Velocity Clinical Research, Inc.’s Post

Cognivue, Inc.'s FOCUS study, just published in June 2024 in The Journal of Alzheimer’s Disease, examined the use of Cognivue Clarity® as a valid measure of cognitive performance in a diverse population. Link: https://bit.ly/3RSGjLv Main Takeaways: 👍 Based on a diverse sample that reflects many of the demographic characteristics of the US population, study data suggest Cognivue Clarity offers a quick, valid, and reliable measure of cognitive functions with limited practice effects when compared to a gold standard neuropsychological testing instrument. 👍 Cognivue Clarity can be used to effectively evaluate cognitive performance and screen individuals for cognitive impairment over time and can improve detection of cognitive changes, including MCI, in community settings, which is important in early detection and screening for cognitive changes across diverse populations. #research #diversity #cognitivehealth #cognitivescreening #cognitivechanges #cognivue Reference: Galvin JE, Chang LC, Estes PW, et al. Cognitive Assessment with Cognivue Clarity®: Psychometric Properties and Normative Ranges in a Diverse Population. Journal of Alzheimer’s Disease. 2024 Jun 14. doi: 10.3233/JAD 240331. Online ahead of print.

🧠 Exciting Research on Bipolar Disorder and Cognition! 🧠 A neuroimaging study from NEAD Centre has uncovered crucial insights into cognitive impairments in Bipolar Disorder (BD) and potential avenues for improvement. This research explores the resting-state neural foundations of cognitive challenges in BD patients. Here are the key findings: ✨ Cognitively impaired BD patients showed increased positive functional connectivity within the Default Mode Network (DMN) compared to healthy controls. 🤝 Conversely, they exhibited decreased negative functional connectivity within the Executive Central Network (ECN) compared to healthy controls. 🧩 The study highlights the potential role of aberrant DMN and ECN connectivity in cognitive performance in BD patients. 🔗 Dive into the full study for detailed insights: https://lnkd.in/e3SXAHwJ These neuroimaging findings contribute to insights that can pave the way for targeted pro-cognitive interventions, offering hope for improved cognitive functioning in BD. Let's continue to advance our understanding of mental health! 💪🧠 #BipolarDisorder #CognitionResearch #mentalhealthmatters Lydia Fortea González Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Hospital Clínic de Barcelona

Individuals differ in their traits and preferences, which shape their interactions, their prospects for survival and their susceptibility to diseases. These correlations are well documented, yet the neurophysiological mechanisms underlying the emergence of distinct personalities and their relation to vulnerability to diseases are poorly understood. Social ties, in particular, are thought to be major modulators of personality traits and psychiatric vulnerability, yet the majority of neuroscience studies are performed on rodents in socially impoverished conditions. Rodent micro-society paradigms are therefore key experimental paradigms to understand how social life generates diversity by shaping individual traits. Dopamine circuitry is implicated at the interface between social life experiences, the expression of essential traits, and the emergence of pathologies, thus proving a possible mechanism to link these three concepts at a neuromodulatory level. Evaluating inter-individual variability in automated social testing environments shows great promise for improving our understanding of the link between social life, personality, and precision psychiatry – as well as elucidating the underlying neurophysiological mechanisms. Introduction Inter-individual variability refers to differences in the expression of one or more behaviors between members of a population. For instance, some people express a shyer attitude than others, take more risks, or are more attracted to immediate gains. This variability is also evident in the way one responds to environmental and social challenges, resulting in a heterogeneous expression of emotional, cognitive, and task-related behaviors; and underlies, in particular, the emergence of distinct strategic approaches (i.e., how agents find different solutions to the same problem). In human studies, such behavioral variations have long been associated with the notion of personality (McAdams and Pals, 2006). In animal research, however, behavioral variability has largely been considered as unwanted noise, or as an experimental confound, and thus disregarded. But the consistency of these inter-individual differences across time and contexts has become harder to overlook, and it is now generally acknowledged that animal personalities are ubiquitous, quantifiable, and biologically meaningful (Sih et al., 2004; Bach, 2009; Bergmüller. #snsinstitutions #sndesignthinkers #designthinking

📃Scientific paper: Differential Patterns of Domain-Specific Cognitive Complaints and Awareness Across the Alzheimer's Disease Spectrum Abstract: International audience; Background: Characterizing self- and informant-reported cognitive complaints, as well as awareness of cognitive decline (ACD), is useful for an early diagnosis of Alzheimer's disease (AD). However, complaints and ACD related to cognitive functions other than memory are poorly studied. Furthermore, it remains unclear which source of information is the most useful to distinguish various groups on the AD spectrum. Methods: Self- and informant-reported complaints were measured with the Everyday Cognition questionnaire (ECog-Subject and ECog-StudyPartner) in four domains (memory, language, visuospatial, and executive). ACD was measured as the subject-informant discrepancy in the four ECog scores. We compared the ECog and ACD scores across cognitive domains between four groups: 71 amyloid-positive individuals with amnestic AD, 191 amnestic mild cognitive impairment (MCI), or 118 cognitively normal (CN), and 211 amyloid-negative CN controls, selected from the ADNI database. Receiver operating characteristic curves analysis was performed to evaluate the accuracy of the ECog and ACD scores in discriminating clinical groups. Results: Self- and informant-reported complaints were generally distributed as follows: memory, language, executive, and visuospatial (from the most severe to the least severe). Both groups of CN participants presented on average more memory and language complaints than their informant. MCI participants showed good a... Continued on ES/IODE ➡️ https://etcse.fr/szdL ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: Psychometric Evaluation of Self-assessment Persian Version of the Alzheimer Questionnaire (AQ) Abstract: INTRODUCTION: Mild cognitive impairment (MCI) is a primary disorder intensified by aging. Rapid diagnosis of MCI can prevent its progression towards the development of dementia. Thus, the present study was conducted to evaluate the psychometric features of the self-assessment Persian version of the Alzheimer questionnaire (AQ) in the elderly to detect MCI. METHODS: First, the AQ was translated into the Persian language; then, its content validity was evaluated by the content validity index (CVI) and content validity ratio (CVR) method, and face validity was determined by two checklists for expert panel and the elderly. The convergent validity of the self-assessment AQ with the Montreal cognitive assessment (MoCA) was assessed using the Pearson correlation. The test-retest and internal consistency reliability were evaluated using intra-class correlation (ICC) and Kuder-Richardson coefficients, respectively. Moreover, the receiver operating characteristic curve was used to determine the optimal cut-off point of self-assessment AQ. Among 148 older people who took part in this study, 93 met our inclusion criteria (aged 60 years old or older, had reading and writing skills, and were able to speak and communicate). RESULTS: A translated version of the questionnaire was named “M-check.” The developed test showed good content and face validity. Statistically significant correlations were found between M-check and MoCA (r=−0.83, P<0.05). The Kuder–Richardson and ICC coeff... Discover the rest of the scientific article on es/iode ➡️https://etcse.fr/f5qB #alzheimer #science #health

