Absolute Hospital Medicine Review
Absolute Hospital Medicine Review
Editor
Absolute Hospital
Medicine Review
An Intensive Question
and Answer Guide
123
Kevin Conrad
Editor
Editor
Kevin Conrad
Med. Dir. Comm. Aff. and Health Policy
Ochsner Health Systems Queensland
School of Medicine
New Orleans
Louisiana
USA
ISBN 978-3-319-23747-3
ISBN 978-3-319-23748-0
DOI 10.1007/978-3-319-23748-0
(eBook)
Preface
Welcome to Absolute Hospital Medicine Review: A Intensive Question and Answer Guide
This book reflects the evolution of hospital medicine from its inception to its current rapidly
expanding role in the delivery of healthcare. There is an emphasis in this book on the problems
that hospitalists encounter daily. The goal of the book is to have an up-to-date referenced
question-based learning text that encompasses all aspects of hospital care. It is divided into
three sections: inpatient medicine, consultative and co-management, and hospital systems
management. It is suitable for junior and senior clinicians, for those preparing for boards, and
for those in training who would like to be exposed to the complexities of hospital medicine.
The content of this is book follows the framework set forth by the Society of Hospital
Medicine. It relies heavily on the actual cases presenting to our facility and solutions that are
based on available research.
These questions reflect the great variety of clinical, ethical, and administrative situations a
hospitalist encounters. The definitive role of the hospitals has been somewhat of a moving
target. I have been part of a program that began in the early days of hospital medicine. In the
past 20 years since its formal inception, hospital medicine has grown to nearly 40,000 practitioners. No specialty has come so far so fast. The original intent of our own hospitalist program
was to provide stability to our house staff teaching program. This has continued to be a major
component, but we have also been called upon to co-manage surgical patients, provide costeffective services, provide perioperative services, and lead a wide variety of quality
initiatives.
As soon as the scope of our practice and our goals have been defined, they are changed. No
doubt this trend will continue as hospitalists are viewed as the solution to many of the everincreasing financial pressures on the healthcare system. As hospitalists, we have learned to be
adaptable. Each week we face a new set expectations, requirements, and time constraints.
Our clinical future is uncertain as studies attempt to define which specialty provides the
highest quality and most cost-effective care to the hospitalized patient. We need to understand
the limitations of those studies, conduct our own research, and advocate for our clinical privileges. I believe the questions in this book will illustrate some of those issues.
Hospitalists often understand the acutely ill patient best. Their physical, emotional, and
social needs can be rapidly assessed by our skill sets. We are often called upon to be the
patients advocate. With that comes the challenge of understanding the treatment options and
proven efficacy of the options offered.
Now more so than ever, it is important that we define what we do, do it well, and communicate our value to the healthcare system. I hope that this question-based guide helps that
process by demonstrating the issues that hospitalists are expert at solving and reveal those
areas that need further research.
We hope to receive your feedback in improving future editions. Please share your thoughts
on what topics should be added and how they should be presented.
New Orleans, LA, USA
Kevin Conrad, MD
Contents
Inpatient Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Laura Bateman and Kevin Conrad
vii
Contributors
Editor in Chief
Kevin Conrad, MD, MBA Department of Hospital Medicine, Ochsner Health Systems,
New Orleans, LA, USA
Tulane University School of Medicine, New Orleans, LA, USA
University of Queensland School of Medicine, New Orleans, LA, USA
Associate Editors
Laura E. Bateman, MD Internal Medicine Department, Ochsner Health Systems,
New Orleans, LA, USA
Ashley Casey, Pharm.D, BCPS, MT, ASCP Department of Pharmacy,
Ochsner Health Systems, New Orleans, LA, USA
Marianne Maumus, MD Department of Hospital Medicine, Ochsner Health Systems,
New Orleans, LA, USA
ix
Inpatient Medicine
Laura Bateman and Kevin Conrad
L. Bateman, MD
Internal Medicine Department, Ochsner Clinic Foundation,
1521 Jefferson Hwy, New Orleans 70121, LA, USA
e-mail: [email protected]
K. Conrad, MBA, MD (*)
Department of Hospital Medicine, Ochsner Medical Center,
1521 Jefferson Hwy, New Orleans 70121, LA, USA
e-mail: [email protected]
5. A 26-year-old woman presents to the emergency department with shortness of breath as her primary complaint,
which has been progressively increasing for several days
Inpatient Medicine
His pulmonary examination is notable for bilateral crackles. Initial workup is unrevealing. A chest radiograph
reveals interstitial abnormalities bilaterally. Urine dipstick testing reveals proteinuria and hematuria. A blood
test for cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) is pending. A subsequent biopsy reveals a
necrotizing granulomatous vasculitis.
This patients findings are most consistent with which
of the following diagnoses?
A) Lymphomatoid granulomatosis
B) Systemic lupus erythematosus (SLE)
C) Granulomatosis with polyangiitis (GPA)
D) Churg-Strauss syndrome
E) Goodpasture disease
Answer: C
This patient has granulomatosis with polyangiitis (GPA),
which was formerly known as Wegeners disease. It is
associated with both distinctive and nonspecific mucocutaneous signs. Palpable purpura suggestive of vasculitis is
one of the most common skin findings. A variety of other
dermatologic conditions have been reported including
ulcers, papules, and nodules. In addition to upper and
lower pulmonary symptoms, nasal ulcerations and septal
perforation should suggest the diagnosis. Biopsy is
required. Diagnosis is made by the demonstration of a
necrotizing granulomatous vasculitis in a patient with
upper and lower respiratory tract disease and glomerulonephritis. C-ANCA autoantibodies make several autoimmune diseases less likely.
The absence of asthma makes the diagnosis of Churg-Strauss
syndrome unlikely. Patients with lymphomatoid granulomatosis present with a predominance of pulmonary and
nervous system manifestations, and tests for ANCA autoantibodies are usually negative.
Reference
Cartin-Ceba R, Peikert T, Specks U. Pathogenesis of ANCAassociated vasculitis. Curr Rheumatol Rep. 2012;14(6):
48193.
7. A 68-year-old male was admitted to the hospital for pneumonia. He had a chest X-ray done that reveals a left lung
infiltrate and pleural effusion. He underwent a thoracentesis that revealed an exudative effusion. With no resolution
of the effusion, a repeat thoracentesis and chest tube was
placed 2 days later. Three days later, he is spiking temperatures to 103 F. Repeat chest X-ray reveals a worsening effusion on the left.
Which of the following is the best option in management at this time?
A) Expand antibiotic coverage
B) Repeat chest tube placement
Inpatient Medicine
only day off. He is eager to get back to work. After initial workup and imaging, a DVT is confirmed in the
upper extremity.
What would be an appropriate therapy to start?
A) Rivaroxaban
B) Warfarin plus Enoxaparin 1 mg/kg SQ BID x minimum 5 days
C) Warfarin alone
D) Enoxaparin 1 mg/kg for 2 weeks alone
E) A or B
Answer: E
Rivaroxaban may be a great choice for this patient due to his
age and work lifestyle. It can be started without the need
for bridging therapy. Coumadin monitoring can be problematic and leads to a great deal of noncompliance.
If agreeable to the patient, warfarin plus enoxaparin is also
an acceptable option. This dosing regimen is well established and validated.
Current guidelines recommend that patients with upper
extremity DVTs require treatment similar to lower
extremity DVT. Option C is incorrect because of the lack
of bridging required initially for this disease state.
References
Ansel J, et al. Pharmacology and management of the vitamin K
antagonists ACCP evidence-based clinical practice guidelines (8th edition). Chest. 2008;133(6_suppl):160S98S.
The EINSTEIN Investigators. Oral Rivaroxaban for treatment of VTE. N Engl J Med. 2010;363:2499510.
12. A 38-year-old female patient with a history of end-stage
renal disease on home peritoneal dialysis presents with a
chief complaint of new onset abdominal pain. A peritoneal catheter was placed 6 months ago and since that
time has had no complications.
On physical exam, the abdomen is diffusely tender.
She is afebrile. Serum WBC count is 15,000/L.
Initial therapy for treatment of suspected peritoneal
dialysis-induced peritonitis would include which of the
following?
A) Ceftriaxone
B) Vancomycin plus ceftriaxone
C) Vancomycin, ceftriaxone, and diflucan
D) Vancomycin
E) Ceftriaxone and catheter removal
Answer: B
Peritonitis is a common complication seen in peritoneal dialysis patients. Unlike peritonitis seen in end-stage liver
disease, the majority of infections are gram-positive bacteria. For this reason, vancomycin or other MRSAcovering antibiotic should be included in the initial
Inpatient Medicine
Reference
The Acute Respiratory Distress Syndrome Network.
Ventilation with lower tidal volumes as compared with
traditional tidal volumes for acute lung injury and the
acute respiratory distress syndrome. N Engl J Med.
2000;342(18):13018.
19. A 75 year old Vietnamese male presents with a one
month history of bilateral hand swelling and recurrent
ulcerations. Over that time period he has been treated
with several course of oral antibiotics for presumed
cellulitis with no improvement. The family reports
that he has had several ulcerations on his fingers
develop in the past month that have resolved. He is an
active gardener and spends several hours per day
tending to his plants. He has no other past medical
history.
On physical exam one 3x 3cm superative ulceration
is noted distally on his right fifth finger. Some erythema
around the ulceration is noted. Both hands are markedly
swollen. He is admitted and started on IV vancomycin.
After three days no improvement is seen. No fever or
elevation in WBC is noted.
On day three, one new lesion similar to the previous lesion develops on the dorsum of his hand. On
day four another lesion develops proximally on the
forearm.
Which of the following is the most likely diagnosis?
A) Rheumatoid arthritis
B) Cutaneous Sporotrichosis
C) Mycobacterium Marinum
D) Hypersensitivity Reaction
E) Small Vessel Vasculitis
Answer: B
A non healing cellulitis with ulceration is suugestive of an
atypical bacterial or fungal infection. In this patient with
significant environmental exposure and classic lymphatic
spread, Sporotrichosis is the likely diagnosis.
Sporotrichosis is a subacute infection caused by the saprophytic dimorphic fungus Sporothrix schenckii.
The characteristic infection involves ulcerative subcutaneous
nodules that progress proximally along lymphatic channels. The primary lesion develops at the site of cutaneous
inoculation, typically in the distal upper extremities. After
several weeks, new lesions appear along the lymphatic
tracts. Patients are typically afebrile and not systemically
ill. The lesions usually cause minimal pain. Many affected
patients have received one or more courses of antibacterial therapy without benefit.
Sporotrichosis may involve other organs, including the eye,
prostate oral mucosa, paranasal sinuses, larynx and joints.
In such patients, the clinical manifestations depend on the
organs involved.
Inpatient Medicine
tion, it has been suggested that Rocky Mountain spotted fever and leptospirosis which can have a similar
presentation be ruled out serologically to confirm the
diagnosis. This patient is at very low risk for these
diagnoses.
References
Lappin E, Ferguson AJ. Gram-positive toxic shock syndromes. Lancet Infect Dis. 2009 May. 9(5):28190.
Schlievert PM, Kelly JA. Clindamycin-induced suppression
of toxic-shock syndrome-associated exotoxin production.
J Infect Dis. 1984;149(3):471.
21. What is the appropriate rivaroxaban dose for an indication of pulmonary embolism (weight = 77 kg,
CrCl = 89 ml/min)?
A) 15 mg PO BID 3 weeks, then 20 mg PO daily
B) 20 mg PO daily
C) 15 mg PO daily
D) 10 mg PO BID 3 weeks, then 5 mg PO daily
Answer: A
Per package labeling by the pharmaceutical manufacturer,
for patients with a CrCl > 30 ml/min and for the treatment
of DVT/PE, take 15 mg PO BID 3 weeks, and then
20 mg PO daily. 15 mg PO daily is a renally adjusted regimen for atrial fibrillation. A 10 mg daily dose is indicated
for postoperative VTE prophylaxis.
Reference
Garcia DA, et al. CHEST guidelines parenteral anticoagulants. Chest. 2012;141(2_suppl):e24S43S.
22. An 18-year-old male is admitted for a 2-day history of
fever, abdominal pain, and left knee pain. In the past
year, he has had three similar episodes, each lasting 2
days. He feels well between episodes. He takes no medications and reports no other medical history. He is sexually active with one partner.
On physical examination, the temperature is
38.2 C (100.8 F), blood pressure is 144/86 mmHg,
heart rate is 90/min, and respiration rate is 18/min.
There is diffuse abdominal tenderness without
rebound. There is no evidence of hepatosplenomegaly.
No lymph nodes are palpable. The left knee has a
small effusion. Flexion of the knee is limited to 90. A
well-demarcated, raised, erythematous rash is noted
on the right lower extremity overlying the shin. It is
tender to touch.
Laboratory studies reveal an elevated erythrocyte
sedimentation rate of 56 mm/h. Screening antinuclear
antibody test results are negative. Urinalysis reveals 1+
protein with no cells or casts.
10
A)
B)
C)
D)
E)
Answer: C
Familial Mediterranean fever (FMF) also known as recurrent
polyserositis presents with monoarticular arthritis and
systemic complaints. It is episodic and recurrent which
suggests an autoimmune disease. The symptoms presented here are most compatible with familial
Mediterranean fever (FMF). It is an autosomal recessive
disorder characterized by recurrent 1272 h episodes of
fever with serositis, synovitis, most often monoarticular.
Ten percent of patients experience their first episode in
early adulthood. FMF is most prevalent in persons of
Mediterranean ethnicity. Laboratory studies are consistent with acute inflammation. Serology results are negative for autoimmune disease. Proteinuria may occur from
renal amyloidosis. Colchicine is the standard therapy. It
reduces both acute attacks and amyloidosis.
Adult-onset Still disease (AOSD) which may have a similar
presentation is characterized by fever, rash, joint pain, and
serositis. Pleuritis or pericarditis may occur. Fever associated with AOSD is quotidian, lasting less than 4 h, and
often peaks in the early evening. The characteristic rash is
evanescent, salmon-colored, and not painful. Abdominal
pain is rare. Finally, a markedly elevated serum ferritin
level occurs in most patients with AOSD.
Reference
Kuky O, Livneh A, Ben-David A, et al. Familial
Mediterranean Fever (FMF) with proteinuria: clinical features, histology, predictors, and prognosis in a cohort of
25 patients. J Rheumatol. 2013;40:20837.
23. Which of the following is NOT consistent with selfinduced infection or factitious fever?
A) Tachycardia with fever
B) Polymicrobic bacteremia
C) Recurrent soft tissue infections
D) Self inoculation with body fluids
E) Healthcare background
Answer: A
Factitious fever and self-induced infections are encountered
in the hospital with some frequency. The literature suggests an increase in all forms of factitious illness. In factitious fever, high temperatures are often not associated
with tachycardia or skin warmth. Many creative methods
have been described in the literature to induce an elevated
Inpatient Medicine
and a negative screening HIV antibody test result confirms the diagnosis of acute HIV infection.
Reference
Delaney KP, Branson BM, Uniyal A, Phillips S, Candal D,
Owen SM, et al. Evaluation of the performance characteristics of 6 rapid HIV antibody tests. Clin Infect Dis. 2011
Jan 15. 52(2):25763.
25. A 22-year-old female is admitted with the acute onset of
fever, severe throat pain, and inability to handle her oral
secretions.
On physical examinations, she has an erythematous
oropharynx and cervical lymphadenopathy. The patient
has no known history of drug allergy. She is started on
an empirical regimen of amoxicillin for streptococcal
pharyngitis.
The next day she developed an erythematous maculopapular rash on several areas. The mono spot test comes
back positive.
Which of the following statements regarding this
patients exanthematous drug eruption is true?
A) Fever is common in viral-related exanthematous
eruptions.
B) Systemic corticosteroids are required to treat this
drug eruption.
C) In the future she will be able to tolerate all -lactam
antibiotics, including ampicillin.
D) The mechanism of exanthematous eruption caused
by ampicillin is mast cell degranulation.
E) This patients rash can be expected to be severe.
Answer: C
This patient has ampicillin- or amoxicillin-related exanthematous eruption that can frequently occur with mononucleosis. This does not appear to be IgE mediated and is not a
penicillin allergy. Patients may receive penicillins in the
future. The etiology of the ampicillin rash that occurs in
association with a viral infection is unknown.
Fever is not associated with simple exanthematous eruptions. These eruptions usually occur within 1 week after
the beginning of therapy and generally resolve within
714 days. Scaling or desquamation may follow resolution. The treatment of exanthematous eruptions is generally supportive. Oral antihistamines used in conjunction
with soothing baths may help relieve pruritus. Topical
corticosteroids are indicated when antihistamines do not
provide relief. Systemic corticosteroids are used only in
severe cases. Discontinuance of ampicillin is
recommended.
Reference
Kagan B. Ampicillin rash. West J Med. 1977;126(4):3335.
11
12
Answer: B
Phencyclidine, or PCP, often presents with severe agitation,
psychosis, and violent behavior. Often, multiple people
are required to restrain the patient. Vertical or rotatory
nystagmus is a unique finding characteristic of PCP intoxication. Management of phencyclidine intoxication
mostly consists of supportive care. Benzodiazepines have
been used for agitation and for the treatment of seizures
that can occur with PCP ingestion.
Cocaine intoxication may present with similar symptoms but is
not reported to cause nystagmus. Lysergic acid diethylamide
(LSD) is a typical hallucinogen, but no significant amount of
violent behavior is reported. MDMA and ecstasy are both
hallucinogenic and a stimulant. Violent behavior is not usually seen. Heroin causes a typical opioid symptom profile
consisting of constricted pupils, sedation, and respiratory
depression.
Since its peak use in urban areas, the 1970s PCP use has declined.
References
Frederiksen SG, Hedenbro JL, Norgren L. Enoxaparin effect
depends on body-weight and current doses may be inadequate in obese patients. Br J Surg. 2003;90:5478.
Garcia DA, et al. CHEST guidelines parenteral anticoagulants. Chest 2012;141(2_suppl):e24S43S.
Nutescu EA, Spinler SA, Wittkowsky A, Dager WE. Lowmolecular-weight heparins in renal impairment and obesity: available evidence and clinical practice
recommendations across medical and surgical settings.
Ann Pharmacother. 2009;43:106483.
A)
B)
C)
D)
E)
Reference
Zukin SR, Sloboda Z, Javitt DC. Phencyclidine PCP. In:
Lowinson JH, Ruiz P, Millman RB, et al., editors.
Substance abuse: a comprehensive textbook, 4th ed.
Philadelphia: Lippincott Williams & Wilkins; 2005.
Inpatient Medicine
13
Initial therapy for suspected Clostridium difficile disease would include the following:
A) Oral metronidazole 500 mg q 8
B) Oral vancomycin 125 mg q 6
C) IV metronidazole 500 mg q 6
D) Oral vancomycin 125 g q 6
Answer: D
The treatment for Clostridium difficile infections is changing
as new protocols and therapies are developed. The patient
in this question is characterized as having moderate
Clostridium difficile infection. First-line treatment is based
on the severity of illness and initial clinical response.
Symptoms of moderate disease include 612 bowel movements per day, fever of 37.538.5 C, a WBC count
between 15,000 and 25,000 cells/l, or visible GI bleeding. Oral vancomycin is the treatment of choice for moderate disease. For severe disease, oral vancomycin 125 mg q
6 and IV metronidazole 500 mg q 6 is the treatment of
choice. For mild disease, oral Flagyl can be used alone,
500 mg q 8. New treatment modalities, such as fidaxomicin as well as stool replacement therapy, have shown
promising results and are currently undergoing trials.
Reference
Ananthakrishnan AN. Clostridium difficile infection: epidemiology, risk factors and management. Nat Rev
Gastroenterol Hepatol. 2011;8(1):1726.
32. A 54-year-old man is admitted with abdominal pain. He
had a similar episode 6 months ago for which he was
seen in the emergency room several days after the onset
of pain and was discharged home without a definitive
diagnosis. He has a history of poorly controlled diabetes
mellitus. He has pain for the past 3 days. He denies any
alcohol use, which is confirmed by family members.
On physical exam, he is tachycardic and has diminished bowel sounds and epigastric tenderness. He has a
papular rash on his knees.
Initial laboratory studies are significant for the following: leukocytes, 16,000 cells/mm3; blood glucose
level of 400 mg/dl. An amylase level is normal.
Which of the following is the most likely diagnosis
for this patient?
A) Acute or chronic idiopathic pancreatitis
B) Gallstone pancreatitis
C) Alcoholic pancreatitis
D) Pancreatitis secondary to hypertriglyceridemia
E) Malignancy-induced pancreatitis
Answer: D
This patient has triglyceride induced pancreatitis. The serum
amylase level may be normal in some patients with acute
14
Answer: E
In this case, there are no absolute contraindications to thrombolytic therapy.
The patient meets ECG criteria for the administration of
thrombolytic therapy. This includes ST segment elevation
greater than 0.1 mm in two contiguous leads.
Age greater than 75 years is not a contraindication to thrombolysis. In patients older than 75 years, there is an
increased risk of hemorrhagic stroke. Overall mortality is
reduced in such patients without other contraindications.
A prior history of hemorrhagic stroke is an absolute contraindication to thrombolytic. A history of an ischemic
stroke less than 1 year is an absolute contraindication. A
stroke more than 1 year before presentation is a relative
contraindication. Blood pressure >180/110 mmHg is a
relative contraindication to thrombolytic therapy.
Reference
OGara PT, Kushner FG, Ascheim DD et al. 2013 ACCF/
AHA guideline for the management of ST-elevation
myocardial infarction: a report of the American College
of Cardiology Foundation/American Heart Association
Task Force on Practice Guidelines. Circulation.
2013;127:e362452.
34. A 65-year-old male presents with progressive shortness of breath over the past month. He has a 40 packyear history of smoking. CT scan of the chest reveals a
right middle lobe mass for which he subsequently
undergoes biopsy, which reveals adenocarcinoma.
Magnetic resonance imaging of the brain reveals a
1 cm tumor in the left cerebral cortex, which is consistent with metastatic disease. The patient has no history
of seizures or syncope. The patient is referred to outpatient therapy in the hematology/oncology service as
well as follow-up with radiation oncology. The patient
is ready for discharge.
Which of the following would be the most appropriate therapy for primary seizure prevention?
A) Seizure prophylaxis is not indicated.
B) Valproate.
C) Phenytoin.
D) Phenobarbital.
E) Oral prednisone 40 mg daily.
Answer: A
There is no indication for antiepileptic therapy for primary
prevention in patients who have brain metastasis who
have not undergone resection. Past studies have revealed
no difference in seizure rates between placebo and antiepileptic therapy in patients who have brain tumors.
Antiepileptic therapy has high rates of adverse reactions
and caution should be used in their use.
Inpatient Medicine
Reference
Sirven JI, Wingerchuk DM, Drazkowski JF, Lyons MK,
Zimmerman RS. Seizure prophylaxis in patients with
brain tumors: a meta-analysis. Mayo Clin Proc.
2004;79(12):148994.
35. A 52-year-old male presents with new onset hemoptysis
and shortness of breath. He is recovering from an ankle
fracture. CT angiography reveals an intraluminal defect
in the left lower lobar pulmonary artery and right upper
lobe subsegment.
What additional measurements from CT angiography
have been shown to have prognostic significance?
A) Clot burden (e.g., amount of clot seen)
B) Clot location
C) Right versus left ventricular volume
D) Clot size
E) Collateral flow
Answer: C
Risk stratification for pulmonary embolism is the goal of
many current studies. A reliable method is currently being
developed. In patients who are hemodynamically stable, a
number of tests have been examined in this effort. Clot
size and location are not good at predicting mortality or
right ventricular strain.
Examination of ventricular volumes comparing right to left
may be the best measurement for predicting outcomes. A
ratio >1.2 that is suggestive of right ventricular strain has
utility in predicting adverse outcome and death.
Echocardiograms may look for right heart strain as well.
Other tools that are being considered include biomarkers
such as troponin and pro-brain natriuretic peptide
(proBNP) levels, and clinical models such as PESI
(Pulmonary Embolism Severity Index) and PREP (prognostic factors for PE).
References
Aujesky D, et al. Derivation and validation of a prognostic
model for pulmonary embolism. Am J Respir Crit Care
Med. 2005;172:10416.
Becattini C, et al. Acute pulmonary embolism: external validation of an integrated risk stratification model. Chest.
2013. doi:10.1378/chest.12-2938.
Sanchez O, et al. Prognostic factors for pulmonary embolism: the PREP study, a prospective multicenter cohort
study. Am J Respir Crit Care Med. 2010;181:16873.
36. A 68-year-old male with a history COPD presents with
a 3-day history of worsening shortness of breath and
fever. On the day prior to presentation, he developed
abdominal pain and diarrhea. He is employed as an air
conditioner repair technician.
15
16
nausea, vomiting, fever, or weight loss. He had a colonoscopy 1 year ago that showed a benign polyp and
extensive diverticulosis. He has a single 22 g IV access.
Stat laboratory studies reveal a hemoglobin of 7.5 g/
dL. The leukocyte count is 5600/L. Prothrombin time
and activated partial thromboplastin times are normal.
Which of the following is the most appropriate next
step in the management of this patient?
A) Colonoscopy
B) Esophagogastroduodenoscopy
C) Increased intravenous access
D) Placement of a nasogastric tube with lavage
E) Technetium-labeled red blood cell scan
Answer: C
This patient is volume depleted and not hemodynamically
stable. Survival may be dependent upon the correct
management sequence. Two large-bore peripheral catheters or a central line for volume repletion is urgently
required. Fluid resuscitation should be started as well as
an urgent type and match for blood transfusion. Although
rapid diagnosis may be of benefit, early resuscitation
measures should not be delayed by diagnostic workup.
A nasogastric tube may be considered after volume resuscitation,
if an upper source of gastrointestinal bleeding is likely.
Regardless of the source of bleeding at this point in the management, the first rule is to achieve hemodynamic stability.
Although a colonoscopy is the diagnostic test of choice to
evaluate for sources of lower gastrointestinal bleeding,
this should not occur before volume resuscitation. A
bleeding scan may be indicated if an endoscopic evaluation is not immediately possible or if an endoscopic evaluation has been non-revealing. Diverticular bleed is
certainly a possibility in this case. If a bleeding diverticulum is detected on colonoscopy, it can be treated with
thermal coagulation or epinephrine injection. Up to 90 %
of diverticular bleeding resolves without intervention.
References
Laine L, Shah A. Randomized trial of urgent vs. elective
colonoscopy in patients hospitalized with lower GI bleeding. Am J Gastroenterol. 2010;105(12):263641.
Scottish Intercollegiate Guidelines Network (SIGN).
Management of acute upper and lower gastrointestinal
bleeding. A national clinical guideline. SIGN publication;
no. 105. Edinburgh (Scotland): Scottish Intercollegiate
Guidelines Network (SIGN); 2008.
38. An 81-year-old female who is admitted to the hospital
with a diagnosis of healthcare-associated pneumonia
(HCAP). She is empirically started on vancomycin, ciprofloxacin, and piperacillin/tazobactam.
Inpatient Medicine
tract is the probable cause for most cases of febrile neutropenia. Vancomycin may be considered but alone would
not be sufficient coverage for this patient. Empiric antifungal therapy is usually reserved for patients who are
febrile after the source of infection is not found following
47 days of broad-spectrum antimicrobial therapy. Viral
infections are not common, and empiric therapy with antiviral agents such as acyclovir is not warranted.
Reference
Hughes WT, Armstrong D, Bodey GP, et al. 2002 guidelines
for the use of antimicrobial agents in neutropenic patients
with cancer. Clin Infect Dis. 2002;34(6):73051.
40. An 82-year-old female presents to the emergency department complaining nausea and vomiting. She is admitted
for dehydration due to probable viral gastroenteritis. On
admission her serum creatinine is noted to be 3.0 mg/dL,
her baseline is 1.2 mg/dl.
After transfer to the floor, she acutely develops dizziness with a heart rate of 34/min. 12-lead ECG shows
marked sinus bradycardia without any ST segment
changes. Stat glucose is 95 mg/dl.
Home medications include atenolol 100 mg daily and
hydrochlorothiazide 25 mg daily. Blood pressure is
85/68 mmHg.
Which of the following medications is the most
appropriate to administer next?
A) Intravenous 50 % dextrose solution and insulin
B) Intravenous glucagon
C) Intravenous calcium gluconate
D) Intravenous magnesium sulfate
E) Intravenous atropine
F)B or E
Answer: F
This patient has bradycardia and hypotension from betablocker toxicity. This is caused by a reduced clearance
of atenolol, which is renally excreted and impaired
because of her prerenal kidney failure. Glucagon is
used to reverse beta-blocker toxicity and is often used
as a first-line agent when beta-blocker toxicity is the
confirmed issue. Atropine may be used according protocols as well.
She should also receive fluid resuscitation with intravenous
normal saline solution. If she does not improve with glucagon and IV fluids, external pacemaker or transvenous
pacemaker can also be used.
Reference
Hoot NR, Benitez JG, Palm KH. Hemodynamically unstable: accidental atenolol toxicity?. J Emerg Med.
2013;45(3):3557.
17
18
Inpatient Medicine
Reference
Huff JS, Decker WW, Quinn JV, et al. Clinical policy: critical issues in the evaluation and management of adult
patients presenting to the emergency department with
syncope. Ann Emerg Med. 2007;49(4):43144.
44. A 50-year-old male is admitted with complaints of moderate mid-epigastric pain in his upper abdomen for a few
weeks. He reports moderate heartburn for the past 2
months. He also complains of weight loss of 10 lbs in
the last 2 months as well. He does not take any medications except occasional ibuprofen for back pain.
On physical exam he has moderate tenderness in the
epigastric area. The patients amylase and lipase are normal. CT scan of the abdomen is normal.
What is the next appropriate step in the management
of this patient?
A) Start PPI.
B) H. pylori treatment.
C) Stop ibuprofen.
D) Manometry studies.
E) Upper endoscopy.
Answer: E
Many patients with gastroesophageal reflux disease are
appropriately treated with empiric therapy. Endoscopy is
reserved for those with chronic symptoms who are at risk
for Barretts esophagus and those with alarm symptoms.
Alarm symptoms include dysphagia, odynophagia, gastrointestinal bleeding or anemia, weight loss, and chest pain.
Other alarm features are age greater than 55 years and
family history of gastric cancer. This patients weight loss
would warrant endoscopic evaluation.
Reference
DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am
J Gastroenterol. 1999;94:143442.
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20
Inpatient Medicine
Answer: E
This patient has drug-induced lupus erythematosus (DILE).
The most common drugs that cause DILE are hydralazine, procainamide, quinidine, isoniazid, diltiazem, and
minocycline.
He has new-onset fever, arthralgia, myalgia, nonblanching
purpuric rash, pleuritis, pancytopenia, and proteinuria
with active urine sediment.
Testing for antinuclear antibodies (ANA), as well as antidouble-stranded DNA antibodies and complement levels,
is indicated. This multiorgan pattern is suggestive of an
autoimmune disorder, in particular of systemic lupus erythematosus (SLE). No specific criteria establish the diagnosis of DILE. Excluding other underlying autoimmune
diseases must first be done. SLE is typically ruled out
first.
Drugs that cause DILE may take months to years before the
associated symptoms occur. In addition similar drugs can
also induce flairs of SLE.
21
Answer: E
A vegetative state of wakefulness without awareness was
first described in 1972. In the vegetative state, patients
may open their eyelids occasionally and demonstrate
sleep-wake cycles, but completely lack cognitive function, communication, or purposeful movement. In addition, extensive neurologic and medical test must be made
to rule out treatable causes.
Answer: E
The current guidelines recommend that adults older than age
40 who are hospitalized for medical reasons and are
expected to be less mobile for 3 days or more be given some
form of deep venous thrombosis (DVT) prophylaxis. This is
based on several randomized controlled trials.
However, whether these recommendations should apply to
older adults is less uncertain. A systematic review and
References
Fritzler MJ. Drugs recently associated with lupus syndromes.
Lupus. 1994;3(6):4559.
Lowe G, Henderson CL, Grau RH, Hansen CB, Sontheimer
RD. A systematic review of drug-induced subacute cutaneous lupus erythematosus. Br J Dermatol.
2011;164(3):46572.
22
meta-analysis examined the evidence for harm and efficacy of pharmacologic prophylaxis of DVT in older
adults. For the most part older adults with comorbidities
have been excluded from studies. The majority of events
prevented in studies are asymptomatic DVTs. There is no
consistent reduction in fatal pulmonary embolism or mortality. When data from the three trials with patients older
than age 75 are pooled, a similar reduction in endpoints to
other trials is seen. However, two-thirds of these events
are asymptomatic DVTs. In the general population, the
absolute bleeding risk is generally increased by 2 % in the
heparin treatment group. Older age with its comorbidities
may increase this risk.
The current data suggest that this patient would gain a very
small absolute risk reduction for symptomatic DVTs and
an even smaller risk for pulmonary embolism. Given her
wishes, it is reasonable to stop heparin and encourage
ambulation.
References
Greig MF, Rochow SB, Crilly MA, Mangoni AA. Routine
pharmacological venous thromboembolism prophylaxis
in frail older hospitalized patients: where is the evidence?
Age Ageing. 2013;42:42834.
Wakefield TW, Proctor MC. Current status of pulmonary
embolism and venous thrombosis prophylaxis. Semin
Vasc Surg. 2000;13(3):17181.
52. A 26-year-old female presents with cellulitis of her left
forearm. The patient has a history of IV heroin abuse but
denies any recent heroin use. Current medications are
lorazepam and methadone.
On presentation, her temperature is 35.8 C (96.4 C),
respirations are 10 per minute, and blood pressure is
124/72 mmHg. Electrocardiogram reveals wide complex variable focus tachycardia. Toxicology screen is
positive for cannabis, alcohol, and opiates.
Which of the following medications is the most likely
cause of this patients arrhythmia?
A) Cannabis
B) Benzodiazepines
C) Alcohol
D) Methadone
E) Oxycodone
Answer: D
Cardiac arrhythmias in methadone users have been reported
for several decades. The most serious have been wide
complex tachycardias. Risk factors include female sex,
hypokalemia, high-dose methadone, drug interactions,
underlying cardiac conditions, and unrecognized congenital long Q-T interval syndrome.
In methadone patients, an ECG should be obtained on admission. QT prolongation may predict subsequent malignant
arrhythmias and possible need to alter methadone treatment.
Methadone has been used to treat heroin addicts for nearly
50 years, but little is known about its long-term side effects.
Reference
Justo D, Gal-Oz A, Paran Y et al. Methadone-associated torsades de pointes (polymorphic ventricular tachycardia) in
opioid-dependent patients. Addiction. 2006;101:13338.
53. A 38-year-old man is admitted with atypical chest pain
of 3 h duration. While waiting to be seen, his pain resolves.
He reports that he has been smoking marijuana extensively
and denies any other ingestions or substances.
He reports no past medical history and is not on any
meds. He is not sure but may have chest pain prior to this
admission.
On physical exam, his heart rate is 110, temperature
is 37 C (98.6 F), and blood pressure is 180/90. He is
96 % on room air. He is agitated, tachycardic, and diaphoretic. His electrocardiogram reveals slight ST
depressions in leads V3 through V5. Initial troponin
level is 0.1 mg/mL. Toxicology screen is pending.
Initial therapy should include the following:
A) Tissue plasminogen activator (TPA)
B) Percutaneous transluminal coronary angioplasty
(PTCA)
C) Aspirin
D) Abciximab
E) Metoprolol
Answer: C
This patient is exhibiting a sympathomimetic presentation probably due to crack cocaine ingestion. This should be considered as an additive in someone with a history of smoking
marijuana. His possible myocardial ischemia is due to endothelial dysfunction as well as aggregation of platelets. In this
particular scenario, there is no evidence of segment elevation
myocardial infarction, so PTCA, tPA, and GP IIb/IIIa are not
indicated. A reasonable approach would be an aspirin with
further cardiovascular workup considered.
Beta-blockers are relatively contraindicated in cocaine-induced
chest pain as there is a possible risk of increased peripheral
vascular resistance. This has not been well tested.
References
Hobbs WE, Moore EE, Penkala RA, Bolgiano DD, Lpez
JA. Cocaine and specific cocaine metabolites induce von
Willebrand factor release from endothelial cells in a
tissue-specific manner. Arterioscler Thromb Vasc Bio.
2013;33:12307.
Inpatient Medicine
Answer: C
Venous thromboembolism, which includes pulmonary
embolism and deep venous thrombosis, continues to be a
common clinical problem. The American College of
Physicians recommends pharmacologic prophylaxis with
23
Reference
Murphy SW, Barrett BJ, Parfrey PS. Contrast nephropathy. J
Am Soc Nephrol. 2000;11(1):17782.
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Inpatient Medicine
A)
B)
C)
D)
Answer: B
Moxifloxacin is a quinolone antibiotic that does not achieve
adequate concentration in the urine, thereby eliminating
its use in the treatment of urinary tract infections. It does
not matter whether moxifloxacin is given either oral or
IV the bioavailability of the oral is 100 % and the IV
formulation has no ability to concentrate in urine.
Reference
Gupta K, Hooton TM, Naber KG et al. International clinical
practice guidelines for the treatment of acute uncomplicated cystitis pyelonephritis in women: a 2010 Update by
the Infectious Disease Society of America and the
European Society of Microbiology and Infectious
Disease. Clin Inf Dis. 2011;52:e10320.
25
Answer: C
Alcohol use disorders are common and can complicate postoperative recovery. In this particular case, the fever,
tachycardia, hypertension, and tremor are suggestive of
alcohol withdrawal. The alcohol level in trauma patients
should be checked on admission, as withdrawal is a common source of delirium in this population.
About 9 % of US adults meet the criteria for an alcohol use
disorder. Less than 50 % of alcohol-dependent persons
Answer: C
This patient has Cushing syndrome due to excessive ACTH
production. This is almost certainly due to underlying
malignancy such as lung cancer which is the case here.
Approximately half of all cases of ectopic ACTH secretion are due to small cell lung cancer, which has a long list
of paraneoplastic syndromes associated with it.
Adrenal adenomas can be associated with hypercortisolism,
but the features tend to cause a mild Cushing syndrome.
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Inpatient Medicine
27
Reference
Runyon BA, AASLD Practice Guidelines Committee.
Management of adult patients with ascites due to cirrhosis: an update. Hepatology. 2009;49:2087107.
66. A 76-year-old female is admitted for respiratory failure.
She has a history of prior dementia. On her previous
admissions, she has had episodes of delirium, which
have resulted in prolonged hospitalization. On admission she is on no sedatives or antipsychotic meds. The
family is concerned about the possibility of hospitalinduced delirium and would like efforts be made to prevent this.
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Inpatient Medicine
Which of the following studies is most likely to confirm patients cause of hypoxia?
A) Ventilation perfusion scan of the lungs
B) High contrast CT scan of the chest
C) Pulmonary arteriography
D) Lung biopsies
E) Echocardiography with saline bubble contrast
Answer: E
This patient has hepatopulmonary syndrome. In these cases,
contrast- or bubble-enhanced echocardiography will
reveal a intrapulmonary shunt. Hepatopulmonary syndrome is associated with platypnea, which is increased
dyspnea in the upright position, and orthodeoxia, which is
increased hypoxia when transitioning from the lying to
the standing position. Hypoxemia, in this case due to
intrapulmonary shunt, is not significantly affected by an
increase in inhaled O2 concentration. This syndrome may
resolve with liver transplantation and does not exclude the
patient from being considered for transplant.
Reference
Rodriguez-Roisin R, Krowka MJ. Hepatopulmonary syndrome a liver-induced lung vascular disorder. N Engl J
Med. 2008;358:237887.
69. You have just admitted a 28-year-old man with a witnessed seizure. He has a prior history of seizure disorder. The event was witnessed by family members. His
family describes movement of his right hand that
spread to involve the entire arm. He did not lose
consciousness.
On physical examination, sensation is intact in the
affected limb, but his strength is 0 out of 5 in the musculature of the right hand. . His electrolytes and complete
blood count are within normal limits. A toxicology
screen is normal. A noncontrast CT scan of his head is
unremarkable.
What is the best course of action at this time?
A) Cerebral angiogram
B) Magnetic resonance angiogram
C) Reassess in a few hours
D) Psychiatric evaluation
E) Lumbar puncture
Answer: C
The patient has Todds paralysis, which may take minutes to
many hours to return to normal. The abnormal motor movements that begin in a restricted area and then progress to
involve a larger area are termed Jacksonian march. If his
symptoms were to persist beyond several hours, it would be
reasonable to investigate a different etiology of his hand
weakness with imaging studies. The symptoms are too lim-
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Inpatient Medicine
Answer: C
Quetiapine can be used for agitation in critically ill patients.
In a prospective, randomized, double-blind, placebocontrolled study conducted on 36 adult critically ill
patients with delirium, quetiapine in escalating doses was
shown to be effective in palliating agitation.
The use of lorazepam may worsen her agitation in her medically fragile state. The use of zolpidem will address this
patients disrupted sleep but may increase her agitation.
Supporting the family with rapid control of behavior
issues is needed. While inclusion of psychosocial support
is helpful, this patient is rapidly declining and medication
can provide immediate benefit.
References
Devlin JW, Roberts RJ, Fong JJ, et al. Efficacy and safety of
quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind,
placebo-controlled pilot study. Crit Care Med.
2010;38(2):41927.
Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E,
Hynan LS, Reisch JS, Schidt FV, Ostapowicz G, Shakil
AO, Lee WM, Acute Liver Failure Study Group.
Acetaminophen-induced acute liver failure: results of a
United States multicenter, prospective study. Hepatology.
2005;42(6):136472.
74. A 34-year-old female is admitted with a 2-day history of
right eye redness and pain, photophobia, and decreased
visual acuity. She has a 2-year history of recurrent oral
ulcerations and tender nodules on her shins. She has had
mild rotating joint tenderness for the past 4 months. Her
only medication is ibuprofen. She has been treated for
genital herpes in the past.
