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Long-Term Antagonism of κ Opioid Receptors Prevents Escalation of and Increased Motivation for Heroin Intake
Joel E. Schlosburg, Timothy W. Whitfield, Jr, Paula E. Park, Elena F. Crawford, Olivier George, Leandro F. Vendruscolo, George F. Koob
J Neurosci. 2013 Dec 4; 33(49): 19384–19392. doi: 10.1523/JNEUROSCI.1979-13.2013
PMCID:
PMC3850049
Abstract Article PDF–2.5M

Is Cited by the Following 68 Articles in this Archive:

The ultrasonic vocalization (USV) syllable profile during neonatal opioid withdrawal and a kappa opioid receptor component to increased USV emissions in female mice
Kelly K. Wingfield, Teodora Misic, Kaahini Jain, Carly S. McDermott, Nalia M. Abney, Kayla T. Richardson, Mia B. Rubman, Jacob A. Beierle, Sophia A. Miracle, Emma J. Sandago, Britahny M. Baskin, William B. Lynch, Kristyn N. Borrelli, Emily J. Yao, Elisha M. Wachman, Camron D. Bryant
Version 2. bioRxiv. Preprint. 2024 Jul 4 [revised 2024 Sep 1]. doi: 10.1101/2024.07.02.601766
PMCID:
PMC11244951
Abstract Article PDF–1.3M
Kappa Opioid Receptors in Mesolimbic Terminals Mediate Escalation of Cocaine Consumption
L. Gordon-Fennell, R.D. Farero, L.M. Burgeno, N.L. Murray, A.D. Abraham, M.E. Soden, G.D. Stuber, C. Chavkin, L.S. Zweifel, P.E.M. Phillips
Version 1. bioRxiv. Preprint. 2023 Dec 23. doi: 10.1101/2023.12.21.572842
PMCID:
PMC10769440
Abstract Article PDF–1.2M
Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice
Yongsheng Zhu, Kejia Wang, Tengfei Ma, Yuanyuan Ji, Yin Lou, Xiaoyu Fu, Ye Lu, Yige Liu, Wei Dang, Qian Zhang, Fangyuan Yin, Kena Wang, Bing Yu, Hongbo Zhang, Jianghua Lai, Yunpeng Wang
J Clin Invest. 2023 Sep 15; 133(18): e163266. Published online 2023 Sep 15. doi: 10.1172/JCI163266
PMCID:
PMC10503809
Abstract Article PDF–13M
De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework
Leslie Salas-Estrada, Davide Provasi, Xing Qiu, Husnu Ümit Kaniskan, Xi-Ping Huang, Jeffrey F. DiBerto, João Marcelo Lamim Ribeiro, Jian Jin, Bryan L. Roth, Marta Filizola
J Chem Inf Model. 2023 Aug 28; 63(16): 5056–5065. Published online 2023 Aug 9. doi: 10.1021/acs.jcim.3c00651
PMCID:
PMC10466374
Abstract Article PDF–3.0M
Strain and Sex-Related Behavioral Variability of Oxycodone Dependence in Rats
Michelle R. Doyle, Angelica R. Martinez, Ran Qiao, Selen Dirik, Francesca Di Ottavio, Glenn Pascasio, Rémi Martin-Fardon, Christopher Benner, Olivier George, Francesca Telese, Giordano de Guglielmo
Neuropharmacology. Author manuscript; available in PMC 2023 Oct 1.
Published in final edited form as: Neuropharmacology. 2023 Oct 1; 237: 109635. Published online 2023 Jun 15. doi: 10.1016/j.neuropharm.2023.109635
PMCID:
PMC10353778
Abstract Article PDF–983K
Ranking the contribution of behavioral measures comprising oxycodone self-administration to reinstatement of drug-seeking in male and female rats
Suman K. Guha, Yanaira Alonso-Caraballo, Gillian S. Driscoll, Jessica A. Babb, Megan Neal, Nicholas J. Constantino, Tania Lintz, Elizabeth Kinard, Elena H. Chartoff
Front Behav Neurosci. 2022; 16: 1035350. Published online 2022 Nov 24. doi: 10.3389/fnbeh.2022.1035350
PMCID:
PMC9731098
Abstract Article PDF–5.2M
Endogenous opioid systems alterations in pain and opioid use disorder
Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly, Jose A. Morón
Front Syst Neurosci. 2022; 16: 1014768. Published online 2022 Oct 19. doi: 10.3389/fnsys.2022.1014768
PMCID:
PMC9628214
Abstract Article PDF–799K
Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal
Matthew B. Pomrenze, Daniel F. Cardozo Pinto, Peter A. Neumann, Pierre Llorach, Jason M. Tucciarone, Wade Morishita, Neir Eshel, Boris D. Heifets, Robert C. Malenka
Neuron. Author manuscript; available in PMC 2023 Dec 21.
