Skip to main content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
κ Opioid Receptors in the Nucleus Accumbens Shell Mediate Escalation of Methamphetamine Intake
Timothy W. Whitfield, Jr., Joel E. Schlosburg, Sunmee Wee, Adam Gould, Olivier George, Yanabel Grant, Eva R. Zamora-Martinez, Scott Edwards, Elena Crawford, Leandro F. Vendruscolo, George F. Koob
J Neurosci. 2015 Mar 11; 35(10): 4296–4305. doi: 10.1523/JNEUROSCI.1978-13.2015
PMCID:
PMC4355200
Abstract Article PDF–1.3M

Is Cited by the Following 44 Articles in this Archive:

Pharmacological Treatments for Methamphetamine Use Disorder: Current Status and Future Targets
Justin R Yates
Subst Abuse Rehabil. 2024; 15: 125–161. Published online 2024 Aug 30. doi: 10.2147/SAR.S431273
PMCID:
PMC11370775
Abstract Article PDF–1.3M
Kappa Opioid Receptors in Mesolimbic Terminals Mediate Escalation of Cocaine Consumption
L. Gordon-Fennell, R.D. Farero, L.M. Burgeno, N.L. Murray, A.D. Abraham, M.E. Soden, G.D. Stuber, C. Chavkin, L.S. Zweifel, P.E.M. Phillips
Version 1. bioRxiv. Preprint. 2023 Dec 23. doi: 10.1101/2023.12.21.572842
PMCID:
PMC10769440
Abstract Article PDF–1.2M
Intermittent Access Cocaine Self-Administration Produces Context-Specific Escalation and Increased Motivation
Madeline M. Beasley, Brendan J. Tunstall, David N. Kearns
Drug Alcohol Depend. Author manuscript; available in PMC 2024 Apr 1.
Published in final edited form as: Drug Alcohol Depend. 2023 Apr 1; 245: 109797. Published online 2023 Feb 4. doi: 10.1016/j.drugalcdep.2023.109797
PMCID:
PMC10033440
Abstract Article PDF–922K
Acute Wheel-Running Increases Markers of Stress and Aversion-Related Signaling in the Basolateral Amygdala of Male Rats
Kolter B. Grigsby, Nathan R. Kerr, Taylor J. Kelty, Xuansong Mao, Thomas E. Childs, Frank W. Booth
J Funct Morphol Kinesiol. 2023 Mar; 8(1): 6. Published online 2022 Dec 30. doi: 10.3390/jfmk8010006
PMCID:
PMC9844436
Abstract Article PDF–1.4M
Intermittent access training produces greater motivation for a non-drug reinforcer than long access training
Madeline M. Beasley, Tommy Gunawan, Brendan J. Tunstall, David N. Kearns
Learn Behav. Author manuscript; available in PMC 2023 Dec 1.
Published in final edited form as: Learn Behav. 2022 Dec; 50(4): 509–523. Published online 2022 Feb 7. doi: 10.3758/s13420-022-00512-w
PMCID:
PMC10237344
Abstract Article PDF–966K
Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder
Kaitlin M. Best, Marissa M. Mojena, Gordon A. Barr, Heath D. Schmidt, Akiva S. Cohen
J Neurotrauma. January 2022; 39(1-2): 1–19. Published online 2022 Jan 11. doi: 10.1089/neu.2021.0063
PMCID:
PMC8978570
Abstract Article PDF–1.0M
Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKMζ and increased κOR in the hippocampus of female mice
Jorge A. Avila, Nicoletta Memos, Abdurrahman Aslan, Tytus Andrejewski, Victoria N. Luine, Peter A. Serrano
J Psychopharmacol. Author manuscript; available in PMC 2022 May 9.
Published in final edited form as: J Psychopharmacol. 2021 Oct; 35(10): 1240–1252. Published online 2021 Sep 29. doi: 10.1177/02698811211048285
PMCID:
PMC9083019
Abstract Article PDF–1.3M
Stress decreases serotonin tone in the nucleus accumbens in male mice to promote aversion and potentiate cocaine preference via decreased stimulation of 5-HT1B receptors
Harrison M. Fontaine, Phillip R. Silva, Carlie Neiswanger, Rachelle Tran, Antony D. Abraham, Benjamin B. Land, John F. Neumaier, Charles Chavkin
Neuropsychopharmacology. 2022 Mar; 47(4): 891–901. Published online 2021 Sep 25. doi: 10.1038/s41386-021-01178-0
PMCID:
PMC8882182
Abstract Article PDF–2.9M
Animal Models of the Behavioral Symptoms of Substance Use Disorders
Louk J.M.J. Vanderschuren, Serge H. Ahmed
Cold Spring Harb Perspect Med. 2021 Aug; 11(8): a040287. doi: 10.1101/cshperspect.a040287
PMCID:
PMC8327824
Abstract Article PDF–805K
Improving the Utility of a Dynorphin Peptide Analogue Using Mannosylated Glycoliposomes
Jordan D. Lewicky, Nya L. Fraleigh, Alexandrine L. Martel, Thi M.-D. Nguyen, Peter W. Schiller, Leila Mousavifar, René Roy, Anh Dzung Le, Douglas Funk, Hoang-Thanh Le
Int J Mol Sci. 2021 Aug; 22(15): 7996. Published online 2021 Jul 27. doi: 10.3390/ijms22157996
PMCID:
PMC8348236
Abstract Article PDF–1.4M
Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis
Jacques D. Nguyen, Yanabel Grant, Michael A. Taffe
Br J Pharmacol. Author manuscript; available in PMC 2022 Sep 1.