On physical examination, the temperature is
37.4 C (99.3 F), blood pressure is 130/80 mmHg,
pulse rate is 110/min, and respiration rate is 16/min.
Oral ulcerations are noted on the inner cheek, palate,
and tongue. The lungs are clear. The abdomen is nontender. No bruits are noted. The right knee and right
ankle are swollen. Peripheral pulses are normal. An
ophthalmology consultation reveals anterior and posterior uveitis.
Complete blood count and the basic metabolic panel
and INR are within normal limits. Chest X-ray reveals a
prominent right pulmonary artery. CT of the chest demonstrates an aneurysm of the right pulmonary artery.
Which of the following is the most likely diagnosis?
A) Behet disease
B) Granulomatosis with polyangiitis
C) Polyarteritis nodosa
D) Gonococcal arthritis
E) Reiters syndrome
31
Answer: A
This patient has Behet disease. Behet disease is characterized by the triad of recurrent oral aphthous ulcers, genital
ulcers, and uveitis.
Behet disease is a systemic disorder characterized by vasculitis
and multiple organ involvement. The diagnostic clues are intermittent mucous membrane ulcerations and ocular involvement.
Gastrointestinal, pulmonary, musculoskeletal, and neurologic
manifestations may be present. This patient has a 2-year history
of recurrent oral ulcerations. The skin lesions are erythema
nodosum. She now presents with panuveitis. Pulmonary artery
aneurysm also strongly suggests Behet disease.
Exposure to an infectious agent may trigger a cross-reactive
immune response. Proposed infectious agents have
included herpes simplex virus, Streptococcus species,
Staphylococcus species, and Escherichia coli. There may
be relationship to flora of the mouth.
The treatment approach depends on the severity of the disease and major organ involvement. This may include systemic corticosteroids, azathioprine, pentoxifylline,
dapsone, interferon-alfa, colchicine, and thalidomide.
References
Hatemi G, Silman A, Bang D, et al. EULAR recommendations for the management of Behet disease. Ann Rheum
Dis. 2008;67(12):165662.
Study Group for Behets Disease. Criteria for diagnosis of
Behets disease. International Study Group for Behets
Disease. Lancet. 1990;335(8697):107880.
75. A 58-year-old female is admitted for nausea, vomiting,
and a diffuse rash. Four days before admission, she was
bitten on her hand by her neighbors dog. The patient
reports no other symptoms. Ten years ago, she underwent
splenectomy following a motor vehicle collision. On physical exam, temperature is 36.8 C (98.2 F), pulse rate is 90
per minute, respirations are 16 per minute, and blood pressure is 120/76 mmHg. The patient appears alert and cooperative. The neck is supple. The lungs are clear. Two deep
lesions are noted on the dorsum of the left hand. Faint
purple, macular lesions are seen on the trunk and extremities. The lesions are not compressible, painful, or pruritic.
The leukocyte count is 17,000/L with 15 % band
forms . Despite rapid administration of intravenous fluids, vancomycin, piperacillin/tazobactam, and clindamycin, the patients blood pressure drops and is transferred
to the ICU for vasopressor support.
Which of the following organisms is the most likely
cause of the findings in this patient?
A) Pasteurella multocida
B) Neisseria meningitidis
C) Streptococcus pneumoniae
D) Capnocytophaga canimorsus
32
Answer: D
This patient has disseminated C. canimorsus infection due to
a dog bite and asplenia. C. canimorsus is a normal colonizing bacterium of dog and cat saliva. Canimorsus is
Latin for dog bite.
Clinical symptoms usually begin 56 days after the dog bite,
scratch, or other exposure. Patients typically present with
signs of sepsis including fever, vomiting, and abdominal
pain. There is progressive cutaneous hemorrhage with
infarction that leads to extensive skin necrosis.
Several other organisms can produce purpura fulminans
including endotoxin-producing Neisseria meningitidis
and encapsulated Streptococcus pneumoniae and
Haemophilus influenzae.
References
Pers C, Gahrn-Hansen B, Frederiksen W. Capnocytophaga
canimorsus septicemia in Denmark, 19821995: review
of 39 cases. Clin Infect Dis. 1996;23(1):715.
Eefting M, Paardenkooper T. Capnocytophaga canimorsus
sepsis. Blood. 2010;116(9):1396.
76. A 28-year-old male is admitted with acute agitation. He
was brought to the hospital by emergency medical services, which was called by his neighbor. He was found
on the roof of his house. Little is known of his past medical history.
On physical exam, he is actively hallucinating, diaphoretic, and is nonresponsive to painful stimuli. In
addition to emergency room staff, he requires four security guards to restrain. Drug screen is negative. Computed
tomography of his head is not possible due to agitation.
Over the course of next 2 days, he requires large doses
of benzodiazepines and haloperidol for management
and sedation. In addition he requires physical restraints.
He gradually returns to his usual functional status in 5
days with little recollection of the event.
The most likely ingested substance was:
A) Synthetic cathinones bath salts
B) Hallucinogenic mushrooms
C) Heroin
D) Cocaine
E) Ecstasy
Answer: A
Synthetic cathinones, drugs known as bath salts, were first
described in the United States in 2010. Users of bath salts
experience vivid disturbing hallucinations, agitation,
paranoia, and extreme pain intolerance. They are more
potent as compared to other hallucinogens. Episodes of
intoxication are unpredictable and are often prolonged
lasting several days. Large dose of sedatives are often
required as well as careful use of physical restraints.
Decreased pain sensation makes physical restraint difficult and reports of injury during sedation are common.
Reference
Coppola M, Mondola R. Synthetic cathinones: Chemistry,
pharmacology and toxicology of a new class of designer
drugs of abuse marketed as bath salts or plant food.
Toxicol Lett. 2012;211(2):1449. doi:10.1016/j.toxlet.2012.03.009. PMID 22459606.
77. A 22-year-old male college student is admitted for having a witnessed generalized tonic-clonic seizure. This
occurred in the morning as witnessed by his roommate.
The patient reports that he was out late the night
before and drank more than usual over the course of the
evening. He reports having sudden jerks of his arms this
morning before the generalized seizure was witnessed.
He has had similar muscular jerks in the previous mornings. This has particularly occurred on days when he has
little sleep. He reports no history of excessive alcohol
use or illicit substance abuse. He takes no medications.
Neurologic examination is normal. He is oriented and
feeling well the day after admission.
Results of laboratory studies are normal. A CT scan
of the head shows no abnormalities.
Which of the following is the most likely diagnosis?
A) Alcohol withdrawal seizure
B) Benign rolandic epilepsy
C) Illicit drug-induced seizure
D) Temporal lobe epilepsy
E) Juvenile myoclonic epilepsy
Answer: E
This patient has juvenile myoclonic epilepsy. A history of
rapid, unprovoked jerks and generalized tonic-clonic seizures on awakening is a common presentation. Onset is usually in adolescence, but may occur in an early adulthood.
Juvenile myoclonic epilepsy may affect 510 % of all
patients with epilepsy. Seizures are often provoked by
sleep deprivation, alcohol, video games, or exposure to
flickering lights.
Recognizing the specific epilepsy syndrome affecting a
patient is important in selecting the appropriate therapy.
Alcohol withdrawal seizures develop in chronic users of
alcohol. It is generally seen in combination with other
signs and symptoms of alcohol withdrawal, such as delirium, tremor, tachycardia, and diaphoresis.
Benign rolandic epilepsy is a syndrome seen in younger children who have seizures, usually during sleep. Temporal
lobe epilepsy is the most common of the localizationrelated epilepsies. This often is due to a specific brain
malformation, such as trauma, infarct, or congenital. The
most common seizure occurring with temporal lobe epi-
Inpatient Medicine
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34
neurosurgical consult is warranted with significant clinical decline. Three separate European studies reveal that
hemicraniectomy reduces mortality and severe disability
in patients with malignant middle cerebral artery infarction. This benefit is greatest if performed within the first
48 h after stroke and optimally before clinical herniation
has occurred. This patient has evidence of elevated clinical intracranial pressure, and urgent neurosurgical consultation is needed as well as repeat imaging. The
neurosurgical consult should come first while arranging
for imaging, intensive care unit transfer, and further supportive measures.
Reference
Gupta R, Connolly ES, Mayer S, Elkind MSV. Hemicraniectomy
for massive middle cerebral artery territory infarction: a systematic review. Stroke. 2004;35:53943.
80. A 54-year-old male is admitted for observation after suffering a concussion in a syncopal episode and suffering
a laceration of the head. This occurred while getting up
at night to go to the bathroom. On presentation he continues to feel slightly dizzy and is noted to be
dehydrated.
He has no past medical history and no meds. He also
reports increased thirst and urination for the past month.
Urinalysis reveals 2+ glucose. His blood sugar is
305 mg/dl. His hemoglobin A1C is 11 %. He is started
on intravenous fluids in the emergency room.
What is an appropriate initial diabetic regimen for
this patient?
A) Metformin 500 mg PO BID
B) Insulin
C) Januvia 100 mg PO daily
D) Metformin 500 mg PO BID and glipizide 5 mg PO
daily
Answer: B
Initial diabetic therapy is guided by hemoglobin A1C and
symptoms. According to the American Diabetes
Association (ADA), the recommended goal A1C for this
patient is less than 7 %. Metformin as monotherapy, if not
contraindicated, may be first-line therapy. However, in
newly diagnosed type 2 diabetics with marked symptoms
and/or highly elevated blood glucose or A1C, insulin
therapy is indicated.
The American Association of Clinical Endocrinology has
more specific guidelines with respect to initiating therapy. Specifically, when the entry level A1C is greater
than 9 % and/or the patient is symptomatic (urinalysis
2+ glucose, polydipsia, polyuria), insulin plus or minus
other agents is recommended. Monotherapy is recommended when the entry A1C is less than 7.5 %. Similarly,
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36
85. A 57-year-old male patient is scheduled for urgent coronary angiography. His estimated glomerular filtration
rate is 30 mL/min per 1.68 m2 He has poorly controlled
diabetes and hypertension.
On physical exam, his blood pressure is 137/75 mm/
Hg. His renal function is at baseline. The procedure is
due to begin in 2 h, and you would like to prevent or
reduce the risk of contrast nephropathy.
Which agent will best reduce the risk of contrast
nephropathy?
A) Dopamine
B) Fenoldopam
C) Indomethacin
D) N-acetylcysteine
E) Sodium bicarbonate
Answer: E
Of the other measures mentioned here, only sodium bicarbonate or N-acetylcysteine is recommended for clinical use to reduce the risk of contrast nephropathy.
Sodium bicarbonate begun within 1 h of the procedure
has shown a significant benefit in randomized controlled trials.
Patients with chronic kidney disease, diabetes mellitus, heart
failure, multiple myeloma, and volume depletion are at
the highest risk of contrast-induced nephropathy.
Hydration with normal saline is an effective measure to
prevent contrast nephropathy. Dopamine and fenoldopam
have been proven an ineffective agent to prevent contrast
nephropathy. Although several small clinical studies have
suggested a clinical benefit to the use of N-acetylcysteine,
a meta-analysis has been inconclusive. In addition,
N-acetylcysteine should be given well in advance of 4 h
as is needed here.
Answer: E
This patient is in respiratory distress. Continued current oxygen via nasal cannula or nonrebreathing mask is not
appropriate. It is unlikely that increasing delivered oxygen will resolve this patients ventilation issues. Avoidance
of intubation is desired as well.
This patient has several factors that make NPPV the best
option. In patients who have severe exacerbations of
COPD defined as PCO2 > 45 mmHg, use of NPPV resulted
in decreased mortality, decreased need for intubation, and
reduction in treatment failure compared to standard therapy. Factors that predict success with NPPV include
higher pH, lower PaCO2, and higher FVC.
Poor outcomes were associated with a diagnosis of pneumonia, decreased compliance with the apparatus, and severe
accessory muscle use. There is no guarantee that NPPV
will resolve the respiratory distress. Close observation is
needed after initiation.
Reference
Merten G, Burgess W, Gray L, Holleman J, Roush T,
Kowalchuk G, Bersin R, Van Moore A, Simonton C,
Rittase R, Norton H, Kennedy T. Prevention of contrastinduced nephropathy with sodium bicarbonate:
a randomized controlled trial. JAMA. 2004;291(19):
232834.
References
Berkius J, Fredrikson M, Nilholm L, Sundh J, Walther
SM. What determines immediate use of invasive ventilation in patients with COPD? Acta Anaesthesiol Scand.
2013;57(3):312319.
Delclos GL, Lee W, Tsai C, et al. Comparative effectiveness of
noninvasive ventilation vs invasive mechanical ventilation
in chronic obstructive pulmonary disease patients with acute
respiratory failure. J Hosp Med. 2013;8(4):16572.
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A)
B)
C)
D)
E)
Answer: D
Daptomycin is known to cause rhabdomyolysis. Weekly
serum creatine kinase tests are recommended. If the CK
level is greater than or equal to five times the upper limit
of normal, or if the patient develops symptoms suggestive
of rhabdomyolysis, daptomycin should be discontinued.
In addition in July 2010, the FDA issued a warning that daptomycin could cause life-threatening eosinophilic pneumonia.
Reference
Vilhena C, Bettencourt A. Daptomycin: a review of properties, clinical use, drug delivery and resistance. Mini Rev
Med Chem. 2012;12:2029.
95. A 44-year-old female is admitted for severe alcoholic
hepatitis and is started on prednisolone. Her last alcoholic drink was 3 days prior to admission. At hospital
day 7, she is not responding to corticosteroids based on
calculation of her Lille score.
What is the most appropriate next step in management?
A) Stop prednisolone, start pentoxifylline.
B) Palliative care consultation.
C) Continue prednisolone, start octreotide.
D) Continue prednisolone, refer to liver transplantation.
E) Continue prednisolone, start plasmapheresis.
The Lille score is a predictor of response to therapy in acute alcoholic hepatitis. This patient is a nonresponder as determined
by Lille score and there is little clinical benefit for continuing
prednisolone. Her prognosis is poor given that she is a nonresponder to corticosteroids and it is reasonable to involve palliative care. Switching to pentoxifylline has been evaluated in a
prospective randomized trial and has no proven clinical benefit. The overall 30-day mortality rate in patients hospitalized
with alcoholic hepatitis is approximately 15 %. In patients
with severe chronic liver disease, the rate approaches or
exceeds 50 %. Liver transplantation would not be an option in
the United States for fulminant alcoholic hepatitis given his
recent alcohol use. A consultation with the liver transplant service may be needed to review and communicate these issues.
Reference
Louvet A, Naveau S, Abdelnour M, et al. The Lille model: a
new tool for therapeutic strategy in patients with severe
alcoholic hepatitis treated with steroids. Hepatology.
2007;45:134854.
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On physical examination, he is afebrile. Blood pressure is 140/70. Heart rate is 90. Respiration rate is 18.
Cardiovascular examination reveals normal S1 and S2
without an S3.
Serum troponin is pending. The hematocrit is 44 %.
Which of the following is the most appropriate
treatment?
A) Thrombolytic therapy.
B) Await laboratory results.
C) Antiplatelet therapy.
D) Consult cardiology for urgent cardiac catheterization(PCI) and intervention.
Answer: D
Treatment options include percutaneous coronary intervention, thrombolytic therapy, and medical management. If
available, the patient should undergo urgent percutaneous
coronary intervention. PCI performed within 90 min of a
patients arrival is superior to fibrinolysis with respect to
combined endpoints of death, stroke, and reinfarction.
He has an ECG consistent with acute anterior myocardial
infarction. Therapy for an acute MI presenting with 12 h
of symptoms should be thrombolytic therapy or percutaneous intervention. This patient has a relative contraindication to thrombolytic therapy with his history of recent
peptic ulcer disease. Absolute contraindications to thrombolytic therapy include any history of cerebrovascular
hemorrhage, known cerebrovascular lesion, an ischemic
stroke within 3 months, significant facial trauma or closed
head injury within 3 months. Relative contraindications
are poorly controlled hypertension. Medical management
of the patient including aggressive anticoagulation should
be delayed until definitive percutaneous coronary
intervention.
Reference
Rokos IC, French WJ, Mattu A, et al. Appropriate cardiac
cath lab activation: optimizing electrocardiogram interpretation and clinical decision-making for acute STelevation myocardial infarction. Am Heart J. 2010;
160(6):9951003.
101. You are asked to see a 60-year-old man in the emergency department for shaking chills, cough, and productive sputum. He has a 37-pack-year history of
cigarette smoking but has no other significant medical
history.
On physical examination, the temperature is 38.6 C
(101.5 F), the blood pressure is 160/90 mmHg, the
heart rate is 115 bpm and regular, and the respiration
rate is 27/min. There is increased dullness upon percussion at the right base, crackles in the right mid-lung
field, and diffuse anterior wheezes.
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43
Answer: C
The symptoms of diarrhea, abdominal pain, and weight loss
with recent travel suggest tropical sprue. Findings of steatorrhea, malabsorption, and villous atrophy by biopsy
are adequate to make a diagnosis. Response to treatment
is considered to be the conclusive evidence that confirms
the diagnosis.
An individual needs to be in a tropical country for at least
one month to consider this as a diagnosis. The exact etiology of tropical sprue is uncertain. It may be caused by
endemic E. coli or Klebsiella. Other infectious etiologies have been suggested as well. Treatment of tropical
sprue is usually with prolonged course of tetracycline.
In addition vitamins, particularly folic acid, should be
given.
The first description of tropical sprue is attributed to William
Hillarys 1759 account of his observations of chronic
diarrhea while in Barbados. Subsequently, tropical sprue
was described in tropical climates throughout the world.
Reference
Brown IS, Bettington A, Bettington M, et al. Tropical sprue:
revisiting an underrecognized disease. Am J Surg Pathol.
2014;38(5):66672.
103. A 38-year-old male is admitted with the acute onset of
fever and headaches for the past two days. He denies
any recent sick contacts.
On physical exam, the patient has significant neck
stiffness. Temperature is normal. He responds to questions appropriately.
Lumbar puncture is performed in the emergency
room and cerebrospinal fluid (CSF) studies are
obtained. Opening pressure is noted at 285 mm
H2O. CSF analysis reveals 1700 WBCs/L, a PMN
predominance, 10 RBCs, glucose 22 mg/dL, and protein 104 mg/dL. Serum glucose is 80 mg/dL.
Which of the following is the most likely
diagnosis?
A) St. Louis encephalitis
B) Herpes simplex encephalitis (HSV)
C) Early bacterial meningitis
D) West Nile virus
E) Bacterial meningitis
Answer: C
This patient has early bacterial meningitis. Several classic
factors point toward this including an elevated opening
pressure, high CSF neutrophil count, and low CSF glucose. Symptoms in bacterial meningitis are reliable, with
95 % of patients having two out of the four classical
symptoms of fever, headache, stiff neck, and altered mental status.
44
Surgery is indicated in patients with small bowel obstructions that have not shown signs of resolution in 2448 h.
NG tube decompression is used to clear gastric contents,
decompress the small bowel, and prevent aspiration. The
tube should be placed on intermittent suction and output
recorded. The NG tube is removed when obstruction is
resolved. If resolution is uncertain, the NG tube should
be clamped for a 4-h period and can be removed as
residuals are <100 mL and no nausea and vomiting is
noted.
It is reasonable to admit this patient to a medical service with
surgery consult. Suspected complete obstruction or those
where surgery is anticipated should be admitted to a surgical team.
Reference
Diaz JJ Jr, Bokhari F, Mowery NT, Acosta JA, Block EF,
Bromberg WJ, et al. Guidelines for management of small
bowel obstruction. J Trauma. 2008;64(6):165164
105. A 72-year-old female is admitted with sepsis, pneumonia, and hypotension. In the emergency room, the
patient has received 0.9 % saline at a rate of 150 cm3/h.
Broad-spectrum antibiotics have been administered.
Laboratory studies on admission reveal a hematocrit of
30 %, a serum creatinine of 1.9, and a serum lactate
level of 3.7 mm/l. A serum albumin is 2.7 g/dL. Her
blood pressure is noted to be 90/50 with decreased urine
output.
Which of the following should be selected for ongoing volume resuscitation?
A) 0.9 % saline
B) 6 % hydroxyethyl starch (HES) solution
C) Packed red blood cells
D) Normal saline with 5 % albumin infusion
E) D5 1/2 normal saline
Answer: A
Several studies have looked at fluid resuscitation in sepsis.
Among ICU patients, 90-day mortality was observed
between patients resuscitated with 0.9 % saline and with
6 % hydroxyethyl starch (HES) solution. In the study, no
significant difference was noted.
Other studies have looked at crystalloid and albumin for fluid
resuscitation and have found no benefit as compared to
0.9 % saline.
In this particular case, blood products should not be employed
for volume expansion unless there is a specific need.
Reference
van Haren F, Zacharowski K. What's new in volume therapy
in the intensive care unit? Best Pract Res Clin Anaesthesiol.
2014;28(3):27583.
Inpatient Medicine
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46
Answer: D
This patient has aseptic meningitis. The term aseptic is frequently a misnomer, implying a lack of infection. Many
cases of aseptic meningitis represent infection with
viruses, many of which are known causes of generalized
viral illnesses. Polymerase chain reaction testing has
increased the ability of clinicians to detect viruses such as
enterovirus, cytomegalovirus, and herpes virus in the
CSF. However, except for the herpes virus, this is not
widely done.
When CSF findings are consistent with meningitis, and
microbiological testing is unrevealing, clinicians typically assign the diagnosis of aseptic meningitis. In most
instances, morbidity is low. There is no indication for
waiting until cultures are negative in obvious cases of
aseptic meningitis. In this particular case, the patient can
be safely discharged home.
References
Logan, SA; MacMahon, E "Viral meningitis.". BMJ
2008;336 (7634): 3640.
Khetsuriani, N; Quiroz, ES; Holman, RC; Anderson, LJ
"Viral meningitis-associated hospitalizations in the
United States, 19881999.". Neuroepidemiology 2003 22
(6): 34552.
110. A 26-year-old white female is admitted for left forearm
MRSA cellulitis. She is currently receiving vancomycin 1 g IV every 12 h. A vancomycin trough returns as
41 ug/ml. However, per her MAR, she received her 4th
dose of vancomycin at 6:30 A.M. and the trough was
drawn at 6:45 A.M.
Which statement is correct?
A) Trough drawn inappropriately
B) Trough drawn appropriately, continue current dose
C) Trough drawn appropriately, increase current
dose
D) Trough drawn appropriately, decrease current dose
Answer: A
Vancomycin serum trough concentrations should be obtained
at steady-state conditions, prior to the fourth or fifth dose.
Her trough level was drawn immediately following the
fourth dose, likely while the drug was still infusing. Thus
this was not considered a trough and was drawn
inappropriately.
In the past, it was fairly routine to measure both peak and
trough concentrations; now, many clinicians monitor only
the trough concentration or do not monitor drug concentrations at all. Using vancomycin concentrations to monitor patients therapeutic response is not typically
suggested if the duration of therapy is expected to be less
than 72 h.
References
Liu C et al. Clinical Practice Guidelines by the Infectious
Disease Society of America for the Treatment of
Methicillin-Resistant Staphylococcus aureus in Adults
and Children. CID 2011;52:138.
Ryback M et al. Therapeutic Monitoring of Vancomycin in
Adult Patients. Am J Health-Syst Pharm 2009;66:8298.
111. A 19-year-old man presents with lethargy, fever, and
decreased appetite. In the past three years, he has been
admitted for similar symptoms twice with no obvious
source found. Prior extensive diagnostic workup has not
found evidence of lymphoma, leukemia, or other malignancies. Further extensive infectious workup has been
negative for HIV, tuberculosis, histoplasmosis, Q fever,
typhoid fever, EpsteinBarr virus, infectious mononucleosis, cytomegalovirus, human herpes virus (HHV)-6,
viral hepatitis, and Whipples disease. He was born in
Honduras and moved to the United States 16 year ago.
On presentation the only abnormal physical finding
is hepatosplenomegaly and possibly an audible pericardial friction rub. The estimated sedimentation rate is 45
and there are mild elevations of his liver function studies. He is noted to have fever as high as 39.6 C
(103.3 F), which occurs twice per day.
The most likely diagnosis is:
A) Lymphoma
B) Juvenile arthritis
C) Somatoform disorder
D) Endocarditis
Answer: B
The most difficult causes of fever of unknown origin (FUO)
involve those without specific diagnostic tests, many auto
immune diseases such as juvenile rheumatoid arthritis (JRA)
adult Stills disease fall into that category. In a young adult
with a prolonged or recurrent FUO, an ongoing negative
workup suggests autoimmune or somatoform disorder. One
of the key goals of an FUO admission is the controlled observation of fever curves. Several factors can be accomplished
during the admission: is it factitious, what is the fevers pattern, and does the fever respond to antipyretics. In this case,
the double quotidian pattern is suggestive of JRA. Other
clues to the diagnosis include hepatosplenomegaly, serositis,
and mild hepatitis. Other clues include tenosynovitis, lymphadenopathy, and transient salmon pink macules.
References
Hoffart C and Sherry DD Early identification of juvenile
idiopathic arthritis. Journal of Musculoskeletal Medicine.
2010;247 (2).
Ringold S, Burke A, Glass R (2005). "JAMA patient page.
Juvenile idiopathic arthritis". JAMA 294 (13): 1722.
Inpatient Medicine
Answer: A
A large randomized trial looked at low dose, based on home
furosemide dose versus high (2.5 times the home dose)
furosemide treatment strategies and bolus versus continuous infusion. There was no difference in in-hospital or
overall mortality or length of hospital stay.
There was a very slight benefit for patients in the high-dose
strategy group who had dyspnea.
Reference
Felker GM, Lee KL, Bull DA, et al. Diuretic strategies in
patients with acute decompensated heart failure. N Engl J
Med. 2011;364(9):797805.
113. A 58-year-old woman who has COPD was admitted for
an acute exacerbation. She is now ready for discharge.
You bring up the issue of smoking cessation.
The patient has smoked one pack of cigarettes daily
for 30 years. In the hospital she expresses a desire to
quit smoking, but she is unwilling to set a definite quit
date. The patient is physically active, and she has no
other medical problems. Her COPD symptoms have
been well controlled with inhaled tiotropium. One year
ago, FEV1 was 60 % of predicted, and FVC was 80 %
of predicted.
47
114. A 20-year-old college student presents to the emergency room with a chief complaint of diarrhea, nausea,
vomiting, abdominal pain, fever, and chills. He also
reports decreased urine output. He recently returned
from Central America where he has been taking an
archaeology course.
On physical examination, his temperature is
38.3 C,(101 F), blood pressure is 120/80, and pulse
rate is 120. Oral mucosa is dry. He has diffuse abdominal pain with mild guarding.
Laboratory studies reveal hemoglobin of 8.5 g/dL,
leukocyte count of 16,000 l, and a platelet count of
38,000 l. Peripheral blood smear reveals many
schistocytes. Urinalysis reveals many erythrocytes
and erythrocyte casts. Urine protein-to-creatinine
ratio is 0.6.
48
Inpatient Medicine
49
50
Answer: A
The differential diagnosis of a rapidly progressive dementia is limited. The clues to CJD in this patient are the
relatively normal head imaging, the unexplained rapid
onset of dementia, and the eventual appearance of
myoclonus.
Initially, individuals experience problems with muscular
coordination; personality changes, including impaired
memory, judgment, and thinking; and impaired vision.
EEG, which may initially be normal, but often demonstrates a typical triphasic spike pattern. Criteria have been
developed to confirm the diagnoses. A confirmatory protein can be measured in cerebrospinal fluid. CJD remains
a diagnostic challenge with an average of seven months
passing before initial symptoms and confirmation of a
diagnosis.
Imaging studies are emerging as valuable tools in diagnosing
CJD, with evidence that diffusion-weighted imaging
(DWI) and magnetic resonance imaging (MRI) sequences
are more useful than electroencephalography.
Paraneoplastic syndromes which can cause a rapid diffuse
encephalopathy can present in a similar picture. A focused
workup for malignancy would be warranted in this case as
well.
There are investigational therapies available, but treatment is
primarily supportive. Rapid progression of the disease
and death are the usual outcome.
Reference
Takada LT, Geschwind MD. Prion diseases. Semin Neurol.
2013;33(4):34856.
120. A 38-year-old female with a history of heroin addiction is admitted for withdrawal symptoms consisting of diarrhea, nausea, and vomiting. On admission,
her pulse is 120 beats per minute, respirations are
20 per minute, and blood pressure is 120/70. Oxygen
saturation is 94 %. She is mildly agitated. Her agitation and mild psychosis is treated with benzodiazepines and haloperidol. Her nausea is treated with
Phenergan.
On her second day of hospitalization, you are
urgently called to her bedside. On physical examination, the patient has marked increased muscle tone. Her
eyes are deviated superiorly, and she states that she has
difficulty moving them. She appears distressed but can
follow commands.
Which of the following treatments is most
appropriate?
A) Lorazepam
B) Benztropine
C) Naloxone
D) Phenytoin load
Answer: B
This patient is likely experiencing an acute dystonic reaction. Acute drug-induced dystonia can be treated with
anticholinergic agents such as benztropine or diphenhydramine. It is unlikely that this patient is experiencing a
seizure. Acute dystonic reactions can include ocular dystonia with eye deviation. Typically, this is superior.
Dystonic reactions are rarely life threatening but the adverse
effects often cause distress for patients and families.
Medical treatment is usually rapidly effective. Motor disturbances resolve within minutes, but they can reoccur
over subsequent days. IV is the route of choice.
Reference
Christodoulou C, Kalaitzi C. Antipsychotic drug-induced
acute laryngeal dystonia: two case reports and a mini
review. J Psychopharmacol. May 2005;19:30711
121. A 38-year-old female is admitted to the hospital with
fever, abdominal pain, and jaundice. She drinks
approximately one-half liter of vodka per day. Her
family reports a possible recent increase in alcohol
intake. She is not taking any medications.
On physical examination, she appears ill and disheveled. Heart rate is 126 beats/min, blood pressure
92/56 mmHg, respiratory rate 22 bpm, temperature
38.4 C (101.1 F), and oxygen saturation 94 % on
room air. She has scleral icterus, and spider angiomata
are present on the trunk. There is a fullness in the right
upper quadrant. It is smooth and tender upon palpation.
The spleen is not palpable.
Laboratory studies demonstrate an AST of 543U/L,
ALT of 215 U/L, bilirubin of 8.7 mg/dL, alkaline phosphatase of 217U/L, and lipase of 38U/L. Total protein
is 4.9 g/dL, and albumin is 2.7 g/dL. The prothrombin
time is 30.2 (control is 11) seconds. What is the best
approach to the treatment of this patient?
A) Administer IV fluids, thiamine, and folate, and
observe for improvement in liver function studies.
B) Administer IV fluids, thiamine, folate, and broadspectrum antibiotics.
C) Administer prednisone 40 mg daily for 4 weeks.
D) Perform abdominal ultrasound.
E) Perform an abdominal CT with IV contrast to
assess for necrotizing pancreatitis.
Answer: C
This patient has severe acute alcoholic hepatitis. Treatment
with prednisone 40 mg daily for four weeks should be initiated. If steroids are contraindicated, pentoxifylline
400 mg three times daily for four weeks can also be used.
A discriminate function (DF) can be calculated as (4.6 the
prolongation of prothrombin time above control) + serum
Inpatient Medicine
51
tive study to date demonstrating benefit or harm of thyroid hormone replacement in euthyroid sick states. The
most appropriate management consists of observation.
Thyroid function studies will return to normal in weeks
to months.
References
McCullough AJ, O'Connor JF. Alcoholic liver disease: proposed recommendations for the American College of
Gastroenterology". Am. J. Gastroenterol.1998 93 (11):
202236.
Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O
Pentoxifylline improves short-term survival in severe acute
alcoholic hepatitis: a double-blind, placebo-controlled trial.
Gastroenterology.2000; 119 (6): 163748.
Reference
Docter R, Krenning EP, de Jong M, Hennemann G. The sick
euthyroid syndrome: changes in thyroid hormone serum
parameters and hormone metabolism. Clin Endocrinol
(Oxf). 1993;39(5):499518.
52
Answer: B.
Norepinephrine and dopamine are considered first-line
agents in the setting of septic shock nonresponsive to
fluid. Norepinephrine has emerged from the various trials
as the first choice of vasopressors based on randomized
controlled trials, meta-analyses, and international consensus guidelines.
The surviving sepsis campaign lists norepinephrine as
the first-line vasopressor with an evidence grade of
1BA. According to their guidelines, norepinephrine
increases MAP due to its vasoconstrictive effects,
with little change in heart rate and less increase in
stroke
volume
compared
with
dopamine.
Norepinephrine is more potent than dopamine and
may be more effective at reversing hypotension in
patients with septic shock.
Reference
Miller RG, Jackson CE, Kasarskis EJ et al. Practice Parameter
update: The care of the patient with amyotrophic lateral
sclerosis: Drug, nutritional, and respiratory therapies (an
evidence-based review). Report of the Quality Standards
Subcommittee of the American Academy of Neurology.
Neurology. 2009;73:12181226
Reference
Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis
Campaign: international guidelines for management of
severe sepsis and septic shock: 2008. Crit Care Med.
2008;36:296327.
125. A 32-year-old man with amyotrophic lateral sclerosis
(ALS) is admitted for feeding tube placement. During
a preoperative exam, finger pulse oximetry is 86 % on
room air, his lungs are clear. He reports feeling at his
baseline and is not short of breath. His condition is
intact. Chest radiograph shows low lung volumes but is
otherwise normal.
On physical exam he appears mildly cachectic, no
accessory respiratory muscles are being used. Lung
sounds are diminished but clear.
Which of the following is most likely the source of
his low oxygen saturation?
A) Atelectasis
B) Mucous plug
C) Elevated PaCO2
D) Pneumonia
E) Methemoglobinemia
Answer: C
The patient has a progressive neuromuscular disease and is at
risk for the development of hypoventilation. Many
patients with hypoventilation are relatively asymptomatic. Symptoms have a gradual onset, which is typical of
Inpatient Medicine
Reference
Hayakawa K, Ramasamy B, Chandrasekar PH. Fever of
unknown origin: an evidence-based review. Am. J. Med.
Sci.2012;344(4), 307316)
127. A 31-year-old woman present with fever, dysuria and
nausea. Her past medical history is unremarkable
except for Vaginal delivery of a healthy baby one year
ago, she has no known past medical history.
On physical exam, her temperature is
39.0 C(102.2 F). Her pulse is 120 and BP is 160/90.
Otherwise, her physical exam is unremarkable.
Her urine culture is positive for Staph. aureus. Her
first set of blood cultures are negative.
Further initial workup and treatment should include:
A) Oral bactrim
B) IV vancomycin
C) Echocardiography
D) Repeat urine cultures, no antibiotics
E) B and C
Answer: E
Despite no predisposing factors for S. aureus infection, isolation of the organism in the urine should always prompt
an evaluation for alternative site of infection. This should
include examinations of bone, joint, or vascular sources
of infection. Patients with a known S. aureus urinary tract
infection should have blood cultures drawn prior to the
initiation of antibiotics to detect occult bacteremia.
It is not unusual to see a patient who is suspected of having a
S. aureus UTI that is later shown to have a deep-seated S.
aureus infection.
Fowler VG Jr., Sanders LL, Sexton DJ, et al. Outcome of
Staphylococcus aureus bacteremia according to compliance with recommendations of infectious diseases specialists: experience with 244 patients. Clinical Infect Dis.
1998;27:47886
128. A 67-year-old female is admitted to the hospital for
progressive weakness over the past two months. She
states she has been feeling depressed lately and is
having a difficult time adjusting to the cold weather.
Her family reports that she rarely leaves the house. She
has no bowel movements for the past week. She denies
any fluctuations of her weight.
On physical exam, her blood pressure is 94/60 mmHg.
She is thin. Her skin appears smooth and tan. Her mood
is depressed, but she denies suicidal thoughts.
Her sodium is 134 mEq/L, potassium 5.9 mEq/L,
chloride 106 mEq/L, bicarbonate 19 mEq/L, BUN
10 mg/dL, creatinine 1.0 mg/dL, glucose 54 mg/
dL,TSH 18 U/mL, and free T4 0.1 ng/dL.
53
54
Reference
Laine, Loren MD, Jensen, Dennis MD. Management of
Patients with Ulcer Bleeding. Guidelines from the
American College of Gastroenterology. Am J
Gastroenterol 2012; 107:345360;
131. A 63-year-old male with end-stage liver disease is
admitted with spontaneous bacterial peritonitis and
possible sepsis. He is started on broad-spectrum antibiotics. Twelve hours after admission, he is noted to be
oozing from venipuncture sites. Platelet count is
35,000/L, international normalized ratio is 2.9, hemoglobin is 6.1 mg/dL, and D-dimer is elevated to 4.8.
DIC and his underlying liver disease are considered
as possible source of his bleeding.
What is the best way to distinguish between newonset DIC and his underlying chronic liver disease?
A) Blood culture
B) Elevated fibrinogen degradation products
C) Prolonged aPTT
D) Serial laboratory analysis
E) Reduced platelet count
Answer: D
Liver disease and disseminated intravascular coagulation
(DIC) can present with similar coagulation profiles. Both
entities may present with elevated fibrinogen degradation
products, prolonged activated partial thromboplastin time
and prothrombin time, anemia, and thrombocytopenia.
Both may cause spontaneous bleeding.
When suspecting DIC, these tests should be repeated over a
period of 6 h. Abnormalities may change in patients with
severe DIC. In chronic liver disease, coagulation profiles
would remain relatively stable.
Reference
Levi, M; Toh, C-H et al. (2009). "Guidelines for the diagnosis and management of disseminated intravascular coagulation". British Journal of Haematology 2009 145 (5):
2433.
132. A 32-year-old female presents to the emergency room
with severe pain in her upper back and knees for the
past 12 h. She reports that this is typical for her usual
sickle cell attacks. She also reports a mild productive
cough and moderate shortness of breath. She states she
is usually admitted 34 times per year.
On physical examination, her temperature is 39.1 C
(102.4 F), pulse rate is 100 beats per minute, and respirations are 26 per minute. Her blood pressure is
150/68. Oxygen saturation is 86 % by pulse oximetry.
The lungs have diffuse moderate wheezes. No joint
infiltration or edema is noted. Chest radiograph reveals
Inpatient Medicine
55
56
Answer: A
Amiodarone is the best option for managing symptomatic
atrial fibrillation in the setting of congestive heart failure
(CHF). Patients with heart failure and myocardial infarction are at an increased risk of developing atrial fibrillation. Amiodarone has -blocking properties that can help
with rate control.
Amiodarone has a class IIa recommendation from the
American College of Cardiology for use as a rate-controlling agent for patients who are intolerant to other agents.
Patients with CHF may not tolerate diltiazem or metoprolol. Caution should be exercised in those who are not
receiving anticoagulation, as amiodarone can promote
cardioversion. Flecainide is contraindicated after a myocardial infarction because it increases the risk of polymorphic ventricular tachycardia.
Disopyramide has negative inotropic effects, which would
detrimental in the setting of reduced left ventricular function and heart failure. It is contraindicated in this setting.
References
McNamara RL, Tamariz LJ, Segal JB, Bass EB. Management
of atrial fibrillation: review of the evidence for the role of
pharmacologic therapy, electrical cardioversion, and echocardiography. Ann Intern Med. 2003;139(12):101833
Siddoway LA. Amiodarone: guidelines for use and monitoring. American Family Physician.2003; 68 (11): 218996
135. A 55-year-old man with a past medical history of gallstones presents to the emergency department with
acute onset of fever, jaundice, and abdominal pain.
On physical exam, the temperature is
38.3 C(101.0 F), heart rate of 92 bpm, and BP of
98/50. He has diffuse abdominal pain.
Lab work is pertinent for elevated WBC of 16,500/
L predominantly with neutrophils, lipase of 600
units/L, AST 150 units/L, ALT 165 units/L, and a bilirubin of 4.0 mol/L.
Which is the following is the least appropriate next
step?
A) Aggressive hydration with 250500 ml per hour of
isotonic crystalloid solution.
B) Stat trans abdominal ultrasound
C) MRCP
D) Empiric antibiotics
E) Nasogastric suction
Answer: C
The diagnosis of acute pancreatitis is established by the presence of two of the three following criteria: abdominal
pain consistent with the disease, serum amylase and/or
lipase greater than three times the upper limit of normal,
and/or characteristic findings from abdominal imaging.
Inpatient Medicine
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58
Answer: C
Although IV pantoprazole is often initiated, oral pantoprazole has nearly 100 % bioavailability and may be utilized
when the patient is able to take pills, and there is a low
risk of rebleeding, as in this case. Investigators compared
30-day rebleeding rates in patients randomized to receive
intravenous (IV) versus oral high-dose PPI treatment after
successful endoscopic therapy for bleeding peptic ulcers.
Rebleeding rates were similar in the IV-PPI and oral-PPI
groups at 72 h 7 days and 30 days.
Octreotide is beneficial in acute variceal bleeding and may
have a role in severe peptic ulcer disease when endoscopy
is deferred or not available. H2-receptor antagonists are
inferior to proton-pump inhibitors in the management of
acute gastrointestinal bleeds.
Reference
JY Sung, Bing-Yee Suen, Justin CY Wu, James YW Lau,
Jessica YL Ching, Vivian WY Lee, Philip WY Chiu,
Kelvin KF Tsoi and Francis KL Chan. Effects of
Intravenous and Oral Esomeprazole in the Prevention of
Recurrent Bleeding from Peptic Ulcers after Endoscopic
Therapy. The American Journal of Gastroenterology.
2014; 109, 10051010
141. A 37-year-old woman is admitted for dysphagia. She
has not seen a physician in many years. She says her
swallowing difficulty started two weeks ago. She has
lost 20 lb in the past 6 months. She also complains of
diarrhea and blurry vision. She has had occasional
fevers for the past 4 or 5 months.
