Abstract
In this report we present data demonstrating the endogenous expression of I-region associated (Ia) antigens on a cloned line of mouse T cells, CTLL, as well as transcription of the invariant chain gene in these cells. We demonstrate further that this Ia-bearing T-cell clone, CTLL, can utilize the expressed Ia molecules to present antigen to Ia-restricted antigen-specific T cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibody Formation
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Antigen-Presenting Cells / immunology*
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Clone Cells
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Histocompatibility Antigens Class II / analysis*
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Histocompatibility Antigens Class II / genetics
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Mice
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RNA, Messenger / genetics
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T-Lymphocytes / immunology*
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Transcription, Genetic
Substances
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Histocompatibility Antigens Class II
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RNA, Messenger