Published in final edited form as: Br J Pharmacol. 2021 Sep; 178(18): 3797–3812. Published online 2021 Jun 8. doi: 10.1111/bph.15520
PMCID:
PMC8387405
Abstract Article PDF–1.3M
κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats
Renata C.N. Marchette, Adriana Gregory-Flores, Brendan J. Tunstall, Erika R. Carlson, Shelley N. Jackson, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro F. Vendruscolo
Neurobiol Stress. 2021 May; 14: 100325. Published online 2021 Apr 14. doi: 10.1016/j.ynstr.2021.100325
PMCID:
PMC8095052
Abstract Article PDF–1.5M
Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects
Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D. Volkow, Zhicheng Lin, Congwu Du
Front Pharmacol. 2021; 12: 624127. Published online 2021 Apr 12. doi: 10.3389/fphar.2021.624127
PMCID:
PMC8072657
Abstract Article PDF–3.1M
Expression and Distribution of Neuropeptide-Expressing Cells Throughout the Rodent Paraventricular Nucleus of the Thalamus
Genevieve R. Curtis, Kathleen Oakes, Jessica R. Barson
Front Behav Neurosci. 2020; 14: 634163. Published online 2021 Jan 14. doi: 10.3389/fnbeh.2020.634163
PMCID:
PMC7873951
Abstract Article PDF–891K
Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors
Angélica del Pilar Escobar, José Patricio Casanova, María Estela Andrés, José Antonio Fuentealba
Front Pharmacol. 2020; 11: 57. Published online 2020 Feb 18. doi: 10.3389/fphar.2020.00057
PMCID:
PMC7040183
Abstract Article PDF–1.1M
THE RISE AND FALL OF KAPPA-OPIOID RECEPTORS IN DRUG ABUSE RESEARCH
Matthew L. Banks
Handb Exp Pharmacol. Author manuscript; available in PMC 2021 Jan 1.
Published in final edited form as: Handb Exp Pharmacol. 2020; 258: 147–165. doi: 10.1007/164_2019_268
PMCID:
PMC7756963
Abstract Article PDF–355K
Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking
Atul P Daiwile, Subramaniam Jayanthi, Bruce Ladenheim, Michael T McCoy, Christie Brannock, Jennifer Schroeder, Jean Lud Cadet
Int J Neuropsychopharmacol. 2019 Nov; 22(11): 710–723. Published online 2019 Sep 28. doi: 10.1093/ijnp/pyz050
PMCID:
PMC6902093
Abstract Article PDF–405K
Dopaminergic Cellular and Circuit Contributions to Kappa Opioid Receptor Mediated Aversion
Elyssa B. Margolis, Anushree N. Karkhanis
Neurochem Int. Author manuscript; available in PMC 2020 Oct 1.
Published in final edited form as: Neurochem Int. 2019 Oct; 129: 104504. Published online 2019 Jul 10. doi: 10.1016/j.neuint.2019.104504
PMCID:
PMC6702044
Abstract Article PDF–854K
Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain
Shiwei (Steve) Liu, Sarah Pickens, Nicole E. Burma, Ines Ibarra-Lecue, Hongyan Yang, Lihua Xue, Chris Cook, Joshua K. Hakimian, Amie L. Severino, Lindsay Lueptow, Kristina Komarek, Anna M.W. Taylor, Mary C. Olmstead, F. Ivy Carroll, Caroline E. Bass, Anne M. Andrews, Wendy Walwyn, Tuan Trang, Christopher J. Evans, Frances M. Leslie, Catherine M. Cahill
J Neurosci. 2019 May 22; 39(21): 4162–4178. doi: 10.1523/JNEUROSCI.0274-19.2019
PMCID:
PMC6529867
Abstract Article PDF–4.7M
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study
Diana Martinez, Mark Slifstein, David Matuskey, Nabeel Nabulsi, Ming-Qiang Zheng, Shu-fei Lin, Jim Ropchan, Nina Urban, Alexander Grassetti, Dinnisa Chang, Michael Salling, Richard Foltin, Richard E. Carson, Yiyun Huang
Neuropsychopharmacology. 2019 Sep; 44(10): 1720–1727. Published online 2019 Apr 26. doi: 10.1038/s41386-019-0398-4
PMCID:
PMC6785004
Abstract Article PDF–997K
Atypical Dopamine Transporter Inhibitors Attenuate Compulsive-like Methamphetamine Self-Administration in Rats
Brendan J. Tunstall, Chelsea P. Ho, Jianjing Cao, Janaína C.M. Vendruscolo, Brooke E. Schmeichel, Rachel D. Slack, Gianluigi Tanda, Alexandra J. Gadiano, Rana Rais, Barbara S. Slusher, George F. Koob, Amy H. Newman, Leandro F. Vendruscolo
Neuropharmacology. Author manuscript; available in PMC 2019 Mar 15.