On physical exam, there is no thrush. The patients
chest and abdominal examinations are unremarkable; her
cardiovascular examination shows tachycardia and her
stools are heme positive. HIV rapid screen is positive.
What is the most likely diagnosis?
A) EpsteinBarr
B) Herpes simplex
C) Candida
D) Cytomegalovirus (CMV)
E) Kaposis sarcoma
Answer: D
This patient has CMV esophagitis and probable CMV retinitis. The gastrointestinal tract is a major site of disease in
HIV infection. Almost half of HIV-infected patients have
GI symptoms as their first complication. In addition most
HIV patients develop GI complications at some point.
Endoscopy is the diagnostic test of choice for upper gastrointestinal HIV-associated esophageal disease.
Diseases commonly found include candidiasis, cytomegalovirus and herpes simplex virus infection (HSV), and
Kaposis sarcoma.
Inpatient Medicine
59
threatening bleeding. Plasmapheresis is not first-line therapy for ITP nor is rituximab, which may be considered as
second-line therapy. Splenectomy is reserved for resistant
cases and should not be considered at this time. HIV
screening is appropriate as ITP commonly occurs in this
group and may be the first sign of HIV infection.
Reference
Stasi R, Evangelista ML, Stipa E, et al. Idiopathic thrombocytopenic purpura: current concepts in pathophysiology
and management. Thromb Haemost. 2008;99(1):413.
143. A 56-year-old woman is admitted with worsening confusion. She has a history of hepatitis C virus infection.
She currently takes phenytoin 100 mg TID for seizure
disorder. She has been on the same dose for many
years. Lactulose 30 g TID and spironolactone 25 mg
daily are taken for her liver disease.
On physical examination, her blood pressure is
110/65 mmHg, heart rate is 87 beats/min, respiratory rate is 22 breaths/min, and oxygen saturation is
97 % on room air. She is afebrile. She is minimally
responsive to voice and follows no commands. Her
abdomen is distended with a positive fluid wave but
without tenderness. She does not appear to have
asterixis. She has a horizontal nystagmus on examination. The white blood cell count is 12,000/L with
a normal differential. Her liver function tests are
unchanged from baseline with the exception of an
albumin that is now 2.1 g/dL compared with three
months ago when her level was 2.9 g/dL. The ammonia level is 15 mol/L, and her phenytoin level is
17 mg/L. A paracentesis shows a white blood cell
count of 90/L.
What test would be most likely to demonstrate the
cause of the patients change in mental status?
A) CT scan of the head
B) Free phenytoin level
C) Electroencephalogram (EEG))
D) Gram stain of ascites fluid
E) Gram stain of cerebrospinal fluid (CSF)
Answer: B
This patient has phenytoin toxicity due to her chronic liver
disease. Signs and symptoms of phenytoin toxicity
include slurred speech, horizontal nystagmus, and altered
mental status that can progress to obtundation and coma.
Worsening hypoalbuminemia can lead to increased free
levels of drugs that are more highly protein bound. This
can lead to drug toxicity at total drug levels that are not
typically considered toxic.
Medications that are bound to plasma proteins include phenytoin, warfarin, valproic acid, and amiodarone. Although
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pation. The spleen is not enlarged. There are no stigmata of chronic liver disease. His AST is 1475 U/L,
ALT is 1678 U/L, alkaline phosphatase is 547 U/L,
total bilirubin is 13.8 mg/dL, and direct bilirubin is
13.2 mg/dL. His INR is 2.4, and aPTT is 49 s. Serologic
tests for hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) immunoglobulin M
(IgM) are positive.
Which of the following is the correct treatment?
A) Administration of anti-hepatitis A virus IgG.
B) Administration of lamivudine.
C) Administration of pegylated interferon plus
ribavirin.
D) Administration of prednisone
E) Do nothing and observe
Answer: E
No treatment is recommended for acute hepatitis B in most
individuals. Close observation is warranted with possible
hepatology consultation. Full recovery is the expected
outcome. 99 % of infected individuals recover without
intervention.
However, patients with hepatitis B disease and fulminant
hepatic failure should be hospitalized in the intensive care
unit and be considered as liver transplant candidates in the
event that they do not recover.
Reference
Sorrell MF, Belongia EA, Costa J, Gareen IF, Grem JL,
Inadomi JM, et al. National Institutes of Health Consensus
Development Conference Statement: Management of
hepatitis B. Ann Intern Med. 2009;150(2):10410.
147. A 63-year-old woman with primary biliary cirrhosis
which is being considered for liver transplantation is
admitted for worsening ascites and shortness of breath.
She has been followed closely by the hepatology
service.
In the past six weeks, she has had three paracenteses
performed. Today, the shortness of breath has returned,
but she has no fever, cough, or chills. She reports
meticulous attention to her sodium-restricted diet.
On physical examination, she is afebrile. Pulse rate
is 90 per minute, respirations are 24 per minute, and
blood pressure is 108/57 mmHg. Breath sounds are
absent in the lower half of the right lung field; other
pulmonary findings are normal. The abdomen is distended, with a prominent, fluid wave. She exhibits no
confusion or asterixis.
Ultrasonography of the liver reveals a nodular liver
with patent hepatic vasculature; no focal mass was
detected. Labs reveal an of INR 1.5, a serum creatinine of
1.4 mg/dL, and a sodium of 140. Her MELD score is 18.
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A)
B)
C)
D)
Answer: D
Refractory ascites may be treated with a TIPS procedure.
Previous meta-analysis shows possible benefit, especially
in those listed for transplant. Indications for TIPS include
uncontrolled variceal hemorrhage from esophageal, gastric, and intestinal varices that do not respond to endoscopic and medical management, refractory ascites, and
hepatic pleural effusion (hydrothorax). Repeat paracentesis is unlikely to be of benefit in this patient. Chest tube
placement is not recommended in patients with end-stage
liver disease.
All patients undergoing transjugular intrahepatic portosystemic shunt placement should receive prophylactic antibiotics. Resuscitation with fluid and blood products is
indicated prior to the procedure. Portal vein patency
should be confirmed prior to attempts at TIPS
placement.
References
Fidelman N, Kwan SW, LaBerge JM, et al. The transjugular
intrahepatic portosystemic shunt: an update. AJR Am J
Roentgenol. 2012;199(4):746755.
Krok KL, Cardenas A. Hepatic hydrothorax. Semin Respir
Crit Care Med. 2012;33(1):310. Epub 2012 Mar 23.
148. A 71-year-old woman is admitted from a nursing home
with confusion, fever, and flank pain. She has a presumed urinary tract infection.
On physical exam, temperature is 38.8 C (101.8 F),
blood pressure is 86/52 mmHg, pulse rate is 130/min,
and respiration rate is 23/min. Mucous membranes are
dry and tender, and poor skin turgor is noted. She is
oriented to name and place.
Hemoglobin concentration is 9.5 g/dL and leukocyte count is 15,600/L; urinalysis reveals 100 to
150leukocytes/hpf and many bacteria/hpf. The patient
has an increase anion gap metabolic acidosis. The
patient is admitted to the intensive care unit and antibiotic therapy is started.
Which of the following is the first goal of therapy?
A) Aggressive fluid resuscitation
B) Hemodynamic monitoring with a pulmonary artery
catheter
C) Maintaining hemoglobin concentration above 12 g/
dL (120 g/L)
D) Maintaining PCO2 below 50 mmHg
E) Initiation of vasopressor drugs
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Answer: A
The patient has severe sepsis from pyelonephritis. Initial
treatment includes respiratory and circulatory support.
The first 6 h of resuscitation of a critically ill patient with
sepsis or septic shock are the most critical. Resuscitation
of the circulation should target a central venous oxygen
saturation or mixed venous oxygen saturation of at least
70 %.
This often requires of 5 to 6 L of fluid. The time required to
achieve resuscitative goals matters to survival. Early goaldirected therapy that within the first 6 h maintains a
SCVO2 of greater than 70 % and resolves lactic acidosis
results in higher survival rates than more delayed resuscitation attempts.
Blood transfusion may be part of resuscitation for anemic
patients in shock. In stable patients who are not in
shock, a transfusion threshold of 7 g/dL is acceptable.
There are no data to support that maintaining a lower
PCO2 is of any benefit. Placement of a pulmonary
artery catheter would not help to increase survival in
this patient.
Reference
Rivers, E; Nguyen, B; Havstad, S; Ressler, J et al.. Early
goal-directed therapy in the treatment of severe sepsis and
septic shock. The New England Journal of Medicine 345
(19): 136877
149. A 63-year-old female smoker presents to the emergency department with an onset of worsening dyspnea,
wheezing, and coughing x 3 days. She denies any fever
or chills. She has not been treated for COPD in the
past. The results of her spirometry test three week ago
are FEV1 < 60 % of predicted and DLCO was
decreased.
She is on short-acting inhaled beta agonists at
home. She is admitted for COPD exacerbation and
improves to her baseline respiratory status with steroids and nebulized albuterol treatments. Her oxygen
saturation on discharge is 89 % on room air with a
PaO2 of 54 mmHg.
Which of the following are appropriate treatment
modalities to initiate for this patient upon discharge?
A) Initiate long-acting inhaled B-agonist in conjunction with break through inhaled short-acting anticholinergic agent.
B) Prescribe continuous supplemental oxygen therapy.
C) Recommend wearing oxygen supplementation
only during exertion.
D) Begin inhaled corticosteroids as monotherapy.
E) All of the above.
F) A and B.
G) B and D.
Answer: F
Guidelines suggest that clinicians may administer a combination of long-acting inhaled anticholinergics, longacting inhaled -agonists, or inhaled corticosteroids for
symptomatic patients with stable COPD and FEV1 < 60 %
predicted.
The American College of Chest Physicians recommends that
clinicians should prescribe continuous oxygen therapy in
patients with COPD who have severe resting hypoxemia
defined as Pao2 55 mmHg or Spo2 88 %.
Spirometry is used to diagnose obstructive airway disease in
a patient with respiratory symptoms. Spirometry is best
assessed outside of periods of exacerbation. A diagnosis
of obstructive airway disease is defined as a FEV1 < 80 %
or an FEV1/FVC ratio < 70 % of predicted.
Reference
Amir Qaseem, MD, PhD, MHA; Timothy J. Wilt, MD, MPH
et al. Diagnosis and Management of Stable Chronic
Obstructive Pulmonary Disease: A Clinical Practice
Guideline Update from the American College of
Physicians, American College of Chest Physicians,
American Thoracic Society, and European Respiratory
Society. Ann Intern Med. 2011;155(3):179191.
150. An 81-year-old man is admitted to the hospital for
altered mental status. He was found at home, confused
and lethargic, by his son. His medical history is significant for metastatic prostate cancer.
On physical examination, he is afebrile. Blood pressure is 110/50 mmHg, and the pulse rate is 115 bpm.
He is lethargic and minimally responsive to sternal rub.
He has bitemporal wasting, mucous membranes are
dry and poor skin turgor is noted. He is obtunded. The
patient has an intact gag reflex and withdraws to pain in
all four extremities. The rectal tone is normal.
Laboratory values are significant for a creatinine of
4.2 mg/dL, a calcium level of 14.6 meq/L, and an albumin of 2.6 g/dL.
All of the following are appropriate initial management steps EXCEPT:
A) Normal saline
B) Dexamethasone
C) Pamidronate
D) Furosemide when the patient is euvolemic
E) Calcitonin
Answer: B
In vitamin D toxicity or extrarenal synthesis of 1,25(OH) D3
such as sarcoid or lymphoid malignancies steroids may help
reduce plasma calcium levels by reducing intestinal calcium
absorption. However, in this patient with prostate cancer,
dexamethasone will have little effect on the calcium level.
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Answer: D
This patient has giant cell arteritis (GCA). The onset of GCA
may be either abrupt or insidious. GCA may begin with
constitutional manifestations such as anorexia, fever,
myalgia, night sweats, and weight loss. These symptoms
may occur for a few days or weeks.
Patients suspected of GCA should undergo immediate treatment with prednisone therapy, followed by temporal
artery biopsy. Patients who present with visual symptoms
have a 22-fold increased chance of visual improvement if
therapy is started within the first day.
Further diagnostic workup should not delay the initiation of
steroid therapy. In this patient who is >50 years of age
who develops new-onset headaches with elevated sedimentation rate, temporal arteritis is the probable diagnosis. Available data suggests that when the biopsy is
performed within four weeks of initiating corticosteroid
therapy, the results will be unaffected.
Few studies exist regarding the efficacy of different dosing
protocols for corticosteroids in GCA. Several dosing regimens are recommended depending on the severity of
symptoms.
References
Bhatti MT, Tabandeh H. Giant cell arteritis: diagnosis and
management. Curr Opin Ophthalmol. 2001;12(6):3939
Borchers AT, Gershwin ME. Giant cell arteritis: a review of
classification, pathophysiology, geoepidemiology and
treatment. Autoimmun Rev. 2012;11(67):A544-54.
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Inpatient Medicine
Reference
Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ,
Demaerschalk BM. Guidelines for the early management
of patients with acute ischemic stroke: a guideline for
healthcare professionals from the American Heart
Association/American Stroke Association. Stroke.
2013;44(3):870947.
164. A 47-year-old man has been admitted for an asthmatic
exacerbation. Over the past 2 days, he has developed
fever and erythema at the site of a peripherally inserted
central catheter. He had a catheter placed upon admission. Medical history is also significant for the vancomycin hypersensitivity reaction characterized by
urticaria, bronchospasm, and hypotension.
On physical examination, the temperature is 39.0 C
(102.2 F), blood pressure is 110/80 mmHg, pulse rate
is 107/min, and respiration rate is 21/min. Erythema
and tenderness are noted at the catheter insertion site in
the left antecubital fossa.
Laboratory studies show hemoglobin 8.0 g/dL, leukocyte count 3500/L, with 70 % neutrophils and
platelet count 20,000. Blood cultures reveal growth of
methicillin-resistant Staphylococcus aureus. The vancomycin MIC is >1 g/mL. A chest radiograph and
electrocardiogram are unremarkable. A transthoracic
echocardiogram reveals vegetation on the tricuspid
valve.
Which of the following is the most appropriate
treatment?
A) Cefazolin
B) Clindamycin
C) Daptomycin
D) Nafcillin
E) Vancomycin
Answer: C
This patient has nosocomially acquired methicillin-resistant
Staphylococcus aureus (MRSA) bacteremia, and endocarditis. In addition to catheter removal, this patient
requires a 6-week course of intravenous antibiotics.
Daptomycin is currently approved for treatment for bacteremia and right-sided endocarditis.
Daptomycin has been shown to be non-inferior to standard
therapies in the treatment of bacteremia and right-sided
endocarditis caused by S. aureus. Daptomycin resistance
is still uncommon.
Clindamycin is not included in the consensus guidelines for
treatment of MRSA-associated infective endocarditis.
Clindamycin has a primarily bacteriostatic effect. It has
been associated with treatment failure and relapse when
used to treat methicillin-susceptible S. aureus bacteremia
and infective endocarditis.
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70
Reference
Simonetto DA, Oxentenko AS, Herman ML, Szostek
JH. Cannabinoid hyperemesis: a case series of 98 patients.
Mayo Clin Proc. 2012;87(2):114119.
166. A 54-year-old woman is admitted with episodes of diaphoresis, asthenia, near syncope, and confusion. She reports
these symptoms for several months. These episodes most
commonly occur several hours after she eats. She has no
other significant medical history and takes no medications.
She has checked her glucose with her husbands glucometer and at times it has been below 50 mg/dl.
She is admitted for the confirmation of hypoglycemia. A prolonged fast is begun. During this period the
patient becomes symptomatic. Her serum glucose concentration at the time is 41 mg/dl. The insulin level is
elevated, and no insulin antibodies are present. The
C-peptide level is high. Tests for the use of sulfonylureas and meglitinides are negative.
What is the diagnosis and most effective therapy for
this patients condition?
A) Factitious insulin use, psychiatric consultation.
B) Observe the patient and schedule a follow-up fast 2
to 3 months from now.
C) Begin diazoxide 400 mg TID and verapamil 180 mg
QD.
D) Refer the patient to surgery for imaging and resection.
E) Begin phenytoin and octreotide.
Answer: D
This patient has an insulinoma. C -peptide levels are high in
patients with insulinomas as well as with sulfonylurea
ingestion. Insulinoma is characterized by hypoglycemia
caused by elevated levels of endogenous insulin.
Insulinomas are rare and alternative diagnosis should be
actively pursued in cases of hypoglycemia.
Once a clinical and biochemical diagnosis of insulinoma is
made, the next step is localization. There are several
effective modalities. They include abdominal ultrasound,
triple-phase spiral computed tomography, magnetic resonance imaging, and octreotide scan. This should be
guided by a surgical consultation.
The treatment of choice for insulinomas is surgical removal.
Approximately 9095 % of insulinomas are benign, and
long-term cure with total resolution of preoperative symptoms is expected after complete resection on the lesion.
Medical therapy is less effective than tumor resection but can
be used in patients who are not candidates for surgery.
Diazoxide is the drug of choice because it inhibits insulin
release from the tumor. Adverse effects must be treated
with hydrochlorothiazide. In patients not responsive to or
intolerant of diazoxide, somatostatin may be indicated to
prevent hypoglycemia.
References
Phan GQ, Yeo CJ, Hruban RH, et al. Surgical experience
with pancreatic and peripancreatic neuroendocrine
tumors: review of 125 patients. J Gastrointest Surg.
1998;2(5):47282.
Mathur A, Gorden P, Libutti SK. Insulinoma. Surg Clin
North Am. 2009;89(5):110521
167. A 31-year-old woman is admitted with episodes of dizziness, lightheadedness, palpitations, sweats, anxiety,
and confusion. On the morning of admission, she
reports that she almost passed out. Her husband checked
her blood sugar level and noted it to be low. Her symptoms resolved after drinking some orange juice.
Physical exam is unremarkable and she is admitted
for glucose monitoring. A prolonged fast is started.
After 18 h, she becomes symptomatic, and her blood is
drawn. The serum glucose concentration is 48 mg/dl,
the serum insulin level is high, and test results are negative for insulin antibodies. The C-peptide level is low,
and tests for sulfonylurea and meglitinides are
negative.
Which of the following is the most likely diagnosis
for this patient?
A) Insulinoma
B) Factitious hypoglycemia
C) Noninsulinoma pancreatogenous hypoglycemia
syndrome (NIPHS)
D) Insulin autoimmune hypoglycemia
Answer: B
A review of the medical literature indicates a considerable
increase in the frequency of recognized factitious disorders. This has a significant impact on the practice of hospital medicine. Factitious hypoglycemia should be
considered in any patient who requires a fasting glucose
test. Factitious hypoglycemia, one of the bestcharacterized factitious diseases, is a deliberate attempt to
induce hypoglycemia by means of insulin or oral hypoglycemic drugs. Diagnosis of sulfonylurea-induced hypoglycemia requires the measurement of the drug in the
serum or urine. When a diagnosis of factitious hypoglycemia is suspected, the patients medical records should be
reviewed for similar hospital admissions.
Factitious hypoglycemia is more common in women. It occurs
most often in the third or fourth decade of life. Many of
these patients work in health-related occupations.
Reference
Grunberger G, Weiner JL, Silverman R, et al. Factitious
hypoglycemia due to surreptitious administration of insulin. Diagnosis, treatment, and long-term follow-up. Ann
Intern Med. 1988;108:252257
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References
Del Boca FK, Darkes J. The validity of self-reports of alcohol consumption: state of the science and challenges for
research. Addiction 2003;98(S2):112.
Gleason OC . Delirium. Am Fam Physician. 2003; 67 (5):
102734. 313)
References
PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S,
Curry SH, et al. Natural history and course of acquired
lactic acidosis in adults. DCA-Lactic Acidosis Study
Group. Am J Med. 1994;97(1):4754
Colquitt JL, Pickett K, Loveman E, Frampton GK. Surgery
for weight loss in adults. Cochrane Database Syst Rev.
2014
175. A 72-year-old man presents to the emergency department with severe abdominal distention and pain. He is
found to have a palpable bladder, and after Foley catheter placement, 2.0 L of urine passes. His BUN is
85 mg/dL and creatinine is 7.2 mg/dL on admission.
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Answer: B
Amebic liver abscess is the most common extraintestinal
manifestation of infection with Entamoeba histolytica.
Untreated, it is associated with significant morbidity and
mortality. It has a worldwide distribution, but amebiasis is
more prevalent in tropical areas. E. histolytica is transmitted via the fecal-oral route. It is generally acquired by the
ingestion of contaminated food and water containing the
infective cysts. The incubation period for E. histolytica
infection is commonly 24 weeks but may range from a
few days to years. Most patients with amebic liver abscess
present within 24 weeks of infection and almost all
within 5 months. Some cases may present years after
travel to endemic areas.
The mainstay of therapy is metronidazole, which is usually
effective in eliminating the intestinal and extraintestinal
amoeba. Amebic liver abscess of up to 10 cm can be cured
with metronidazole without drainage. Indications for percutaneous drainage include large liver abscess, abscesses
in the left hepatic lobe at risk for rupturing into the pericardium, and treatment failure. This is defined as fever
and pain persist for 3 to 5 days after the initiation of
therapy.
Reference
Stanley SL Jr. Amoebiasis. Lancet 2003;361:10251034.
178. An 80-year-old woman presents with a two-day history
of persistent vomiting. She is lethargic and weak and
has myalgia. Her mucous membranes are dry. She is
diagnosed as having gastroenteritis and dehydration
and is admitted.
Measurement of arterial blood gas shows pH 7.51,
PaO2 86 mmHg, PaCO2 46 mmHg, and HCO3
38 mmol/L.
What acidbase disorder is shown?
A) Metabolic alkalosis/respiratory acidosis
B) Metabolic alkalosis
C) Respiratory alkalosis
D) Metabolic alkalosis/respiratory alkalosis
E) None of the above
Answer: B
The primary disorder is metabolic alkalosis. Contraction
alkalosis is by far the most common cause in the hospitalized patient. CO2 is the strongest driver of respiration. It
generally will not allow hypoventilation as a full compensation for metabolic alkalosis. An elevated serum bicarbonate concentration may also be observed as a
compensatory response to primary respiratory acidosis. If
continuous removal of gastric contents occurs, gastric
acid secretion can be reduced with H2-blockers or more
efficiently with proton-pump inhibitors.
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This patient should be treated with normal saline and electrolyte replacement. This should be delivered slowly, to
expand the extracellular fluid volume. In this elderly
patient, evidence of volume overload should be followed
closely. As the body rehydrates, the kidneys will excrete
the excess HCO3 and correct the alkalosis.
Reference
HJ, Madias NE. Secondary responses to altered acidbase
status: the rules of engagement. J Am Soc Nephrol
2010;21:920-3ty.
179. A 72-year-old woman has been admitted during the
day for a bronchitis. You are called to see her urgently
for chest pain that night. On physical exam, she has
developed acute pulmonary edema. Blood pressure is
110/60 mmHg. Evidence of myocardial ischemia is
seen on telemetry. An ECG shows ST segment elevation of 3 mm in the precordial leads.
She has no known prior contraindications to thrombolytic therapy.
Which of the following statements regarding thrombolytic therapy is true?
A) Thrombolytic therapy or direct revascularization is
indicated.
B) Thrombolytic therapy is contraindicated because of
her age.
C) Thrombolytic therapy is contraindicated because of
the presence of cardiogenic shock.
D) Thrombolytic therapy will establish antegrade coronary artery perfusion in 75 % of cases.
E) Thrombolytic therapy is contraindicated because of
her low blood pressure.
Answer: A
This patients age or underlying medical condition is not a
contraindication to thrombolytic therapy nor is the presence of cardiogenic shock. Direct revascularization is
preferable if it can be obtained quickly.
Patients who develop cardiogenic shock because of a myocardial infarction have high mortality rates. Mortality can be
lowered from 85 % to less than 60 % if flow can be reestablished in the infarct-related artery. Thrombolytic therapy is
able to achieve this in only 50 % of cases. Percutaneous
angioplasty has a higher success rate. If angioplasty is not
available or delayed, thrombolytic therapy is indicated.
O'Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF/
AHA Guideline for the Management of ST-Elevation
Myocardial Infarction: A Report of the American College
of Cardiology Foundation/American Heart Association
Task Force on Practice Guidelines. Circulation.
2013;127:e362-e452.
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Answer: B
This
patient
has
gallstone-induced
pancreatitis.
Ultrasonography of the abdomen is the most useful initial
test in determining the etiology of pancreatitis. It is more
sensitive than CT for the diagnosis of gallstone disease.
CT is better at demonstrating morphologic changes in the
pancreas caused by inflammation. It is generally indicated
in those with severe pancreatitis. Findings on plain film
are of little benefit. ERCP can be useful in the management of pancreatitis but has no role in diagnoses.
His age and elevated total bilirubin make alcohol a less
likely cause. The median age at onset depends on the
etiology. For alcohol, it is 39 and for biliary tract disease
it is 69.
References
Telem DA, Bowman K, Hwang J, Chin EH, Nguyen SQ, Divino
CM. Selective management of patients with acute biliary
pancreatitis. J Gastrointest Surg. 2009;13(12):21838.
Tenner S, Baillie J, Dewitt J, et al. American College of
Gastroenterology Guidelines: Management of Acute
Pancreatitis. Am J Gastroenterol. Jul 30 2013
182. A 75-year-old male presents with bright red blood per
rectum. He states he has had bleeding for the past eight
years for which he has been admitted several times to
various hospitals outside of the current state. He occasionally is transfused during these admissions. He has
had several colonoscopies but reports they are always
normal. He reports no weight loss and, otherwise, is
enjoying good health.
The most likely diagnosis is:
A) Diverticula
B) Arterial venous malformations
C) Malignancy
D) Hemorrhoids
Answer: B
Arterial venous malformations (AVM) are a common cause
of lower intestinal bleeding. Over half are located in the
right colon, and approximately 50 % of patients experience painless hematochezia. Colonic lesions most often
bleed chronically and slow. However, as many as 15 % of
patients present with acute massive hemorrhage. AVMs
can be acute, chronic, and intermittent in nature.
Angiography is considered the gold standard in diagnosing arterial venous malformations.
Management of AVMs is often difficult. Electrocautery has
been used to obliterate angiodysplasias. However, bleeding recurs in approximately 50 % of subjects. A reduction
in the posttherapy transfusion requirements in patients
cauterized was not reported to be statistically superior to
no therapy.
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Answer: B
The most likely cause of this patients hypernatremia is diabetes insipidus (DI). Nonresponse to vasopressin indicates a nephrogenic source. Generally, lithium
nephrotoxicity will occur within a month of the onset of
use of the drug. The first symptoms are usually polyuria
and polydipsia. This may also occur in the presence of
accelerating dose regimens.
Correcting electrolyte abnormalities is the first step in
management. Treatment should be initiated with normal saline at 200250 cm3/hour to replete hypovolemia
This should be followed by administration of hypotonic
fluid.
For patients with greater degrees of lithium toxicity, dialysis
is indicated. Diuretics and NSAIDs are used in the longterm treatment of stable lithium-induced nephrogenic diabetes insipidus.
Reference
Garofeanu CG, Weir M, Rosas-Arellano MP, et al. Causes of
reversible nephrogenic diabetes insipidus: a systematic
review. Am J Kidney Dis. 2005;45(4):62637.
188. A 28-year-old woman is evaluated in the emergency
department because of dizziness for the last week. She
has not experienced chest pain, dyspnea, or orthopnea.
She was ill six weeks ago with fever, fatigue, and myalgias. Her husband reports an erythematous rash on her
abdomen that resolved over two weeks. She has no significant medical history and is on no medicines. Her
travel history is significant for a camping trip seven
weeks ago.
On physical examination, temperature is normal,
blood pressure is 126/65 mmHg, and pulse rate is 42/
min. The cardiac examination reveals bradycardia. The
remainder of the physical examination is normal.
An electrocardiogram shows variable heart block
and a junctional escape rate of 50/min. She is admitted
to the telemetry unit.
Which of the following would be the initial appropriate treatment?
A) Electrophysiology study
B) Intravenous ceftriaxone
C) Permanent pacemaker placement
D) Temporary pacemaker placement
E) No treatment until further serological testing
Answer: B
This patient should be treated with intravenous ceftriaxone.
Patients with atrioventricular (AV) heart block with early
Lyme disease may be treated with either oral or parenteral
antibiotic therapy for 14 days. Continuous monitoring is
advisable for patients with second- or third-degree heart block.
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The prognosis is good, usually with the resolution of atrioventricular block within days to weeks. Ceftriaxone is the drug
of choice followed by a 21-day course of oral therapy.
Temporary pacing would be required if the patient were
hemodynamically unstable with bradycardia. However,
this rarely occurs.
Patients with probable erythema migrans and a recent tick
exposure should be started with treatment without blood
tests. For serologic testing, the CDC recommends a twotier testing procedure. An ELISA test can be done initially
followed by confirmation with Western blot testing.
Reference
Cameron DJ, Johnson LB, Maloney EL. Evidence assessments and guideline recommendations in Lyme disease:
the clinical management of known tick bites, erythema
migrans rashes and persistent disease. Expert Rev Anti
Infect Ther. 2014;12(9):110335.
189. A 72-year-old man with a history of COPD and hypertension is admitted for severe lower back pain that
began suddenly two days ago. He also reports an unexplained syncopal episode. Since that time, he has had
vague lower abdominal and back discomfort.
On physical examination, temperature is 37.4 C
(99.3 F), blood pressure is 110/65 mmHg, pulse rate is
96/min and regular, and respiration rate is 18/min.
Abdominal examination shows moderate tenderness
upon palpation in the infraumbilical and suprapubic
regions. Some mild local distension is noted in that
area. Findings on rectal examination are unremarkable,
with guaiac-negative stool.
Laboratory results include hematocrit of 34 %.
Results of liver chemistry studies and urinalysis are
normal. Plain abdominal radiograph shows no free air
or air-fluid levels. Computed tomography of the abdomen is pending.
Which of the following is the most likely diagnosis?
A) Acute myocardial infarction
B) Diverticulitis
C) Nephrolithiasis or renal colic
D) Ruptured abdominal aortic aneurysm
E) Incarcerated hernia
Answer: D
This patient has a classical presentation of a locally contained
ruptured aortic abdominal aneurysm. Severe abdominal or
back pain with syncope, followed by vague discomfort, is
typical. Patients at greatest risk for abdominal aortic aneurysms are those who are older than 65 years and have
peripheral atherosclerotic vascular disease. The temporary
loss of consciousness is also a potential symptom of rupture.
The most typical manifestation of rupture is the acute onset
80
FiO2: 100 %
PEEP: 0 cm H2O
Reference
Archambault PM, St-Onge M. Invasive and noninvasive ventilation in the emergency department. Emerg Med Clin
North Am. 2012;30(2):42149,
191. You are called to see a 24-year-old patient on the floor
which has become markedly obtunded. He was recently
admitted two hours ago for possible suicide attempt by
ingestion of an unknown substance. His respiratory status
was good on admission but he is having difficulty handling secretions and a decision is made to intubate him
urgently. Chest radiograph on admission was normal.
Initial tidal volumes (TV) on the ventilator should
be set to what setting?
A) 4 ml/kg
B) 6 ml/kg
C) 10 ml/kg
D) 12 ml/kg
Answer: B
Synchronous intermittent mandatory ventilation (SIMV) and
assist-control ventilation (A/C) are versatile modes that
can be used for initial settings. Lower tidal volumes (TV)
are recommended than in the past years, when tidal volumes of 1015 mL/kg were routinely used. This is thought
to reduce barotrauma.
An initial TV of 58 mL/kg of ideal body weight is generally
recommended. The lower range is recommended in the
presence of obstructive airway disease and ARDS. The
goal is to adjust the TV so that plateau pressures are less
than 35 cm H2 O.
Reference
Hess DR, Thompson BT. Ventilatory strategies in patients
with sepsis and respiratory failure. Curr Infect Dis Rep.
Sep 2005;7(5):3428.
192. Clindamycin as compared to trimethoprimsulfamethoxazole in the treatment of uncomplicated soft tissue infections resulted in what outcomes?
A) Improved outcome
B) More side effects
C) Worse outcomes
D) Less side effects
E) None of the above
Answer: E
Outpatients with uncomplicated skin infections who took
clindamycin or a trimethoprimsulfamethoxazole combination (TMP-SMX) experienced similar benefits and
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82
on room air. There are no focal neurologic abnormalities, but neck stiffness is noted.
Empiric treatment is initiated with ampicillin, ceftriaxone, and vancomycin.
Complete blood count reveals a leukocyte count of
21,000/L. Noncontrast computed tomographic scan
of the head is normal. Blood cultures are obtained.
A lumbar puncture is performed, and the cerebrospinal fluid (CSF) examination reveals that leukocyte
count is 950/L with 85 % neutrophils and 20 % lymphocytes; the protein level is 95 mg/dL; and the glucose level is 15 mg/dL. Gram stain of the CSF reveals
gram-positive bacillus. She improves in the first 12 h of
treatment.
This patients antibiotic regimen should be narrowed to intravenous administration of which of the
following?
A) Ampicillin
B) Ceftriaxone
C) Vancomycin
D) No change of antibiotic regimen
Ampicillin is included in empiric therapy for bacterial meningitis in patients who are at risk for developing invasive
infections with this Gram-positive bacillus. L. monocytogenes meningitis develops most frequently in neonates,
older adults (>50 years of age), and those who are immunocompromised. Cases have been reported in patients
with no underlying disorders.
Although Listeria may cause a limited gastrointestinal
syndrome, there are few clinical features distinguishing
the presentation Listeria meningitis from other acute
bacterial meningitides. Foods that have sometimes
caused outbreaks of Listeria include hot dogs, deli
meats, pasteurized or unpasteurized milk, cheeses, raw
and cooked poultry, raw meats, ice cream, raw fruits,
and smoked fish.
Gram stain is positive approximately 50 % of the time and
culture is positive nearly 100 % of the time. Meningitis is
often complicated by encephalitis, a pathology that is
unusual for bacterial infections. Patients should be treated
for three weeks.
Reference
Cherubin CE, Appleman MD, Heseltine PN, Khayr W,
Stratton CW. Epidemiological spectrum and current treatment of listeriosis. Rev Infect Dis. 1991;13(6):110814
197. A 72-year-old woman is admitted with worsening
behavior that her husband is having a difficult time
managing.
She has had progressive behavioral change over the
course of two years. Recently, she has begun eating
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198. A 58-year-old male is transferred from an outside hospital because of ascites and worsening renal function.
He has hepatitis C cirrhosis, portal hypertension, and
near end-stage liver disease. Contrast-enhanced computed tomography of the abdomen was performed at
the outside hospital 3 days before transfer because of
abdominal pain. His oral fluid intake has been restricted.
Urine output in the past 24 h is 300 mL.
On physical examination today, he is afebrile. Pulse
rate is 75 per minute, and blood pressure is
100/70 mmHg. Decreased breath sounds are noted in
the bases of both lungs. He has tense ascites, no worse
than his baseline and pitting edema (3+) in his legs.
His MELD score is 25. Creatine is 5.1 g/dl with a
baseline of 1.5 two weeks ago.
Paracentesis reveals a peritoneal fluid leukocyte
count of 1672/L.
Which of the following is the most important next
step in this patients management?
A) Trial of octreotide and midodrine
B) Nephrology consultation
C) Listing for emergency liver transplantation
D) Fluid challenge test
E) Hemodialysis
Answer: D
Requirements for the diagnosis of hepatorenal syndrome
(HRS) include a doubling of the serum creatinine level and
at least a 1.5 L fluid challenge. This should be considered
despite the presence of ascites. Urgent transplantation or
hemodialysis may be considered after HRS has been
established. Octreotide and midodrine may be of some
limited benefit once the diagnosis of HRS has been made.
Reference
Hasper D, Jorres A. New insights into the management of hepato-renal syndrome. Liver Int. 2011;31(Suppl 3):2730
199. A 39-year-old woman is admitted for diarrhea. The purpose of the admission is to quantify and document her diarrhea before and after a fast has begun. She has been seen in
clinic for diarrhea many times in the past two months.
She reports that the diarrhea has been present since she
developed a presumed food-borne illness three months ago.
At that time, she had severe nausea, vomiting, and watery
diarrhea for two days. Although her symptoms improved,
she has continued to have episodic diarrhea with four to five
watery stools each day, often following meals. She also has
had excessive flatus and abdominal distension over the past
two months. She denies nocturnal stools, weight loss, fever,
or blood in her stool. She denies any recent antibiotics.
Medical history is notable for diabetes, hypertension, and a
cholecystectomy performed two years ago.
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85
Answer: D
This patient is at high risk for Pseudomonas pneumonia.
The most appropriate empiric antibiotic therapy for this
patient is vancomycin, piperacillin/tazobactam, and
amikacin. Pseudomonas pneumonia is observed in
patients with immunosuppression and chronic lung disease. It can be acquired nosocomially in the intensive
care unit (ICU) setting and is associated with positivepressure ventilation and endotracheal tubes. Other risk
factors for Pseudomonas pneumonia include broadspectrum antibiotic use in the previous month, recent
hospitalization, malnutrition, neutropenia, and glucocorticoid use.
Most guidelines recommend starting with two anti pseudomonal antibiotics and then de-escalating to monotherapy
in five days. It remains controversial whether combination therapy is more efficacious than monotherapy.
Combination therapy has been recommended to broaden
the empiric coverage and prevent the emergence of antibiotic resistance during therapy.
Answer: D
The patient presents with a clinical picture that is consistent
with acute prostatitis. If there is no clinical improvement
after 36 to 72 h of treatment, the most likely cause is a
complication, such as a prostatic abscess. Appropriate
management for this patient is a transrectal ultrasound to
evaluate for a prostatic abscess. If a prostatic abscess is
identified, ultrasound-guided or surgical drainage may be
indicated.
Causative organisms of acute prostatitis in older men are
usually Gram-negative bacteria, with Escherichia coli
being the most common. Transurethral catheterization
should be avoided in acute prostatitis. If bladder drainage is necessary, suprapubic drainage may be considered to reduce the risk of prostatic abscess and
septicemia. Furthermore, there is no indication for
placement of a bladder catheter, such as outflow
obstruction.
At one time prostate massage was believed to be therapeutically useful as a treatment for acute prostatitis.
Vigorous massage of the prostate should be avoided in
acute prostatitis. It is not helpful diagnostically or
therapeutically.
References
Chamot E, Boffi El Amari E, Rohner P, Van Delden
C. Effectiveness of combination antimicrobial therapy for
Pseudomonas aeruginosa bacteremia. Antimicrob Agents
Chemother. 2003;47(9):275664.
Cunha BA. Pseudomonas aeruginosa: resistance and therapy.
Semin Respir Infect. 2002;17:231239.
Reference
Ludwig M, Schroeder-Printzen I, Schiefer HG, Weidner
W. Diagnosis and therapeutic management of 18 patients
with prostatic abscess. Urology.1999;53:340345.
86
medical history of chronic obstructive pulmonary disease. Vasopressors were needed but now have been
stopped. She has been transferred to the floor. The
patient now has fluctuating level of consciousness. She
has no prior history of dementia. She does not consistently follow commands and, at times, appears confused.
She has no focal neurologic findings. Her lungs are
cleared upon auscultation. The last time that she received
a narcotic and sedatives was in the ICU 2 days ago.
Which of the following should you do now?
A) Obtain an electroencephalogram.
B) Obtain a computed tomography scan of the head.
C) Start an antipsychotic medication.
D) Start a benzodiazepine.
E) Rapidly taper the corticosteroids.
Answer: E
Corticosteroids are associated with delirium and when possible should be either rapidly tapered or stopped. They are
often overused in the hospital setting. In this patient, no
clear indication exists for continued steroid use and rapid
taper may resolve the delirium.
Steroid psychosis may be dose dependent. In one study
patients receiving more than 80 mg/day of prednisone or
its equivalent had an 18.4 % incidence of steroid
psychosis.
Reference
Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium
in adult patients in the intensive care unit. Crit Care Med.
2013;41:263306
205. A 58-year-old female presents with right upper quadrant pain, leukocytosis, and fever. CT scan reveals a
gangrenous gallbladder and emergency surgery is recommended. She is on warfarin for atrial fibrillation but
has not had levels checked in over two months. Her
INR is 6. Some bleeding from her gums is noticed.
Despite extensive conversations, she refuses any blood
product that has any chance of transmitting a virus.
The best agent to administer is:
A) Fresh frozen plasma (FFP)
B) Prothrombin complex concentrate (PCC)
C) Recombinant factor VII
D) Vitamin K
Answer: B
Prothrombin complex concentrates (PCC) may be used as
therapy for the patient who has bleeding related to vitamin K antagonists. In 2013, the FDA approved PCC therapy in adult patients needing an urgent surgery or other
invasive procedure.
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Answer: A
Middle Eastern respiratory syndrome (MERS) is an emerging concern among recent travelers to the Middle East.
The incubation time is 5.2 days. The interval is 7.6 days.
It is only a possibility in a patient who has had traveled
within 14 days to the Middle East.
MERS presents with a nonspecific triad of cough, fever, and
shortness of breath. Most individuals with confirmed
MERS have developed significant acute respiratory illness.
There has been a reluctance among some countries to provide accurate statistics concerning MERS. Among the
probably underreported 536 cases reported through May
12, 2014, the mortality rate has been 30 %.
Diagnosis for MERS is best done using polymerase chain
reaction (PCR) testing of induced sputum or blood.
Serology, which is not widely available, can identify previous exposure.
References
Arabi YM et al. Clinical course and outcomes of critically ill
patients with Middle East respiratory syndrome coronavirus infection. Ann Intern Med 2014;160(6):389397.
de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C,
Enjuanes L, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus
Study Group. J Virol. 2013;87(14):77902.
