Wesley Greiner’s Post

🔬 CMC Analytical Comparability: Methods & Strategies For Biologics 🔬 Join us for an exclusive online live stream event featuring Prof. Dr. Johannes Buchner, a renowned expert in protein science! 🧪🧬 🌍 Date: 23 - 24 January 2024 📍 Location: Vienna, Austria | Online Live Stream 📚 About the Speaker: After attaining his PhD in biochemistry in 1991, Prof. Dr. Johannes Buchner worked at the National Institute of Health in Bethesda, USA. With an illustrious career, he has been holding a chair at the department of chemistry at the Technische Universität München since 1998. As a former dean of the department, he has extensive expertise in protein folding, stability, and cellular protein folding machinery. 🧪 🎓 Learn from the best: During this session, Prof. Dr. Buchner will delve into the fascinating world of CMC Analytical Comparability for Biologics. Discover the latest methods and strategies employed in the field, and gain valuable insights into the cutting-edge research conducted by one of the industry's leading experts! 🌟 💡 Don't miss out on this opportunity to expand your knowledge and network with like-minded professionals. Register now for the online live stream event and be part of this exciting learning experience! 🔗 Register here: https://lnkd.in/dXVZJW2i 👥 Tag someone who would be interested in this event and let's spread the word about this incredible opportunity! 📢 #CMCAnalyticalComparability #BiologicsResearch #ProteinScience #OnlineEvent #KnowledgeSharing #ProfessionalDevelopment

🔬 CMC Analytical Comparability: Methods & Strategies For Biologics 🔬 Join us for an exclusive online live stream event featuring Prof. Dr. Johannes Buchner, a renowned expert in protein science! 🧪🧬 🌍 Date: 23 - 24 January 2024 📍 Location: Vienna, Austria | Online Live Stream 📚 About the Speaker: After attaining his PhD in biochemistry in 1991, Prof. Dr. Johannes Buchner worked at the National Institute of Health in Bethesda, USA. With an illustrious career, he has been holding a chair at the department of chemistry at the Technische Universität München since 1998. As a former dean of the department, he has extensive expertise in protein folding, stability, and cellular protein folding machinery. 🧪 🎓 Learn from the best: During this session, Prof. Dr. Buchner will delve into the fascinating world of CMC Analytical Comparability for Biologics. Discover the latest methods and strategies employed in the field, and gain valuable insights into the cutting-edge research conducted by one of the industry's leading experts! 🌟 💡 Don't miss out on this opportunity to expand your knowledge and network with like-minded professionals. Register now for the online live stream event and be part of this exciting learning experience! 🔗 Register here: https://lnkd.in/deJG9iPP 👥 Tag someone who would be interested in this event and let's spread the word about this incredible opportunity! 📢 #CMCAnalyticalComparability #BiologicsResearch #ProteinScience #OnlineEvent #KnowledgeSharing #ProfessionalDevelopment

If you are attending Drug Discovery Chemistry in San Diego, drop by poster P031 to find out about Domainex's Direct-to-Biology platform, and how it can accelerate your project by utilizing high throughput synthesis, assay biology and ADME. #DrugDiscoveryChemistry #MedicinalChemistry #DirectToBiology #HighThroughput #AccelerateResearch

Here is a summary of all #Chemspace news and highlights for June, in case you missed it:   News & Collaborations: 1. Olena Strapak took part in the 38th ACS National Medicinal Chemistry Symposium! 2. A new Chemspace co-authored article is out! DOI:10.1126/science.adn6354 3. Special offer - Get a CCK-8 kit from TargetMol for just 1 USD/EUR. 4. Hot offer - free Antibody Samples from ProSci!     Weekend article and corresponding service: Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency   NEW Library Sets & Updates: Our General Pre-Plated Library is updated!   #Meet_Chemspace_team: Meet our Account Manager - Olena Liutikova!   Building Block and Screening Compound Sets: Building Blocks for Analogs of Seltorexant   Meet a new post in the “Biologics for Research” series: Spleen tyrosine kinase (Syk) #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures

🌟 Call for Abstracts: 2nd EFMC International Symposium on Chemical Biology (EFMC-ISCB 2025) 🌟 📍 Basel, Switzerland 🗓 January 29-31, 2025 The EFMC - European Federation for Medicinal Chemistry and Chemical Biology and the Swiss Medicinal Chemistry and Chemical Biology (by the DMCCB, Swiss Chemical Society), are thrilled to announce the 2nd International Symposium on Chemical Biology (EFMC-ISCB)! 🧪 DO NOT MISS THE OPPORTUNITY TO PRESENT YOUR RESEARCH! We invite researchers from around the globe to submit their abstracts for this event. This symposium will feature at least one selected Oral Communication for each of the following topics: 🔹 Advances in High-Throughput Chemical Proteomics 🔹 Cell Targeted Therapeutics: Mechanistic Insights and Drug Discovery 🔹 Chemical Biology of Chromatin and the Epitranscriptome 🔹 Complementary Advancements in Probe Design and Platform Technologies for Uncovering Biological Pathways and Drug Target Space 🔹 Discovery and Application of Peptide Macrocycles in Drug Discovery 🔹 New Modalities and Specific Strategies for RNA Modification and Degradation (LS-EuChemS Session) 🔹 Proximity-Based Chemical Biology and its Application to Drug Discovery (ICBS Session) Don't miss this opportunity to share your research with leading scientists, engage in stimulating discussions, and gain valuable feedback. 👉 Submit your abstract now and be a part of this premier scientific gathering! #EFMC_ISCB2025 #ChemicalBiology #CallForAbstracts #Research #MedicinalChemistry #DrugDiscovery

