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Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes
Judith Krysiak, Andreas Unger, Lisa Beckendorf, Nazha Hamdani, Marion von Frieling-Salewsky, Margaret M. Redfield, Cris G. dos Remedios, Farah Sheikh, Ulrich Gergs, Peter Boknik, Wolfgang A. Linke
Nat Commun. 2018; 9: 262. Published online 2018 Jan 17. doi: 10.1038/s41467-017-02483-3
PMCID:
PMC5772059
Abstract Article PDF–5.9M

Is Cited by the Following 24 Articles in this Archive:

Titin: roles in cardiac function and diseases
Dawson Stroik, Zachery R. Gregorich, Farhan Raza, Ying Ge, Wei Guo
Front Physiol. 2024; 15: 1385821. Published online 2024 Apr 10. doi: 10.3389/fphys.2024.1385821
PMCID:
PMC11040099
Abstract Article PDF–2.7M
Summary statistics-based association test for identifying the pleiotropic effects with set of genetic variants
Deliang Bu, Xiao Wang, Qizhai Li
Bioinformatics. 2023 Apr; 39(4): btad182. Published online 2023 Apr 7. doi: 10.1093/bioinformatics/btad182
PMCID:
PMC10115469
Abstract Article PDF–1.6M
Hypoxia-induced tracheal elasticity in vector beetle facilitates the loading of pinewood nematode
Xuan Tang, Jiao Zhou, Tuuli-Marjaana Koski, Shiyao Liu, Lilin Zhao, Jianghua Sun
eLife. 2023; 12: e84621. Published online 2023 Mar 30. doi: 10.7554/eLife.84621
PMCID:
PMC10063229
Abstract Article PDF–4.6M
Regulation of cardiac function by cAMP nanodomains
Milda Folkmanaite, Manuela Zaccolo
Biosci Rep. 2023 Feb 27; 43(2): BSR20220953. Published online 2023 Feb 27. doi: 10.1042/BSR20220953
PMCID:
PMC9970827
Abstract Article PDF–1.8M
Increased protein phosphatase 5 expression in inflammation-induced left ventricular dysfunction in rats
Ashmeetha Manilall, Lebogang Mokotedi, Sulè Gunter, Regina Le Roux, Serena Fourie, Colleen A. Flanagan, Aletta M. E. Millen
BMC Cardiovasc Disord. 2022; 22: 539. Published online 2022 Dec 9. doi: 10.1186/s12872-022-02977-z
PMCID:
PMC9732989
Abstract Article PDF–1.1M
Cryo-electron microscopy reveals cardiac myosin binding protein-C M-domain interactions with the thin filament
Cristina M. Risi, Edwin Villanueva, Betty Belknap, Rachel L. Sadler, Samantha P. Harris, Howard D. White, Vitold E. Galkin
J Mol Biol. Author manuscript; available in PMC 2023 Dec 30.