210. A 48-year-old man is admitted for increasing shortness
of breath. This admission is thought to be multifactorial
including volume overload, reactive airway disease, and
pulmonary hypertension. He has a history of sleep apnea
and he is obese. The patient also has hypertension and
hyperlipidemia. He drinks on average one alcoholic beverage every three days. He takes no medications.
On physical examination diffuse mild crackles are
heard with 1+ lower extremity edema. The abdomen is
soft and nontender.
Laboratory studies reveal an ALT of 107 U/L and an
AST of 95 U/L. Serum bilirubin is 0.5 mg/dL. Serum
alkaline phosphatase is 78 U/L. Hepatitis A, B, and C
serologies are negative.
Which of the following is the most likely cause of
his elevated liver functions?
A) Alcoholic hepatitis
B) Autoimmune hepatitis
C) Gallbladder inflammation
D) Liver cancer
E) Nonalcoholic fatty liver disease
F) Congestive heart failure
Answer: E
Nonalcoholic fatty liver disease(NAFLD) is the most common cause of elevated liver enzymes in American adults.
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90
References
Tadi JM, Heming N, Serve E, Weiss N, Day N, Imbert A,
et al. Drowning associated pneumonia: a descriptive
cohort. Resuscitation. 2012;83(3):399401.
Wood C. Towards evidence-based emergency medicine: best
BETs from the Manchester Royal Infirmary: BET 1: prophylactic antibiotics in near-drowning. Emerg Med J
2010;27:393394.
213. A 68-year-old female is admitted to the hospital for
symptoms of shock. She has a history of recurrent
pyelonephritis and that is the presumed source of her
sepsis. Other history is significant for hypertension.
Physical examination reveals pulse rate of 130 per
minute and blood pressure of 62/45 mmHg. She is
lethargic, and her extremities are cool.
Fluid resuscitation is started with 0.9 % sodium
chloride and albumin. In addition, vasopressor therapy
with norepinephrine is started because the patients calculated mean arterial pressure (MAP) is only 48 mmHg.
Urine and blood cultures are pending. Intravenous
antibiotic therapy is started.
Which of the following is the most likely result of
increasing this patients MAP to high blood pressure
target of 75 mmHg as opposed to a low blood pressure
target of 65 mmHg?
A) Reduced need for renal replacement therapy.
B) Decreased risk of a cardiac arrhythmia.
C) Mortality will be improved.
D) Increased need for renal replacement therapy.
Answer: A
The specific target blood pressure of a patient with septic
shock is complex. All authorities recommend fluid resuscitation as the first form of therapy. The traditional pressure target is a (MAP) of 6570 mmHg. A recent study
has shown that the level of MAP targeted makes no difference in the outcomes of patients. There may be reasons to
target a higher MAP in patients with preexisting hypertension since perfusion may decrease in these patients at
a higher MAP.
In a recent study, MAP higher than 75 was associated with a
reduced need for renal replacement therapy. This target also
caused an increased incidence of atrial arrhythmias.
Reference
Asfar P, Meziani F, Hamel J-F, et al. High versus low bloodpressure target in patients with septic shock. N Engl J
Med. 2014;370:15841593.
214. A 65-year-old man has a long-standing history of
hypertension. His current medications are accupril
(40 mg daily), amlodipine (10 mg daily), and metoprolol (100 mg twice daily).
Inpatient Medicine
Answer: A
Intoxication with bath salts and similar derivatives (synthetic cathinones) have been increasingly reported.
Patients exhibit extreme agitation, hallucinations, and
manic behavior that often leads to dehydration and excessive muscle breakdown. There have been reports of associated acute kidney injury, secondary to acute tubular
necrosis due to rhabdomyolysis. Recommended treatment is aggressive volume repletion.
References
Adebamiro A, Perazella MA. Recurrent acute kidney injury
following bath salts intoxication. Am J Kidney Dis.
2012;59(2):273275.
Ross EA, Watson M, Goldberger B. "Bath salts" intoxication. NEJM. 2011;365:967968.
216. A 78-year-old female with type I diabetes presents
with a cellulitis and a chronic ulcer of her great toe. She
reports the ulcer has been present for several weeks and
lately her entire foot has become erythematous.
On physical examination a 5 cm by 8 cm. Ulcer is
observed on her right great toe. There is surrounding
edema. On magnetic resonance imaging changes consistent with necrosis and osteomyelitis are noted in the
first metatarsal. Podiatry is consulted. At this time, no
surgical intervention is planned.
What is the expected duration and route of antibiotics for this patient?
A) Two weeks of parenteral antibiotics
B) Six weeks of oral antibiotics
C) Three months of parenteral and oral antibiotics
D) Two months of parenteral antibiotics
Answer: C
The choice for diabetic foot infections (DFI) can be complex.
The current practice that is beginning to emerge is that the
role of parenteral antibiotics may be primarily to treat
acute, severe soft tissue infection, which may be life- or
limb-threatening, followed by transition to oral antibiotics.
Treating chronic osteomyelitis is not an urgent matter, and
the results may be just as good and more cost-effective
with oral antibiotics as opposed to parenteral therapy. The
recommended duration of antibiotic therapy for bone
infections if identified has traditionally been six weeks.
The Infectious Diseases Society of America (ISDA) clinical
practice guidelines for the diagnosis and treatment of
DFIs are useful for estimating the length of therapy
required based on the extent of the infection and viability
of affected bone. Initial parenteral and then switching to
oral for at least three months may be appropriate for a
patient who will not undergo extensive resection of the
infected bone. Current guidelines recommend at least
three months or more of antibiotic therapy when diabetic
91
foot osteomyelitis is not treated surgically or when residual dead bone remains after surgery.
A definitive plan cannot be established at time of diagnoses,
and close follow-up must be arranged to modify therapy
as needed based upon cultures and healing response..
Reference
Lipsky BA, Berendt AR, Deery HG et al. Infectious Diseases
Society of America. Diagnosis and treatment of diabetic
foot infections. Clin. Infect. Dis.2004 39, 885910.
217. A 33-year-old male athlete who is in excellent health
presents with headache, nausea, and cramping abdominal pain three hours into a triathlon being held in July.
He reports drinking water at every station. He takes no
medications and otherwise enjoys good health.
On physical exam, the patient is anxious, diaphoretic, has a headache, and feels lightheaded. His temperature is 37.1 C (98.8 F). Heart rate is 90 bpm,
respirations are 20 per minute, and blood pressure is
110/80 mmHg. Mucous membranes are dry, and skin is
warm and clammy. Lungs are clear. No peripheral
edema is noted.
His sodium is 115 mEq/L; bicarbonate is 21 mEq/L.
Which of the following is the most appropriate initial intravenous therapy for this patient?
A) Infuse 0.9 % sodium chloride at 100 mL/h.
B) Infuse 0.9 % sodium chloride at 200 mL/h.
C) Administer 100-mL boluses of 3 % sodium chloride every 10 min for up to three boluses or until
her symptoms resolve.
D) Fluid restriction alone.
Answer: C
This patient has early signs of encephalopathy from exerciseassociated hyponatremia (EAH). This is a dilutional
hyponatremia due to excessive intake of hypotonic fluids.
Rapid correction of the serum sodium with hypertonic
saline is required to avoid further brain swelling, seizures,
and death. The clinical manifestations of EAH-induced
hyponatremia include dizziness, nausea, and vomiting to
seizures, coma, and death. Hyponatremic patients with
mild to moderate symptoms should be treated with fluid
restriction and observed.
A study conducted on participants of the 2002 Boston
Marathon found that thirteen percent finished the race with
hyponatremia. Hyponatremia was just as likely to occur in
runners who chose sports drinks as those who chose water.
References
Bennett BL, Hew-Butler T, Hoffman MD, Rogers IR, Rosner
MH. Wilderness Medical Society practice guidelines for
treatment
of
exercise-associated
hyponatremia.
Wilderness Environ Med. 2013;24(3):228240.
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Inpatient Medicine
symptoms of dyspepsia, individual symptoms of postprandial fullness, early satiation, and upper abdominal
bloating.
Reference
Tack J, Janssen P, Masaoka T, et al. Efficacy of buspirone, a
fundus-relaxing drug, in patients with functional dyspepsia. Clin Gastroenterol Hepatol. 2012;10:12391245.
93
94
Answer: E
Many drugs are implicated in interstitial nephritis, including antibiotics, proton-pump inhibitors, allopurinol,
and NSAIDs. NSAID-induced interstitial nephritis
presents with the absence of eosinophils on urine
microscopy.
With the exceptions of interstitial nephritis induced by
NSAIDs, patients commonly present with rash, fever,
eosinophilia, eosinophiluria, and elevated immunoglobulin E (IgE) levels.
Recovery in renal function is usually observed after cessation of the offending agent. Implementing a short course
of steroid therapy is generally recommended for patients
that do not have a rapid recovery. No controlled studies
exist on the effect of corticosteroids. Most practitioners
recommend a relatively high dose with a rapidly tapering
regimen within several weeks.
Reference
De Broe ME, Elseviers MM. Over-the-counter analgesic use.
J Am Soc Nephrol. 7 2009
224. A 62-year-old female is evaluated for a 5-week history
of nonproductive cough and fatigue over the past several months. The patient underwent resection of localized rectal carcinoma 16 months ago. This was
followed by chemotherapy and radiation therapy. Chest
radiograph at that time was normal.
Chest radiograph now shows multiple pulmonary
nodules. Contrast-enhanced CT scan of the chest shows
three nodules ranging from 1.6 to 1.9 cm in diameter.
Two nodules are in the right lung, and one is in the left
lower lobe.
What is the most appropriate next step in the management of this patient?
A) Bronchoscopy and biopsy
B) PET scan
C) Transthoracic needle aspiration of a nodule
D) Observe for now and repeat CT chest in 3 months
E) Video-assisted thoracoscopic surgery (VAT)
Answer: C
The reported yield for transthoracic needle aspiration is
about 90 % for nodules of 1 to 2 cm compared to less than
50 % for bronchoscopy. The diagnostic yield of fiberoptic
bronchoscopy depends on the lesion location and size.
The diagnostic yield for lesions greater than 3 cm in
diameter by bronchoscopy is 80 %. For lesions located in
the lower lobe, basilar segments or in the apical segments
of the upper lobes, yield is 58 %, compared with 83 % for
other locations. CT-guided transthoracic needle biopsy
would have significantly higher yield for nodules of this
size than would bronchoscopy.
Reference
Lacasse Y, Wong E, Guyatt GH, Cook DJ. Transthoracic needle
aspiration biopsy for the diagnosis of localized pulmonary
lesions: a meta-analysis. Thorax. 1999;54(10):88493.
225. You are called to see a patient on the cardiology service
with right-sided weakness. He is a 75-year-old male
who underwent cardiac catheterization procedure
because of typical chest pain presentation. A coronary
angiogram revealed significant in-stent restenosis,
which was managed by balloon angioplasty. The
patient was given 300 mg of Plavix in the catheterization lab.
On physical exam, his blood pressure is
180/95 mmHg, heart rate of 110 BPM, and his temperature was normal. Cardiac and chest examination
are normal. On neurologic examination, the right side
of the body is 3/5, while the left side is 5/5. The patient
denies chest pain, no nausea, or vomiting.
What is your next step in management?
A) MRI of the head
B) CT angiogram of the chest
C) Start tissue plasminogen activator (TPA)
D) Carotid Doppler ultrasound
E) Transesophageal echocardiogram (TEE)
Answer: A
Ischemic stroke related to catheterization should be suspected in a patient who develops neurologic symptoms
during or immediately post catheterization. MRI of the
head would be appropriate to diagnose the stroke early as
CT scan may miss early changes.
In most cases, the etiology is felt to be embolic due to atherosclerotic debris and not thrombus, and therefore acute
therapy with systemic thrombolysis is not routinely
performed.
CT angiogram of the chest will help in diagnosing aortic dissection, which may also complicate cardiac catheterization. This patient did not have chest pain to suggest
dissection.
Reference
Lazar JM, Uretzky BF, Denys BG, et al. Predisposing risk
factors and natural history of acute neurologic complications of left-sided cardiac catheterization. Am J Cardiol
1995;75:1056--1060.
226. You are the admitting hospital medicine physician in
the emergency room. A previously healthy 25-year-old
woman presents with a one-week history of polyuria,
polydipsia, and 20-lb weight loss. On the day of presentation, she developed nausea and abdominal pain.
Emergency room staff asks you to assess the patient.
Inpatient Medicine
95
Answer: B
This patient has choledocholithiasis with possible obstruction. At the current time there is no evidence of cholangitis. Her current laboratory workup reveals a decline in the
degree of obstruction consistent with a passed stone. An
emergent ERCP or cholecystostomy is not indicated at
this time. The best plan for this patient would be to hold
clopidogrel and proceed with an elective inpatient ERCP
with sphincterotomy and stone extraction after seven
days. An ERCP done while on clopidogrel would make
sphincterotomy risky. In the interim, antibiotics may be
started and observed for obstruction requiring urgent
decompression or ERCP without sphincterotomy.
Reference
Cotton PB, Garrow DA, Gallagher J, Romagnuolo J. Risk
factors for complications after ERCP: a multivariate analysis of 11,497 procedures over 12 years. Gastrointest
Endosc. 2009;70(1):808.
228. An 82-year-old female presents with a chief complaint of shortness of breath. She states that two
weeks prior, she describes a viral-type upper respiratory illness. On presentation, she is noted to have a
multilobar loculated infiltrates. Blood cultures taken at
the time of admission grow out methicillin-resistant
Staph. aureus (MRSA). She reports a significant
allergy to vancomycin.
Her temperature on presentation is 39 C
(102.2 F), pulse rate is 120 per minute, respirations
are 30 per minute, and blood pressure is 110/60.
Diffuse crackles are noted throughout her left and
right lung fields. Cardiac examination reveals
tachycardia.
Which of the following is the most appropriate medications for this patients presumed MRSA pneumonia?
A) Vancomycin
B) Daptomycin
C) Linezolid
D) Ceftriaxone and erythromycin
E) Clindamycin
Answer: C
United States guidelines recommend either linezolid or vancomycin as the first-line treatment for hospital-acquired
(nosocomial) MRSA pneumonia. Some studies have suggested that linezolid is better than vancomycin against
probable MRSA nosocomial pneumonia. This may be due
to the fact that the penetration of linezolid into bronchial
fluids is much higher than that of vancomycin. However
this is debated.
Daptomycin is inhibited by pulmonary surfactant and this is
not indicated here.
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Reference
Vilhena C, Bettencourt A. Daptomycin: a review of properties, clinical use, drug delivery and resistance. Mini Rev
Med Chem 2012;12:2029.
229. A 47-year-old man is admitted to the hospital with an
acute decompensation of his alcoholic-related cirrhosis.
He presents to the emergency room confused with ascites.
On physical exam, he is clearly jaundiced with
icteric sclera. Additionally, he has a distended abdomen
with a fluid wave on physical exam. There is poor skin
turgor. He has asterixis on extension of his hands.
Preliminary workup reveals an ammonia level of
110 mg/dL, a total bilirubin of 7.1, an INR of 1.6, and
a platelet count of 95,000. The potassium level is 3.1,
BUN is 37, and creatinine is 1.5.
Which of the following is NOT likely to be contributing to this patients confusion?
A) Bacterial infection of the ascites
B) Hypokalemia
C) Acute kidney injury
D) Volume depletion
E) Jaundice
Answer: E
The morbidity and mortality associated with elevated conjugated hyperbilirubinemia result from the underlying disease process. Conjugated bilirubin causes no direct
toxicity to neural tissue in adults.
Bilirubin levels often correlate strongly with, but do not contribute to, short-term mortality.
Bacterial infections, including spontaneous bacterial peritonitis, dehydration, acute renal failure, electrolyte abnormalities, and metabolic acidosis are all very common
causes of worsening hepatic encephalopathy.
Reference
Bustamante J, Rimola A, Ventura PJ, Navasa M, Cirera I,
Reggiardo V, et al. Prognostic significance of hepatic
encephalopathy in patients with cirrhosis. J Hepatol.
1999;30(5):8905.
230. A 58-year-old male is admitted for worsening ascites.
His past medical history is significant for chronic hepatitis C and hypertension. He denies nausea or vomiting.
On physical examination, he is afebrile, blood pressure is 110/70 mmHg, heart rate is 100 bpm, and respiratory rate is 22/min. There is ascites and bipedal
pitting edema. Lung auscultation reveals minimal
crackles in both lung bases. Laboratory test reveals a
serum creatinine of 3.7 mg/dL. Furosemide was
stopped. He was given 1.5 l of isotonic saline with no
improvement of his renal function.
Which of the following is the most appropriate diagnostic test to perform next?
A) Paracentesis
B) Serum osmolality
C) Urine electrolytes and urine creatinine
D) ALT and AST
E) Renal ultrasound
Answer: C
This patient has possible hepatorenal syndrome. Urine electrolytes and urine creatinine should be performed to
calculate the fractional excretion of sodium (FENa).
A FENa value below 1 % would suggest prerenal causes,
such as hepatorenal syndrome or hypovolemia. A repeat
fluid challenge may help rule out hypovolemia as a cause.
Reference
Moreau R, Lebrec D. Diagnosis and treatment of acute renal
failure in patients with cirrhosis. Best Pract Res Clin
Gastroenterol. 2007;21(1):11123.
231. A 64-year-old male with no prior medical history had a
witnessed arrest and was found to have ventricular fibrillation. He was successfully resuscitated and was admitted
to the hospital medicine service. All tests done on admission were within normal limits. Cardiac catheterization
was performed and revealed nonobstructive coronary
artery disease. He has no residual neurologic deficits.
What is the next step in management?
A) Discharge the patient on metoprolol.
B) Intracardiac defibrillator implantation.
C) Electrophysiology study.
D) Cardiac MRI.
E) 24-h home halter monitor.
Answer: B
The patient had survived a cardiac arrest with no obviously
reversible cause of his ventricular fibrillation. According
to American College of Cardiology (ACC) guidelines,
intracardiac defibrillator implantation is indicated for secondary prevention. This is a class 1 recommendation.
Reference
Epstein AE, Dimarco JP, Ellenbogen KA, et al. ACC/AHA/
HRS 2008 Guidelines for device-based therapy of cardiac
rhythm abnormalities. Heart Rhythm. 2008;5(6):e1-62.473)
232. A 72-year-old female is admitted for a three-week rash
not improving with topical steroids. He has a past medical history of hypertension and hyperlipidemia and has
smoked at least one pack per day for the last 40 years. He
is on lisinopril 20 mg daily and simvastatin 40 mg at and
has been taking these medications for the last 5 years.
Inpatient Medicine
97
References
Heyde EC (1958). Gastrointestinal bleeding in aortic stenosis. N. Engl. J. Med.1958.259 (4): 19
Warkentin TE, Moore JC, Morgan DG (1992). "Aortic stenosis and bleeding gastrointestinal angiodysplasia: is
acquired von Willebrand's disease the link?". Lancet 340
(8810): 357
234. A 71-year-old man with a history of congestive heart
failure, EF 30 %, and hypertension was admitted five
days ago for septic shock due to pneumonia. He was
intubated but is now extubated. He is now hemodynamically stable.
The patient developed the new onset of persistent
abdominal pain and bloody stool. Urgent C-scope
revealed ischemic colitis. He is doing better, blood
counts are stable but remains lethargic. No nutrition
has been started yet.
Which of the following would be the most appropriate nutritional support?
A) No nutrition
B) Post-pyloric feedings
C) Peripheral parenteral nutrition
D) Intragastric tube feeding
E) Central parenteral nutrition
Answer: E
The patient has been on NPO for five days. His ability to
have an adequate oral intake in the next few days is
unlikely. Initiation of nutritional support is warranted. He
has history of congestive heart failure and will not tolerate
the large IV fluid volume that has to be given with peripheral parenteral nutrition to keep solution osmolality less
than 900. Ischemic colitis will make enteral nutrition a
poor option.
Although used with caution, the best option for this patient is
central or total parenteral nutrition.
Reference
Stapelton RD, Jones NE, Heyland DK. Feeding critically ill
patients: what is the optimum amount? Crit Care Med.
2007;35(9 suppl):S535-S540
98
A)
B)
C)
D)
E)
Answer: A
Guidelines from the American Heart Association (AHA)
advise that either catheter embolectomy and fragmentation or surgical embolectomy should be considered for
patients with massive pulmonary embolism who have
contraindications to fibrinolysis. Thrombolytics are
relatively contraindicated for this patient with his recent
diagnosis of intracranial neoplasm.
Reference
Jaff MR, McMurtry MS, Archer SL, Cushman M, Goldenberg
N, Goldhaber SZ, et al. Management of Massive and
Submassive Pulmonary Embolism, Iliofemoral Deep
Vein Thrombosis, and Chronic Thromboembolic
Pulmonary Hypertension: A Scientific Statement From
the American Heart Association. Circulation. 26
2011;123(16):17881830.
236. A 55-year-old female with a past medical history of
diabetes, hyperlipidemia, and coronary artery disease
was admitted with septic shock from cellulitis. She was
admitted to the ICU for respiratory failure and was subsequently intubated. On day three she was extubated
and transferred to the floor. On day five she spiked a
low-grade temperature and blood cultures from that
day subsequently grew Candida albicans. Her vital
signs are stable. She was started on intravenous fluconazole and vancomycin.
What is the next appropriate step?
A) Remove all lines and start diflucan
B) Start double antifungal therapy
C) Start an echinocandin
D) Ophthalmology consult
E) A and D
Answer: E
In patients without neutropenia, fluconazole is the drug of
choice in most cases of candidemia and disseminated candidiasis. An echinocandin is recommended for candidemia
in most patients with neutropenia. A critical component in
the management of candidemia and disseminated candidiasis is the removal of the possible focus of infection, such as
intravenous and Foley catheters. Double antifungal therapy
is not needed for management of candidemia.
A number of studies have shown that in the setting of candidemia, ocular problems such as endophthalmitis may
Inpatient Medicine
References
Aasheim ET. Wernicke encephalopathy after bariatric surgery: a systematic review. Ann Surg. 2008;248(5):
71420.
Attard O, Dietemann JL, Diemunsch P, Pottecher T, Meyer
A, Calon BL. Wernicke encephalopathy: a complication
of parenteral nutrition diagnosed by magnetic resonance
imaging. Anesthesiology. Oct 2006;105(4):8478.
Donnino MW, Vega J, Miller J, et al. Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should know. Ann Emerg Med. Dec
2007;50(6):71521.
238. A type 1diabetic patient with chronic renal insufficiency is admitted with cellulitis. She has intermittent
claudication and was found to have ABI of 0.4. Lower
extremity angiogram will be performed. Her creatinine
level 1.4 mg/dl.
Which of the following pretreatments should be
received to decrease the risk of contrast-induced
nephropathy?
A) Intravenous steroid
B) N-acetylcysteine
C) Intravenous hydration
D) Intravenous magnesium
E) No pretreatment is needed
Answer: C
Contrast medium-induced nephropathy (CIN) is the third
leading cause of acute renal failure in hospitalized
patients. Administration of fluids remains the cornerstone
of preventive therapy to reduce the risk of CIN. It has
proven to have renal protective effect even in patient with
normal baseline renal function and is a reasonable option
here.
If volume restriction is not an issue, the usual recommended
infusion rate of intravenous 0.9 % sodium chloride is 1 ml/
kg/h. This should be started 12 h before and continued for
12 h after the procedure. N-acetylcysteine may be of benefit in patients with baseline creatinine above 2 mg/dl.
Reference
Mueller C, Buerkle G, Buettner HJ, et al. Prevention of contrast media-associated nephropathy. Arch Intern Med
2002;162:32936.
239. A 57-year-old male with a past medical history of diabetes, COPD was admitted for a severe exacerbation.
He declined rapidly in the emergency room and was
intubated.
His current ventilator settings are a rate of 15, tidal
volume of 700 ml, FiO2 of 60 %, and a PEEP of 15.
His PCO2 on ABGs was 60 cm of H2O. His rate was
99
100
Inpatient Medicine
101
102
Inpatient Medicine
Reference
Banerjee S, Shen B, Baron TH, et al. Antibiotic prophylaxis for
GI endoscopy. Gastrointest Endosc. May 2008;67(6):7918
249. A 27-year-old female is admitted with complaints of
intermittent abdominal discomfort. She has had several
admissions over the last three years, but her status is
getting worse. She has difficulty working and stays at
home most of the time.
On physical exam, vital signs are within normal
limits and abdominal exam is unremarkable. Laboratory
values include WBC of 6,000, hematocrit of 30 %, normal electrolyte panel, and erythrocyte sedimentation
rate of 57 mm/h. Stool studies show fecal leukocytes.
Irritable bowel syndrome has been the diagnosis in the
past and is suspected now.
Which intervention is most likely indicated at this time?
A) Reassurance
B) Fluoroquinolone antibiotic
C) Stool bulking agents
D) Selective
serotonin
reuptake
inhibitor
(antidepressant)
E) Colonoscopy
103
Answer: E
Although irritable bowel syndrome (IBS) is suspected, there
are alarm features that warrant further investigation. The
patients low hematocrit, elevated erythrocyte sedimentation rate, and positive fecal leukocytes may suggest
underlying gastrointestinal disorders. Colonoscopy would
be warranted as the next step in management for a
diagnosis.
The American College of Gastroenterologists (ACG) statement on the management of IBS does not recommend
laboratory testing or diagnostic imaging in patients
younger than 50 years with typical IBS symptoms and
without alarm features. In addition to the above, alarm
features include weight loss, iron-deficiency anemia, and
a family history of colonic disease.
Answer: A
Much of our information concerning the treatment of severe
influenza comes from the 2009 H1N1 epidemic. In those
patients, therapy with oseltamivir reduced length of hospital stay, need for intensive care, and progression to
severe disease or death. Ideally oseltamivir should be
administered within 48 h of symptom onset. For critically
ill patients with influenza infection, initiation of oseltamivir therapy up to 68 days from onset of symptoms may
reduce mortality.
Adjuvant treatments are often considered for patients with
life-threatening illnesses related to influenza. A study from
Argentina described excellent outcomes in 13 patients with
presumed H1N1 influenza A pneumonitis receiving a combination of oseltamivir and methylprednisolone (1 mg/kg/
day) or hydrocortisone (300 mg/day). However, previous
studies during earlier viral epidemics failed to demonstrate
a beneficial effect of corticosteroids.
Severe and even fatal bronchospasm has been reported during treatment with zanamivir, and it should not be in individuals with underlying airway diseases.
Peramivir has not been extensively tested.. The drug was used
on a compassionate and emergency basis during the H1N1
pandemic. It appeared to be relatively well tolerated but too
few patients were enrolled to establish its efficacy. Its
advantage is that it can be given intravenously.
References
Brandt LJ, Chey WD, Foxx-Orenstein AE, Schiller LR,
Schoenfeld PS, Spiegel BM, et al. An evidence-based
position statement on the management of irritable bowel
syndrome. Am J Gastroenterol. 2009;104 Suppl 1:S1-35.
Longstreth GF, Thompson WG, Chey WD, Houghton LA,
Mearin F, Spiller RC. Functional bowel disorders.
Gastroenterology. Apr 2006;130(5):148091.
References
Beigel JH, Farrar J, Han AM, Hayden FG, Hyer R, de Jong
MD, et al. Avian influenza A (H5N1) infection in humans.
N Engl J Med. Sep 29 2005;353(13):137485.
Domnguez-Cherit G, Lapinsky SE, Macias AE, Pinto R,
Espinosa-Perez L, de la Torre A, et al. Critically Ill
patients with 2009 influenza A(H1N1) in Mexico.
JAMA. Nov 4 2009;302(17):18807.
250. A 78-year-old female is admitted with acute respiratory distress. Symptoms began abruptly 48 h ago with
acute onset of fever muscle aches and cough. In the
emergency room, she is placed on 100 % nonrebreather.
251. A 37-year-old woman is admitted with moderate persistent epigastric abdominal pain. She reports drinking
one-half liter of vodka per day. She rates the pain as
7/10. It is not associated with food intake. This is the
104
Inpatient Medicine
105
and after surgery performed on the central nervous system. This patient has a potentially life-threatening intracranial bleeding. The bleeding source is probably
secondary to hypertensive disease and not thrombocytopenia. However, the patient is at continued risk for extension of the intracerebral bleeding because of her
thrombocytopenia. Guidelines do not suggest additional
benefits to maintaining platelet counts >100,000.
References
British Committee for Standards in Haematology, Blood
Transfusion Task Force. Guidelines for the use of platelet
transfusions. Br J Haematol. 2003;122:1023.
Vavricka SR, Walter RB, Irani S et al. Safety of lumbar puncture for adults with acute leukemia and restrictive prophylactic platelet transfusion. Ann Hematol 2003;82:5703.
255. A 44-year-old woman undergoes preoperative evaluation prior to surgery to repair a congenital defect of her
pelvis. Her expected blood loss is 2.0 l. She has a prior
history of severe anaphylactic reaction to a prior erythrocyte transfusion that she received for postpartum
hemorrhage at age of 27 years. In addition she has a
history of rheumatoid arthritis.
On physical examination, the temperature is 36.8 C
(98.5 F), blood pressure is 140/70 mmHg, and heart
rate is 76 bpm. Laboratory studies indicate a hemoglobin level of 12.0 g/dL, a leukocyte count of 6500 L,
and a platelet count of 150,000 L.
Previous laboratory studies indicate an IgG level of
800 mg/dL and an IgM level of 65 mg/dL.
Which of the following is the most appropriate
erythrocyte transfusion product for this patient?
A) Leuko-reduced blood
B) Cytomegalovirus-negative blood
C) Irradiated blood
D) Phenotypically matched blood
E) Washed blood
107
108
Answer: E
This patient has IGA deficiency. The most appropriate product to minimize the risk of an anaphylactic transfusion
reaction in this case is washed erythrocytes. Most patients
with an IgA deficiency are asymptomatic. They are prone
to gastrointestinal infections such as giardia. They also
have an increased risk of autoimmune disorders such as
rheumatoid arthritis and systemic lupus erythematosus.
Some patients with IgA deficiency have anaphylactic
reactions to blood products containing IgA. Fresh frozen
plasma (FFP) is the main blood component containing
IgA antibodies. Anaphylaxis may occur with a variety of
transfusions including FFP, platelets, and erythrocytes.
Washing erythrocytes and platelets removes plasma proteins and greatly decreases the incidence of anaphylaxis.
Reference
Wang N, Hammarstrm L. IgA deficiency: what is new?. Curr
Opin Allergy Clin Immunol. 2012 Dec. 12(6):6028.
256. A 34-year-old man with a history of superficial thrombophlebitis presents with bilateral foot pain of 3-days
duration. Over the 6 months, he has had several distinct
episodes of severe burning pain of the foot and several
toes. The pain persists at rest and is debilitating. The
patient smokes one to two packs of cigarettes a day.
On physical examination, he is thin; his feet are erythematous and cold. There are ulcerations noted distally on both feet. The femoral pulses are strong and
intact, and the dorsalis pedis and posterior tibialis
pulses are absent bilaterally. No discoloration is noted
on his leg and a normal hair pattern is noted on his legs.
The pain is not worsened by deep palpation.
What is the most likely diagnosis for this patient?
A) Plantar fasciitis
B) Spinal stenosis
C) Thromboangiitis obliterans
D) Raynaud phenomenon
E) Atherosclerotic claudication
Answer: C
This patient has thromboangiitis obliterans, also called
Buergers disease. This results from inflammatory blockage
of arterioles in the distal extremities and is usually seen in
male smokers who are typically less than 40 years of age.
Other typical features include a history of recurrent thrombophlebitis and rest pain. Distal pulses are often absent.
Plantar fasciitis is usually relieved with rest. Weight bearing and
exercise exacerbate it. Spinal stenosis usually occurs in older
patients. It is exacerbated by standing or walking and is
relieved by rest. Atherosclerotic claudication is also seen in
older patients. It has a steady progression. It starts with
exercise-related pain and progresses slowly to pain at rest.
Raynaud phenomenon is seen mostly in women. It is caused
109
Answer: C
This patient has several factors that suggest malingering. He
presents with two relatively easy to mimic symptoms.
First, he has a seizure with no eleptiform activity and then
paralysis with a normal MRI. His recent travel from
another area is also suggestive of the diagnosis.
Malingering is not considered a mental illness and its diagnosis and treatment can be difficult. Direct confrontation
may not work best. Hostility, lawsuits, and occasionally
violence may result. It may be best to confront the person
indirectly by remarking that the objective findings do not
meet the objective criteria for diagnosis. It is important to
demonstrate to the patient that his abnormal behavior has
been observed and will be documented. At the same time
an attempt should be made to allow the patient who is
malingering the opportunity to save face. Obviously this
can be a challenge.
Invasive diagnostic maneuvers, consultations, and prolonged hospitalizations often do more harm than good and add fuel to the
fire. People who malinger rarely accept psychiatric referral,
and the success of such consultations is minimal. It may be
considered to address a specific psychiatric complaint.
The most common goals of people who malinger in the
emergency department are obtaining drugs and shelter. It
may be beneficial to offer the patient some limited assistance in these areas. In the clinic or office, the most common goal is financial compensation.
Answer: A
American College of Chest Physician guidelines for chronic
obstructive pulmonary disease exacerbation support inhaled
beta agonists and steroids alone for mild flares. In this particular case, the patient is having a mild exacerbation of his
typical chronic obstructive pulmonary disease. Antibiotics
should be reserved for moderate to severe cases. The criteria
for moderate disease exacerbation include cough, change in
color of sputum, and increased shortness of breath.
References
McDermott BE, Feldman MD. Malingering in the medical
setting. Psychiatr Clin North Am. 2007;30(4):64562.
Purcell TB. The somatic patient. Emerg Med Clin North Am.
1991;9(1):13759.
259. A 60-year-old male with chronic obstructive pulmonary
disease is admitted for a hip fracture sustained after a fall.
He undergoes surgery without complication. On the second day of hospitalization, he develops some mild dyspnea and nonproductive cough. He is currently on 2 l of
oxygen at home and states that he will often get somewhat
short of breath with any change in his living situation.
On physical exam, the patient appears comfortable.
His temperature is 37.8 C (100.1 F), heart rate is
70 bpm, and respirations are 16 per minute. Oxygen
saturation is 96 % on pulse oximetry with 2 l.
References
Vollenweider DJ, Jarrett H, Steurer-Stey CA, GarciaAymerich J, Puhan MA. Antibiotics for exacerbations of
chronic obstructive pulmonary disease. Cochrane
Database Syst Rev. 2012;(12):CD010257.
Walters JA, Tan DJ, White CJ, Wood-Baker R. Different
durations of corticosteroid therapy for exacerbations of
chronic obstructive pulmonary disease. Cochrane
Database Syst Rev. 2012;(12):CD006897.
260. A 74-year-old man is admitted for cough, dyspnea, and
altered mental status. The patient is noted to be minimally responsive on arrival. Results of physical examination are as follows: temperature, 38.9 C (102.1 F);
heart rate, 116 bpm; blood pressure, 96/60 mmHg; respiratory rate, 35 breaths/min; and O2 saturation, 74 % on
100 % O2 with a nonrebreather mask. The patient is intubated urgently and placed on mechanical ventilation.
On physical exam, coarse rhonchi are noted bilaterally. A portable chest X-ray reveals good placement of
the endotracheal tube and lobar consolidation of the
right lower lobe. Empirical broad-spectrum antimicrobial therapy is started.
Which is true concerning his nutritional management?
A) Enteral nutrition is less likely to cause infection
than parenteral nutrition.
B) Parenteral nutrition has not consistently been
shown to result in a decrease in mortality, compared with standard care.
C) The use of oral supplements in all hospitalized
elderly patients has been shown to be beneficial.
D) Immune-modulating supplements are no better
than standard high-protein formulas in critically ill
patients.
E) All of the above
110
Answer: E
Comparisons of enteral nutrition with parenteral nutrition
have consistently shown fewer infectious complications
with enteral nutrition. Several studies have looked at specialized feeding formulas in the treatment of the critically
ill. There is little evidence to support their use over standard high-protein formulas.
In one study among adult patients breathing with the aid of
mechanical ventilation in the ICU, immune-modulating
formulas compared with a standard high-protein formula
did not improve infectious complications or other clinical
end points.
Elderly patients require special consideration. A trial in 501
hospitalized elderly patients randomized to oral supplements or a regular diet showed that, irrespective of their
initial nutritional status, the patients receiving oral supplements had lower mortality, better mobility, and a
shorter hospital stay.
References
Langer G, Schloemer G, Knerr A, Kuss O, Behrens J. Nutritional
interventions for preventing and treating pressure ulcers.
Cochrane Database Syst Rev. 2003;(4):CD003216.
Zanten AR, Sztark F, Kaisers UX et al. High-protein enteral
nutrition enriched with immune-modulating nutrients vs
standard high-protein enteral nutrition and nosocomial
infections in the ICU: a randomized clinical trial. JAMA.
2014;312:51424.
261. You are called to see a patient urgently in the postpartum ward. She is a 32-year-old female who, 20 min
prior, had an uneventful vaginal delivery. In the past 20
min, the patient has become abruptly short of breath,
hypoxic, and severely hypotensive with a blood pressure of 72/palpation mm Hg. On physical exam, she is
obtunded and in serve respiratory distress. She has no
significant past medical history documented and has
had an uneventful pregnancy. Mild wheezes with
decreased breath sounds are heard. Chest radiograph
and arterial blood gasses are pending.
The most likely diagnosis is?
A) Pulmonary embolism
B) Sepsis
C) Peripartum cardiomyopathy
D) Amniotic fluid embolism
E) Eclampsia
Answer: D
Amniotic fluid embolism is a rare complication of pregnancy.
It presents acutely during and immediately after delivery,
usually within 30 min. The exact mechanisms are unclear,
but it is thought that amniotic fluid gains entry into the
maternal circulation. This triggers an intensive inflamma-
References
Howard L, Ament M, Fleming CR et al. Current use and clinical
outcome of home parenteral and enteral nutrition therapies in
the United States. Gastroenterology. 1995;109(2):35565.
Lord LM, Schaffner R, DeCross AJ et al. Management of the
patient with short bowel syndrome. AACN Clin Issues.
2000;11(4):60418.
263. A 45-year-old female presents with left calf swelling.
She states that she has been feeling well and reports no
other constitutional symptoms. She has no family history of venous thromboembolism and has no personal
history of venous thromboembolism as well. She
denies recent travel, injury, or past medical problems.
She currently takes no medications and has been on no
medications in the past year. Physical examination
reveals swelling of the left leg from mid-thigh to ankle.
Doppler ultrasonography shows deep vein thrombosis
in the femoral vein.
Prior to initiating heparin therapy, which of the following tests should be performed to determine the risk
of reoccurrence and duration of treatment?
A) Factor V Leiden mutation
B) No further testing indicated
C) Prothrombin gene mutation
D) Factor V Leiden and prothrombin gene mutation
E) Erythrocyte sedimentation rate
Answer: B
This patient has an unexplained deep vein thrombosis. Current
guidelines recommend treatment for 6 months. Recent
studies have revealed that factor V Leiden and prothrombin
mutation are not sufficiently predictive of future recurrence.
They are currently not recommended unless the patient has
a family history of thrombosis. Even with a family history,
the utility of these tests is of uncertain benefit. Future studies may clarify the predictive value of these tests.
Reference
Kearon C, Crowther M, Hirsh J. Management of patients
with hereditary hypercoagulable disorders. Annu Rev
Med. 2000;51:16985.
264. A 58-year-old female who underwent an elective cholecystectomy is noted to be in atrial fibrillation by telemetry. Her heart rate is 108 bpm. She has a history of
hypertension. Her medications are verapamil and fullstrength aspirin. She states that several years ago, she
had palpitations after exercise, but that has since
resolved, and she has noticed no problems. You are consulted by the surgical team for management of her heart
rate in preparing her for discharge. On physical exam
she appears in no distress and is not short of breath.
111
Which of the following is the appropriate management of the patients atrial fibrillation?
A) Maintain her current dose of verapamil.
B) Increase her dose of verapamil with a target rate of
80 beats per minute.
C) Add digoxin to control her heart rate to a target of
80 beats per minute.
D) Consult cardiology for possible cardioversion.
Answer: A
A 2010 study compared lenient control of heart rate less than
110 beats per minute to more strict control of less than 80
beats per minute. The study found that achieving strict heart
rate control resulted in multiple admissions with no perceivable benefit outcomes. In this particular case, a heart rate of
108 bpm is acceptable, and patient the can be discharged on
her current medications. Follow-up with her primary care
physician should be obtained to monitor heart rate.
Digoxin can be used in the acute setting but does little to
control the ventricular rate in active patients. It is rarely
used as monotherapy. Caution should be exercised in
elderly patients with renal failure due to toxicity. Digoxin
is indicated in patients with heart failure and reduced LV
function.
Reference
Van Gelder IC, Groenveld HF, Crijns HJ et al. Lenient versus
strict rate control in patients with atrial fibrillation. N
Engl J Med. 2010;362:136373.
265. A 52-year-old, morbidly obese man is in the ICU for
treatment of pneumonia, sepsis, and acute respiratory
distress syndrome. Prior to this admission, he was
receiving therapy for hypertension, type 2 diabetes
mellitus, hyperlipidemia, obstructive sleep apnea, and
chronic obstructive pulmonary.
He is on the ventilator for his second day and tube
feeds are to be started. His BMI is 41.
What weight should be used to calculate his caloric
needs?
A) Ideal body weight
B) Actual body weight
C) Adjusted body weight
D) None of the above
Answer: C
The use of actual body weight in determining the caloric needs
of obese patients in the ICU routinely leads to overfeeding.
The use of ideal body weight leads to underfeeding.
Morbidly obese patients have, on average, 20 % to 30 %
increased lean body mass compared with individuals of the
same sex and similar height. Adjusted body weight would
be the best starting point for determining caloric needs.