Published in final edited form as: Neuron. 2022 Dec 21; 110(24): 4125–4143.e6. Published online 2022 Oct 5. doi: 10.1016/j.neuron.2022.09.024
PMCID:
PMC9789200
Abstract Article PDF–3.5M
Altered Accumbal Dopamine Terminal Dynamics Following Chronic Heroin Self-Administration
Brianna E. George, Monica H. Dawes, Emily G. Peck, Sara R. Jones
Int J Mol Sci. 2022 Aug; 23(15): 8106. Published online 2022 Jul 23. doi: 10.3390/ijms23158106
PMCID:
PMC9332320
Abstract Article PDF–2.3M
Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder
Kaitlin M. Best, Marissa M. Mojena, Gordon A. Barr, Heath D. Schmidt, Akiva S. Cohen
J Neurotrauma. January 2022; 39(1-2): 1–19. Published online 2022 Jan 11. doi: 10.1089/neu.2021.0063
PMCID:
PMC8978570
Abstract Article PDF–1.0M
Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKMζ and increased κOR in the hippocampus of female mice
Jorge A. Avila, Nicoletta Memos, Abdurrahman Aslan, Tytus Andrejewski, Victoria N. Luine, Peter A. Serrano
J Psychopharmacol. Author manuscript; available in PMC 2022 May 9.
Published in final edited form as: J Psychopharmacol. 2021 Oct; 35(10): 1240–1252. Published online 2021 Sep 29. doi: 10.1177/02698811211048285
PMCID:
PMC9083019
Abstract Article PDF–1.3M
Animal Models of the Behavioral Symptoms of Substance Use Disorders
Louk J.M.J. Vanderschuren, Serge H. Ahmed
Cold Spring Harb Perspect Med. 2021 Aug; 11(8): a040287. doi: 10.1101/cshperspect.a040287
PMCID:
PMC8327824
Abstract Article PDF–805K
Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis
Jacques D. Nguyen, Yanabel Grant, Michael A. Taffe
Br J Pharmacol. Author manuscript; available in PMC 2022 Sep 1.
Published in final edited form as: Br J Pharmacol. 2021 Sep; 178(18): 3797–3812. Published online 2021 Jun 8. doi: 10.1111/bph.15520
PMCID:
PMC8387405
Abstract Article PDF–1.3M
Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain
Olga Nosova, Igor Bazov, Victor Karpyak, Mathias Hallberg, Georgy Bakalkin
Molecules. 2021 Jun; 26(11): 3458. Published online 2021 Jun 7. doi: 10.3390/molecules26113458
PMCID:
PMC8201134
Abstract Article PDF–2.3M
κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats
Renata C.N. Marchette, Adriana Gregory-Flores, Brendan J. Tunstall, Erika R. Carlson, Shelley N. Jackson, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro F. Vendruscolo
Neurobiol Stress. 2021 May; 14: 100325. Published online 2021 Apr 14. doi: 10.1016/j.ynstr.2021.100325
PMCID:
PMC8095052
Abstract Article PDF–1.5M
Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction
Caroline B. Pantazis, Luis A. Gonzalez, Brendan J. Tunstall, Stephanie A. Carmack, George F. Koob, Leandro F. Vendruscolo
Sci Adv. 2021 Apr; 7(15): eabf0364. Published online 2021 Apr 7. doi: 10.1126/sciadv.abf0364
PMCID:
PMC8026136
Abstract Article PDF–294K
Expression and Distribution of Neuropeptide-Expressing Cells Throughout the Rodent Paraventricular Nucleus of the Thalamus
Genevieve R. Curtis, Kathleen Oakes, Jessica R. Barson
Front Behav Neurosci. 2020; 14: 634163. Published online 2021 Jan 14. doi: 10.3389/fnbeh.2020.634163
PMCID:
PMC7873951
Abstract Article PDF–891K
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
George F. Koob
Pharmacol Rev. 2021 Jan; 73(1): 163–201. Published online 2021 Jan. doi: 10.1124/pharmrev.120.000083
PMCID:
PMC7770492
Abstract Article PDF–1.3M
Strategies for Developing κ Opioid Receptor Agonists for the Treatment of Pain with Fewer Side Effects
Kelly F. Paton, Diana V. Atigari, Sophia Kaska, Thomas Prisinzano, Bronwyn M. Kivell
J Pharmacol Exp Ther. 2020 Nov; 375(2): 332–348. Published online 2020 Nov. doi: 10.1124/jpet.120.000134
PMCID:
PMC7589957
Abstract Article PDF–288K
Female rats self-administer heroin by vapor inhalation
Arnold Gutierrez, Jacques D. Nguyen, Kevin M. Creehan, Michael A. Taffe
Pharmacol Biochem Behav. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: Pharmacol Biochem Behav. 2020 Dec; 199: 173061. Published online 2020 Oct 24. doi: 10.1016/j.pbb.2020.173061
PMCID:
PMC7725943
Abstract Article PDF–1.1M
Insights into the Neurobiology of Craving in Opioid Use Disorder
Lindsay M. Lueptow, Elizabeth C Shashkova, Margaret G Miller, Christopher J. Evans, Catherine M. Cahill
Curr Anesthesiol Rep. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: Curr Anesthesiol Rep. 2020 Dec; 10(4): 378–387. Published online 2020 Sep 29. doi: 10.1007/s40140-020-00420-7
PMCID:
PMC7790122
Abstract Article PDF–496K
The Nucleus Accumbens: A Common Target in the Comorbidity of Depression and Addiction
Le Xu, Jun Nan, Yan Lan
Front Neural Circuits. 2020; 14: 37. Published online 2020 Jun 30. doi: 10.3389/fncir.2020.00037
PMCID:
PMC7338554
Abstract Article PDF–1.2M
Neuropeptide and cytokine regulation of pain in the context of substance use disorders
Elizabeth C. Delery, Scott Edwards
Neuropharmacology. Author manuscript; available in PMC 2021 Aug 11.