Interested in Synthesis of Sugar-Derived Heterocycles via Multicomponent Reactions, then read this detail review highlighting the growing utility of multicomponent reactions (MCRs) for the synthesis of diverse sugar-derived heterocyclic compounds. Divya Mathur and co authors provide an in-depth look at how sugars can be leveraged in a range of MCR methodologies. Key MCR approaches covered include the Passerini, Ugi, Petasis, Prins-Ritter, Mannich, and Hantzsch reactions, among others. The review showcases how the combination of sugars with diverse reactants can generate extensive libraries of glycoconjugate structures with potential biomedical applications. This work underscores the power of MCRs as efficient tools for diversity-oriented synthesis, harnessing the unique properties of sugars. The review is a must-read for synthetic and medicinal chemists interested in innovative approaches to accessing complex heterocyclic scaffolds. #ChemistryResearch #OrganicChemistry #SynthesisChemistry #Multicomponent_Reactions #SugarChemistry #HeterocyclicCompounds #DiversityOrientedSynthesis #DrugDiscovery SYNTHESIS Journal

On this day in science Dorothy Hodgkin was born. Hodgkin is one of the most famous female chemists, and is known for her investigations into the structure of natural products using x-ray analysis. She was awarded the Nobel Prize in Chemistry in 1964 for these contributions. #chemistry #science #nobelprize #xray #biopharmaceuticals #pharmaindustry #sciencecommunication #scienceandtechnology #science #stem #womeninbusiness #womeninmedicine #womenempowerment #womeninscience #researchanddevelopment #medicalsciences #infographic via Compound Interest | Chemistry infographics

#Therapeutics are an ever-evolving landscape of modalities which range in complexity but can be grouped into two broad categories: small molecules (chemically synthesized) and large molecules (#biologics). Small molecule therapeutics have historically dominated the marketplace and currently account for roughly 75% of all #pharmaceutical #drugs. The first therapeutic classified as a large molecule biologic (aka molecular elephant) to be approved by the #FDA was recombinant human insulin in 1982. The first FDA approval of a large molecule #antibody therapeutic, the murine antibody Muromonab-CD3 (OKT3), quickly followed in 1986. Since then, large molecules have become increasingly prevalent in drug development pipelines with more recent successes including many products with worldwide recognition such as the top-selling drug #Humira which is an antibody-based therapeutic for treatment of rheumatoid arthritis. Examples of large molecule therapeutics are: #Monoclonal antibodies Bispecific #antibodies #Antibody-drug conjugates (ADCs) #Recombinant enzymes #Polypeptides Adoptive cell therapies (ex. Chimeric Antigen Receptor or CAR T cells) Viral vector gene therapies (ex. Adeno-associated Virus or AAV) Non-viral vector gene therapies (ex. Lipid Nanopartical or LNP) Recombinant cytokines and growth factors. LC/MS has the ability to monitor multiple signature peptides throughout the protein structure which allows multiplexing during analysis for differentiation between the drug and its metabolites or between #protein isoforms, distinctions which can’t always be made with a traditional LBA or immunoassay. LC/MS is highly selective which aids in the assay performance when a therapeutic is homologous to endogenous protein(s). It also has a large dynamic range (4 orders) and can usually be implemented much faster than traditional LBA methods.

"Electrospray Wings for Molecular Elephants"   On this day in science John B. Fenn was born. Fenn who shared the Nobel Prize for Chemistry in 2002 for developing techniques to identify and analyse proteins and other large biological molecules. When electrically charged molecules—ions—are accelerated by an electrical field, their speed depends on the ion’s charge and weight. By measuring the time, it takes for the ions to pass a certain distance, the incidence of different molecules in a test can be determined. It was impossible, however, to use this technique on large molecules. John Fenn et al. demonstrated the use of Electrospray ionisation (ESI) for the ‘soft ionization’ of biologically important ‘molecular elephants’, allowing high molecular weight biopolymers (i.e., proteins) to be analysed by mass spectrometry. In 1988 Fenn's group demonstrate that it was possible to transfer large molecules, such as proteins, as ions into the gas phase without breaking them apart. #chemistry #electrical #massspectrometry #massspec #biopharmaceuticals #biopharma #chemistry #biochemistry #bioanalysis #lcms #lcmsms #electrospray #scienceandtechnology #sciencecommunication #scienceeducation #proteins #analyticalchemistry #analytics #pharma

Exploring the Realm of Science: M.Sc. Clinical Biochemistry and Clinical Microbiology students delve into practical learning at LPU's Central Instrumentation Facility. Witnessing innovation firsthand, they embrace the forefront of research and technology. #MLS #CIF #innovation #researchidea #LPU #ThinkBig