112
266. You are called to the floor to see a patient who has
developed acute onset of shortness of breath. She is a
56-year-old female who was admitted for upper GI
bleed. She is currently receiving her first unit of packed
erythrocytes, which was started 1.5 h ago.
On physical examination, temperature is
38.9 C(102 F), blood pressure is 110/65, pulse rate is
115 beats per minute, and respirations are 22 per minute. Her current oxygenation is 83 %. She has been
placed on 3 l by nasal cannula. No peripheral edema is
noted. Mild wheezes and diffuse crackles are heard
throughout her lung fields.
A stat X-ray is ordered which reveals diffuse bilateral
infiltrates. On review of her records, type and screen
reveal an A+ blood type with a negative antibody screen.
Which of the following is the most likely diagnosis?
A) Transfusion-related acute lung injury
B) Acute hemolytic transfusion reaction
C) Febrile nonhemolytic transfusion reaction
D) Transfusion-associated circulatory overload
E) Transfusion-related sepsis
Answer: A
This patient has likely developed transfusion-related acute lung
injury (TRALI). The patient developed dyspnea, diffuse pulmonary infiltrates, and hypoxia acutely during the blood
transfusion. It usually occurs shortly after the transfusion or
can be delayed for several hours. Both the classic and delayed
TRALI syndromes are among the most frequent complications following the transfusion of blood products. They are
associated with significant morbidity and increased mortality.
Antileukocyte antibodies in the donor blood product
directed against the recipient leukocytes cause this
Reference
Garcia DA et al. CHEST guidelines parenteral anticoagulants. Chest. 2012;141(2_suppl):e24S43S.
Answer: A
Per package labeling by the pharmaceutical manufacture,
discontinue warfarin and initiate rivaroxaban as soon as
INR falls to <3.0. Answer B represents the correct conversion from warfarin to dabigatran.
INR is not used to monitor rivaroxaban; however, its an indicator of warfarins effectiveness, thus aiding in predicting
a safe time to initiate a different anticoagulant.
Rivaroxaban starts working in 24 h. Warfarin takes 35
days to start working and 35 days to be eliminated.
Answer: E
Vitamin and other nutritional deficiencies are common after
bariatric procedures. This may be due to diet changes,
change in gastric function, or malabsorption. In these
patients, notable deficiencies occur with iron, zinc, and
B12. Lifelong nutritional supplementation is essential.
Many patients often stop taking supplements after a few
years after being lost to follow up. Despite improved surgical outcomes, complications from weight-loss surgery
are frequent. A study of insurance claims of patients who
had undergone bariatric surgery showed 21.9 % complications during the initial hospital stay. Over the next 6
months, 40 % developed complications. This occurred
more often in those over 40. The rate of complications is
reduced when the procedure is performed by an experienced, trained surgeon. Guidelines recommend that surgery be in a dedicated unit.
Reference
Chauhan V, Vaid M, Gupta M, Kalanuria A, Parashar
A. Metabolic, renal, and nutritional consequences of bariatric surgery: implications for the clinician. South Med J.
2010;103(8):77583; quiz 7845.
269. A 52-year-old male presents for preop clearance for
knee replacement surgery. He has hepatitis C cirrhosis.
He has child A cirrhosis. He is suffering from disability
due to his knee pain. He is a high school football coach
and is considering retiring due to his knee-related
issues.
Which of the following should you tell this patient
about his surgical risks?
A) He should not have surgery because of the significant mortality risk.
B) He has a slightly increased risk of death compared
with patients who do not have cirrhosis.
C) He should defer surgery until after he is successfully treated for hepatitis C.
D) He should defer surgery until after he undergoes
liver transplantation.
E) He has no increased risk.
Answer: B
Patients with cirrhosis of all causes and stage are at an
increased mortality risk from surgery. Even though this
patient has a low MELD score and is a child A patient,
there is clear evidence that he is at increased risk. Since he
has severe morbidity, elective surgery is a reasonable
option. He should be informed of the small but significant
increased risk of death associated with surgery as compared to a someone without cirrhosis. Treatment for hepatitis C would not have an impact on surgical outcomes.
Waiting for transplant, which is many years away, is not
the best option.
113
Reference
Teh SH, Nagorney DM, Stevens SR et al. Risk factors for
mortality after surgery in patients with cirrhosis.
Gastroenterology. 2007;132(4):12619.
270. A 55-year-old, black woman undergoes a total colectomy for ruptured diverticulum. Her preoperative score
on the Mini-Mental State Examination (MMSE) was
28 out of 30. Forty-eight hours after surgery, significant
delirium develops. This is the first episode of delirium
the patient has experienced. The patients family members are concerned about whether she will regain cognitive function and in what time frame.
Which of the following is most likely regarding
cognitive function in patients such as this?
A) Return to baseline in an average of 5 days
B) Return to baseline in 2 weeks
C) Return to baseline in an average of 30 days
D) Return to baseline in an average of 6 months
E) Permanent loss of cognitive function
Answer: A
Postoperative cognitive dysfunction (POCD) is common in
adult patients of all ages, recovery in the younger age
group is usually within 5 days, and complete recovery is
the norm for patients less than 60 years old.
Patients older than 60 years of age are at significant risk for
long-term cognitive problems, and in this group recovery
from POCD may last as long as 6 months and may be
permanent.
Patients with POCD in all age groups are at an increased risk
of all-cause death in the first year after surgery.
Reference
Newfield P. Postoperative cognitive dysfunction. F1000 Med
Rep. 2009;1(14):281.
271. A 48-year-old man is admitted with acute onset of dizziness. He describes it as a sensation that the room is
spinning.
All of the following would be consistent with a central cause of vertigo EXCEPT:
A) Absence of tinnitus
B) Gaze-evoked nystagmus
C) Hiccups
D) Inhibition of nystagmus by visual fixation
E) Purely vertical nystagmus
Answer: D
Deafness, tinnitus, or hearing loss is typically absent with
central lesions. Dizziness is a common complaint affecting approximately 20 % of the population over the course
of the year. It results in many emergency room visits and
hospitalizations.
114
Answer: A
Mortality of patients diagnosed with end-stage dementia is
significant. In a 2009 study, 323 nursing home residents
with advanced dementia were followed. The patients
were assessed at baseline and quarterly for 18 months
through chart reviews, nursing interviews, and physical
examinations. Mortality from all causes was greater than
half at 54.8 %. In the last 3 months of life, 40.7 % of subjects underwent one or more intensive interventions that
were defined as hospitalization, ED visit, parenteral therapy, or tube feeding.
Families and designated surrogate decision-makers were
also followed and questioned on an understanding of the
prognosis. Those families that demonstrated an understanding of the prognosis had fewer interventions.
Reference
Kerber KA. Vertigo and dizziness in the emergency department.
Emerg Med Clin North Am. 2009;27(1):3950. doi:10.1016/j.
emc.2008.09.002.
Reference
Mitchell SL, Teno JM, Kiely DK et al. The clinical course of
advanced dementia. N Engl J Med. 2009;361(16):152938.
viruses, immune system dysfunction, trace mineral deficiencies, and genetics as possible causes.
References
Elkayam U, Akhter MW, Singh H et al. Pregnancy-associated
cardiomyopathy: clinical characteristics and a comparison between early and late presentation. Circulation.
2005;111(16):20505.
Murali S, Baldisseri MR. Peripartum cardiomyopathy. Crit
Care Med. 2005;33(10 Suppl):S3406.
275. A 65-year-old male presents with progressive shortness
of breath over the past month. He has a 40-pack-year
history of smoking. CT scan of the chest reveals a right
middle lobe mass for which he subsequently undergoes
biopsy, which reveals adenocarcinoma. Magnetic resonance imaging of the brain reveals a 1-cm tumor in the
left cerebral cortex, which is consistent with metastatic
disease. The patient has no history of seizures or syncope. The patient is referred to outpatient therapy in the
hematology/oncology service as well as follow-up with
radiation oncology. The patient is ready for discharge.
Which of the following would be the most appropriate therapy for primary seizure prevention?
A) Seizure prophylaxis is not indicated.
B) Valproate.
C) Phenytoin.
D) Phenobarbital.
E) Oral prednisone 40 mg daily.
Answer: A
There is no indication for antiepileptic therapy for primary prevention in patients who have brain metastasis who have not undergone resection. Past studies have revealed no difference in seizure
rates between placebo and antiepileptic therapy in patients who
have brain tumors. Antiepileptic therapy has high rates of adverse
reactions and caution should be used in their use.
Reference
Sirven JI, Wingerchuk DM, Drazkowski JF, Lyons MK,
Zimmerman RS. Seizure prophylaxis in patients with
brain tumors: a meta-analysis. Mayo Clin Proc.
2004;79(12):148994.
276. A 78-year-old male is admitted due to swelling over his
chest wall. During discussion with the patient, he notes that
he had an AICD implanted in the area of the swelling over
3 years ago. His postoperative course had been uneventful
and he had never developed any wound dehiscence before.
On physical examination, there are palpable swelling and fluctuance over the right upper chest wall at the
site of a well-healed incision. The patient notes some
fevers and chills on and off the last few weeks. You are
very concerned for a cardiovascular implantable electronic device (CIED) infection.
115
116
Answer: B
Hospitalists are often asked to provide guidance regarding
the postoperative risk of complications after a variety of
noncardiac surgical procedures. A frailty score for older
patients may be more predictive than current models.
It is useful to categorize the surgical procedures into a low,
intermediate, or higher risk category. Individuals who are
at the highest risk include those undergoing an emergent
major operation. This risk is amplified in elderly adults.
High-risk procedures include aortic and other noncarotid
major vascular surgery and surgeries with a prolonged
operative time. Surgeries that are an intermediate risk
include major thoracic surgery, major abdominal surgery,
head and neck surgery, carotid endarterectomy, orthopedic surgery, and prostate surgery. Lower risk procedures
include eye, skin, and endoscopy.
Reference
Seymour DG, Pringle R. Post-operative complications in the
elderly surgical patient. Gerontology. 1983;29(4):26270.
281. A 68-year-old female was admitted to the hospital 8
days ago for hernia repair. She was discharged without
complications. Three days ago, the patient began to
have progressive high-volume diarrhea. She presents to
the emergency room with severe rigors and cramps to
her lower abdomen.
On physical exam, she has marked abdominal pain.
Her temperature is 39.5 C (103.0 F), heart rate is 100
beats per minute, and respirations are 15 per minute.
Her blood pressure is 100/62. She has marked hyperactive bowel sounds as well as significant abdominal distention. Laboratory studies include a leukocyte count of
28,000 and hematocrit of 25 %; and blood cultures are
negative. Stools are sent for Clostridium toxin which is
positive.
Which of the following is the most appropriate
treatment for the patients diarrhea?
A) Metronidazole orally
B) Metronidazole intravenously
C) Vancomycin oral
D) Vancomycin intravenously
Answer: C
This patient has severe Clostridium difficile-associated diarrhea (CDI). For patients with severe CDI, suitable antibiotic regimens include vancomycin (125 mg four times
daily for 10 days; may be increased to 500 mg four times
daily) or fidaxomicin (200 mg twice daily for 10 days).
Vancomycin has been shown to be superior to metronidazole in severe cases.
Fidaxomicin has been shown to be as good as vancomycin, for
treating CDI. One study also reported significantly fewer
recurrences of infection, a frequent problem with C. difficile.
117
118
Reference
Lisenmeyer TA, Stone JM. Neurogenic bladder and bowel
dysfunction. In: De Lisa J, editor. Rehabilitation medicine. Philadelphia: Lippincott-Raven; 1998. p. 1073106.
283. A 37-year-old male has been admitted for alcohol-related
pancreatitis. After six days, he continues with severe
midepigastric pain that radiates to the back with nausea
and vomiting. He has not been able eat or drink and has
not had a bowel movement since being admitted.
On physical examination, the temperature is 37.6 C
(99.5 F), the blood pressure is 120/76 mmHg, the pulse
rate is 90 bpm, and the respiratory rate is 20 breaths/
min. There is no scleral icterus or jaundice. The abdomen is distended and with hypoactive bowel sounds.
Laboratory studies show leukocyte count 12,400/
L, amylase 388 /L, and lipase 924 /L.
Repeat CT scan of the abdomen shows a diffusely
edematous pancreas with multiple small peripancreatic
fluid collections. Some improvement from the CT scan
3 days ago is noted. He is now afebrile.
Which of the following is the most appropriate next
step in the management of this patient?
A) Enteral nutrition by nasojejunal feeding tube
B) Intravenous imipenem
C) Pancreatic debridement
D) Parenteral nutrition
E) Continue with NPO status
Answer: A
This patient has ongoing moderate pancreatitis. With his
possible underlying poor nutritional status due to alcoholism and expected inability to eat, the patient will need
nutritional support. This patient will likely be unable to
take in oral nutrition for several days.. Enteral nutrition is
preferred over parenteral nutrition because of its lower
complication rate and proven efficacy in pancreatitis.
Enteral nutrition is provided through a feeding tube ideally
placed past the ligament of Treitz so as not to stimulate
the pancreas.
Broad-spectrum antibiotics such as imipenem therapy are primarily
of benefit in acute pancreatitis when there is evidence of pancreatic necrosis. Randomized, prospective trials have shown no
benefit from antibiotic use in acute pancreatitis of mild to moderate severity without evidence of infection. Pancreatic debridement is undertaken with caution and is not indicated here.
References
Eatock FC, Chong P et al. A randomized study of early nasogastric vs. nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol. 2005;100:4329.
Eckerwall GE, Axelsson JB, Andersson RG. Early nasogastric feeding in predicted severe acute pancreatitis: a clinical, randomized study. Ann Surg. 2006;244:95965.
284. A 64-year-old female with a past medical history significant for type 2 diabetes mellitus is admitted with
increasing shortness of breath. She is admitted for
mild congestive heart failure and responds well to
therapy.
Of note she reports increasing left knee pain. The
pain is heightened when she tries to walk with physical
therapy. Three months ago she had left knee arthroplasty, and postoperative course was uneventful. Her
vital signs are stable. The patients knee exam reveals a
surgical scar but no joint effusion or redness.
What should be done next?
A) Orthopedics consult
B) Arthrocentesis
C) Discharged with mild opioid
D) Order a knee MRI
E) Discharged home with a trial of NSAIDs
Answer: A
At 3 months, new-onset pain signals a mechanical complication of the prosthesis. Orthopedics consult is indicated.
Infection is certainly possible, but a prosthetic joint infection would have localized or systemic signs of infection.
Reference
Lentino JR. Prosthetic joint infections, bane of orthopedists,
challenge for infectious disease specialists. Clin Infect
Dis. 2003;36:115761.
285. A 82-year-old female is admitted to the hospital service with urinary tract infection and sepsis. On admission she is noted to be lethargic and unable to swallow
medicines. She develops progressive respiratory failure
and is intubated. A CXR is consistent with ARDS. An
NG tube is placed for administration of medicines. You
are considering starting tube feeds in this patient.
Which of the following is the most accurate statement regarding enteral tube feeds in this patient?
A) Early enteral tube feeds can be expected to reduce
her mortality risk.
B) The use of omega-3 fatty acids will reduce her
mortality risk.
C) Enteral tube feeds will increase the risk of infection.
D) The benefits of early nutrition can be achieved with
trophic rates.
Answer: D
The benefits of early enteral tube feedings in the critically ill
patient are uncertain. Studies have revealed inconsistent
results. There is some suggestion that the incidences of
infection can be reduced, but there is no data to suggest
long-term mortality improvement. In patients with ARDS,
trophic tube feedings at 10 ml/h seem to concur the same
benefit as early full-enteral tube feedings.
References
Elpern EH, Stutz L, Peterson S, Gurka DP, Skipper A. Outcomes
associated with enteral tube feedings in a medical intensive
care unit. Am J Crit Care. 2004;13(3):2217.
Gramlich L, Kichian K, Pinilla J, Rodych NJ, Dhaliwal R,
Heyland DK. Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill
adult patients? A systematic review of the literature.
Nutrition. 2004;20(10):8438.
286. Which of the following is an acceptable indication for
urinary catheter placement?
A) A patient who has urinary incontinence and a stage
II pressure ulcer
B) A patient who is under hospice care and requests a
catheter for comfort
C) A patient who is delirious and has experienced several falls
D) A patient who is admitted for congestive heart failure whose urine output is being closely monitored
Answer: B
Urinary tract infections (UTIs) are the most common hospitalacquired infections. Most attributed to the use of an indwelling catheter. There should always be a justifiable indication
for placement of a urinary catheter, and whenever possible
prompt removal should occur. This may be assisted by hospital protocols that trigger automatic reviews of catheter use.
Reference
Gould CV, Umscheid CA, Agarwal RK, Kuntz G, Pegues
DA. Guideline for prevention of catheter-associated urinary tract infections 2009. Infect Control Hosp Epidemiol.
2010;31(4):31926.
287. An 88-year-old man in hospice care is admitted for dyspnea.
He has advanced dementia, severe COPD, and coronary
artery disease. He has been in hospice for 2 months. He and
his family would like to be discharged to home hospice as
soon as possible. He is only on albuterol and ipratropium.
On physical examination, he is afebrile, and his blood
pressure is 110/76 mmHg, pulse rate is 110 beats/min, and
respiratory rate is 28 breaths/min. Oxygen saturation is
90 %. He is cachectic, tachypneic, and disoriented. He is
in moderate respiratory distress. Chest examination reveals
decreased breath sounds and fine inspiratory crackles.
In addition to continuing his bronchodilator therapy,
which of the following is the most appropriate next
step in the treatment of this patient?
A) Ceftriaxone and azithromycin
B) Morphine
C) Methylprednisolone
D) Haloperidol
E) Lorazepam
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Answer: B
This patient is enrolled in hospice. Every effort should be
made to ensure comfort and limit unnecessary treatments.
Dyspnea is one of the most common symptoms encountered in palliative care. Opioids are effective in reducing
dyspnea in patients with chronic pulmonary disease. A
5-mg dose of oral morphine given four times daily has
been shown to help relieve dyspnea in patients with endstage heart failure. Extended-release morphine, starting at
a 20 mg given daily has been used to relieve dyspnea in
patients with advanced COPD.
Bronchodilator therapy should be continued to maintain
comfort. Antibiotics and corticosteroids are not indicated.
They would not provide immediate relief and would also
be inconsistent with care focusing primarily on comfort
measures.
Benzodiazepines have not demonstrated consistent benefit in
treating dyspnea. They may be useful in specific patients
who have significant anxiety associated with their
dyspnea.
Reference
Currow DC, McDonald C, Oaten S, Kenny B, Allcroft P,
Frith P et al. Once-daily opioids for chronic dyspnea: a
dose increment and pharmacovigilance study. J Pain
Symptom Manage. 2011;42(3):38899.
288. A 59-year-old man presents with fever and a diffuse
blistering skin rash. He is recently started on allopurinol for gout. The patient also complains of sore throat
and painful watery eyes.
On physical examination, the patient is found to
have blisters developing over a quarter of his body.
Oral mucosal lesions are noted involvement. The estimated body surface area that is currently affected is
15 %.
Which of the following statements regarding this
patients diagnosis and treatment are TRUE?
A) Immediate treatment with intravenous immunoglobulin has been proven to decrease the extent of
the disease and improve mortality.
B) Immediate treatment with glucocorticoids will
improve mortality.
C) The expected mortality rate from this syndrome is
about 10 %.
D) The most common drug to cause this syndrome is
diltiazem.
E) Younger individuals have a higher mortality than
older individuals with this syndrome.
Answer: C
This patient has Stevens-Johnson syndrome (SJS). There is no
definitive evidence that any initial therapy changes outcomes in SJS. Early data suggested that intravenous
120
immunoglobulin (IVIG) was beneficial, and this traditionally has been the recommended treatment. However, more
recent studies have not shown consistent benefit with IVIG.
Immediate cessation of the offending agent or possible agents
is necessary. Systemic corticosteroids may be useful for the
short-term treatment of SJS, but these drugs increase longterm complications and may have a higher associated mortality. Therapy to prevent secondary infections is important.
In principle, the symptomatic treatment of patients with
Stevens-Johnson syndrome does not differ from the treatment of patients with extensive burns, and in many
instances, these patients are often treated in burn wards.
Future studies are required to determine the role of IVIG in
the treatment of SJS. The lesions typically begin with blisters developing over target lesions with mucosal involvement. In SJS, the amount of skin detachment is between 10
and 30 % . Mortality is directly related to the amount of
skin detachment with a mortality of about 10 % in
SJS. Other risk factors for mortality in SJS include older
age and intestinal or pulmonary involvement. The most
common drugs to cause SJS are sulfonamides, allopurinol,
nevirapine, lamotrigine, and aromatic anticonvulsants.
References
Mockenhaupt M. The current understanding of Stevens
Johnson syndrome and toxic epidermal necrolysis. Expert
Rev Clin Immunol. 2011;7(6):80315.
Ward KE, Archambault R, Mersfelder TL. Severe adverse
skin reactions to nonsteroidal antiinflammatory drugs: a
review of the literature. Am J Health Syst Pharm.
2010;67(3):20613.
289. A 57-year-old woman with a history of diabetes and
familial history of breast cancer is admitted with malaise,
an appetite decline, and new-onset ascites. She denies
having fevers, chills, diarrhea, nausea, and vomiting.
On physical exam, there is no evidence of spider
nevi or palmar erythema. Her serum albumin is 3.4 g/
dL. On chest X-ray, a right-sided pleural effusion is
noted. A diagnostic paracentesis reveals a glucose of
85 mg/dl, an albumin of 2.8 g/dL, and a WBC of 250/
ul, of which 45 % are neutrophils.
Based on the data provided, what is the most likely
cause of her ascites?
A) Cirrhosis
B) Metastatic disease
C) Pelvic mass
D) Spontaneous bacterial peritonitis
E) Tuberculous peritonitis
Answer: C
Meigs syndrome is the triad of benign ovarian tumor with
ascites and pleural effusion that resolves after resection of
Reference
Schneider JI, Olshaker JS. Vertigo, vertebrobasilar disease,
and posterior circulation ischemic stroke. Emerg Med
Clin North Am. 2012;30(3):68193.
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this case, the episode was probably caused by succinylcholine and/or inhalational anesthetic.
This syndrome occurs in individuals with inherited abnormality of skeletal muscle sarcoplasmic reticulum. More
than 30 mutations account for human malignant hyperthermia. Genetic testing is available to establish a
diagnosis. The caffeine halothane contracture test remains
the criterion standard. This is a muscle biopsy and performed at a designated center.
The syndrome presents with hyperthermia or a rapid increase
in body temperature that exceeds the ability of the body to
lose heat. Muscular rigidity, acidosis, cardiovascular
instability, and rhabdomyolysis also occur. Antipyretics
such as acetaminophen, ibuprofen, and corticosteroids are
of little use.
The dantrolene dose is 2.5 mg/kg rapid IV bolus and may be
repeated PRN.
Occasionally a dose up to 30 mg/kg is necessary.
References
MacLennan DH. The genetic basis of malignant hyperthermia. Trends Pharmacol Sci. 1992;13(8):3304.
Schneiderbanger D, Johannsen S, Roewer N, Schuster
F. Management of malignant hyperthermia: diagnosis and
treatment. Ther Clin Risk Manag. 2014;10:35562.
294. A 70-year-old female is seen for preoperative evaluation for elective total knee replacement. She has a
mechanical bileaflet aortic valve and takes warfarin.
She has no history of stroke. On physical examination,
there is a regular rhythm with a noted mechanical click.
Recent echocardiography of the heart is normal. Lungs
are clear to auscultation. INR is 2.1.
Which of the following is the most appropriate perioperative recommendation regarding anticoagulation
in this patient?
A) Discontinue warfarin 5 days before surgery and
bridge with full-dose IV heparin before and after
surgery.
B) Discontinue warfarin 5 days before surgery and
restart on the evening of the surgery.
C) Continue with warfarin.
D) Reverse anticoagulation with fresh frozen plasma
transfusion 1 h before surgery and restart warfarin
on the evening of the surgery.
Answer: B
In patients with mechanical valves and at low risk for thromboembolism, low-dose low-molecular-weight heparin or
no bridging is recommended. The short-term risk of anticoagulant discontinuation in this patient is small. The current recommendation is to stop warfarin 5 days before the
procedure. The INR goal is 1.5. Warfarin should be
restarted within 24 h after the procedure.
Answer: C
UEDVT is common secondary to increased interventions in
the upper extremity. It has become more easily recognized due to improvement and availability of noninvasive
ultrasound technology. UEDVT accounts for up to 10 %
of all DVT.
American College of Chest Physicians guidelines recommend treating UEDVT patients with unfractionated heparin or low-molecular-weight heparin with the addition of
warfarin, with an INR goal of 23 for at least 3 months
depending upon the overall clinical scenario.
Two previous small studies evaluating catheter-related
thrombosis reported no subsequent embolic phenomenon.
However, since UEDVT has been more widely recognized, most authors are recommending three months of
treatment until further studies define the correct duration
of treatment.
Reference
Margey R, Schainfeld RM. Upper extremity deep vein
thrombosis: the oft-forgotten cousin of venous thromboembolic disease. Curr Treat Options Cardiovasc Med.
2011;13(2):14658.
297. An 88-year-old female who was admitted to the hip
fracture service for a right hip fracture has currently
become agitated and confused. She underwent hip
fracture repair two days prior. She has a history of
osteoporosis, dementia, and type 2 diabetes.
Her postoperative medicines include oxycodone
5 mg every 4 h as needed for pain as well as IV morphine 12 mg/h as needed for the pain. During the
patients first night, she was calm and relatively free of
pain. However, on her second night, she has become
acutely agitated and is reported by the nurse to be
screaming and pulling out lines and drains. Her temperature is 99.1 F. Her pulse rate is 100 beats/min. Her
respirations are 20 per minute. Her oxygenation is 92 %
on room air. Her hematocrit and hemoglobin are within
normal limits as well as the rest of her electrolytes.
Which of the following is the appropriate response/
treatment for this patients delirium?
A) Four-point restraints
B) One 2 mg dose of intravenous lorazepam
C) One 5 mg dose of oral haloperidol
D) One 0.5 mg dose of oral haloperidol
E) One 5 mg dose of intravenous haloperidol
Answer: D
Treatment of postoperative-induced delirium is a common
issue confronted in the hospital setting. Delirium that
causes injury to the patient or others should be treated
with medications. This can be a difficult management
issue. No medication is currently approved by the Food
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References
Girish M, Trayner E Jr, Dammann O et al. Symptom-limited
stair climbing as a predictor of postoperative cardiopulmonary complications after high-risk surgery. Chest.
2001;120:1147.
Reilly DF, McNeely MJ, Doerner D et al. Self-reported exercise tolerance and the risk of serious perioperative complications. Arch Intern Med. 1999;159:2185.
299. A 74-year-old female was admitted for emergent colectomy to treat a presumed diverticular bleed. The patient
also has breast cancer treated with hormonal therapy.
She had been started on warfarin 3 weeks ago as therapy for a deep venous thrombus of the left femoral vein.
Prior to the colectomy, her INR was 3.4. She was
treated with intravenous vitamin K and fresh frozen
plasma prior to surgery.
The surgery was uneventful. On hospital day 2, she
has a sudden onset of tachypnea and hypoxemia. A
computed tomography pulmonary angiogram reveals a
thrombus in the pulmonary artery to the right lower
lobe. Her INR is 1.0.
What is the most likely cause of her thrombosis?
A) Surgery-induced thrombosis
B) Depletion of thrombin due to the surgical acutephase response
C) Thrombogenesis due to postoperative hypovolemia
D) Undetected prior thrombus
E) Rebound hypercoagulability and subsequent
thromboembolism
Answer: E
Rebound hypercoagulability is the most likely cause. This
may occur after abrupt cessation of warfarin. In addition,
surgery increases the risk of thromboembolic events.
Following an abrupt withdrawal of warfarin, thrombin
and fibrin formation increase and very high levels of
thrombin activation are seen. If possible, warfarin withdrawal should be gradual which would not have been feasible in the current case. Safely resuming anticoagulation
after surgery should be a goal as well.
References
Garcia DA et al. Risk of thromboembolism with short-term
interruption of warfarin therapy. Arch Intern Med.
2008;168:63.
Malato A et al. Patients requiring interruption of long-term
oral anticoagulant therapy: the use of fixed sub-therapeutic
doses of low-molecular-weight heparin. J Thromb
Haemost. 2010;8:107.
300. A 40-year-old female with no significant past medical
history is admitted with radiating flank pain. She
believes she may have passed a small renal stone. She is
admitted for IV pain control and intravenous fluids. She
never passed a stone before. She has no dysuria, abdominal pain, nausea, or fever. She is on no medications.
What should NOT be considered in the management
plan for this patient?
A) CT scan of the abdomen and pelvis without
contrast
B) Ultrasound of the kidneys
C) Urinalysis to rule out UTI
D) 24-h urinalysis
Answer: D
Most guidelines recommend diagnostic imaging to confirm
the diagnosis in first-time episodes of ureterolithiasis.
Noncontrast computed tomography (CT) scans of the
abdomen and pelvis have become the imaging modality
of choice. Renal ultrasonography or a contrast study such
as intravenous pyelography (IVP) may be preferred in
ceratin circumstances.
Initial workup should also include microscopic examination
of the urine for evidence of hematuria and infection.
Measurements of serum electrolyte, creatinine, calcium,
and uric acid are required. Serum WBC may indicate
infection.
For first episodes of renal colic, 24-h urine and stone analysis
are not usually recommended.
Reference
Cooper JT, Stack GM, Cooper TP. Intensive medical management of ureteral calculi. Urology. 2000;56(4):5758.
301. A 60-year-old man who has metastatic lung cancer
and painful bone metastases reports severe pruritus
that started when he began to take morphine for his
pain. Pain in his chest wall and legs has been successfully treated with sustained-release morphine (80 mg
every 12 h) and short-acting morphine (15 mg orally
every 2 h as needed for breakthrough pain) which he
uses two or three times daily, depending on his level of
activity.
On physical examination, the temperature is 37 C
(98.6 F), pulse rate is 80 beats per minute, respirations
are 16 per minute, and blood pressure is 115/70 mmHg.
Oxygen saturation by pulse oximetry is 95 % on room
air. The patient is alert and oriented. His pupils are
4 mm initially and constrict to 2 mm with a light stimulus. The lungs are clear. Cardiac examination shows a
normal rate and regular rhythm. No rash is seen.
Examination of the abdomen is significant for suprapubic dullness and sensitivity. Neurological examination
is nonfocal.
Which of the following should be done next?
A) Change to oxycodone, 40 mg every 12 h, and oxycodone, 510 mg every 2 h as needed
B) Lower the dosage of sustained-release morphine to
30 mg every 12 h
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benefits in morbidity and mortality. Although tight control has been advocated in the past, current consensus
guidelines recommend less stringent glycemic goals,
typically between 80 and 150 mg/dL. The ultimate goal in
the management of diabetic patients (DM) is to achieve
outcomes equivalent to those in patients without DM.
A meta-analysis of 15 studies reports that hyperglycemia
increased both in-hospital mortality and incidence of
heart failure in patients admitted for acute myocardial
infarction. Several other studies have also demonstrated
the benefits of glycemic control in the perioperative area.
Type 2 diabetes mellitus often requires insulin while in the
hospital. The requirements may be unpredictable. This
may be due to the stress of hospitalization, dietary
changes, glucose added to IV fluids, and medicine
interactions.
Sliding scale alone has often been traditionally used in the
past. However, this method of control often results in
wide fluctuations in glycemic control. The optimal plasma
glucose level postoperatively is not known, and certainly
tight control has its risks.
References
Clement S, Braithwaite SS, Magee MF et al. Management of
diabetes and hyperglycemia in hospitals. Diabetes Care.
2004;27(2):55391.
Lazar HL, Chipkin SR, Fitzgerald CA et al. Tight glycemic
control in diabetic coronary artery bypass graft patients
improves perioperative outcomes and decreases recurrent
ischemic events. Circulation. 2004;109(12):1497502.
306. A 55-year-old female has been admitted for cellulitis.
She has responded well to antibiotics and is ready for
discharge. On admission she was noted to be in atrial
fibrillation. She has been treated with low-molecularweight heparin in the hospital. She first noted the irregular heartbeat 4 weeks ago. She denies chest pain,
shortness of breath, nausea, or gastrointestinal symptoms. Past medical history is unremarkable. There is no
history of hypertension, diabetes, or tobacco use. Her
medications include metoprolol.
On physical examination, she has a blood pressure
of 124/76 mmHg and a pulse of 70 beats/min. An echocardiogram shows a left atrial size of 3.5 cm. Left ventricular ejection fraction is 63 %. There are no valvular
or structural abnormalities.
Which of the following would be the appropriate
treatment of her atrial fibrillation?
A) She requires no antiplatelet therapy or anticoagulation because the risk of embolism is low.
B) Lifetime warfarin therapy is indicated for atrial
fibrillation in this situation to reduce the risk of
stroke.
C) She should be started on IV heparin and undergo
electrical cardioversion.
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310. What body mass index in males is considered a probable mortality endpoint in males?
A) 20.5 kg/m
B) 16 kg/m
C) 13 kg/m
D) 11 kg/m
Answer: C
It is important to understand the thresholds of body mass
index (BMI) that indicate end-stage malnutrition. Normal
BMI ranges between 20 and 25 kg/m2, and a patient is
considered underweight with likely moderate malnutrition at a BMI of 18.5 kg/m2. Severe malnutrition is
expected with a BMI of less than 16 kg/m2. In men, a BMI
of less than 13 kg/m2 is near end stage.
Reference
Romero-Corral A, Montori VM, Somers VK, Korinek J,
Thomas RJ, Allison TG, Mookadam F, Lopez-Jimenez
F. Association of bodyweight with total mortality and
with cardiovascular events in coronary artery disease: a
systematic review of cohort studies. Lancet. 2006;
368(9536):66678.
311. Which of the following statements is true concerning
percutaneous esophageal gastrostomy tubes (PEG)?
A) PEG tubes reduce aspiration as opposed to nasogastric tubes.
B) In end-stage advanced malignancy with cachexia,
PEG tubes have been proven to improve survival
and reduce morbidity.
C) PEG tubes have been proven to improve survival in
end-stage dementia.
D) Mean survival after PEG tube placement for failure
to thrive is 6 months.
Answer: D
The physician is often faced with this decision in a variety of
end-of-life situations to consider placement of a PEG
tube. Survival benefits of PEG tube placement are often
minimal at best. There is a wide range of cultural expectations in reference to this issue. It is important to understand the facts concerning the possible benefits or lack of
benefits of PEG tube placement when counseling the
patient and family. As noted in this question, survival benefits for PEG tube placement in a patient with failure to
thrive to variety of conditions are modest at best.
312. A 29-year-old woman develops left leg swelling during
week 18 of her pregnancy. Left lower extremity ultrasonogram reveals a left iliac vein deep venous thrombosis (DVT).
Proper management includes:
A) Bedrest
B) Catheter-directed thrombolysis
C) Enoxaparin
D) Inferior vena cava filter placement
E) Warfarin
Answer: C
Pregnancy causes a hypercoagulable state and may result in
deep venous thrombosis (DVT). DVT occurs in 1 in 2000
pregnancies. DVT occurs more commonly in the left leg
than the right leg during pregnancy because of compression of the left iliac vein by the gravid uterus.
Approximately 25 % of pregnant women with DVT have a
factor V Leiden mutation, which also predisposes to preeclampsia. Warfarin is contraindicated because of a risk
of fetal abnormality. Low-molecular-weight heparin
(LMWH) is appropriate therapy at this point in pregnancy. This is typically switched to unfractionated heparin 4 weeks before anticipated delivery. Ambulation,
rather than bedrest, should be encouraged. There is no
proven role for local thrombolytic therapy or an inferior
vena cava filter in pregnancy. This would be considered
only when anticoagulation is not possible.
References
Dulitzki M, Pauzner R, Langevitz P et al. Low molecular
weight heparin during pregnancy and delivery: a preliminary experience with 41 pregnancies. Obstet Gynecol.
1996;87:830.
James AH, Jamison MG, Brancazio LR, Myers ER. Venous
thromboembolism during pregnancy and the postpartum
period: incidence, risk factors, and mortality. Am J Obstet
Gynecol. 2006;194(5):13115.
313. A 59-year-old man has been admitted for congestive
heart failure. His symptoms have resolved. Prior to discharge the cardiology service would like him to
undergo placement of an automatic implantable cardiac converter defibrillator (AICD).
He is on warfarin with an INR of 2.9. His other
problems include rate-controlled atrial fibrillation
and coronary artery disease. An echocardiogram
performed 2 weeks ago showed a left ventricular
ejection fraction of 25 % and a well-functioning
mechanical mitral valve. Trace edema is noted in the
extremities.
How should his warfarin be managed prior to placement of his AICD?
A) Continue warfarin, with a target INR of 3.5 or less
on the day of the procedure.
B) Discontinue warfarin 5 days before the procedure
and resume the day after the procedure.
C) Discontinue warfarin 5 days before the procedure
and bridge with an unfractionated heparin
infusion.
D) Discontinue warfarin 5 days before the procedure
and bridge with low-molecular-weight heparin.
Answer: A
Not all procedures require warfarin to be stopped. In some
cases, there is data to support continuing warfarin as
opposed to bridging therapy. A randomized, controlled
trial found that patients at high risk for thromboembolic
events on warfarin who need a pacemaker or implantable
cardioverter defibrillator (ICD) can safely continue warfarin without bridging anticoagulation. Continuing warfarin treatment at the time of pacemaker in patients with
high thrombotic risk was associated with a lower incidence of clinically significant device-pocket hematoma,
as opposed to bridging with heparin.
Reference
Birnie DH, Healey JS, Wells GA et al. Pacemaker or defibrillator surgery without interruption of anticoagulation. N
Engl J Med. 2013;368:208493.
314. A 56-year-old male is admitted to the hospital with
fever and cough. He was well until 1 week before
admission when he noted progressive shortness of
breath, cough, and productive sputum. On the day of
admission, the patients wife noted him to be lethargic.
The past medical history is notable for alcohol abuse
and hypertension.
On examination, the patient is lethargic.
Temperature is 38.9 C (102 F), blood pressure is
110/85 mmHg, and oxygen saturation is 86 % on
room air. There are decreased breath sounds at the
right lung base. Heart sounds are normal. The abdomen is soft. There is no peripheral edema. Chest radiography shows a right lower lobe infiltrate with a
moderate pleural effusion.
The white blood cell count is 15,000/L and 6 %
bands. He is admitted and started on broad-spectrum
antibiotics. On hospital day 3 he is not eating due to
lethargy. A nasogastric tube is inserted, and tube feedings are started. The next day, plasma phosphate is
found to be 1.2 mg/dL and calcium is 9.2 mg/dL.
What is the most appropriate approach to correcting
the hypophosphatemia?
A) Administer IV calcium gluconate 1 g followed by
infusion of IV phosphate at a rate of 8 mmol/h for 6 h.
B) Administer IV phosphate alone at a rate of
4 mmol/h for 6 h.
C) Administer IV phosphate alone at a rate of
8 mmol/h for 6 h.
D) Stop tube feedings, phosphate is expected to normalize over the course of the next 2448 h.
E) Initiate oral phosphate replacement at a dose of
1750 mg/day.
Answer: C
Severe hypophosphatemia occurs when the serum concentration falls below 2 mg/dL . In this circumstance, IV
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when a patients status of the hypothalamic pituitary adrenal axis is uncertain. It is usually not needed in the preoperative evaluation. Without any evidence of overt adrenal
insufficiency, perioperative steroids are not recommended. In this particular case, the patient may proceed
with surgery without the need for supplemental steroids.
Reference
Marik PE, Pastores SM, Annane D et al. Recommendations
for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American
College of Critical Care Medicine. Crit Care Med.
2008;36(6):193749.
316. An 86-year-old male is admitted for cough, dyspnea,
and dysphagia. He has a known large non-small cell
cancer in the upper lobe of the right lung and is on
week 4 of palliative irradiation. He reports anorexia,
difficulty swallowing solid food, and right shoulder
pain. His wife and family are concerned about dehydration. They request IV fluids and nutrition.
On physical examination, the patient is thin and
appears weak but alert. Pulse rate is 120 beats per minute, respirations are 24 per minute, and blood pressure
is 150/70 mmHg. There are temporal wasting and a dry
oropharynx. The patients breathing is shallow, with
mild tachypnea. Breath sounds are diminished in the
upper lobe of the right lung. You convene a family
meeting to discuss options.
Which of the following would be the most likely
outcome of intravenous hydration or nutrition in this
patient?
A) Reduced BUN/serum creatinine ratio
B) Prolonged survival
C) Increased albumin level
D) Improved quality of life
Answer: A
Families feel an important obligation to provide nutrition
and hydration to the dying patient. A randomized controlled trial found that parenteral hydration did not
improve quality of life in advanced cancer. The intravenous fluids would likely reduce this patients prerenal
azotemic state in the short term but would not have a beneficial impact on his quality of life. These facts can guide
counseling of patients and families in seeking noninvasive
measures for this stage of advanced cancer.
Reference
Medically assisted hydration for adult palliative care patients.
Cochrane Database Syst Rev. 2014 Apr 23 ;4:CD006273.
doi: 10.1002/14651858.CD006273.pub3.
C)
D)
E)
F)
Answer: C
CT scan is indicated for the diagnoses of acute appendicitis.
It has been shown to be superior to ultrasound or plain
radiograph in the diagnosis of acute appendicitis, The
appendix is not always visualized on CT, but nonvisualization of the appendix on CT scan is associated with surgical findings of a normal appendix 98 % of the time.
This patient presented with classic findings for acute appendicitis. Initial anorexia progressed to vague periumbilical
pain. This was followed by localization to the right lower
quadrant. Low-grade fever and leukocytosis may be present. Acute appendicitis is primarily a clinical diagnosis.