📃Scientific paper: Differential Patterns of Domain-Specific Cognitive Complaints and Awareness Across the Alzheimer's Disease Spectrum Abstract: International audience; Background: Characterizing self- and informant-reported cognitive complaints, as well as awareness of cognitive decline (ACD), is useful for an early diagnosis of Alzheimer's disease (AD). However, complaints and ACD related to cognitive functions other than memory are poorly studied. Furthermore, it remains unclear which source of information is the most useful to distinguish various groups on the AD spectrum. Methods: Self- and informant-reported complaints were measured with the Everyday Cognition questionnaire (ECog-Subject and ECog-StudyPartner) in four domains (memory, language, visuospatial, and executive). ACD was measured as the subject-informant discrepancy in the four ECog scores. We compared the ECog and ACD scores across cognitive domains between four groups: 71 amyloid-positive individuals with amnestic AD, 191 amnestic mild cognitive impairment (MCI), or 118 cognitively normal (CN), and 211 amyloid-negative CN controls, selected from the ADNI database. Receiver operating characteristic curves analysis was performed to evaluate the accuracy of the ECog and ACD scores in discriminating clinical groups. Results: Self- and informant-reported complaints were generally distributed as follows: memory, language, executive, and visuospatial (from the most severe to the least severe). Both groups of CN participants presented on average more memory and language complaints than their informant. MCI participants showed good a... Continued on ES/IODE ➡️ https://etcse.fr/szdL ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: Differential Patterns of Domain-Specific Cognitive Complaints and Awareness Across the Alzheimer's Disease Spectrum Abstract: International audience; Background: Characterizing self- and informant-reported cognitive complaints, as well as awareness of cognitive decline (ACD), is useful for an early diagnosis of Alzheimer's disease (AD). However, complaints and ACD related to cognitive functions other than memory are poorly studied. Furthermore, it remains unclear which source of information is the most useful to distinguish various groups on the AD spectrum. Methods: Self- and informant-reported complaints were measured with the Everyday Cognition questionnaire (ECog-Subject and ECog-StudyPartner) in four domains (memory, language, visuospatial, and executive). ACD was measured as the subject-informant discrepancy in the four ECog scores. We compared the ECog and ACD scores across cognitive domains between four groups: 71 amyloid-positive individuals with amnestic AD, 191 amnestic mild cognitive impairment (MCI), or 118 cognitively normal (CN), and 211 amyloid-negative CN controls, selected from the ADNI database. Receiver operating characteristic curves analysis was performed to evaluate the accuracy of the ECog and ACD scores in discriminating clinical groups. Results: Self- and informant-reported complaints were generally distributed as follows: memory, language, executive, and visuospatial (from the most severe to the least severe). Both groups of CN participants presented on average more memory and language complaints than their informant. MCI participants showed good a... Continued on ES/IODE ➡️ https://etcse.fr/szdL ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: Differential Patterns of Domain-Specific Cognitive Complaints and Awareness Across the Alzheimer's Disease Spectrum Abstract: International audience; Background: Characterizing self- and informant-reported cognitive complaints, as well as awareness of cognitive decline (ACD), is useful for an early diagnosis of Alzheimer's disease (AD). However, complaints and ACD related to cognitive functions other than memory are poorly studied. Furthermore, it remains unclear which source of information is the most useful to distinguish various groups on the AD spectrum. Methods: Self- and informant-reported complaints were measured with the Everyday Cognition questionnaire (ECog-Subject and ECog-StudyPartner) in four domains (memory, language, visuospatial, and executive). ACD was measured as the subject-informant discrepancy in the four ECog scores. We compared the ECog and ACD scores across cognitive domains between four groups: 71 amyloid-positive individuals with amnestic AD, 191 amnestic mild cognitive impairment (MCI), or 118 cognitively normal (CN), and 211 amyloid-negative CN controls, selected from the ADNI database. Receiver operating characteristic curves analysis was performed to evaluate the accuracy of the ECog and ACD scores in discriminating clinical groups. Results: Self- and informant-reported complaints were generally distributed as follows: memory, language, executive, and visuospatial (from the most severe to the least severe). Both groups of CN participants presented on average more memory and language complaints than their informant. MCI participants showed good a... Continued on ES/IODE ➡️ https://etcse.fr/szdL ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health