Published in final edited form as: J Mol Biol. 2022 Dec 30; 434(24): 167879. Published online 2022 Nov 10. doi: 10.1016/j.jmb.2022.167879
PMCID:
PMC9771592
Abstract Article PDF–1.6M
Titin (TTN): from molecule to modifications, mechanics, and medical significance
Christine M Loescher, Anastasia J Hobbach, Wolfgang A Linke
Cardiovasc Res. 2022 Oct; 118(14): 2903–2918. Published online 2021 Oct 18. doi: 10.1093/cvr/cvab328
PMCID:
PMC9648829
Abstract Article PDF–1.7M
The ryanodine receptor stabilizer S107 ameliorates contractility of adult Rbm20 knockout rat cardiomyocytes
Wei Guo, Chaoqun Zhu, Zhiyong Yin, Yanghai Zhang, Chunyan Wang, Andrea Sanchez Walk, Ying‐Hsi Lin, Timothy A. McKinsey, Kathleen C. Woulfe, Jun Ren, Herbert G. Chew, Jr
Physiol Rep. 2021 Sep; 9(17): e15011. Published online 2021 Sep 14. doi: 10.14814/phy2.15011
PMCID:
PMC8440945
Abstract Article PDF–1.3M
The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
Robbert J. van der Pijl, Andrea A. Domenighetti, Farah Sheikh, Elisabeth Ehler, Coen A. C. Ottenheijm, Stephan Lange
Biophys Rev. 2021 Oct; 13(5): 653–677. Published online 2021 Sep 9. doi: 10.1007/s12551-021-00836-3
PMCID:
PMC8553726
Abstract Article PDF–5.1M
Mechanisms of Systolic Cardiac Dysfunction in PP2A, PP5 and PP2AxPP5 Double Transgenic Mice
Mara-Francine Dörner, Peter Boknik, Friedrich Köpp, Igor B. Buchwalow, Joachim Neumann, Ulrich Gergs
Int J Mol Sci. 2021 Sep; 22(17): 9448. Published online 2021 Aug 31. doi: 10.3390/ijms22179448
PMCID:
PMC8431312
Abstract Article PDF–47M
Maintaining proteostasis under mechanical stress
Jörg Höhfeld, Thomas Benzing, Wilhelm Bloch, Dieter O Fürst, Sebastian Gehlert, Michael Hesse, Bernd Hoffmann, Thorsten Hoppe, Pitter F Huesgen, Maja Köhn, Waldemar Kolanus, Rudolf Merkel, Carien M Niessen, Wojciech Pokrzywa, Markus M Rinschen, Dagmar Wachten, Bettina Warscheid
EMBO Rep. 2021 Aug 4; 22(8): e52507. Published online 2021 Jul 26. doi: 10.15252/embr.202152507
PMCID:
PMC8339670
Abstract Article PDF–1.6M
Mechanisms of TTNtv-Related Dilated Cardiomyopathy: Insights from Zebrafish Models
Celine F. Santiago, Inken G. Huttner, Diane Fatkin
J Cardiovasc Dev Dis. 2021 Feb; 8(2): 10. Published online 2021 Jan 25. doi: 10.3390/jcdd8020010
PMCID:
PMC7912658
Abstract Article PDF–1.5M
Linagliptin prevents left ventricular stiffening by reducing titin cleavage and hypophosphorylation
Ilona Cuijpers, Anna‐Pia Papageorgiou, Paolo Carai, Melissa Herwig, Andreas Mügge, Thomas Klein, Nazha Hamdani, Elizabeth A. V. Jones, Stephane Heymans
J Cell Mol Med. 2021 Jan; 25(2): 729–741. Published online 2020 Dec 9. doi: 10.1111/jcmm.16122
PMCID:
PMC7812306
Abstract Article PDF–1.4M
C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness
Konstanze Michel, Melissa Herwig, Franziska Werner, Katarina Špiranec Spes, Marco Abeßer, Kai Schuh, Swati Dabral, Andreas Mügge, Hideo A. Baba, Boris V. Skryabin, Nazha Hamdani, Michaela Kuhn
JCI Insight. 2020 Nov 19; 5(22): e139910. Published online 2020 Nov 19. doi: 10.1172/jci.insight.139910
PMCID:
PMC7710274
Abstract Article PDF–11M
Modifications of Titin Contribute to the Progression of Cardiomyopathy and Represent a Therapeutic Target for Treatment of Heart Failure
Charles Tharp, Luisa Mestroni, Matthew Taylor
J Clin Med. 2020 Sep; 9(9): 2770. Published online 2020 Aug 26. doi: 10.3390/jcm9092770
PMCID:
PMC7564493
Abstract Article PDF–2.0M
Structure and function of the co-chaperone protein phosphatase 5 in cancer
Rebecca A. Sager, Natela Dushukyan, Mark Woodford, Mehdi Mollapour
Cell Stress Chaperones. 2020 May; 25(3): 383–394. Published online 2020 Apr 2. doi: 10.1007/s12192-020-01091-3
PMCID:
PMC7193036
Abstract Article PDF–978K
The Giant Protein Titin’s Role in Cardiomyopathy: Genetic, Transcriptional, and Post-translational Modifications of TTN and Their Contribution to Cardiac Disease
Charles A. Tharp, Mary E. Haywood, Orfeo Sbaizero, Matthew R. G. Taylor, Luisa Mestroni
Front Physiol. 2019; 10: 1436. Published online 2019 Nov 28. doi: 10.3389/fphys.2019.01436
PMCID:
PMC6892752
Abstract Article PDF–679K
Overexpression of protein phosphatase 5 in the mouse heart: Reduced contractility but increased stress tolerance – Two sides of the same coin?