However, imaging modalities are frequently employed as
the symptoms are not always classic and take time to
evolve. Plain radiographs are rarely helpful. Ultrasound
may demonstrate an enlarged appendix with a thick wall,
but is most useful to rule out gynecological disease such
as ovarian pathology, tuboovarian abscess, or ectopic
pregnancy, which can mimic appendicitis.
References
Graffeo CS, Counselman FL. Appendicitis. Emerg Med Clin
North Am. 1996;14(4):65371.
Terasawa T, Blackmore CC, Bent S, Kohlwes RJ. Systematic
review: computed tomography and ultrasonography to
detect acute appendicitis in adults and adolescents. Ann
Intern Med. 2004;141(7):53746.
319. A 38-year-old obese woman is admitted to the hospital
for elective cholecystectomy. The surgery is uncomplicated, but postoperatively her urine output is 6 L/day .
She complains of severe thirst. On the second postoperative day, her BUN and creatinine are noted to be
elevated, and you are consulted.
On your questioning, she reports a 1-year history of
extreme thirst and urinary frequency. Aside from oral
contraceptives, she takes no medications and reports no
past medical history.
Which of the following is the most appropriate first
step to confirm her diagnosis?
A) 24-h urine volume and osmolarity measurement
B) Fasting morning plasma osmolarity
C) Fluid deprivation test
D) MRI of the brain
E) Fasting morning glucose
Answer: A
The patient has idiopathic diabetes insipidus. This may present with long-standing urinary frequency and thirst. The
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Reference
Pappagallo M. Incidence, prevalence, and management of
opioid bowel dysfunction. Am J Surg. 2001;182
(suppl 5A):11S8S.
Answer: C
Elective surgery should be delayed at least 1 year after the
placement of a drug-eluting stent. Rapid thrombosis of a
drug-eluting stent (DES) is a catastrophic complication.
The risk of stent thrombosis is increased in the perioperative setting and is strongly associated with the cessation
of antiplatelet therapy. To avoid thrombosis with DES,
aspirin and antiplatelet agents should be continued
throughout surgery. In spite of the increased risk of bleeding, this strategy is acceptable in many types of invasive
surgical procedures with no change in outcome.
In situations where surgery may be needed on a semi-urgent
basis in patients who have received a drug-eluding stent
within 1 year and the risk of bleeding is high. In these
situations, consultation with cardiology is recommended.
Elective surgery with bare metal stents should be delayed for
3090 days.
Reference
Abualsaud AO, Eisenberg MJ. Perioperative management of
patients with drug-eluting stents. J Am Coll Cardiol Intv.
2010;3(2):13142.
323. A 74-year-old female was transferred to the intensive
care unit after an in-hospital cardiac arrest. She has a
history of near end-stage congestive heart failure.
Return of spontaneous circulation occurred after a prolonged code at the 25-min mark of ACLS.
On physical examination, the patients respiratory
rate is greater than the rate set on the ventilator. The
dolls eye reflex is negative, as are the corneal reflexes
and pupillary light reflexes. The only muscle movements are myoclonus.
A family meeting is arranged to discuss prognosis
and treatment. At this point they want all resuscitative
measures to be continued. They want to know if she
will regain consciousness and what is the time frame
for her possible recovery.
At what point after this patients brain injury can
you most accurately give the family a prognosis about
the risk of death or persistent unconsciousness?
A) 24 h
B) 48 h
C) 72 h
D) 96 h
Answer: C
Several prospective studies showed that absent corneal
reflexes and absent motor responses to noxious stimuli at
72 h are highly predictive of no cognitive function return.
Caution should be used to ensure the patient is under limited sedation or other underlying reversible conditions
when these exam findings are made.
References
Labelle A, Juang P, Reichley R et al. The determinants of
hospital mortality among patients with septic shock
receiving appropriate initial antibiotic treatment. Crit
Care Med. 2012;40:201621.
Tweed WA, Thomassen A, Wernberg M. Prognosis after cardiac arrest based on age and duration of coma. Can Med
Assoc J. 1982;126(9):105860.
324. A patient with severe dementia is admitted for worsening anorexia and nausea over the past 6 weeks. She
lives at home with her family. The family would like to
continue palliative care but are looking to improve her
appetite and diminish her nausea. You and the family
meet and agree on a conservative course of action.
Which of the following statements accurately characterizes the treatment of these complications of severe
dementia?
A) Haloperidol has minimal effects against nausea.
B) Even though this patient has severe dementia, it would
be unethical to withhold nutrition and hydration.
C) A feeding tube will reduce the risk of aspiration
pneumonia.
D) A trial of antidepressants is indicated.
E) Impaction may explain all the symptoms.
F) A trial of megestrol acetate.
Answer: E
Anorexia and gastrointestinal symptoms are common near
the end of life. Despite a nonaggressive approach, some
simple measures may improve symptoms. Haloperidol
may be highly effective against nausea and may be less
sedating than many commonly used agents, such as prochlorperazine. Impactions are common and can present
with a variety of symptoms. Treatment can be relatively
easy and can improve comfort.
Because of the terminal and irreversible nature of end-stage
dementia and the substantial burden that continued lifeprolonging care may pose, initiating aggressive hydration
and nutrition would not be indicated.
Appetite stimulants such as megestrol acetate have not been shown
to be of any benefit in the anorexia of end-stage dementia.
Reference
Hanson LC, Ersek M, Gilliam R, Carey TS. Oral feeding
options for patients with dementia: a systematic review.
J Am Geriatr Soc. 2011;59(3):46372.
133
Reference
Riely CA. Liver disease in the pregnant patient. Am J
Gastroenterol. 1999;94:172832.
326. A 66-year-old male is admitted with acute onset of left
hemiplegia. He has a history of hypertension, nonvalvular atrial fibrillation, and thyroid disease. He has
been lost to medical follow-up in recent years and has
been on no anticoagulation.
On physical exam, motor strength is 1/5 in the left
arm and 2/5 in the left leg. Electrocardiogram reveals
atrial fibrillation with a heart rate of 70 beats per minute. MRI performed on presentation reveals a right
middle cerebral artery infarction.
Which of the following is appropriate treatment for
stroke prevention?
A) Aspirin 350 mg daily alone
B) Clopidogrel 25 mg daily
C) Warfarin, adjusted to achieve an INR of 23
D) Unfractionated heparin bolus, followed by
infusion
E) Enoxaparin
134
Answer: C
Guidelines do not support the routine use of anticoagulation
for acute ischemic stroke. In this particular case with a
large territory middle cerebral artery infarct, any urgent
anticoagulation may increase the risk of conversion to
hemorrhage.
Several randomized, controlled trials that used heparin early
after ischemic stroke failed to show a significant overall
benefit of treatment over controls. An exception may be in
patients with acute ischemic stroke ipsilateral to a severe
stenosis or occlusion of the internal carotid artery.
Stroke prevention treatment for atrial fibrillation is most often
determined according to the CHADS2/CHADS2VAS system. Warfarin continues to be the most commonly used
agent, although a number of newer agents including dabigatran are increasingly being prescribed.
Current recommendation is that warfarin be started during
the hospitalization. Bridging with low-molecular-weight
heparin is not usually needed but may be considered in
certain circumstances.
References
Fiorelli M, Bastianello S, von Kummer R et al. Hemorrhagic
transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month
outcome in the European Cooperative Acute Stroke Study
I (ECASS I) cohort. Stroke. 1999;30(11):22804.
Paciaroni M, Agnelli G, Micheli S, Caso V. Efficacy and
safety of anticoagulant treatment in acute cardioembolic
stroke: a meta-analysis of randomized controlled trials.
Stroke. 2007;38(2):42330.
327. A 37-year-old male with a history of intravenous drug
abuse is admitted with fever and hypertension. A diagnosis of mitral valve endocarditis is made by echocardiogram. He is noted to have a large lesion on his mitral
valve with moderate regurgitation. He is started on broadspectrum antibiotics and has a clinically good response.
When is surgery indicated in the presence of
endocarditis?
A) Heart failure
B) After several embolic events
C) Myocardial abscess
D) Confirmed fungal endocarditis
E) All of the above
Answer: E
Fifteen to twenty percent of the patients who have endocarditis will ultimately require surgical intervention.
Congestive heart failure in a patient with native valve
endocarditis is the primary indication for surgery.
The decision to proceed with surgery is often difficult due to
patient comorbidities. Traditional criteria include those
listed above. It is suggested that surgery may be considered
in patients with large lesions and significant valvular disease. Early surgery reduces the risk of embolic events,
although this has not been proven to change overall mortality. Failure of medical treatment is another indication for
surgery, although guidelines are not specific. In addition
surgery should be considered in patients with multiresistant organisms. Endocarditis in many circumstances warrants early cardiothoracic surgery consultation.
References
Kang DH, Kim YJ, Kim SH et al. Early surgery versus conventional treatment for infective endocarditis. N Engl J
Med. 2012;366(26):246673.
Thuny F, Grisoli D, Collart F, Habib G, Raoult D. Management
of infective endocarditis: challenges and perspectives.
Lancet. 2012;379(9819):96575.
328. Which of the following patients with metastatic disease
is potentially curable by surgical resection?
A) A 22-year-old man with a history of osteosarcoma
of the left femur with a 1-cm metastasis to his right
lower lobe
B) A 63-year-old woman with a history of colon cancer with one metastases to the left lobe of the liver
C) Operable non-small cell lung cancer with a single
brain metastasis
D) All of the above
E) None of the above
Answer: D
In colon, non-small cell lung and osteosarcoma cancer cures
have been reported with resection of solitary metastatic
lesions. Metastases typically represent widespread systemic dissemination of disease and are associated with
poor prognosis. Palliative chemotherapy is generally the
accepted method of treatment. Over the last several years,
numerous reports and studies have demonstrated long-term
survival after resection of isolated metastasis. After extensive investigation for further metastatic sites, isolated
metastasis should be considered for reaction in select cases.
Reference
Manfredi S, Bouvier AM, Lepage C et al. Incidence and patterns of recurrence after resection for cure of colonic cancer
in a well defined population. Br J Surg. 2006;93:111522.
329. A 56-year-old white male with known clinical atherosclerotic disease is admitted with severe leg cramps. His
past medical history is significant for a myocardial
infarction (MI) 4 years ago requiring stent placement. At
the time of his MI, he was initiated on a high-intensity
statin; since then he has developed severe leg cramps.
What would be the next best alternative in lipid therapy for this patient?
135
Reference
Kris MG, Hesketh PJ, Somerfield MR et al. American
Society of Clinical Oncology guideline for antiemetics in
oncology:
update
2006.
J
Clin
Oncol.
2006;24(18):293247.
Answer: A
He should be on a high-intensity statin, but he was unable to
tolerate the side effects. According to American College
of Cardiology guidelines, patients with known clinical
atherosclerotic disease should be on a moderate-intensity
statin if not a candidate or cannot tolerate the highintensity regimen. Atorvastatin 20 mg is a moderateintensity statin. The moderate-intensity daily dose will
lower LDL-C by approximately 30 to <50 %, whereas the
high-intensity therapy lowers LDL-C by approximately
50 %. Lastly, pravastatin 10 mg is a low-intensity statin.
Reference
Stone NJ, Robinson J, Lichtenstein AH et al. 2013 ACC/
AHA guideline on the treatment of blood cholesterol to
reduce atherosclerotic cardiovascular risk in adults: a
report of the American College of Cardiology/American
Heart Association Task Force on Practice Guidelines. J
Am Coll Cardiol. 2013. pii: S0735-1097(13)06028-2.
330. A 62-year-old man is admitted for dehydration. He also
reports severe nausea and vomiting that began 24 h
ago. He recently started chemotherapy for non-small
cell lung cancer. His last dose was 48 h ago.
On physical examination his abdomen is soft and
nontender. Bowel sounds are present. He is admitted
and started in intravenous fluids. Despite several doses
of ondansetron, he continues to have near constant
nausea.
What would be the next appropriate treatment for
his nausea and vomiting?
A) Dexamethasone
B) Haloperidol
C) Lorazepam
D) Octreotide
Answer: A
Dexamethasone is recommended for the management of
delayed chemotherapy-induced nausea and vomiting.
Delayed nausea and vomiting are any nausea and vomiting that occurred after the day that chemotherapy is
infused. Nausea and vomiting are two of the most feared
cancer treatment-related side effects for cancer patients.
Dexamethasone has synergistic action with many antiemetic
medications. Its specific antiemetic mechanism of action
is not fully understood. It is generally started at 8 mg once
or twice daily. Corticosteroids may be effective as monotherapy as well.
Answer: A
Gastrointestinal (GI) bleeding affects an estimated 4.5 % of
warfarin-treated patients annually and is associated with a
significant risk of death. These patients present a dilemma
for clinicians regarding when to restart warfarin. A recent
study examined patients who had GI bleeds when on warfarin. They found that warfarin therapy resumption within
1 week after a GI bleed was, after 90 days, associated
with a lower adjusted risk for thrombosis and death without significantly increasing the risk for recurrent GI
bleeding compared to those who did not resume warfarin.
The median time to restart warfarin was 4 days. From this
study, a reasonable period of 7 days is suggested.
References
Lee JK, Kang HW, Kim SG, Kim JS, Jung HC. Risks related
with withholding and resuming anticoagulation in patients
with non-variceal upper gastrointestinal bleeding while
on warfarin therapy. Int J Clin Pract. 2012;66:648.
Qureshi W, Mittal C, Patsias I et al. Restarting anticoagulation and outcomes after major gastrointestinal bleeding in
atrial fibrillation. Am J Cardiol. 2014;113:6628.
136
332. An 82-year-old male is admitted for communityacquired pneumonia. During the first 24 h of admission, he undergoes cardiopulmonary arrest. He was
subsequently successfully coded on the floor. The family cannot be contacted, and full resuscitation measures
are taken. He is transferred to the ICU.
Which of the following will characterize the
patients post-arrest clinical course?
A) Increased intracranial pressure
B) Intact cerebrovascular autoregulation
C) Myocardial dysfunction
D) Minimal inflammatory response
Answer: C
The post-cardiac arrest syndrome (PCAS) is an inflammatory
syndrome that best resembles sepsis. Inflammatory mediators
are released, resulting in activation of the coagulation cascade. Cerebral edema, ischemic degeneration, and impaired
autoregulation characterize the brain injury pattern in the
PCAS. Brain injury alone contributes greatly to overall morbidity and mortality in the resuscitated cardiac arrest patient.
There is impaired autoregulation as well as impaired oxidative metabolism. There is predictable myocardial dysfunction. Myocardial dysfunction in the PCAS seems to be
reversible and is characterized largely by global hypokinesis.
Elevations of intracranial pressure are not prominent.
Treatment during this period involves hemodynamic support and the use of inotropic and vasopressor agents if
warranted. Hyperthermia should be avoided at all costs in
patients with the PCAS. If aggressive therapy is pursued,
consider sedation with hypothermia to improve neurological outcome in the ICU setting.
References
Benson DW, Williams GR Jr, Spencer FC, Yates AJ. The use
of hypothermia after cardiac arrest. Anesth Analg.
1959;38:4238.
Wright WL, Geocadin RG. Postresuscitative intensive care:
neuroprotective strategies after cardiac arrest. Semin
Neurol. 2006;26(4):396402.
333. A 72-year-old female is admitted with abdominal distension. She has history of colon cancer. Her last bowel
movement was 4 days ago despite her taking scheduled
polyethylene glycol. Her cancer was diagnosed 2 years
ago and has been treated with chemotherapy after her
disease was determined to be surgically unresectable.
On physical exam the bowel is distended with absent
bowel sounds. Lungs are normal. A nasogastric tube is
placed with some mild improvement of distension.
CT scan shows dilated loops of small bowel and
colon with a transition point in the mid-descending
colon.
Skin antisepsis with chlorhexidine was found to be associated with a 50 % reduction in the subsequent risk of
CLABSI compared with povidone iodine.
Reference
Maki DG, Stolz SM, Wheeler S, Mermel LA. Prevention of
central venous catheter-related bloodstream infection by
use of an antiseptic-impregnated catheter. A randomized,
controlled trial. Ann Intern Med. 1997;127(4):25766.
335. A 32-year-old female is admitted with multiple sclerosis. She initially undergoes intravenous steroid therapy
with little clinical response. On day 4 of her hospitalization, plasma exchange/plasmapheresis are initiated.
Which of the following electrolytes should be followed closely during her hospitalization?
A) Potassium
B) Calcium
C) Sodium
D) Phosphorous
Answer: B
Patients undergoing plasmapheresis can experience symptoms of hypocalcemia and/or hypomagnesemia during
and after the procedure. Current plasmapheresis regimens
often include prophylactic replacement of calcium.
Hypocalcemia has also been reported following massive
transfusions due to the binding citrate agent. However,
this is transient, and there is no evidence that calcium
supplementation will be of benefit. Septic shock and
severe sepsis are also associated with hypocalcemia. This
is due to abnormalities of vitamin D and parathyroid hormone. There is no evidence that septic patients benefit
from calcium repletion.
References
Drew MJ. Plasmapheresis in the dysproteinemias. Ther
Apher. 2002;6(1):4552.
Mokrzycki MH, Kaplan AA. Therapeutic plasma exchange:
complications and management. Am J Kidney Dis.
1994;23(6):81727.
336. A 65-year-old male with metastatic non-small cell lung
cancer is admitted for increasing pain and exhaustion. The
patient has metastasis to his spine. He states the pain has
become unbearable and is unable to sleep. He describes
the pain in his legs as episodic, shooting and burning. The
pain is worse at night than during daytime. He has been
taking escalating doses of hydromorphone. The initial
hydromorphone dosage of 4 mg several times daily was
not very effective, and he tells you that he is now taking
8-mg hydromorphone tablets four or five times daily. He
states that the hydromorphone provides brief relief.
137
138
139
in
pregnancy.
BMJ.
140
141
142
References
Kaplan RP, Grant JN, Kaufman AJ. Dermatologic features of
the fat embolism syndrome. Cutis. 1986;38:525.
Lindeque B, Schoeman H, Dommisse G, Boeyens MC, Vlok
AL. Fat embolism and the fat embolism syndrome. J
Bone Joint Surg. 1987;69B:12831.
348. A 75-year-old woman who lives in a nursing facility fell
and fractured her hip. She is admitted to the combined
medicine orthopedic service for open reduction and
internal fixation of the hip. She was admitted for an
acute myocardial infarction 5 months prior to the current admission, which was treated with angioplasty and
a drug-eluting stent. Outpatient medications are omeprazole, alendronate, weekly methotrexate, aspirin (325 mg
daily), clopidogrel (75 mg daily), and paroxetine.
The patients outpatient medications are continued
perioperatively. The patient is placed empirically on
ceftriaxone for a possible urinary tract infection. On
day 3 she develops incisional bleeding at the site of her
hip fracture repair site.
On physical exam, temperature is 38.0 C (100.4 F),
pulse rate is 90 beats/per minute, respirations are 22
per minute, and blood pressure is 120/80 mmHg. A
large hematoma with serosanguinous drainage is noted
along the right hip.
Which of the following medications is most likely
to increase the risk of bleeding in this patient?
A) Omeprazole
B) Ceftriaxone
C) Methotrexate
D) Paroxetine
Answer: D
Perioperative use of selective serotonin reuptake inhibitors
(SSRIs) has been linked to an increased risk of bleeding,
transfusion, hospital readmission, and death.
Despite this, stopping SSRIs preoperatively may not be
warranted.
In the preoperative setting, abruptly stopping an SSRI before
surgery could precipitate an SSRI withdrawal syndrome.
In addition worsening of depression or other underlying
conditions being treated by the drug could occur. It is
important for clinicians to be aware of the risk for SSRIassociated bleeding complications.
Reference
Labos A. Risk of bleeding associated with combined use of
selective serotonin reuptake inhibitors and antiplatelet
therapy following acute myocardial infarction. CMAJ.
2011;183(16):1835.
349. A 62-year-old female is admitted for facial and neck
cellulitis. Computed tomography of the neck in the
143
351. Which of the following potential risk factors is associated with severe postextubation dysphagia?
A) Age
B) Weight
C) Sex
D) Intubation in the ED
E) Reintubation
F) C and E
Answer: F
Severe postextubation dysphagia requiring dietary modification is associated with reintubation, male gender, and ventilator days. Age, weight, and place of intubation are not
correlated with dysphagia.
Reference
Macht M et al. Postextubation dysphagia is persistent and
associated with poor outcomes in survivors of critical illness. Crit Care. 2011;15:R231.
352. A 45-year-old attorney presents with midepigastric
pain, nausea, and vomiting. He has no prior medical
history. He denied any alcohol intake and takes no over
the counter medicines.
On physical exam, blood pressure is 140/70 mmHg,
and heart rate is 70 bpm. Mild midepigastric tenderness
is appreciated.
On admission amylase is 235 units/L, lipase is 175
unit/L, and alkaline phospatase is 52 g/dl. He is
started in intravenous fluids and has a rapid resolution of his symptoms the following day. Amylase on
the second day is 38 units/L and lipase is 86
units/L. Ultrasound of the abdomen reveals a gallbladder with several stones. No gallbladder wall
thickening is appreciated.
What is the correct management of this patient?
A) Discharge home with no further intervention.
B) Surgical follow-up for cholecystectomy
C) Cholecystectomy prior to discharge
D) HIDA scan
Answer: C
If possible, patients admitted with gallstone pancreatitis
should undergo cholecystectomy before discharge, rather
than being scheduled as an outpatient. Patients discharged
without a cholecystectomy are at high risk for recurrent
bouts of pancreatitis. Recurrent episodes may be more
severe than the original presentation.
In one study, patients with mild gallstone pancreatitis who
underwent laparoscopic cholecystectomy within 48 h of
admission resulted in a shorter hospital stay. There was no
apparent impact on the technical difficulty of the procedure or the perioperative complication rate.
144
systems compared with systemic analgesics in opioidrefractory patients. A trial of intrathecal medication is
important, to determine the effect, prior to permanent
placement of an implanted device.
His previous laminectomy and associated scarring may limit
the effect of intrathecal delivery as well as make catheter
placement difficult. The use of palliative sedation therapy
is indicated in patients with refractory symptoms at the
end of life. Although his pain is severe and unresponsive
to systemic medications, she is not at the end of life, nor
have all interventions been pursued to address her pain.
Reference
Deer TR, Smith HS, Burton AW et al. Comprehensive consensus based guidelines on intrathecal drug delivery systems in the treatment of pain caused by cancer pain. Pain
Physician. 2011;14(3):E283312.
356. A 56-year-old woman has widely metastatic breast cancer. She is admitted for sepsis. The decision has been
made to withdraw care and to allow a natural death
preferably as an inpatient. The family is at the bedside.
Oxygen saturation is 85 % with the patient receiving
supplemental oxygen, 2 L/min by nasal cannula.
On physical examination, she is nonverbal and restless in bed. Her respirations have become more difficult. The family appears fatigued and anxious.
Which of the following should you do now?
A) Request a sitter.
B) Provide 100 % oxygen by face mask.
C) Administer a dose of parenteral haloperidol.
D) Administer a dose of parenteral morphine.
E) Administer a dose of parenteral dexamethasone.
145
Reference
Ben-Aharon I, Gafter-Gvili A, Leibovici L, Stemmer
SM. Interventions for alleviating cancer-related dyspnea:
a systematic review and meta-analysis. Acta Oncol.
2012;51(8):9961008.
358. A 68-year-old female is evaluated for preoperative clearance before she goes in for left knee elective surgery.
She has a history of chronic hypertension. She has on
amlodipine but has been noncompliant with her medicines. Her knee pain limits her activities but she is able
to walk up two flights of stairs with minimal difficulty.
On physical exam her blood pressure is 145/99 mmHg,
heart rate is 55 bpm, and respiratory rate is 11 breaths/
min. Extremities pulses are 2+ and bilateral. An echo
done 7 months ago shows an ejection fraction of 30 %.
The patient denies any new complaints.
What is the next step?
A) Proceed with surgery without additional preoperative testing.
B) Control BP to ideal measurement of <130/85.
C) Delay elective surgery for further evaluation or
treatment.
D) Exercise stress test.
E) Start metoprolol.
Answer: A
Preoperative hypertension is frequently a hypertensive
urgency, not an emergency. In general, patients with
chronic hypertension may proceed to low-risk surgery as
long as the diastolic BP is <110 mmHg.
Answer: D
Morphine is the drug of choice with air hunger at the end of
life. It is preferred over other sedation. There is no evidence that supplemental oxygen is beneficial at the end of
life. In addition, many patients experience increased agitation when a mask is placed over the mouth and nose.
Family members may not desire a face mask for the
patient as well during this special time.
146
There continues to be some debate over the use of betablockers preoperatively. Current guidelines state that in
patients with no risk factors, starting beta-blockers in the
perioperative setting provides unknown benefit.
Reference
Thomas DR, Ritchie CS. Preoperative assessment of older
adults. J Am Geriatr Soc. 1995;43(7):81121.
359. You are asked to admit a 32-year-old female for a 4-day
history of lower abdominal pain that she describes as
intermittent cramps. She denies nausea or vomiting. She
also denies having urinary frequency, dysuria, and flank
pain. Her only medication is an oral contraceptive agent.
On physical examination, her temperature is 38.5 C
(101.4 F), blood pressure is 120/68 mmHg, pulse rate
is 100 beats/min, and respiratory rate is 18 breaths/min.
Abdominal examination is normal. There is no flank
tenderness. Pelvic examination shows cervical motion
tenderness. Bilateral adnexal tenderness is appreciated
on bimanual examination. She is in minimal distress
and is tolerating liquids. The hematologic and serum
chemistries are normal. Urine and serum pregnancy
tests are negative.
What is the next best step in the management of this
patient?
A) Consult for laparoscopic diagnosis and treatment.
B) Admit the patient to the hospital, obtain pelvic
ultrasound, and start ceftriaxone.
C) Administer a single-dose IM ceftriaxone and discharge the patient.
D) Administer a single-dose IM ceftriaxone and oral
doxycycline for 14 days.
E) Obtain pelvic and abdominal ultrasound and prescribe oral doxycycline with metronidazole.
Answer: D
This patients clinical findings are compatible with pelvic
inflammatory disease (PID). Women with mild to moderate PID may receive outpatient medical treatment without
increased risk of long-term sequelae.
Laparoscopy is the criterion standard for the diagnosis of
PID, but the diagnosis of PID in emergency departments
is often based on clinical criteria, without additional laboratory and imaging evidence.
She should receive intramuscular ceftriaxone and oral doxycycline for 14 days. All women with suspected PID should
be tested for infection with gonorrhea and chlamydia. In
severe cases, imaging should be performed to exclude a
tuboovarian abscess.
Patients with PID should be hospitalized if there is (1) no
clinical improvement after 4872 h of antibiotics, (2) an
inability to tolerate food or medicine, (3) severe symp-
toms, (4) suspected abscess, (4) pregnancy, or (5) predicted noncompliance with therapy.
References
Ness RB, Soper DE, Holley RL, Peipert J, Randall H, Sweet
RL et al. Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: results from the Pelvic Inflammatory Disease
Evaluation and Clinical Health (PEACH) Randomized
Trial. Am J Obstet Gynecol. 2002;186:92937.
Paavonen J. Chlamydia trachomatis infections of the female
genital tract: state of the art. Ann Med. 2012;44(1):1828.
360. Which of the following is the most common cause of
erythema multiforme?
A) Mycoplasma pneumoniae
B) Herpes simplex
C) Amoxicillin
D) Cytomegalovirus
Answer: B
One of the most common predisposing factors for erythema
multiforme is infection with herpes simplex virus, which
may or may not be active at the time of the EM eruption.
EM is an acute, self-limited, and sometimes recurring
skin condition that is considered to be a type IV hypersensitivity reaction. It is associated with infections, medications, and other various triggers. Patients with recurrent
EM are typically treated with acyclovir or valacyclovir.
Mycoplasma pneumonia, amoxicillin, ibuprofen, and
cytomegalovirus may cause EM, but are not as common.
Reference
Aurelian L, Ono F, Burnett J. Herpes simplex virus (HSV)associated erythema multiforme (HAEM): a viral disease with
an autoimmune component. Dermatol Online J. 2003;9:1.
361. A 65-year-old male with a long history of type II diabetes is admitted with the chief complaint of hematuria.
His blood pressure is 130/65 mmHg. Otherwise his
physical exam is normal. Urinalysis shows blood 3+ and
protein 3+. No casts are seen. A 24-h urinary protein
shows 8 g of protein and serum creatinine is normal.
Urine microscopy shows isomorphic red blood cells
with no casts. Renal and bladder ultrasound are normal.
His hematuria is less by day 2 of his admission.
What is the next most appropriate investigation?
A) Renal angiogram
B) Renal biopsy
C) Doppler ultrasound of the kidneys
D) CT scan of the abdomen and thorax alone
E) Cystoscopy
F) Observation alone
Answer: E
This man has hematuria without evidence of dysmorphic red
cells or casts in urinary sediment. Macroscopic hematuria
in the absence of significant proteinuria or RBC casts is
an indication for imaging to exclude malignancy or cystic
renal disease. Approximately 8090 % of patients with
bladder cancer present with painless gross hematuria.
Urine cytology is extremely valuable but would not eliminate the need for cystoscopy, which is the standard for
diagnosing bladder cancer.
Many bleeding urinary tract lesions arise in the bladder and
lower urinary tract, and no imaging technique is completely satisfactory for ruling out disease at these sites.
Further imaging may be of use but cystoscopy will ultimately be needed.
Reference
Grossfeld GD, Litwin MS, Wolf JS Jr, Hricak H, Shuler CL,
Agerter DC et al. Evaluation of asymptomatic microscopic
hematuria in adults: the American Urological Association
best practice policy part II: patient evaluation, cytology,
voided markers, imaging, cystoscopy, nephrology evaluation, and follow-up. Urology. 2001;57(4):60410.
362. A 47-year-old woman with a history of ulcerative colitis
(UC) is hospitalized for progressive cramping abdominal pain, hematochezia, fever, and up to 15 bloody
bowel movements daily. She is resuscitated with IV fluids, and methylprednisolone 60 mg is started. After 5
days of steroids, she continues to have ten bloody bowel
movements with persistent abdominal pain.
Which of the following is NOT an appropriate
course of action?
A) Infectious workup.
B) Consider starting infliximab.
C) Surgery consult.
D) Consider starting cyclosporine.
E) Increase the dose of steroids.
Answer: E
The American College of Gastroenterology practice guidelines define severe colitis as the passage of six or more
stools per day with evidence of systemic toxicity.
Intravenous corticosteroids, which are essential in severe
cases, are effective in the induction of remission in the
majority of cases. A daily intravenous steroid dose of
hydrocortisone 300 mg or methylprednisolone 60 mg is
suggested. Fortunately, most patients with severe UC
respond to intravenous steroid therapy. However, 30 % of
patients fail to respond after 57 days. These patients are
considered to be steroid refractory.
One of the simplest algorithms predicts that at the third day
of intravenous steroid therapy, patients with a stool
147
148
149
150
Two years ago, an automatic implantable cardioverter defibrillator (AICD) was placed with a transvenous approach for persistent ventricular arrhythmias.
In the past 2 weeks, the AICD has fired six times. The
patients daughter reports that since his last hospital
discharge, the patient has spent most of his time sleeping in a recliner or in bed and has a poor appetite.
On physical examination, the patient is dyspneic
and poorly communicative, but denies current chest
pain.
Which of the following is the correct treatment?
A) Initiation of a milrinone infusion
B) Angiography for possi(ble percutaneous
intervention
C) Insertion of an intra-aortic balloon pump
D) Deactivation of the AICD
E) AICD recalibration
Answer: D
This patient has multiple indicators for the definition of
advanced chronic heart failure, including symptom-based
high New York Heart Association (NYHA) classification,
severe chronic obstructive pulmonary disease, and left ventricular ejection fraction below 30 %. Palliative care is appropriate and should be offered. The most reasonable intervention
at this time is deactivation of the automatic implantable cardioverter defibrillator (AICD). Failure to deactivate the AICD
leaves many patients vulnerable to inappropriate device discharge, unnecessary discomfort, and intense anxiety. Other
measures, such as infusion of positive inotropes, are used on
a temporary basis with a plan for more definitive therapies.
The use of intermittent infusions to control symptoms is not
recommended by the AHA/ACC guidelines unless the patient
is awaiting definitive therapy, such as transplantation.
371. A 64-year-old man has been admitted for a large subarachnoid hemorrhage (SAH) from a ruptured cerebral
aneurysm. He has no spontaneous movement for the
past week. He remains intubated. There is concern that
the patient has brain death.
What test is most commonly used to diagnose brain
death in this situation?
A) Cerebral angiography
B) Apnea testing
C) Demonstration of absent cranial nerve reflexes
D) Demonstration of fixed and dilated pupils
E) Performance of transcranial Doppler ultrasonography
Answer: B
Brain death is defined as lack of cerebral function with continued cardiac activity. This state requires support by artificial means. If an individual is determined to have brain death,
life-sustaining therapies may be withdrawn. This can occur
without the consent of the family. It is important to have
151
ongoing communication with the family to allow the withdrawal of care without conflict. Most hospitals have developed specific protocols in line with state law to diagnose a
patient with brain death.
Three elements should be demonstrated for the diagnosis
of brain death. The patient should have widespread cortical
damage with the complete absence of response to all external
stimuli. Second, the patient should have no evidence of medullary function demonstrated by a lack of oculovestibular
and corneal reflexes. A common test is to assess pupillary
reaction to light. Finally, there should be no evidence of
medullary activity. This is manifested by apnea. Specific
protocols have been developed to perform the apnea test.
References
Allen LA, Stevenson LW, Grady KL, et al. AHA scientific
statement: decision making in advanced heart failure.
Circulation. 2012;125:192852.
Wijdicks EFM. The diagnosis of brain death. N Engl J Med.
2001;344:121521.
372. A 56-year-old woman is admitted for severe nausea
and diarrhea. She complains of nausea and diarrhea
that began early that afternoon. She reports that she ate
a sandwich from a street vendor for lunch, and she
began experiencing symptoms several hours later. She
reports no similar experiences in the past; she has no
recent travel history, nor has she had any contacts with
sick persons. She was treated with a 5-day course of
ciprofloxacin for a urinary tract infection 2 months ago
and is otherwise healthy.
On physical exam she is heme negative. Abdomen
is mildly tender. She is afebrile. Which organism is the
most likely cause of this patients acute diarrheal
illness?
A) Campylobacter jejuni
B) Salmonella enteritidis
C) Staphylococcus aureus
D) C. difficile
E) E. coli
Answer: C
Most acute diarrheas are caused by viral infections, such as
adeno, norwalk, and rotavirus. They and are self-limited.
Some are caused by bacteria. The most common agents in
urban areas are Campylobacter, Salmonella, Shigella, and
Escherichia coli. Protozoa such as Giardia lamblia and
Entamoeba histolytica account for other common causes.
One mechanism for acute diarrhea is ingestion of a preformed toxin. Several species of bacteria, such as S. aureus,
C. perfringens, and Bacillus cereus, can produce toxins that
produce syndrome commonly designated as food poisoning.
This occurs within 4 h of ingestion. In such cases, the bacteria
do not need to establish an intraluminal infection; ingestion
152
of the toxin alone can produce the disease. Symptoms subside after the toxin is cleared, usually by the next day.
Symptoms are usually localized and fever is minimal.
Reference
Loir YL, Baron F,Gautier M. Review Staphylococcus aureus
and food poisoning. Genet Mol Res. 2003;2(1):6376.
373. A 52-year-old female with a history of renal transplant
5 years prior presents with headache, fever, and purulent rhinorrhea. This has occurred over the past 5 days.
She has been on steroids intermittently over the past 6
months for episodes of acute rejection.
On physical exam, she is lethargic but able to
respond to questions appropriately. Her lungs are
cleared to auscultation. She has diffuse maxillary tenderness and is noted to have a black nasal discharge.
Which of the following is the likely cause of her
illness?
A) Coccidioides immitis
B) Rhizopus (mucormycosis)
C) Histoplasmosis capsulatum
D) Blastomyces dermatitidis
E) Cryptococcus neoformans
Answer: B
This patients symptoms are consistent with mucormycosis
which is an invasive fungal infection caused by a variety of
fungi most commonly rhizopus. This is a rapid opportunistic infection that invades the vascular system. It is a lifethreatening condition and urgent consultation with
otolaryngology and infectious disease is warranted.
Mucormycosis is acquired by inhalation of the spores that
are found ubiquitously in soil, decaying fruit, and old bread.
Although a black eschar is the classic finding of mucormycosis, it is present in less than half of the patients. The presence of a black eschar indicates vascular invasion and
predicts a poor prognosis.
The prognosis of mucormycosis is poor and has varied
mortality rates depending on its form and severity. Patients
who are immunocompromised have a significantly higher
mortality rate from 60 to 80 %. In the rhinocerebral form, the
mortality rate is between 30 and 70 %. Disseminated mucormycosis has a very poor prognosis with a mortality rate of up
to 90 %
Reference
Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology
and outcome of Mucormycosis: a review of 929 reported
cases. Clin Infect Dis. 2005;41(5):63453.
374. A 68-year-old male with a past medical history of diabetes mellitus II, hypertension, hypothyroidism, and
153
154
Answer: A
The adjusted incidence of sudden death was significantly
associated with increased benzodiazepine dosage during
4.8 years of follow-up in a 2014 study.
Reference
Wu CK, et al. Anti-anxiety drugs use and cardiovascular outcomes in patients with myocardial infarction: a national
wide assessment. Atherosclerosis. 2014;235(2):496502.
379. A 72- year-old female is admitted with communityacquired pneumonia. On chest X-ray, she is noted to
have a marked pleural effusion. You plan to perform a
therapeutic thoracentesis of a large right-sided pleural
effusion.
In addition to confirming the patients identity verbally and noting the site of the procedure, which of the
following has the Joint Commission identified as being
a critical component of the time-out in the Universal
Protocol for invasive procedures?
A) The patients admitting diagnosis
B) The patients date of birth
C) The type of procedure
D) The patients age and date of admission
E) The follow-up plan after the procedure
Answer: C
The Joint Commission has defined several critical components of the time-out in an effort to improve patient safety
and reduce medical errors. All components must be performed prior to the procedure. This includes confirming the
patients identity, the site of the procedure, and the type of
the procedure.
Reference
A follow-up review of wrong site surgery. Sentinel Event
Alert. 2001;24:3.
155
Which of the following statements does not accurately characterize the benefits of a geriatric acute care
unit over a general inpatient ward?
A) The geriatric acute care unit reduces inhospital
functional decline.
B) Patients who receive care in a geriatric acute care
unit have improved functional status 3 months
after discharge.
C) The geriatric acute care unit provides patientcentered care that emphasizes independence.
D) There is an increased likelihood that patients
receiving care in a geriatric acute care unit will be
able to return home upon discharge.
E) The geriatric acute care unit provides intensive
review of medical care to minimize the adverse
effects of medications.
Answer: A
By 90 days after discharge, functional capacity is the same
on geriatric units as it is on nonspecialized acute care units.
Geriatric units have specially prepared environments,
specific protocols for enhanced discharge planning, and
medical care that is designed to minimize the adverse effects
of procedures and medications. The geriatric unit is one of
several models of comprehensive inpatient geriatric care that
have been developed by geriatrician researchers to address
the adverse events and functional decline that often accompany hospitalization.
Despite the assumed benefits, studies so far have been
mixed. Several short-term favorable outcomes have been
recorded. These include reductions in decline of short-term
functionality and readmission. Other long-term endpoints
have not yet been demonstrated.
Reference
Landefeld CS, Palmer RM, Kresevic DM, Fortinski RH,
Kowal J. A randomized trial of care in a hospital medical
unit especially designed to improve the functional outcomes of acutely ill older patients. N Engl J Med.
1995;332:133844.
384. Which of the following bacteria or virus is the most
likely etiology of ventilator-associated pneumonia
(VAP) in an 82-year-old nursing home patient who is in
the medical ICU for congestive heart failure?
A) Legionella pneumonia
B) E. Coli
C) Mycoplasma pneumonia
D) Respiratory syncytial virus
E) Staphylococcus aureus
Answer: E
Despite geographical variations, Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter
156
baumannii, Pseudomonas aeruginosa, and Enterobacter species (ESKAPE) pathogens constitute more than 80 % of ventilator-associated pneumonia (VAP) episodes. The organisms
escape the biocidal actions of many antibiotics and have
developed increasing resistance. As antibiotic development
declines and resistance rises, healthcare-associated infections
remain a constant threat to patient welfare. The ESKAPE
pathogens will be of increasing relevance to antimicrobial
chemotherapy in the coming years.
References
Park DR. The microbiology of ventilator-associated pneumonia. Respir Care. 2005;50:74263.
Sandiumenge A, Rello J. Ventilator-associated pneumonia
caused by ESKAPE organisms: cause, clinical features, and
management. Curr Opin Pulm Med. 2012;18(3):18793.
385. Polymerase chain reaction (PCR) bacterial testing has
been proven to assist in the diagnosis of what
conditions?
A) Community-acquired pneumonia
B) Cellulitis
C) Endocarditis
D) A and B
E) A and C
Answer: E
PCR bacterial testing represents a major advance in the rapid
diagnosis of infectious diseases. They may be used for blood
as well as tissue samples. In a recent study, a broad-range
PCR assay diagnosed infective endocarditis with a specificity of 91 %. Sensitivity was 67 %, positive predictive value
was 96 %, and negative predictive value was 46 %. In situations where early diagnosis is beneficial or where antibiotics
may be given for a long period, it may be cost-effective. So
far PCR has shown promise in diagnosing communityacquired pneumonia and endocarditis tissue samples. As
costs of PCR testing decrease, further use is anticipated.