Published in final edited form as: Neuropharmacology. 2020 Sep 1; 174: 108153. Published online 2020 May 26. doi: 10.1016/j.neuropharm.2020.108153
PMCID:
PMC8356552
Abstract Article PDF–629K
Naltrexone Use in Treating Hypersexuality Induced by Dopamine Replacement Therapy: Impact of OPRM1 A/G Polymorphism on Its Effectiveness
Audrey Verholleman, Caroline Victorri-Vigneau, Edouard Laforgue, Pascal Derkinderen, Celine Verstuyft, Marie Grall-Bronnec
Int J Mol Sci. 2020 Apr; 21(8): 3002. Published online 2020 Apr 24. doi: 10.3390/ijms21083002
PMCID:
PMC7215378
Abstract Article PDF–1.0M
Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors
Angélica del Pilar Escobar, José Patricio Casanova, María Estela Andrés, José Antonio Fuentealba
Front Pharmacol. 2020; 11: 57. Published online 2020 Feb 18. doi: 10.3389/fphar.2020.00057
PMCID:
PMC7040183
Abstract Article PDF–1.1M
THE RISE AND FALL OF KAPPA-OPIOID RECEPTORS IN DRUG ABUSE RESEARCH
Matthew L. Banks
Handb Exp Pharmacol. Author manuscript; available in PMC 2021 Jan 1.
Published in final edited form as: Handb Exp Pharmacol. 2020; 258: 147–165. doi: 10.1007/164_2019_268
PMCID:
PMC7756963
Abstract Article PDF–355K
The Opioid Crisis and the Future of Addiction and Pain Therapeutics
Nathan P. Coussens, G. Sitta Sittampalam, Samantha G. Jonson, Matthew D. Hall, Heather E. Gorby, Amir P. Tamiz, Owen B. McManus, Christian C. Felder, Kurt Rasmussen
J Pharmacol Exp Ther. 2019 Nov; 371(2): 396–408. Published online 2019 Nov. doi: 10.1124/jpet.119.259408
PMCID:
PMC6863454
Abstract Article PDF–224K
Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders
Jamie A. Burns, Danielle S. Kroll, Dana E. Feldman, Christopher Kure Liu, Peter Manza, Corinde E. Wiers, Nora D. Volkow, Gene-Jack Wang
Front Psychiatry. 2019; 10: 626. Published online 2019 Sep 18. doi: 10.3389/fpsyt.2019.00626
PMCID:
PMC6759955
Abstract Article PDF–2.0M
Overexpression of miR-9 in the Nucleus Accumbens Increases Oxycodone Self-Administration
Maria Mavrikaki, Eleni Anastasiadou, Recep A Ozdemir, David Potter, Carolin Helmholz, Frank J Slack, Elena H Chartoff
Int J Neuropsychopharmacol. 2019 Jun; 22(6): 383–393. Published online 2019 Apr 16. doi: 10.1093/ijnp/pyz015
PMCID:
PMC6545539
Abstract Article PDF–591K
Association of variants of prodynorphin promoter 68-bp repeats in Caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use
Vadim Yuferov, Matthew Randesi, Eduardo R Butelman, Wim van den Brink, Peter Blanken, Jan M van Ree, Jürg Ott, Mary Jeanne Kreek
Neurosci Lett. Author manuscript; available in PMC 2020 Jun 21.
Published in final edited form as: Neurosci Lett. 2019 Jun 21; 704: 100–105. Published online 2019 Mar 29. doi: 10.1016/j.neulet.2019.03.038
PMCID:
PMC6594859
Abstract Article PDF–422K