Published in final edited form as: Neuropharmacology. 2018 Mar 15; 131: 96–103. Published online 2017 Dec 5. doi: 10.1016/j.neuropharm.2017.12.006
PMCID:
PMC5820113
Abstract Article PDF–540K
Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence
Alessandra Matzeu, Marsida Kallupi, Olivier George, Paul Schweitzer, Rémi Martin-Fardon
Neuropsychopharmacology. 2018 Apr; 43(5): 1010–1020. Prepublished online 2017 Oct 20. Published online 2017 Nov 22. doi: 10.1038/npp.2017.250
PMCID:
PMC5854806
Abstract Article PDF–482K
Antagonism of the Kappa Opioid Receptor Attenuates THC-Induced Place Aversions in Adult Male Sprague-Dawley Rats
Matthew M. Clasen, Shaun M. Flax, Briana J. Hempel, Kejun Cheng, Kenner C. Rice, Anthony L. Riley
Pharmacol Biochem Behav. Author manuscript; available in PMC 2019 Aug 2.
Published in final edited form as: Pharmacol Biochem Behav. 2017 Dec; 163: 30–35. Published online 2017 Oct 31. doi: 10.1016/j.pbb.2017.10.010
PMCID:
PMC6676491
Abstract Article PDF–618K
Chronic Ethanol Exposure Increases Inhibition of Optically Targeted Phasic Dopamine Release in the Nucleus Accumbens Core and Medial Shell ex vivo
James R. Melchior, Sara R. Jones
Mol Cell Neurosci. Author manuscript; available in PMC 2018 Dec 1.
Published in final edited form as: Mol Cell Neurosci. 2017 Dec; 85: 93–104. Published online 2017 Sep 20. doi: 10.1016/j.mcn.2017.09.007
PMCID:
PMC5698100
Abstract Article PDF–964K
Individual differences in the neuropsychopathology of addiction
Olivier George, George F. Koob
Dialogues Clin Neurosci. 2017 Sep; 19(3): 217–229. doi: 10.31887/DCNS.2017.19.3/gkoob
PMCID:
PMC5741105
Abstract Article PDF–6.4M
Compulsive methamphetamine taking in the presence of punishment is associated with increased oxytocin expression in the nucleus accumbens of rats
Irina N. Krasnova, Maria Carla Gerra, Donna Walther, Subramaniam Jayanthi, Bruce Ladenheim, Michael T. McCoy, Christie Brannock, Jean Lud Cadet
Sci Rep. 2017; 7: 8331. Published online 2017 Aug 21. doi: 10.1038/s41598-017-08898-8
PMCID:
PMC5566486
Abstract Article PDF–1.9M
Role of κ-Opioid Receptors in the Bed Nucleus of Stria Terminalis in Reinstatement of Alcohol Seeking
A D Lê, Douglas Funk, Kathleen Coen, Sahar Tamadon, Yavin Shaham
Neuropsychopharmacology. 2018 Mar; 43(4): 838–850. Prepublished online 2017 Jun 7. Published online 2017 Jul 12. doi: 10.1038/npp.2017.120
PMCID:
PMC5809779
Abstract Article PDF–669K
Selective opioid growth factor receptor antagonists based on a stilbene isostere
David P. Stockdale, Michelle B. Titunick, Jessica M. Biegler, Jessie L. Reed, Alyssa M. Hartung, David F. Wiemer, Patricia J. McLaughlin, Jeffrey D. Neighbors
Bioorg Med Chem. Author manuscript; available in PMC 2018 Aug 15.
Published in final edited form as: Bioorg Med Chem. 2017 Aug 15; 25(16): 4464–4474. Published online 2017 Jun 27. doi: 10.1016/j.bmc.2017.06.035
PMCID:
PMC5567982
Abstract Article PDF–898K
Modeling the Development of Drug Addiction in Male and Female Animals
Wendy J. Lynch
Pharmacol Biochem Behav. Author manuscript; available in PMC 2019 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2018 Jan; 164: 50–61. Published online 2017 Jun 15. doi: 10.1016/j.pbb.2017.06.006
PMCID:
PMC5732087
Abstract Article PDF–390K
Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats
Marta Valenza, Eduardo R. Butelman, Mary Jeanne Kreek
Psychopharmacology (Berl) Author manuscript; available in PMC 2018 Aug 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Aug; 234(15): 2219–2231. Published online 2017 May 27. doi: 10.1007/s00213-017-4647-0
PMCID:
PMC5591939
Abstract Article PDF–1.5M