References
Barken KB, Haagensen JA, Tolker-Nielsen T. Advances in
nucleic acid-based diagnostics of bacterial infections.
Clin Chim Acta. 2007;384(12):111.
Edwards K, Logan J, Langham S, Swift C, Gharbia S. Utility
of Real-time amplification of selected 16S rDNA
sequences as a tool for detection and identification of
microbial signatures directly from clinical samples. J
Med Microbiol. 2012;61(5):64552.
386. Factors not named in the literature as contributing to
higher rates of readmission include:
A) Differences in patient health status
B) Discharge planning and care coordination
C) The availability and effectiveness of local primary
care
157
158
References
Lam LL, Cameron PA, Schneider HG, Abramson MJ, Mller
C, Krum H. Meta-analysis: effect of B-type natriuretic
peptide testing on clinical outcomes in patients with acute
dyspnea in the emergency setting. Ann Intern Med.
2010;153(11):72835.
Maisel A, Mueller C, Adams K Jr, et al. State of the art:
using natriuretic peptide levels in clinical practice. Eur J
Heart Fail. 2008;10(9):82439.
393. An 86-year-old female is admitted from the nursing
home with a diagnosis of urinary tract infection and
sepsis. She has a history of progressive dementia. She
has no known implantable devices or orthopedic, internal hardware.
Blood cultures are drawn which reveal gram-positive
rods. Otherwise, no other source of infection is isolated.
Urine cultures are negative. In the first 48 h she clinically
improves and is back to her baseline mental status.
Which of the following explains the positive blood
cultures?
A) Urinary tract infection
B) Endocarditis
C) Skin contamination
D) Chronic wound infection
Answer: C
There are four bacteria that are common contaminants when
blood cultures are positive. They are coagulase-negative
staph (gram-positive cocci), Corynebacterium (grampositive rods), Propionibacterium acnes (anaerobic grampositive rods), and Bacillus species (anaerobic gram-positive
rods). These may be considered to be true pathogens when
multiple sites are positive, or the patient has prosthetic
implants.
Staphylococcus
aureus,
Streptococcus
species,
Enterococcus, Candida, Pseudomonas, and other gram-negative rods-positive bacillus are usually not a contaminant
from the skin. In this particular case, without signs of overwhelming sepsis, the gram-positive rod is almost certainly a
contaminant.
Reference
Madeo M, Barlow G. Reducing blood-culture contamination
rates by the use of a 2 % chlorhexidine solution applicator
in acute admission units. J Hosp Infect. 2008;
69(3):3079.
394. A 62-year-old Caucasian female with a past medical
history of diabetes and osteoarthritis was admitted
for right hip total arthroplasty. Perioperatively, she
received subcutaneous enoxaparin for anticoagulant
therapy. She is on the hip fracture service managed
by hospital medicine. You are called to see her on
day three for the sudden-onset substernal chest pain.
She has minimal response to two doses of sublingual
nitroglycerin. Initial 12-lead EKG demonstrates
inferior lead ST elevation. Stat labs are drawn and
reveal elevated troponins at 45 ng/mL. Complete
blood count shows a platelet count of 20,000 cells/
mcl which were 238,000 cells/mcl at the time of
admission.
Which drug is FDA approved and is indicated for
management of acute coronary syndrome of this
patient?
A) Oral lepirudin
B) Oral rivaroxaban
C) Intravenous enoxaparin
D) Bivalirudin
E) Fondaparinux
Answer: D
This patient developed heparin-induced thrombocytopenia
(HIT) and an acute STEMI. Bivalirudin is a direct thrombin
inhibitor that is FDA approved for the management of
patients with acute STEMI secondary to or at risk for
HIT. Enoxaparin should be avoided in patients with
HIT. Although fondaparinux and lepirudin are used in acute
coronary syndromes (ACS), they are not indicated in patients
who developed ACS with HIT.
159
Reference
Bittl JA, Chaitman BR, Feit F, et al. Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: final report reanalysis of the bivalirudin
angioplasty study. Am Heart J. 2001;142:9529.
395. Beta-blockers will provide which of the following benefits in elderly patients with congestive heart failure
and preserved ejection fractions?
A) Decreased all-cause mortality
B) Decreased heart failure re-hospitalization
C) All of the above
D) None of the above
Answer: D
Beta-blockers are essential in the treatment of CHF with
reduced ejection fraction. However, in patients with CHF
with preserved ejection fraction, benefits have not been demonstrated. In a study over 6 years in patients over the age of
65, there was no association with individual endpoints of allcause mortality or heart failure re-hospitalization, with the
use of beta-blockers on discharge.
Reference
Patel K, et al. Beta-blockers in older patients with heart failure and preserved ejection fraction: Class, dosage, and
outcomes. Int J Cardiol. 2014;173(3):393401.
160
398. A 47-year-old female is admitted to the hospital medicine service for possible osteomyelitis. Past medical
history includes hypertension, diabetes mellitus type 2,
depression, and hyperlipidemia.
The AHA Get with the Guidelines program was developed to identify improvement opportunities, allow performance comparison among hospitals, and reduce medical
errors through data-driven peer review. The AHA has
reviewed the most up-to-date research and scientific publications in developing this program. The program includes
guidelines for resuscitation, atrial fibrillation, heart failure,
and stroke.
Reference
American Heart Association (AHA) Get with the
Guidelines Resuscitation program 2012. http://www.
h e a r t . o r g / H E A RT O R G / H e a l t h c a r e R e s e a r c h /
GetWithTheGuidelinesHFStroke/Get
WithTheGuidelinesStrokeHomePage/Get-WithGuidelines-Stroke-Overview. Accessed 12 Dec 2014.
400. The US governments National Quality Forumapproved methodology for calculating excess 30-day
readmission rates includes all of the following except:
A) Adjustment for clinically relevant patient
comorbidities
B) The patients socioeconomic status, specifically federally defined income level below the poverty line
C) Established 3-year period for which discharges are
calculated
D) Readmissions from all causes to the same or another
hospital for patients with specified diagnoses
E) Minimum number of cases (25) annually for the
hospital for each listed
Answer: B
Thirty-day hospital readmissions are common and costly and
because they may signal an unnecessary use of resources
have been the focus of US health policy interventions to
reduce cost.
In March 2010, the comprehensive health reform act, the
Patient Protection and Affordable Care Act, went into law.
The law established a program to encourage reduction in
hospital readmissions, which requires the US Centers for
Medicare and Medicaid Services to reduce payments to hospitals with excess readmissions.
Thirty-day hospital readmission calculations do not consider socioeconomic status, race or ethnicity, or English language proficiency in the risk adjustments. These are strong
risk factors for readmission. Some hospital advocates feel
these are factors that clinicians have no control over and
should not be considered in penalty determinations.
Reference
CMS.gov. Readmissions reduction program 2013. www.
cms.gov/Medicare/Medicare-Feefor- Service-Payment/
AcuteInpatientPPS/Readmissions-Reduction-Program.
html. Accessed 14 Nov 2014.
161
162
Answer: C
For most cases of bacterial meningitis, isolation can be discontinued 24 h after the initiation of antibiotics. It is important to remove isolation when it can be safely done to reduce
the psychological stress placed on the patient, improve
patient care, and facilitate discharge planning.
Reference
Chaudhuri A, MartinezMartin P, Martin PM et al. EFNS
guideline on the management of community-acquired
bacterial meningitis: report of an EFNS Task Force on
acute bacterial meningitis in older children and adults.
Eur J Neurol. 2008;15(7):64959.
405. A pharmaceutical company does not publish inconclusive results of new drug that it is marketing. This is an
example of:
A) Reporting bias
B) Underestimation
C) Cofounding
D) None of the above
Answer: A
Reporting bias continues to be a major problem in the assessment of health-care interventions. Several prominent cases
of reporting or publication bias have been described in the
literature. These have included trials reporting the effectiveness of antidepressants, class I anti-arrhythmic drugs, and
selective COX-2 inhibitors. Studies in which drugs are
shown to be ineffective are often not published, delayed, or
modified to emphasize the positive results suggested.
In addition, trials with statistically significant findings
were generally published in academic journals with higher
circulation more often than trials with nonsignificant findings. In general, published evidence tends to overestimate
efficacy and underestimate safety risks. The extent of this is
often unknown.
References
MacAuley D. READER: an acronym to aid critical reading
by general practitioners. Br J Gen Pract. 1994;44:835.
Sterne J, Egger M, Moher D. Addressing reporting biases.
In: Higgins JPT, Green S, editors. Cochrane handbook for
systematic reviews of interventions. Chichester: Wiley;
2008. p. 297334.
406. Compared with central venous catheters (CVCs),
peripherally inserted central catheters (PICCs) are
associated with which of the following?
A) Lower patient satisfaction
B) Lower cost-effectiveness
C) Greater risk of bloodstream infection
D) Greater risk of deep vein thrombosis
Answer: D
PICCs have many advantages over central venous catheters.
PICCs are a reliable alternative to short-term central venous
catheters, with a lower risk of complications. PICCs have
higher patient satisfaction and lower infection rates and are
more cost-effective than other CVCs.
However, PICCs are associated with a higher risk of deep
vein thrombosis than are central venous catheters (CVCs).
This risk is increased in patients who are critically ill or those
with a malignancy. Also, to meet the definition of a PICC, the
distal tip of the catheter must terminate in the superior vena
cava, the inferior vena cava, or the proximal right atrium.
Thrombosis may be a result of PICCs being inserted into
peripheral veins that are narrower and more likely to occlude in
the presence of a catheter than the large veins used for CVCs.
Reference
Chopra V, Anand S, Hickner A, et al. Risk of venous thromboembolism associated with peripherally inserted central
catheters: a systematic review and meta-analysis. Lancet.
2013;382:31125.
407. What is the 30-day hospital readmission rate for
patients in the United States?
A) 20 % of all Medicare discharges
B) 10 % of all Medicare discharges
C) 12 % of hospitalized patients covered by commercial payers
D) 20 % of Medicare and commercial payers
E) None of the above
Answer: A
19.6 % of 11,855,702 Medicare beneficiaries who had been
discharged from a hospital in 2003 and 2004 were rehospitalized within 30 days, and 34 % were rehospitalized within
90 days. Since that time small reductions in readmissions
have occurred.
Reducing readmission rates is a major priority for hospitals given that the Affordable Care Act (ACA) established a
Hospital Readmissions Reduction Program that requires the
Centers for Medicare and Medicaid Services (CMS) to
reduce payments to hospitals with excessive readmissions.
Not all readmissions are avoidable. But unplanned readmissions frequently suggest breakdowns in continuity of
care and unsuccessful transitions of care between settings.
Studies suggest that readmissions are not usually tied to
medical errors committed during the hospital stay, but rather
to social issues, poor follow-up, or the patients lack of
understanding of post-hospital care.
Reducing readmissions has proven to be difficult. No simple fix has been found. Most gains are seen in institutions
that employed a multifactorial approach.
163
Reference
Jencks SF, Williams MV, Coleman EA. Rehospitalizations
among patients in the Medicare fee-for-service program.
N Engl J Med. 2009;360:141828.
408. A 27-year-old man presents painful swelling of the
right knee and swelling of several fingers. He is otherwise healthy but does recall a severe bout of diarrheal
illness about 34 weeks prior that spontaneously
resolved. He takes no medications and reports rare
marijuana use.
On physical exam he has limited motion and swelling of the right knee. You suspect reactive arthritis due
to a diarrheal illness.
Which of the following is the most likely etiologic
agent of his diarrhea?
A) Campylobacter jejuni
B) Clostridium difficile
C) Escherichia coli
D) Helicobacter pylori
E) Shigella flexneri
Answer: E
The most common organism associated with reactive arthritis in diarrheal illness is the Shigella species. Reactive
arthritis refers to an acute, nonpurulent arthritis that occurs
after an infection elsewhere in the body. In shigella infections, it often presents with lower joint inflammatory arthritis occurring 14 weeks after a diarrheal episode. Reactive
arthritis may also include uveitis or conjunctivitis, dactylitis, and urogenital lesions. It can occur with yersinia, chlamydia, and, to a much lesser extent, salmonella and
campylobacter.
Reference
Hannu T, Mattila L, Siitonen A, Leirisalo-Repo M. Reactive
arthritis attributable to Shigella infection: a clinical and
epidemiological nationwide study. Ann Rheum Dis.
2005;64(4):5948.
409. An 82-year-old nursing home resident has been admitted for melena. You are called to see him the first night
because he was found unresponsive in his bed immersed
in black stool. His past medical history is remarkable
for Alzheimers dementia.
On physical his pressure is 85/50 mmHg and
heart rate is 130 beats/min. He is transferred to the
ICU and a central venous catheter is placed that
reveals CVP less than 5 mmHg. Catheterization of
the bladder yields no urine. Anesthesiology has been
called to the bedside and is assessing the patients
airway.
164
410. In which of the following circumstances would albumin infusion be most beneficial?
A) A patient with the end-stage liver disease and ascites requiring paracentesis
B) A patient with hypotension and a serum albumin of
1.8 g/dL
C) A patient with acute blood loss awaiting type and
match for packed red blood cell infusion
D) A patient who is hypotensive with sepsis syndrome
and a serum albumin of 2.0 g/dL
Answer: A
The role of albumin infusion remains uncertain in many clinical situations. Albumin composes 5060 % of blood plasma
proteins. It is effective in preventing the complications of
high-volume paracentesis in patients with cirrhosis and ascites undergoing paracentesis. Indications and the use of albumin administration in critically ill patients are uncertain. In
general, albumin is not given specifically to treat hypoalbuminemia, which is a marker for serious disease.
Reference
McGibbon A, Chen GI, Peltekian KM, van Zanten SV. An
evidence-based manual for abdominal paracentesis. Dig
Dis Sci. 2007;52(12):330715.
411. For patients greater than 65 years of age and hospitalized with heart failure and preserved ejection fraction,
discharging with a new prescription for calcium channel blockers (CCBs) provides what benefit?
A) Decreased mortality
B) Decreased 30-day heart failure admissions
C) Decreased 90-day incidence of myocardial
infarction
D) None of the above
Answer: D
New discharge prescriptions for CCBs have no correlation with
improved endpoints in older patients hospitalized with HF and
ejection fraction 40 %. This is according to 2014 study.
Reference
Patel K, et al. Calcium-channel blockers and outcomes in
older patients with heart failure and preserved ejection
fraction. Circ Heart Fail. 2014;7(6):94552.
165
166
References
Chung SD, et al. Statin use and clinical outcomes among pneumonia patients. Clin Microbiol Infect. 2014;20(9):87985.
Fedson DS. Pandemic influenza: a potential role for statins in
treatment and prophylaxis. Clin Infect Dis. 2006;43(2):
199205.
416. According to a review of available studies, what are the
effects of starting alpha blockers prior to the removal of
a urinary catheter in order to prevent retention?
A) Reduces urinary retention
B) Increased side effects compared to placebo
C) Increase success rate of catheter removal
D) Prevents long-term urinary retention
E) No better than placebo in catheter removal success
rate
Answer: C
The limited available evidence suggests that alpha blockers
increase success rates of catheter removal in high-risk
patients. Fortunately, alpha blocker side effects are low and
comparable to placebo. It is uncertain whether alpha blockers reduce the risk of recurrent urinary retention. The costeffectiveness and recommended duration of alpha blocker
treatment remain unknown. Alpha blockers prior to removal
of a catheter for acute urinary retention in adult men caused
few vasodilatation-related side effects.
Reference
Zeif H-J, Subramonian K. Alpha blockers prior to removal of
a catheter for acute urinary retention in adult men.
Cochrane Database Syst Rev. 2009;(4):CD006744.
417. Which of the following patient groups would be adequately treated for pneumonia utilizing ceftriaxone and
azithromycin therapy upon presentation to the emergency department?
A) A 77-year-old female who attends dialysis on
Tuesday, Thursday, and Saturday
B) A 22-year-old male undergoing chemotherapy for
acute leukemia
C) An 82-year-old female with a history of hypertension
and glaucoma which has never been hospitalized
D) A 54-year-old male who resides in a nursing home
due to early-onset dementia
Answer: C
The majority of hospitalized patients with communityacquired pneumonia can be treated with either a respiratory fluoroquinolone or a combination or cephalosporin
and a macrolide. Currently, duration of treatment is recommended between 7- and 10-day total therapy course.
It is important for physicians to assess patients who are
at increased risk for bacterial resistance to this empirical
antibiotic regimen. Patients that meet criteria for healthcare-associated pneumonia should be identified as their
antibiotic regimens may need to include coverage for
methicillin-resistant Staphylococcus aureus (MRSA) and
multidrug-resistant (MDR) gram-negative pathogens.
Criteria for Health-Care-Associated Pneumonia:
Hospitalization for 2 days during the previous 90
days
Development of pneumonia greater than 4872 h postadmission to hospital
Residence in a nursing home or extended-care facility
Long-term use of infusion therapy at home, including
antibiotics
Hemodialysis during the previous 30 days
Home wound care
Family member with multidrug-resistant pathogen
Immunosuppressive disease or therapy such as organ
transplantation or active chemotherapy
Reference
Solomon C. Community-acquired pneumonia. N Engl J
Med. 2014;270:54351.
Reference
Wilkinson ST, DSouza DC. Problems with the medicalization of marijuana. JAMA. 2014;311:23778.
167
168
B) A 62-year-old female who is unable use the bedside commode and is requesting a Foley catheter
while in the hospital
C) An 85-year-old man with urinary incontinence
who has a stage 4 sacral ulcer
D) All of the above
E) A and C
F) B and C
Answer: E
Some acceptable indications for an indwelling urinary catheter include the following:
1) Clinically significant urinary retention for temporary
relief
2) For comfort in a terminally ill patient
3) Accurate urine output monitoring in the critically ill
patient
4) During prolonged surgical procedures with general or
spinal anesthesia
5) To aid in healing stage 4 sacral decubitus ulcer that has failed
treatment and is worsened due to urinary incontinence
Patient preference, urinary incontinence, and monitoring
urinary output in the stable patient are not indications for
indwelling urinary catheters and should be avoided.
Reference
Hooton TM, Bradley SF, Cardenas DD, Colgan R, Geerlings
SE, Rice JC, Saint S, Schaeffer AJ, Tambayh PA, Tenke P,
Nicolle LE; Infectious Diseases Society of America.
Diagnosis, prevention, and treatment of catheter-associated
urinary tract infection in adults: 2009 International Clinical
Practice Guidelines from the Infectious Diseases Society
of America. Clin Infect Dis. 2010;50:62563.
169
Increased levels of air pollutants, including carbon monoxide, nitrogen dioxide, ozone, sulfur dioxide, and particulate
matter, are well-known risk factors for the development of
pneumonia, asthma, COPD, and other pulmonary diseases
In a study of 457 patients with HIV and microscopically
confirmed PcP, hospital admissions were significantly higher
in the summer than in other seasons. Increases in temperature and sulfur dioxide levels were independently associated
with hospital admissions for PcP.
Reference
Dyawe K, et al. Environmental risk factors for Pneumocystis
pneumonia hospitalizations in HIV patients. Clin Infect
Dis. 2013;56(1):7481.
170
may increase urine output and sodium excretion but are ineffective and even detrimental in the prevention and treatment
of AKI. They neither shorten the duration of AKI nor reduce
the need for renal replacement therapy.
Reference
Dennen P, Douglas IS, Anderson R. Acute kidney injury in
the intensive care unit: an update and primer for the intensivist. Crit Care Med. 2010;38:26175.
431. Cardiovascular events contribute to what percentage of
deaths at long-term follow-up in patients with
community-acquired pneumonia (CAP)?
A) 37 %
B) 30 %
C) 15 %
D) 10 %
E) Less than 5 %
Answer: B
CAP increases the risk for cardiovascular events in the 90
days after discharge. Both plaque-related and plaqueunrelated cardiovascular events are increased. The 90-day
incidence of cardiovascular events in discharged communityacquired pneumonia patients was 1.5 % for myocardial
infarction, 10.2 % for congestive heart failure, 9.5 % for
arrhythmia, 0.8 % for unstable angina, and 0.2 % for stroke.
Overall 30 % of patients who died in long term did so from
cardiovascular events.
Reference
Soto-Gomez N, et al. Pneumonia: an arrhythmogenic
Disease? Am J Med. 2013;126(1):438.
432. A 63-year-old male is admitted with a diagnosis of urosepsis. On his admission, his hemoglobin is noted to be
9.3 g/dL. The patient has clinical improvement. On the
third day of his admission, his hemoglobin is noted to
be 6.1 g/Dl. Hemoccult studies are negative. Fecal
hemoccult is negative. A peripheral smear reveals
schistocytes on the blood smear.
What is the most likely cause of this patients druginduced hemolytic anemia (DIHA)?
A) Piperacillin/tazobactam
B) Haloperidol
C) Fentanyl
D) Metformin
Answer: A
A variety of drugs can cause drug-induced hemolysis. Of the
drugs listed, piperacillin/tazobactam has the highest risk, followed by metformin. In the 30-year experience of a reference laboratory, cefotetan, ceftriaxone, and piperacillin were
171
172
References
Macedo E, Mehta RL. When should renal replacement therapy be initiated for acute kidney injury? Semin Dial.
2011;24(2):1327.
Palevsky PM, Zhang JH, OConnor TZ, Chertow GM,
Crowley ST, Choudhury D, et al. Intensity of renal support in critically ill patients with acute kidney injury. N
Engl J Med. 2008;359(1):720.
434. Compared to middle age and younger adults, elderly
patients have an increase in 30-day readmission rates
for which of the following conditions:
A) Heart failure.
B) Pneumonia.
C) Acute MI.
D) All of the answers are correct.
E) None of the above.
Answer: E
Despite social situations that often differ, young and middleaged adults have 30-day readmission rates that are similar for
most conditions.
References
Jencks SF, Williams MV, Coleman EA. Rehospitalizations
among patients in the medicare fee-for-service program.
New Eng J Med. 2009;360:141828.
Ranasinghe I, et al. Readmissions after hospitalization for heart
failure, acute myocardial infarction, or pneumonia among
young and middle-aged adults: a retrospective observational
cohort study. PLoS Med. 2014;11(9):e1001737.
435. A 68-year-old man who has severe coronary artery disease is admitted to the ICU with respiratory failure and
shock. The source of the shock is uncertain. A procalcitonin level is ordered.
Which of the following is true concerning procalcitonin levels?
A) An elevated procalcitonin level mitigates against
myocardial infarction.
B) A procalcitonin-guided strategy will decrease the
patients mortality risk.
C) A low procalcitonin level excludes bacterial
infection.
D) A high procalcitonin level is specific for bacterial
infections.
E) A low procalcitonin level makes septic shock less
likely.
Answer: E
A low procalcitonin level is primarily predictive of a decrease
incidence of septic shock. Procalcitonin (PCT) is a biomarker that exhibits greater specificity than other markers in
References
Cardo DM, Culver KH, Ciesielski C, Srivastava PU, Marcus
R, Abiteboul D, et al, A casecontrol study of HIV seroconversion in health-care workers after percutaneous
exposure. N Engl J Med. 1997;337:148590.
Diprose P, Deakin CD, Smedley J. Ignorance of postexposure prophylaxis guidelines following HIV needlestick injury may increase the risk of seroconversion. Br J
Anaesth. 2000;84 (6):76770.
437. A 67-year-old man with ETOH-related cirrhosis is
admitted with hematemesis. He has been taking twice
daily propranolol for 4 months for esophageal varices.
He has not had prior bleeding before this. He has been
abstinent from alcohol for 3 years. He is stabilized and
given 4 units of fresh frozen plasma and 2 units of
packed red blood cells. His INR on admission is 1.6.
An octreotide infusion is started. An esophagogastroduodenoscopy shows three columns of grade 3
esophageal varices. An active bleeding source is found.
Hemostasis is achieved with band ligation of several
esophageal varices.
His vital signs remain stable post procedure and he
is transferred back to the floor.
Which of the following should be done to increase
this patients survival?
A) Packed red blood cells to achieve a target hematocrit of greater than 30 %
B) Continued octreotide infusion for 5 days total
C) Intravenous ceftriaxone now and daily for 5 days
D) Fresh frozen plasma to correct coagulopathy to an
INR of less than 1.5
E) Intravenous pantoprazole now and twice daily for
2 days
Answer: C
Intravenous antibiotics such as ceftriaxone or ciprofloxacin
have a proven survival benefit in patients who have cirrhosis
with portal hypertensive bleeding. It is recommended that it be
administered early in the course and continued for 57 days.
A target hematocrit of 30 % risks increasing portal pressure. Excessive fresh frozen plasma administration increases
portal pressure and the risk for transfusion-associated lung
injury. There is no clear survival benefit from intravenous
pantoprazole in the setting of variceal bleeding, even after
band ligation. Octreotide infusion can lower portal pressures,
but are usually emergency and recommended for 72 h.
Reference
Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W; Practice
Guidelines Committee of the American Association for
the Study of Liver Diseases; Practice Parameters
Committee of the American College of Gastroenterology.
Prevention and management of gastroesophageal varices
173
174
Reference
Villanueva C, Colomo A, et al. Transfusion Strategies for
acute upper gastrointestinal bleeding. N Engl J Med.
2013;368:1121.
440. Most high-risk peptic ulcer rebleeding after successful
endoscopic hemostasis occurs within how many days?
A) 3
B) 47
C) 1530
D) 814
Answer: A
Most patients with high-risk peptic ulcers rebleed within
the first 72 h. Major clinical parameters for predicting
rebleeding after receiving endoscopic treatment are hemodynamic instability at admission and hemoglobin value.
Major endoscopic predictors for rebleeding are active
bleeding at endoscopy, large ulcer size, and ulcer location.
Reference
El Ouali S, et al. Timing of rebleeding in high-risk peptic
ulcer bleeding after successful hemostasis: a systematic
review. Can J Gastroenterol Hepatol. 2014;28(10):5438.
441. The 2013 American Heart Association Guidelines for
reducing heart failure readmissions include all of the
following except:
A) Identifying patients suitable for guideline-directed
medical therapy
B) Developing patient education programs that emphasize discharge care
C) Developing home electronic monitoring systems
D) Utilizing nursing staff for disease management
E) Conducting patient follow-ups at 3 days and 2
weeks post-discharge
Answer: C
Interventions that were relatively inexpensive and available
to all hospitals were chosen. They include four simple, lowtech interventions. Identify heart failure patients appropriate for goal-directed therapy, developing transitional care,
and discharge planning that emphasizes patient education
to increase treatment compliance, manage comorbid conditions effectively, and tackle psychosocial barriers to care.
Readmissions will continue to be a significant reform
topic because they are seen as maker of overall system quality and can be objectively measured.
References
Dellinger RP, Levy MM, Carlet JM, et al. Surviving sepsis
campaign: international guidelines for management of
severe sepsis and septic shock: 2008. Crit Care Med.
2008;36:296327.
Answer: B
Noninvasive positive pressure ventilation (NPPV) in the
24 h after extubation may reduce the need for reintubation.
As a method of weaning critically ill adults from invasive
ventilation, NPPV was significantly associated with reduced
mortality and ventilator-associated pneumonia. In many circumstances, NPPV is not tolerated.
The use of incentive spirometry reduces the risk of
postoperative pulmonary complications but has a limited
role in the routine management of nonsurgical patients
following extubation. N-acetylcysteine is a mucolytic
agent. In this particular patient, secretions do not seem to
be a confounding factor. In addition, N-acetylcysteine
may trigger bronchospasm and would not be recommended here.
Reference
Ferrer M, Sellares J, Valencia M, et al. Non-invasive ventilation after extubation in hypercapnic patients with chronic
respiratory disorders: randomised controlled trial. Lancet.
2009;374(9695):10828.
175
176
Answer: B
Because the hospitalist field is relatively new, there has been
little formal research as to how malpractice claims against
hospitalists compare against other specialists and internists
for liability risk. Overall malpractice claims against hospitalists appear to be low. Although malpractice claims against
hospitalist are low compared to other specialties, in some
areas hospitalists have seen an increase in claims. This has
probably occurred as hospitalists continue to expand their
scope of practice, particularly in the areas of comanagement
with neurosurgical patients.
A study of closed claims by The Doctors Company found
that the most common allegations involving hospitalists are
improper management of treatment course, delay in treatment, failure to treat, diagnosis-related error improper medication management, and failure to monitor the physiologic
status of the patient.
Reference
Hospital Medicine 2013: Society of Hospital Medicine
(SHM) Annual Meeting. Presented on May 18, 2013.
447. The most common cause of acute mesenteric ischemia is:
A) Superior mesenteric artery embolism
B) Mesenteric vein thrombosis
C) Noninclusive mesenteric vascular disease
D) Thrombosis of the superior mesenteric artery
E) Abdominal aortic aneurysm involving the superior
mesenteric artery
Answer: A
Fifty percent of the cases of acute mesenteric ischemia
(AMI) are caused by an embolism. Emboli usually originate
in the left atrium or ventricle. Often a source is found such as
atrial fibrillation or recent myocardial infarction. Most
emboli lodge distal to a major branch point.
Abdominal distention and gastrointestinal bleeding are
the primary presenting symptoms in as many as 25 % of
patients. Pain may be abrupt, severe, and unresponsive to
opioids. As the bowel becomes gangrenous, rectal bleeding
and signs of sepsis develop.
If not rapidly recognized and treated, AMI has a poor outcome. It should be considered in any patient with abdominal
pain disproportionate to physical findings and the presence
of risk factors, especially age older than 60 years.
Because of the high mortality and the difficulty of diagnosis,
mesenteric ischemia poses a substantial legal risk. Legal risk is
reduced with early surgical consultation and prompt imaging.
Reference
Sachs SM, Morton JH, Schwartz SI. Acute mesenteric ischemia. Surgery. 1982;92(4):64653.
Answer: D
Development of delirium is predictive of cognitive impairment 1 year after a critical illness. In this case, there may be
some permanent cognitive decline. The duration of delirium
is an independent predictor of long-term cognitive impairment. This is noted in patients under the age of 40 as well.
The development of delirium may be a predictor of underlying cognitive impairment, such as dementia.
References
Bergeron N, Dubois MJ, Dumont M et al. Intensive care
delirium screening checklist: evaluation of a new screening tool. Intensive Care Med. 2001;27:85964.
Jackson JC, Gordon SM, Girard TD et al. Delirium as a risk
factor for long-term cognitive impairment in mechanically ventilated ICU survivors. Am J Respir Crit Care
Med. 2007;175:A22.
450. On your first day as a hospitalist, you are called to the
emergency room to admit a case of abdominal pain due
to pancreatitis. The ED physician starts his presentation by stating the patient is an alcoholic. On your
questioning, the patient reports that he has a history of
alcoholism, but denies any recent alcohol intake in the
past several years. You suspect that he still drinks.
Amylase and lipase are normal. ETOH is not detected.
You admit him with the diagnosis of pancreatitis. He is
started in IV fluids and pain control.
Several days later with no resolution of symptoms,
gastroenterology is consulted. They conclude that pancreatitis is unlikely and he undergoes an EGD. The
diagnoses of severe gastritis are made.
Which of the following is the type of medical error
made?
A) Anchoring
B) Heuristic
C) Cultural bias
D) Framing
Answer: A
Anchoring errors occur when clinicians cling to an initial
impression even as conflicting and contradictory data accumulate. There is a tendency to frame a clinical problem
around the first piece of information we receive. There is
often a sense of reward and confidence in going with your
first instinct. In addition, the hierarchical nature of medicine
often places greater emphasis on the opinions of certain staff.
In this case, pancreatitis is certainly possible, but the data
points otherwise. There is a tendency to stick with the original diagnosis and not consider other options even in the face
of conflicting evidence.
Reference
Furnham A, Boo, Hua CH. A literature review of the anchoring effect. J Soc Econ. 2011;40(1):3542.
177
178
Answer: A
Several studies have looked at the presence of family members during cardiac resuscitation. Most have shown positive
outcomes in many parameters. Most who were offered
elected to remain present. Significant findings have demonstrated a lower risk of post-traumatic stress disorder in family members 90 days after the event. Clinical outcomes, as
well as duration of resuscitation, were found to be equal. It is
suggested that the duration of codes may actually be shorter
when family members are present.
Several current guidelines now suggest that family members be offered the opportunity to be present during cardiac
resuscitative measures, if space allows. Hospital staff may
feel uncomfortable with this arrangement and should be provided training prior to establishing this protocol.
Reference
Meyers TA, Eichhorn DJ, Guzzetta CE, et al. Family presence during invasive procedures and resuscitation: the
experience of family members, nurses, and physicians.
Am J Nurs. 2000;100:3241.
454. What percent of patients experiencing refractory recurrent Clostridium difficile infections (CDI) is cured via
intestinal microbiota transplantation (IMT)?
A) 80 %
B) 25 %
C) 50 %
D) 100 %
Answer: A
A small study of 14 patients with severe and refractory CDI
found that 79 % were cured after IMT was delivered via a
nasogastric tube. There were no CDI recurrences in the IMT
group.
Currently, there are several other randomized controlled
studies recruiting patients with recurrent CDI. Evidence continues to increase that donor feces infusion may be superior
to antibiotics in patients with recurrent CDI.
Reference
Van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, Zoetendal
EG, de Vos WM, Visser CE, Kuijper EJ, Bartelsman JF,
Tijssen JG, Speelman P, Dijkgraaf MG, Keller JJ. Duodenal
Infusion of Donor Feces for Recurrent Clostridium difficile. N Engl J Med. 2013;368(5):40715.
Answer: F
Clinical trials suggest that devices that reduced pressure are
superior to standard mattresses. There is no clear advantage
of one device over another. The goal is to maintain tissue
pressures less than 32 mmHg. In theory, reduction of tissue
pressures below capillary filling pressures should allow adequate tissue perfusion.
Any individual thought to be at risk for developing pressure ulcers should be placed on a pressure-reducing device.
Several trials compared different devices: dynamic air
mattresses, water flotation systems, and static support overlay, in terms of the incidence and severity of pressure ulcers
that occurred with their use. In these studies, no device was
more effective than any other in preventing pressure ulcers.
References
Daechsel D, Connine TA. Special mattresses: effectiveness
in preventing decubitus ulcers in chronic neurologic
patients. Arch Phys Med Rehabil. 1985;66:24648. Vilter
RW.
Whitney JD, Fellows BJ, Larson E. Do mattresses make a
difference? J Gerontol Nurs. 1984;10:205.
Answer: B
This patient has a hypertensive emergency. A hypertensive
emergency, formerly called malignant hypertension, is
hypertension with acute impairment of one or more organ
systems. It is defined as a blood pressure greater than 180/120
with progressive target organ dysfunction, encephalopathy,
intracerebral hemorrhage, myocardial infarction, acute left
ventricular failure, unstable angina, dissecting aortic aneurysm, or eclampsia. Hypertensive emergency differs from
hypertensive crisis in that, in the former, there is evidence of
acute organ damage.
The goal of therapy is to reduce blood pressure by 25 %
within the first hour and then to 160/100 within the next 26 h.
Further reductions can then occur over the next 2448 h,
except in the management of acute cerebrovascular accidents.
Excessive reduction in blood pressure can precipitate coronary, cerebral, or renal ischemia and, possibly, infarction.
No trials exist comparing the efficacy of various agents in
the treatment of hypertensive emergencies. Drugs are chosen
based on their onset of action, ease of use, predictability, and
convention.
Reference
Thomas L. Managing hypertensive emergencies in the
ED. Can Fam Physician. 2011;57(10):113797.
456. Which of the following increases with age?
A) Plasma D-dimer concentrations
B) Positive antinuclear antibodies
C) Erythrocyte sedimentation rate
D) All of the above
179
mortality. The most common etiologies for LGIB are diverticulosis (33.5 %), hemorrhoids (22.5 %), and carcinoma (12.7 %)
Diverticulosis is the dominant etiology for massive LGIB in
most publications. Most diverticular bleeding occurs without
concomitant diverticulitis. Risk factors for diverticular bleeding include lack of dietary fiber, constipation, advanced age,
and use of nonsteroidal anti-inflammatory drugs (NSAIDs) and
aspirin. In about 10 % of patients presenting with LGIB, the
source of bleeding is from the upper gastrointestinal (GI) tract.
Reference
Gayer C, Chino A, Lucas C, Tokioka S, Yamasaki T, Edelman
DA, et al. Acute lower gastrointestinal bleeding in 1,112
patients admitted to an urban emergency medical center.
Surgery. 2009;146(4):6006; discussion 6067.
458. Which of the following is a not a predictor of a cardiac
etiology for chest pain?
A) Nonresponse to GI cocktail
B) Duration of pain
C) Location of pain
D) None of the above
Answer: D
Erythrocyte sedimentation rate, plasma D-dimer concentrations, and positivity of antinuclear antibodies increase in the
elderly. Electrolytes are remarkably stable and deviate from the
values in the young adults only in the very old (>90 years). As a
result, traditional thresholds may result in more false positives.
It has been suggested that the D-dimer traditional cutoff of 500
mcg/L be adjusted in the elderly population to 750 mcg/L.
Answer: A
Approximately 5 million patients per year present to the
emergency department with chest pain. In adults the most
common causes of chest pain include gastrointestinal (42 %),
coronary artery disease (31 %), musculoskeletal (28 %),
pericarditis (4 %), and pulmonary embolism (2 %)
A recent review found that for patients with chest pain
and suspected acute coronary syndrome (ACS), use of GI
cocktails did not improve accuracy of diagnosis compared
with standard diagnostic protocols for ACS.
Reference
Spring JL, Winkler A, Levy JH. The influence of various
patient characteristics on d-dimer concentration in critically ill patients and its role as a prognostic indicator in
the intensive care unit setting. Clin Lab Med.
2014;34(3):67568.
Reference
Chan S, Maurice AP, Davies SR, Walters DL. The use of
gastrointestinal cocktail for differentiating gastrooesophageal reflux disease and acute coronary syndrome
in the emergency setting: a systematic review. Lung Circ.
2014;(10):91323.
Answer: A
Lower gastrointestinal bleeding (LGIB) is a frequent cause of
hospital admission and is a factor in hospital morbidity and
180
Answer: B
Some cases of CAP can be safely treated as an outpatient.
CURB-65 guidelines have been developed to assist in appropriate level of care in treating CAP. The CURB-65 acronym
stands for C, confusion; U, uremia; R, respiratory rate greater
than 30/min; B, blood pressure that is low, less than 90 mmHg
systolic or less than 60 mmHg diastolic; and 65, age 65 years
or greater. Each category is assigned 1 point; 01 point total
means the patient can be treated as an outpatient, 2 points
total requires treatment in the medical ward, and 3 or more
points total requires ICU admission
The 66-year-old male with CAP and respiratory rate of 18/
min can be treated as an outpatient. This patient only has one
point, age greater than 65 years of age. The CURB score simply serves a guideline. Other factors such as home situation,
comorbidities, and access to health care must be considered.
References
Aujesky D, Auble TE, Yealy DM, et al. Prospective comparison of three validated prediction rules for prognosis in
community-acquired pneumonia. Am J Med. 2005;118(4):
38492.
Howell MD, Donnino MW, Talmor D, Clardy P, Ngo L,
Shapiro NI. The performance of severity of illness scoring systems in emergency department patients with infection. Acad Emerg Med. 2007;14(8):70914.
460. A 75-year-old female presents with sepsis due to pneumonia. She is admitted to the intensive care unit and is
intubated and started on broad-spectrum antibiotics.
She has a history of vitamin D deficiency. She has been
prescribed replacement therapy but she has noted been
taking them.
She is found to have marked vitamin D deficiency.
Which is true concerning high-dose vitamin D
replacement?
A) Length or stay will be improved.
B) Six-month mortality will be improved.
C) Functional status will be improved.
D) All of the above.
E) None of the above.
Answer: E
Low vitamin D status is linked to increased mortality and
morbidity in patients who are critically ill. The mechanism
through which vitamin D deficiency is associated with
increased mortality in patients with sepsis may be related to
its immunological effects.
It is unknown if replacement therapy improves outcome.
Critically ill patients with vitamin D deficiency did not benefit from D3 replacement as compared with placebo. No
reductions in length of stay, hospital mortality, or 6-month
mortality were noted in a 2014 study.
Reference
Amrein K, Schnedl C, Holl A, et al. Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients
with vitamin D deficiency: the VITdAL-ICU randomized
clinical trial. JAMA. 2014;312(15):152030.
461. An 89-year-old female is admitted for UTI. According
to previous cultures, patient was positive for a pansensitive Escherichia coli. Ciprofloxacin will be
started empirically until new cultures return. In deciding on which dosage regimen to start for this patient,
which renal dosage adjustment equation should be
utilized?
A) Cockcroft-Gault (CG)
B) The modification of diet in renal disease (MDRD)
C) The Chronic Kidney Disease Epidemiology
Collaboration (CKD-EPI)
D) Schwartz
Answer: A
The Cockcroft-Gault (CG) equation provides an estimate of
creatinine clearance and is the equation most commonly
used to determine drug dosages in patients with impaired
kidney function. Currently the MDRD or the CKD-EPI
equations are not recommended in drug dosage adjustment.
Further studies need to be conducted. Also, keep in mind the
package insert for medications bases the recommendations
for renal dosage adjustment on the CG equation, which are
FDA labeled. Lastly, the Schwartz equation is used for the
pediatric population.
Reference
National Kidney patients with renal insufficiency. Can Med
Assoc J 200 Foundation. KDOQI. Clinical Practice
Guidelines and Clinical Practice Recommendations for
Chronic Kidney Disease. Am J Kidney Dis. 2007;49:1180.
181
Answer: D
State laws regulate HIV source patient testing practices in
the United States. The controversy over HIV testing in cases
of occupational exposure is reflected in variations in state
laws and policies. As of 2011, 36 states have laws that allow
unconsented HIV testing of source patients in cases of occupational exposure. Each state has its own requirements for
unconsented HIV testing. Variations exist in numerous procedures, including who can authorize an unconsented test,
how the test is documented in the medical record, and who is
informed of the test results.