Ulrich Gergs, Tina Jahn, Franziska Werner, Carolin Köhler, Friedrich Köpp, Claudia Großmann, Joachim Neumann
PLoS One. 2019; 14(8): e0221289. Published online 2019 Aug 19. doi: 10.1371/journal.pone.0221289
PMCID:
PMC6699691
Abstract Article PDF–2.3M
Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy
Larissa M. Dorsch, Maike Schuldt, Cristobal G. dos Remedios, Arend F. L. Schinkel, Peter L. de Jong, Michelle Michels, Diederik W. D. Kuster, Bianca J. J. M. Brundel, Jolanda van der Velden
Cells. 2019 Jul; 8(7): 741. Published online 2019 Jul 18. doi: 10.3390/cells8070741
PMCID:
PMC6678711
Abstract Article PDF–2.7M
Posttranslational modifications of titin from cardiac muscle: how, where, and what for?
Franziska Koser, Christine Loescher, Wolfgang A. Linke
FEBS J. 2019 Jun; 286(12): 2240–2260. Published online 2019 Apr 29. doi: 10.1111/febs.14854
PMCID:
PMC6850032
Abstract Article PDF–2.2M
Circulating Biomarkers Predicting Longitudinal Changes in Left Ventricular Structure and Function in a General Population
Nicholas Cauwenberghs, Susana Ravassa, Lutgarde Thijs, Francois Haddad, Wen‐Yi Yang, Fang‐Fei Wei, Begoña López, Arantxa González, Javier Díez, Jan A. Staessen, Tatiana Kuznetsova
J Am Heart Assoc. 2019 Jan 22; 8(2): e010430. Published online 2019 Jan 12. doi: 10.1161/JAHA.118.010430
PMCID:
PMC6497333
Abstract Article PDF–576K
Statistical tests for detecting variance effects in quantitative trait studies
Bianca Dumitrascu, Gregory Darnell, Julien Ayroles, Barbara E Engelhardt
Bioinformatics. 2019 Jan 15; 35(2): 200–210. Published online 2018 Jul 6. doi: 10.1093/bioinformatics/bty565
PMCID:
PMC6330007
Abstract Article PDF–2.7M
Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis
Michael Gotzmann, Susanne Grabbe, Dominik Schöne, Marion von Frieling-Salewsky, Cristobal G. dos Remedios, Justus Strauch, Matthias Bechtel, Johannes W. Dietrich, Andrea Tannapfel, Andreas Mügge, Wolfgang A. Linke
JACC Basic Transl Sci. 2018 Jun; 3(3): 335–346. Published online 2018 Jun 25. doi: 10.1016/j.jacbts.2018.02.002
PMCID:
PMC6059007
Abstract Article PDF–1.5M
Four and a half LIM domain protein signaling and cardiomyopathy
Yan Liang, William H. Bradford, Jing Zhang, Farah Sheikh
Biophys Rev. 2018 Aug; 10(4): 1073–1085. Published online 2018 Jun 20. doi: 10.1007/s12551-018-0434-3
PMCID:
PMC6082310
Abstract Article PDF–1.4M