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Measles Art
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Authors
Disclosures: Axel Antonio Bonai Marinovi, PhD; Corien Swaan, MD; Ole Wichmann, MD; Jim van Steenbergen, MD, PhD;
and Mirjam Kretzschmar, PhD, have disclosed no relevant financial relationships.
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RESEARCH
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Table. Definitions of measles outbreak model parameters with assumed values and probability distribution*
Model parameter
Notation
Value/distribution
Duration of incubation period (from
Dinc
Log normal (2.3,0.2); 714 d after infection,
distribution)
mode 10 d.
Duration of latent period (distribution)
Dlat
(Dinc 4) + normal (0.7); latent period ends 4 d
before symptom onset.
Duration of infectious period
Dinf
(Dinc + 4 Dlat) + normal (0.7); infectious period
(from distribution)
ends |4 d after symptom onset.
Duration of symptomatic period
Dsymp
Dlat + Dinf Dinc; assumes that symptomatic period
(from distribution)
ends at same time as infectious period.
Duration of period to build up immunity
Dimm
13.2 + normal (3.0); approximates measles-specific
after vaccination (from distribution)
IgM positivity rates of 2% and 61% after 1 and 2
weeks of vaccination, respectively.
20 + NegBin (0.155,2.2).
Number of daily contacts per person
ncont
(from distribution)
0.12 in the R016 scenario; 0.2348 in the
Infection probability of a susceptible person
Pinf
R031 scenario.
after contact with an infectious person
0.9975.
Vaccination effectiveness
VES
Infection probability of a vaccinated person
Pinf,vac
Pinf (1 VES ); 3 u 104 in the R016 scenario;
after contact with an infectious person
5.869 104 in the R031 scenario.
Reference
(2123)
(2123)
(2123)
(2123)
(24)
(25)
This article
(Model Calibration)
(5)
This article
(Vaccination)
*NegBin, negative binomial probability distribution; R016, scenario in which basic reproduction number R016 is considered; R031, scenario in which
basic reproduction number R031 is considered.
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Infection
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Acknowledgments
We thank Peter Teunis, Michiel van Boven, Susan Hahn,
and Jacco Wallinga for useful discussions and guidance, and
we thank all local and state public health authority staff and
Robert Koch Institute staff who were involved in the outbreak
investigation and collected the relevant data.
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