire - Sarah Reisman, California Institute of Technology Pasadena, USA. Symposium details - https://lnkd.in/evwkdYEt AZD5991 acyl glucuronide poster - https://lnkd.in/e7tHYgWA

From Our International Society of Heterocyclic Chemistry (ISHC) Congress Website: "During July 21-26, 2024, the 29th Congress of the International Society of Heterocyclic Chemistry (ISHC 2024) will be held in Aveiro, Portugal. This series of meetings was initiated in 1967 with the “First International Congress of Heterocyclic Chemistry” that took place in Albuquerque, New Mexico. Since then, the ISHC congresses have established themselves as a major forum for the advancement of heterocyclic chemistry, attracting hundreds of participants. As in previous editions of the ISHC Congresses, Our 2024 meeting will feature the most advanced topics in heterocyclic chemistry presented by leading international experts. Special focus will be given to novel methods in heterocyclic synthesis and the application of heterocycles in medicinal chemistry, sustainable chemistry and materials."

The 2023 Clarivate Impact Factor of #SpringerNature journal Molecular Diversity has increased to 3.9! (CiteScore 2023 = 7.3) Molecular Diversity presents refereed papers describing the development, application and theory of molecular diversity, and combinatorial chemistry in basic and applied research and drug discovery. https://lnkd.in/gyeyaSqV #Impactfactor #Clarivate #CiteScore #journals

This morning, I came across a groundbreaking publication that showcases a novel approach to multistep library synthesis in continuous flow. This method, developed by Brenda Pijper and Janssen Research and Development, significantly expands the chemical space by integrating diverse reactions into a single experimental setup. 🌟 By enabling the combinatorial linkage of multiple elements, this automated synthesis approach not only accelerates drug discovery but also enhances the creation of structurally diverse compounds. This is a major leap forward in medicinal chemistry, facilitating rapid establishment of structure-activity relationships and advancing fragment-based drug design. 💡 Here at NUVISAN The Science CRO, we continue to lead in contract research, providing innovative solutions that drive progress in the pharmaceutical industry. Contact me if you have any questions on our capabilities. #Pharmaceuticals #DrugDiscovery #FlowChemistry #Innovation #Nuvisan #MedicinalChemistry

This edited book of proceedings is a collection of seventeen selected and peer-reviewed contributions from the Virtual Conference on Chemistry and its Applications (VCCA-2022). VCCA-2022 was held online from 8th to 12th August 2022. The theme of the conference was "Resilience and Sustainable Research through Basic Sciences". 500 participants from 55 countries participated in VCCA-2022. This volume 2 reflects the chapters covering computational and industrial aspects. https://sowl.co/s/BmyN8  #chemistry #chemical #chemicalindustry #chemicalengineering #chemicals #chemicalmanufacturing #chemicalsafety #chemicalprocessing #chemicalsindustry #chemicalinnovation #biochemistry #biochemical #toxicology #sustainabledevelopment #science #physicalchemistry #researchanddevelopment #phd #scientist #experimental .

The 2023 Clarivate Impact Factor of #SpringerNature journal Molecular Diversity has increased to 3.9! (CiteScore 2023 = 7.3) Molecular Diversity presents refereed papers describing the development, application and theory of molecular diversity, and combinatorial chemistry in basic and applied research and drug discovery. https://lnkd.in/gYvx_SYS Ingrid B. Fischer #Impactfactor #Clarivate #CiteScore #journals

📯 We are at Frontiers in Medicinal Chemistry (FIMC) 2024 in Munich!   If you’re attending FIMC 2024, make a pitstop at Booth number 5 and have a chat with our experts Franz von Nussbaum, Felix Pape, Arun Narine and Robert R. A. Freund! 🔬 From hit-to-lead and lead optimization to scale-up, biotransformations, and physchem characterizations, our team of scientists helps turn your hit molecules into drugs. #medicinalchemistry #discoverychemistry #drugdiscovery #datascience

Extended application of Benzotriazole. Here it acts as a leaving group.