In this particular case prompt postexposure treatment may
be needed. It is important that state policy be understood to
allow or a rapid decision-making process to occur.
References
Hughes RA, Rees JH. Clinical and epidemiologic features of
Guillain-Barr syndrome. J Infect Dis. 1997;176(Suppl
2):S928.
Rinaldi S. Update on Guillain-Barr syndrome. J Peripher
Nerv Syst. 2013;18(2):99112.
Reference
Henderson DK. Management of needlestick injuries: a house
officer who has a needlestick. JAMA. 2012;307(1):7584.
182
Otherwise, she seems functional and is able to comprehend the patients presented. As far as you know, she has
not had trouble with substance abuse in the past.
The appropriate action should be:
A) Notify hospital administration.
B) Advise colleague to seek care, respecting her right
to privacy.
C) Inform the colleague that she must remove herself
from the practice area immediately.
D) Inform the chief of hospital medicine.
Answer: C
In this circumstance, you are the hospitals advocate and are
responsible for managing the situation until handed off to the
appropriate treatment team. You are secondarily responsible
to the colleague as a patient. Immediate and definitive action
is required.
In the setting of suspected acute intoxication of a physician or health-care provider who provides patient care or
who might be reasonably expected to provide care in the near
future, immediate removal from the practice setting is essential. In such cases, an intervention may include accompanying the suspected physician to an established health care
environment, such as the emergency department. Security if
needed may be involved.
Reference
Baldisseri M. Impaired healthcare professional. Crit Care
Med. 2007;35(2):10616.
466. Which of the following oral anticoagulants affects prothrombin time, partial thromboplastin time, and thrombin time coagulation assays?
A) Apixaban
B) Dabigatran
C) Rivaroxaban
D) Warfarin
Answer: B
Warfarin has been the standard therapy for oral anticoagulation
for decades. Its side effects and efficacy profile are well known.
It is used for atrial fibrillation, venous thromboembolism (VTE)
prophylaxis, VTE treatment, and valvular heart disease.
Newer agents have been developed in an effort to improve
upon warfarins deficiencies. The entire side affect the profile
of the newer agents is not yet known. Of the drugs listed, only
dabigatran causes alteration in all of the coagulation assays.
Reference
Eriksson BI, et al. Comparative pharmacodynamics and
pharmacokinetics of oral direct thrombin and factor Xa
inhibitors in development. Clin Pharmacokin. 2009;
48(1):122.
183
ute, respiratory rate is 28 per minute, and blood pressure is 152/96 mmHg. Oxygen saturation is 84 %.
Crackles are heard in the lower lung fields.
Which of the following is the most important piece
of information that you should obtain before you treat
this patient?
A) Influenza occurrence in the local area
B) Pneumococcal vaccination status of the patient
C) Methicillin-resistant Staphylococcus aureus prevalence of her care facility
D) Prior urine cultures
E) Advance directives
Reference
Hill GB. Archie Cochrane and his legacy. An internal challenge to physicians autonomy? J Clin Epidemiol.
2000;53(12):118992.
Answer: E
A significant number of patients admitted to the hospital
do not want aggressive life-prolonging care. It is important to recognize what hospice, palliative care, and
advance directives have to offer to individuals and families who face serious, life-threatening advanced illness
issues.
Protocol-driven admission processes can make it easy to
overlook the fundamental right of patient autonomy. Goals
of care in this situation should be determined before any significant effort is undertaken.
Reference
Celso B, Meenrajan, S. The triad that matters: palliative
medicine, code status, and health care costs. Am J Hosp
Palliat Med. 2010;27(6):398401.
184
185
Answer: B
Current evidence supports a role for a sitter as part of the
management of patients with delirium. Although once only
used for observation of high-risk psychiatric patients, the use
of sitters is now most commonly employed as part of the
cost-effective management for delirious patients. Of the
choices here it is the only option with proven benefits.
A limiting factor in utilizing sitters is obviously their cost.
It is uncertain in what circumstances sitters are cost-effective.
In studies utilizing sitters, length of stay and duration of
delirium were not significantly reduced; however, falls were.
To help with identification of patients who would benefit
from sitter use and improve the process of sitter requests, an
assessment tool, the Patient Attendant Assessment Tool,
(PAAT), was created. In addition the use of trained volunteers has been suggested as a method to increase sitter use.
476. A 82-year-old man is admitted for a hemorrhagic
stroke. No deep venous thrombosis prophylaxis is
administered because of his central nervous system
bleeding. His outpatient medications included aspirin,
and this was withheld as well.
Recovery is good and the patient will be transferred
to acute rehabilitation 72 h after his admission.
On physical examination, the patient cannot raise
his affected arm or leg off the bed. Since having her
stroke, he is incapable of walking without assistance.
What is the value in ordering intermittent pneumatic
compression (IPC) device for this patient?
A) Reduced risk of deep venous thrombosis
B) Reduced mortality risk
C) Increased risk of falls
D) Increased risk of lower leg ischemia or amputation
Answer: A
IPC devices prevent VTE after stroke. Thromboembolism is
a common complication of stroke and can have lethal consequences, but DVT prophylaxis can be risky. The Clots in
Legs Or Stockings after Stroke (CLOTS 3) trial studied the
efficacy and adverse effects of IPC devices in a stroke population At 30 days, patients receiving IPCs had a significant
reduction in any DVT compared to those who had none. This
protective effect was persistent through 6 months. The effect
was similar whether anticoagulants were used or not. There
was also benefit to IPCs whether the stroke was hemorrhagic
or not. Falls which may be increased with devices that limit
movement were not different between the groups. There was
a slight increase in skin breaks in the IPC group compared to
those who had no IPC with 20 skin breaks. The IPC group did
not have a higher incidence of ischemia or limb amputation.
Reference
Dennis M, Sandercock P, Reid J, et al. Effectiveness of intermittent pneumatic compression in reduction of risk of
186
Answer: B
Flumazenil is a competitive BZD receptor antagonist. It is
the only available specific antidote for BZDs. Its beneficial
use in acute BZD is not well established. Flumazenil does
not consistently reverse central respiratory depression due to
BZDs. Re-sedation occurs in over half the patients, and they
should be followed closely.
In long-term BZD users, flumazenil may precipitate withdrawal and seizures. Flumazenil should not be used in any
patient at an increased risk of having a seizure, such as head
injury and co-ingestion of BZD and tricyclic antidepressant
or other agents which may lower the seizure threshold. The
ideal use for flumazenil may be isolated iatrogenic BZD
overdose in BZD-naive patients
Reference
Marraffa JM, Cohen V, Howland MA. Antidotes for toxicological emergencies: a practical review. Am J Health Syst
Pharm. 2012;69(3):199212.
479. A 72-year-old male is admitted for ETOH withdrawal.
Mild delirium develops, and the patient becomes agitated and combative. He is transferred to the ICU. The
nurse requests an order for physical restraints. You suggest a sitter but none are available. Physical restraints
are applied to the patient.
Compared with nonrestrained patients, which of the
following is this patient at risk for?
A) Increased use of sedation
B) Increased patient safety
C) Decreased days of intensive care
D) Decreased incidence of adverse events
Answer: A
It is important to recognize potential negative physical and
psychological consequences of restraints. The use of physical restraints is often necessary for the protection of staff and
of patients and should be continued to be used judiciously.
Attacks on nurses can be sudden, serious, and life threatening. The trend in health-care literature is that violence against
nurses appears to be a growing problem globally.
Physical restraints placed have been shown to require
higher doses of benzodiazepines, opioids, and antipsychotic
medications. Patients have prolonged length of stay in the
intensive care unit (ICU). Patients have higher rates of selfextubation and accidental removal of intravenous catheters,
urinary catheters, and feeding tubes. After discharge, elderly
patients who have undergone physical restraint have higher
levels of post-traumatic stress disorder. All of these factors
make physical restraints one of the least preferred options.
References
Chang LY, Wang KW, Chao YE. Influence of physical restraint
on unplanned extubation of adult intensive care patients: a
casecontrol study. Am J Crit Care. 2008;17:40815.
187
188
Answer: D
Transferring care does not necessarily increase complications.
Interestingly in one study comparing patient outcomes when
critical care fellows were assigned to cover patients overnight
in an ICU, mortality actually decreased but interventions
increased. This effect could possibly be explained by the
impact of having a new review of existing data or the increased
diligence, which may occur when dealing with new patients.
Reference
Amaral ACK-B, Barros BS, Barros CCPP, et al. Nighttime crosscoverage is associated with decreased intensive care unit mortality. Am J Respir Crit Care Med. 2014;189(11):1395401.
HIV-infected persons worldwide. In developed countries, malignancy, cardiovascular disease, and complications from antiviral
agents have emerged as causes of HIV-related mortality.
Reference
Nahid P, Menzies D. Update in tuberculosis and nontuberculous mycobacterial disease 2011. Am J Respir Crit Care
Med. 2012;185:126670.
189
190
Reference
Shah ND, Montori VM, Krumholz HM, Tu K, Alexander
GC, Jackevicius CA. Geographic variation in the response
to FDA boxed warnings for rosiglitazone. N Engl J Med.
2010;22(455):20814.
491. Which of the following statements regarding the diagnosis of community-acquired pneumonia is true?
A) Directed therapy specific to the suspected causative organism is more effective than empirical
therapy in hospitalized patients.
B) Ten percent of patients hospitalized with
community-acquired pneumonia will have positive
blood cultures.
C) In patients who have bacteremia caused by
Streptococcus pneumoniae, sputum cultures are
positive in more than 70 % of cases.
D) Polymerase chain reaction tests are widely available and should be utilized for diagnosis in patients
hospitalized with community-acquired pneumonia.
E) In 40 % of all case of pneumonia, the specific
infectious agent will be identified.
Answer: B
It can be a challenge to find the specific etiology of communityacquired pneumonia. Overall a cause is found approximately
in only 15 % of cases. Generally, the yield from sputum culture, even in cases of fulminant bacteremic pneumococcal
pneumonia the yield from sputum is no greater than 50 % .
The yield from blood cultures is also low at 514 %.
Empirical broad-spectrum therapy remains the standard
therapy. Expanded polymerase chain reaction assays show
promise as a means to target more specific bacterial etiologies. As availability and cost of these tests continue to
decline, expect more widespread use.
Reference
Hoare Z, Lim WS. Pneumonia: update on diagnosis and
management (PDF). BMJ. 2006;332(7549):10779.
d o i : 1 0 . 1 1 3 6 / b m j . 3 3 2 . 7 5 4 9 .
1077. PMC 1458569. PMID 16675815301).
492. Which one of the following factors suggests that a nonpurulent, para-pneumonic effusion should be drained
by a chest tube?
A) The presence of pneumococcal pneumonia
B) A pleural fluid pH <7.20
C) A temperature of 104 F
D) A pleural fluid nucleated cell count of 30,000/mL
Answer: B
Pleural effusions are a common finding in patients with pneumonia. More than 40 % of patients with bacterial pneumonia
develop para-pneumonic effusions. Several studies have
Answer: E
Treatment with antiretroviral therapy is reserved for high-risk
exposure such needlestick and exposure to bloody fluids and
is not necessary in this case. In the absence of blood, saliva,
sputum, sweat, tears, feces, nasal secretions, urine, and vomitus carry a very low risk of transmission of HCV and HIV.
Reference
Henderson DK, Fahey BJ, Willy M, Schmitt JM, Carey K,
Koziol DE. Risk for occupational transmission of human
immunodeficiency virus type 1 (HIV-1) associated with
clinical exposures. A prospective evaluation. Ann Intern
Med. 1990;113(10):7406.
495. A 52-year-old man is admitted for dysarthria and right
and lower extremity weakness of 20 min duration. He
has a history of diabetes, hypercholesterolemia, and
hypertension. He takes aspirin, hydrochlorothiazide,
metformin, and simvastatin daily. A CT of head without contrast showed no acute abnormalities. tPA was
administered in the radiology interventional lab.
Subsequent CT scan 2 days later of head demonstrated
ischemic stroke involving right parietal area.
Echocardiography of the heart was normal.
What other intervention should be done to reduce
recurrence of the stroke?
A) Add clopidogrel at discharge.
B) Aspirin and warfarin on discharge.
C) Discontinue aspirin and start warfarin.
D) Add dipyridamole at discharge.
E) Nothing else as she is on optimal treatment.
Answer: D
Starting clopidogrel alone and adding dipyridamole to his
aspirin are reasonable options. Guidelines from the Seventh
American College of Chest Physicians (ACCP) Conference
on Antithrombotic and Thrombolytic Therapy suggest that
the combination of extended-release dipyridamole and aspirin is more efficacious than clopidogrel.
The patient was already on aspirin and addition of dipyridamole has shown to reduce risk of stroke recurrence in
ESPRIT and PRoFESS trials. The addition of clopidogrel to
aspirin has increased risk of cerebral and GI bleeds and there
is no substantial increase in benefit. Anticoagulants are not
used to reduce stroke recurrence.
References
Albers GW, Amarenco P, Easton JD, Sacco RL, Teal
P. Antithrombotic and thrombolytic therapy for ischemic stroke:
the Seventh ACCP Conference on Antithrombotic and
Thrombolytic Therapy. Chest. 2004;126(3 Suppl):483S512S.
Meschia JF, Bushnell C, Boden-Albala B, Braun LT, Bravata
DM, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: a Statement for healthcare profession-
191
192
References
Dellit TH, et al. Infectious Diseases Society of America and
the Society for Healthcare Epidemiology of America
guidelines for developing an institutional program to
enhance antimicrobial stewardship. Clin Infect Dis.
2007;44:15977.
Garnacho-Montero J, Gutierrez-Pizarraya A, EscorescaOrtega A, et al. De-escalation of empirical therapy is
associated with lower mortality in patients with severe
sepsis and septic shock. Intensive Care Med.
2014;40(1):3240.
499. Which of the following in acute exacerbations of
COPD is not predicted by a BAP-65 score?
A) Inhospital mortality
B) The risk of mechanical ventilation
C) Length of stay
D) Long-term mortality
E) None of the above
Answer: D
The BAP-65 system represents a simple tool to categorize
patients with acute exacerbation of COPD. It is calculated by
measuring B blood urea nitrogen, A altered mental status, P
pulse, and age. Patients 65 years of age are class 1. For
patients older than 65 years of age, the score is stratified
based upon a number of risk factors: class 3 has one risk factor, class 4 has two risk factors, and class 5 has three risk
factors.
BAP-65 is primarily used to predict the inhospital severity and possible need for intubation. It does not predict outof-hospital mortality.
The BODE index is utilized to predict long-term outcome
for patients with COPD. It is composed of body-mass index,
airflow obstruction, dyspnea, and exercise.
References
Celli BR, Cote CG, Marin JM, et al. The body-mass index,
airflow obstruction, dyspnea and exercise capacity index
in chronic obstructive pulmonary disease. N Engl J Med.
2004;350(10):100512.
Shorr AF, Sun X, Johannes RS, Yaitanes A, Tabak
YP. Validation of a novel risk score for severity of illness
in acute exacerbations of COPD. Chest. 2011;140(5):
117783.
500. In alcohol withdrawal, when does a seizure usually
occur?
A) 68 h after the cessation of drinking
B) 812 h after the cessation of drinking
C) 648 h after the cessation of drinking
D) 72 h after the cessation of drinking
E) 1 week after the cessation of drinking
Answer: C
Withdrawal seizures occur within 648 h of alcohol cessation. Alcohol withdrawal may present with a seizure as the
first sign. No other symptoms of withdrawal may occur after
the seizure abates. About 3040 % of patients with alcohol
withdrawal seizures progress to delirium tremens. Alcohol
withdrawal seizures usually occur only once or recur only
once or twice, and they generally resolve spontaneously.
Withdrawal generally occurs 1072 h after the last drink.
Reference
Eyer F, Schuster T, Felgenhauer N, Pfab R, Strubel T, Saugel
B. Risk assessment of moderate to severe alcohol withdrawal predictors for seizures and delirium tremens in
the course of withdrawal. Alcohol Alcohol.
2011;46(4):42733.
501. How do academic versus nonacademic hospitalists
services compare in the following parameters?
A) Increased length of stay (LOS).
B) Increased all-cause inhospital mortality.
C) Decreased all-cause mortality.
D) No changes were observed.
Answer: A
In studies that compared a teaching hospitalist service with a
staff-only hospitalist service, LOS was significantly shorter
in the staff-only hospitalist group. Other factors remained the
same.
Reference
Everett GD, Anton MP, Jackson BK, Swigert C, Uddin
N. Comparison of hospital costs and length of stay associ-
193
Index
A
Abdominal compartment syndrome
physical examination, 65
surgical depression, 66
Academic vs. nonacademic hospitalists, 193
Acetaminophen, 72, 189
Acetylcysteine, 189
Acid-fast bacilli (AFB), 57
Acute coronary syndrome (ACS), 53, 159, 179
Acute kidney injury (AKI)
cause, 9091
urine output and sodium excretion, 170171
Acute mesenteric ischemia (AMI)
abdominal distention and gastrointestinal bleeding, 176
classification, 24
legal risk, 176
superior mesenteric artery embolism, 176
Acute respiratory distress syndrome (ARDS), 8, 142, 157
Acute tubular necrosis (ATN), 64
Acyclovir
Bells palsy, 4
therapy, 6263
Adenocarcinoma, 6, 14, 85, 115, 155
Adjuvant albumin treatment, 48
Adrenal adenomas, 25
Adrenal insufficiency, 53
Adult-onset Still disease (AOSD), 910
Adult Stills disease, 46
Adverse drug event (ADE), 159160
Advisory Committee on Immunization Practices (ACIP), 156
Affordable Care Act (ACA), 163
Aggressive fluid resuscitation
blood transfusion, 26
fluid requirements, 26
sepsis from pyelonephritis, 61
vasopressor therapy and, 149
Aggressive hydration, 29, 56, 133
Agitation, psychosocial support, 30
Airborne precautions, 184185
Air trapping, COPD, 99
Albumin infusion, 164
Alcoholic hepatitis, 3940, 50
Alcohol withdrawal
diagnosis, 24
pharmacologic treatment, 25
seizures, 32, 192
Alkalosis, 75
Alpha blockers, 166
Amebic liver abscess, metronidazole treatment, 7475
American Academy of Neurology (AAN), 2
American Association of Clinical Endocrinology, 34
195
196
Appetite stimulants, 133
Arrhythmias, 2122
Arterial venous malformations (AVM)
electrocautery, 76
management, 76
Ascites
furosemide and spironolactone, 27
hepatorenal syndrome (HRS), 35
jaundice and, 40
spontaneous bacterial peritonitis (SBP), 6
Aseptic meningitis
management, 45
polymerase chain reaction testing, 45
Aspartate aminotransferase, 9
Aspiration, 68
Aspirin, 22
Assist-control ventilation (A/C), 80
Asthma exacerbations, 80
Asynchronized cardioversion, 81
Atelectasis in postoperative patient, 127
Atherosclerotic cardiovascular disease (ASCVD) risk, 153
Atherosclerotic claudication, 108
Atiretroviral therapy (ART), 89
Atorvastatin, 135, 157158
Atrial fibrillation
ablation, warfarin, 165
amiodarone, 55
management, 34
Atrioventricular (AV) heart block, 79
Atropine, 17
Autoimmune disorders, 108
Autoimmune polyendocrine syndrome, 53
Automatic implantable cardioverter defibrillator (AICD)
deactivation, 151
intermittent infusions, 151
warfarin, 128
Autopsy
missed diagnosis, 176
pulmonary embolism, 176
Azithromycin, 162
B
Bacterial infections, 9596
Bacterial meningitis
ampicillin, 82
isolation, 162
stat lumbar puncture, 30
symptoms, 43
Barotrauma, 8
Barretts esophagus, 18
Bathing with chlorhexidine-impregnated wipes, 150
Bath salts, 9091. See also Synthetic cathinones
Bedside Index of Severity in Acute Pancreatitis (BISAP) score, 169
Beers criteria, 175
Behet disease
diagnosis, 3031
infectious agents, 31
recurrent oral ulcerations, 31
Bells palsy, 4
Benign paroxysmal positional vertigo (BPPV), 2
Benign rolandic epilepsy, 32
Benzodiazepine (BZD)
aggression and, 81
in cardiac patients, 153
overdose, 186
seizures treatment, 11
Index
Benztropine, 50
Beta-blocker
cardiac ischemia, 34
congestive heart failure, 159
toxicity
bradycardia and hypotension, 1617
glucagon and, 17
Bilevel positive airway pressure (BiPAP), 55, 89
Bilirubin, 9596
Biopsychosocial disorder, 92
Bisphosphonates, 62
Bivalirudin, 159
Black box warning and spironolactone, 189
Bleeding. See also Rebleeding
endoscopic hemostasis, 66
gastrointestinal, 135, 173
intracerebral, 107
peptic ulcer, 174
thrombocytopenic, 107
variceal (see Variceal bleeding))
Blood
cultures, 19, 158159
pressure measurement, 18
transfusion, 61
Body mass index (BMI), 128
Bowel regimens, 102
Bradycardia, 15
Brain death
apnea testing, 151
diagnosis, 151
Brain metastasis, 115
Brain natriuretic factor (BNP)
heart failure severity, 158
natriuretic peptides, 158
Breast cancer and spironolactone, 189
Bronchodilator
reactive airway disease, 127
therapy, hospice, 119
Brown recluse spiders
bites, 76
physical examination, 75
violin-shaped markings, 76
B-type natriuretic peptide (BNP), 183
Bubble-enhanced echocardiography, 28
Budd-Chiari syndrome
JAK2 V617F gene mutation, 40
jaundice and ascites, 40
treatment, 40
Buergers disease, 108
Buspirone, 92
C
Calcitonin, 62
Calcium channel blockers (CCBs), 164
Calcium gluconate, 187
Cancer Care Outcomes Research and Surveillance
(CanCORS), 127
Candida
fluconazole, 1
infection, 1
Candidiasis, 98
Cannabis-induced hyperemesis, 69
CAP. See Community-acquired pneumonia (CAP)
Capacity, in decision-making, 125126
Capnocytophaga canimorsus infection, 31
Cardiac arrhythmias, 22
Index
Cardiac catheterization, 96
Cardiac enzymes, 18
Cardiac myxoma, 6
Cardiac resuscitation
family members and, 177178
post-traumatic stress disorder, 177178
Cardiac tumors, 6
Cardiovascular implantable electronic device (CIED)
infection, 115
Cardiovascular Outcomes in Renal Atherosclerotic
Lesions Study (CORAL), 90
Cardioversion, 127
Care transitions on discharge, 156
Carotid sinus massage, 64
Carotid ultrasonography, syncope etiology, 18
Catheter-directed thrombolysis, in deep vein thrombosis, 5657
CDI. See Clostridium difficile infection (CDI)
Cefotaxime
and albumin, 3233
spontaneous bacterial peritonitis (SBP), 6, 33
Ceftriaxone
and erythromycin, 5455
intravenous, 79
Cellulitis, 19, 39
Centers for Disease Control and Prevention, 165
Centers for Medicare and Medicaid Services
(CMS), 163
Central line-associated bloodstream infection
(CLABSI), 136137
Central parenteral nutrition, 97
Cerebral emboli, 142
Cerebrospinal fluid (CSF) shunt infection, 71
Cerebrovascular lesion, 42
CHADS2 score, 165
Chemotherapy
corticosteroids, 135
nausea and vomiting, 135
palliative, 134
Chest pain, 179
Chest syndrome
ceftriaxone and erythromycin, 5455
treatment, 5455, 100
Chikungunya fever, 8788
Cholecystectomy, 60
Choledocholithiasis, 95
Cholestasis of pregnancy, 133
Cholestyramine, 132, 192
Chronic obstructive pulmonary disease (COPD)
bacterial pneumonia, 42
BAP-65 score, 192
doxycycline/azithromycin treatment, 38
exacerbation, 109, 192
CIM. See Critical illness myopathy (CIM)
Ciprofloxacin, 56, 180
CJD. See CreutzfeldtJakob disease (CJD)
Clinical Institute Withdrawal Assessment for Alcohol,
Revised (CIWA-Ar), 41
Clostridial gangrene, 36
Clostridium difficile infection (CDI)
and bone fractures, 45
community-acquired diarrhea, 173
diarrhea, 117
fecal microbiota transplantation, 35
intestinal microbiota transplantation (IMT), 178
polyethylene glycol and loperamide, 191192
proton-pump inhibitors (PPI), 45
treatment, 13, 1920, 92
197
Clostridium perfringens, 36
Clots in Legs Or Stockings after Stroke (CLOTS 3) trial, 185
Cocaine
chest pain, 22
ingestion, 22
intoxication, 11
platelet aggregation and endothelial dysfunction, 78
Cochrane collaboration, 182183
Cockcroft-Gault (CG), 180
Colitis
collagenous, 93
ischemic, 102
microscopic, 93
steroids dose, 147
Colonic lesions, 76
Colonoscopy, 15
Community-acquired methicillin-resistant Staphylococcus aureus
(CA-MRSA), 39
Community-acquired pneumonia (CAP)
deaths percentage, 171
diagnosis, 190
empirical broad-spectrum therapy, 190
microbial cause, 84
nursing homeacquired pneumonia (NHAP), 190
outpatient treatment for, 179180
polymerase chain reaction (PCR) bacterial testing, 156
statin, 165
Compartment syndrome, 17, 66, 139
Complex regional pain syndrome, 138
Compulsive bathing, 69
Concussions, 1718
Congestive heart failure
cardiologists, 170
native valve endocarditis patient, 134
readmission rates, 170
Constipation
bulk-forming laxatives, 131
docusate, 131132
N-methylnaltrexone, 132
Contact
precautions, 185
tracing, 165
Continuous positive airway pressure (CPAP)
in acute cardiogenic edema, 175
death, 175
Contrast-enhanced computed tomography, 56
Contrast-induced nephropathy, 23
Contrast medium-induced nephropathy (CIN), 99
Contrast nephropathy, sodium bicarbonate, 35
Corneal reflexes, 133
Coronary arteriography, 78
Coronary vasospasm, 8
Corticosteroids
chemotherapy-induced nausea and vomiting, 135
delirium, 86
Cortrosyn stimulation test, 129130
Cosyntropin stimulation test, 53
Coughing up yellow stuff, 41
Coumadin monitoring, 5
Crackles, 8
CreutzfeldtJakob disease (CJD)
clinical features of, 88
clinical testing, 77
dementia and, 76
diagnosis, 4950, 77
electroencepgraphy, 77
prions, 77
198
Critical illness myopathy (CIM)
diagnosis, 104
extubation and proximal limb weakness, 104
prevention and treatment, 104
prolonged intubation, 104
Crohns disease, 12
Crohns Disease Activity Index (CDAI), 180181
CURB-65 score, 167
Cutaneous anthrax, 100
Cytomegalovirus (CMV) esophagitis
in AIDS patients, 58
cause, 58
Cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA), 3
D
Dabigatran, coagulation assays, 182
Daptomycin, 39, 67, 95
Decubitus ulcers
devices for, 178
healing, 137138
protein intake, 138
Deep vein thrombosis (DVT)
Doppler ultrasonography, 111
hospital death, preventable cause, 169
management, 128
peripherally inserted central catheters (PICCs), 162163
prophylaxis, in older adults, 21
silent pulmonary embolism (PE), 174
treatment, 152
warfarin, 128, 152
Delirium
after critical illness, 176177
alcohol withdrawal, 73
corticosteroids, 86
and dementia, 78
ear plugs, 170
family and, 27
patients management, 185
physical examination, 72
postoperative confusion, 115
postoperative-induced, 123
and psychosis, 22
rivastigmine, 27
sedative drugs and, 170
Dementia
complications, 133
end-stage, 114
with Lewy bodies, 83
Dermatomyositis
CT chest, 97
malignancy, 97
physical examination, 96
Desmopressin, 63
Dexamethasone, 53, 135
Diabetes
atherosclerotic cardiovascular disease (ASCVD) risk, 153
LDL values, 153
type 2, 126
Diabetes insipidus (DI)
acute central, 63
diuretics and NSAIDs, 78
electrolyte abnormalities, 78
hypernatremia, 78
idiopathic, 131
lithium nephrotoxicity, 78
Index
Diabetic foot infections (DFI)
antibiotics route, 91
physical examination, 91
Diabetic ketoacidosis (DKA)
insulin drip, 37
physical examination, 9495
treatment, 95
Diabetic patients (DM), 126
Diarrhea
arthritis in, 163
food poisoning, 151152
Shigella flexneri, 163
Staphylococcus aureus, 151
Diffuse pulmonary edema, 4647
Digoxin, 111
Direct revascularization, 75
Discriminate function (DF), 50
Disseminated intravascular coagulation (DIC), 54
Diverticular bleed, 15
Diverticulosis, 179
Dizziness, 113114
D-lactic acidosis, 73
Dog bite, 31
Droplet precautions, 185
Drug-eluting stent (DES), rapid thrombosis, 132
Drug-induced hemolytic anemia (DIHA), 171
Drug-induced lupus erythematosus (DILE), 20
Duchenne muscular dystrophy, 3
DVT. See Deep vein thrombosis (DVT)
Dysphagia, bedside screening, 68
Dyspnea
acute myocardial infarction, 161
hospice, 119
Dystonic reaction, 50
E
Ebola virus, 165
Echinocandin, 98
Echocardiograms, 14, 28
Eclampsia
intravenous phenytoin, 130
maternal morbidity and mortality, 130
seizures, 130
Ectopic ACTH secretion
adrenal adenomas, 25
Cushing syndrome, 25
hyperpigmentation, 25
Electroencepgraphy, 77
Electroencephalogram (EEG)
syncope etiology, 18
triphasic waves, 19
Endocarditis, 134, 156
End-of-life care, 141
Endophthalmitis, 98
Endotracheal intubation, 55
End-stage dementia, 114
Enoxaparin, 1, 159
Enteral nutrition, 109110
Enteral tube feedings, 118
Epinephrine injection, 15
EpsteinBarr virus infectious mononucleosis, 116
Erythema
migrans, 79
multiforme, 146
Erythematous maculopapular rash, 1011
Index
Erythrocyte
sedimentation rate, 9, 179
transfusion, 107108
Escherichia coli infection, 6, 56
Esophageal candidiasis, 37
Esophagogastroduodenoscopy (EGD), 191
Ethylenediaminetetraacetic acid (EDTA)-anticoagulated
test tube clump, 105
Euthyroid sick syndrome
management, 5051
Exanthematous eruptions, 11
Exercise-associated hyponatremia (EAH)
hyponatremia, 91
sodium chloride, 91
Exercise tolerance, 123
Exudative pleural effusions, 72
F
Factitious fever, 10
Factitious hypoglycemia, 70
Familial Mediterranean fever (FMF), 910
Families feel, 130
Fasting/starvation, malnutrition, 129
Fat embolism syndrome, 142
Fat-soluble vitamin deficiencies, 99
Febrile neutropenia, 16
Fecal microbiota transplantation, 35
Fesh frozen plasma (FFP), 86
Fever of unknown origin (FUO), 46
Fever patterns, 52
Fidaxomicin, 13, 117
Filter feeders, 48
Financial incentives, 156
Fixed dose therapy, 41
Flecainide, 55
Fluid resuscitation
aggressive, 26
with colloid, 149
DKA patients, 95
NG tube placement and, 44
saline, 44
in sepsis, 44
Flumazenil, 186
Fluphenazine, 11
Fondaparinux, 3839
Fractional excretion of sodium (FENa), 96
Fragmentation, 97, 183
Fresh frozen plasma (FFP), 108
Frontotemporal dementia (FTD), 8283
Functional dyspepsia (FD), 92
Furosemide
and spironolactone, 27
treatment, 4647
G
Gabapentin, 2, 137
Gallstones
and alcohol abuse, 13
management, 60
pancreatitis
laparoscopic cholecystectomy, 143
systemic and pancreatic inflammation, 144
ultrasonography, 76
Gastric residuals, 141
199
Gastroenteritis, 71
Gastroesophageal reflux disease, 18
Gastrointestinal (GI)
anthrax, 100
bleeding, 135, 173
cocktails, 179
complaints, 114
syndrome, 82
Geriatric units, 155
Gestational age, 133
Giant cell arteritis (GCA), 6667
GI cocktails, 179
Granular spike, 71
Granulomatosis with polyangiitis (GPA)
diagnosis, 3, 49
surgical lung biopsy, 49
Gross hematuria, 28
GuillainBarr syndrome (GBS)
diagnosis, 181
intravenous immunoglobulin (IVIG), 38
paralysis with respiratory symptoms, 3
plasma exchange, 3738
H
Haloperidol, 11, 133
Hand hygiene, 136
Hantavirus cardiopulmonary syndrome (HCPS)
human infections, 65
ribavirin, 65
symptoms, 63
Healthcare-associated pneumonia (HCAP)
treatment, 16
Heart failure readmissions, 174
Heart failure with normal left ventricle ejection fraction
(HFNEF), 154155
Hematocrit, 173
Hematology/oncology, 14
Hematuria, 147
Hemicraniectomy, neurosurgical consultation, 33
Hemoconcentration measurements, 157
Hemolytic transfusion, 112
Hemolytic uremic syndrome, acute kidney injury, 4748
Hemorrhagic stroke, 14
Hemorrhagic vesicles, 17
Heparin-induced thrombocytopenia (HIT), 3839, 159
Heparin 5000U SQ TID, 2223
Hepatic encephalopathy, 19
Hepatic failure, 44, 72
Hepatitis B core antibody (anti-HBc), 60
Hepatitis B-induced vasculitis, 60
Hepatitis B surface antigen (HBsAg), 60
Hepatitis C cirrhosis, 113
Hepatitis E, 44
Hepatopulmonary syndrome, bubble-enhanced
echocardiography, 28
Hepatorenal syndrome (HRS)
diagnosis, 35
medicines, 35
octreotide and midodrine, 83
type 1, 160
urine electrolytes and urine creatinine, 96
Herpes simplex, 19, 31, 45, 58, 146
Herpes simplex encephalitis (HSE), 19, 6263
Herpes zoster vaccine, 156
Heterophile antibody testing, 116
200
Heydes syndrome
aortic valve replacement, 97
physical examination, 97
Hip fracture patients, surgery in, 138
HIT. See Heparin-induced thrombocytopenia (HIT)
Hospice
bronchodilator therapy, 119
dyspnea, 119
opioids, 119
Hospital
death, preventable cause, 169
readmission rate, 163
Hospital-acquired pneumonia, 45
Hospitalists
academic vs. nonacademic, 193
diagnosis-related error, 176
fragmentation, 183
malpractice claims, 175176
surgical services, 126
HRS. See Hepatorenal syndrome (HRS)
HSE. See Herpes simplex encephalitis (HSE)
Human immunodeficiency virus (HIV)
death due to infections, 188189
ELISA antibody testing, 10
postexposure management strategy, 188
postexposure prophylaxis, 172
testing, 181
tuberculosis (TB), 188189
Hydromorphone, 102
Hydroxyurea, 55
Hyperbaric oxygen, 36
Hypercalcemia, 62
Hypercoagulability, 124
Hypergastrinemia, 65
Hyperglycemia, 4041, 126
Hyperosmolar nonketotic acidosis, 7
Hyperpigmentation, 25
Hypertension, 34
Hypertensive emergency, 178179
Hyperthermia
antipyretics, 122
dantrolene, 121122
genetic testing, 122
malignant, 121122
Hypertonic saline, 13
Hypertriglyceridemia-induced acute pancreatitis, 13
Hypoalbuminemia, 59
Hypocalcemia, 137
Hyponatremia, 1213, 57
Hypophosphatemia, 129
Hypothyroidism, 53, 74
Hypoxemia, 28, 55
I
Ideal body weight (IBW), 8, 111112
Idiopathic thrombocytopenic purpura (ITP)
anemia/neutropenia, 59
management, 5859
platelet transfusion, 59
IgA deficiency, 108
Immediate R-wave synchronized direct-current cardioversion, 34
Immune-modulating supplements, 109110
Immune reconstitution inflammatory syndrome (IRIS)
antiretroviral therapy (ART), 89
healthcare-associated pneumonia, 89
Index
Implantable cardioverter defibrillator (ICD), 129
Indwelling urinary catheter, 167168
Infectious Diseases Society of America (ISDA), 30, 91, 98
Infectious mononucleosis, 116
Inferior myocardial infarction, 1314
Inferior vena cava (IVC) filters, 184
Inflammatory Bowel Disease Questionnaire (IBDQ), 181
Infliximab, 12
Influenza
adjuvant treatments, 103
fatal bronchospasm, 103
oseltamivir therapy, 103
Inhaled beta2-agonists, 139
Insulin
diabetic ketoacidosis (DKA), 37
infusions, 121
initial diabetic therapy, 3334
meal-time, 4041
therapy, 121
Insulinoma, 6970
Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage
Trial 2 trial, 182
Intensive care unit (ICU)
patient transfer out of, 189
physical restraints, 186
posttraumatic stress disorder (PTSD), 189
propofol usage, 188
residents in training, 188
INTERACT 2, 182
Intermittent pneumatic compression (IPC) device, 185
Intermittent porphyria, 68
Interstitial nephritis
acute renal failure, 23
NSAID-induced, 94
in renal function, 94
Intestinal microbiota transplantation (IMT), 178
Intracardiac defibrillator implantation, 96
Intracerebral bleeding, 107
Intracerebral hemorrhage (ICH), 182
Intraluminal defect, 14
Intraosseous (IO) cannula, 187
Intravenous (IV)
antibiotics, 173
ceftriaxone, 79
methylprednisolone, 2
thiamine, 98
vancomycin, 39
Intravenous immunoglobulin (IVIG), 38
Irritable bowel syndrome (IBS)
colonoscopy, 103
physical examination, 102
Ischemic colitis, 102
Ischemic stroke
catheterization, 94
cerebrovascular hemorrhage, 42
CT angiogram, 94
etiology, 94
head MRI, 94
ITP. See Idiopathic thrombocytopenic purpura (ITP)
J
Jacksonian march, 2829
JAK2 V617F gene mutation, 40
Jaundice and ascites, 40
Jejunoileal bypass, 73
Index
Judicious underfeeding, 112
Juvenile myoclonic epilepsy, 32
Juvenile rheumatoid arthritis (JRA), 46
201
L
Labetalol, 34, 130
Laboratory Risk Indicator for Necrotizing Fasciitis
(LRINEC) score, 39
Lactose malabsorption
bile-salt-induced diarrhea, 83
cause, 83
physical examination, 82
stool osmotic gap, 83
Lactulose, hepatic encephalopathy, 164
12-lead electrocardiography (ECG), 18
Left bundle branch block (LBBB)
causes, 121
exercising imaging tests, 121
Legionella (See also Pneumonia)
serologic testing, 84
urine antigen assays, 84
Legionnaires disease, 15
Lemierres syndrome
computed tomography (CT), 140141
treatment, 141
vascular surgery consultation, 141
Length of stay (LOS), 112, 183
Lille score, 3940
Listeria, 82
Loperamide, 192
Lovenox, 12
Lower gastrointestinal bleeding (LGIB), 179
Low-molecular-weight heparin (LMWH), 128, 140
Lumbar puncture, 30, 43
Lung injury, 8
Lupus cerebritis, 19
Lymph node, 9, 67
Lymphoid malignancies steroids, 62
Lymphoma, 156
Lymphomatoid granulomatosis, 3
Lysergic acid diethylamide (LSD), 11
M
Malignant hypertension, 178179
Malignant hyperthermia, 121122
Malingering, 109
Malnutrition from fasting/starvation, 129
Marijuana
illegal drug, 166
smoking, 22
Meal-time insulin, 4041
Mean arterial pressure (MAP), 90
Mean corpuscular volume (MCV), 42
Medication-related problems, 93
Megestrol acetate, appetite stimulants, 133
Meigs syndrome, 120
Membranoproliferative glomerulonephritis (MPGN), 7071
Meningitis, 82
Mesenteric ischemia, 24
Metabolic equivalent (MET), perioperative complications, 123
N
NAFLD. See Nonalcoholic fatty liver disease (NAFLD)
Naloxone, 4
Naltrexone, 132
Nasogastric tube, 15
Nausea and vomiting, chemotherapy-induced, 135
Necrotizing fasciitis
cause, 39
surgical consultation, 36
V. vulnificus infection, 48
Necrotizing pancreatitis, 29
Neisseria meningitidis, 162
Nephrotic syndrome, 5960
Neuromyelitis optica (NMO), 148
Neutrophil gelatinase-associated lipocalin (NGAL), 64
New York Heart Association (NYHA), 150151
NG tube decompression, 44
Nitrofurantoin, 93
K
Klebsiella pneumonia, 6, 33, 155
202
NMO-IgG test, 148
Nocturnal breathing, 127
Nonalcoholic fatty liver disease (NAFLD)
diagnosis, 8889
elevated liver enzymes, 88
liver biopsy, 89
Noncontrast computed tomography (CT) scans, 124
Noninvasive positive pressure ventilation (NPPV)
incentive spirometry, 175
reintubation, 174
in respiratory distress, 36, 51
Nonsteroidal anti-inflammatory drugs (NSAIDS)
acute pericarditis, 7
chikungunya fever, 8788
ribavirin and steroids, 88
Norepinephrine and dopamine, 5152
NPPV. See Noninvasive positive pressure ventilation (NPPV)
NSAIDS, 72
Nursing homeacquired pneumonia (NHAP), 190
Nystagmus, 114
O
Octreotide, 58, 173
Ocular abnormalities, WE, 98
Oliguria
clinical condition, 163
packed red blood cells (PRBC), 164
volume resuscitation, 164
Ondansetron, 114
Opioids, hospice, 119
Oral anticoagulants, 182
Oral antihistamines, 11
Oral pantoprazole, 58
Oral phosphate repletion, 129
Oral prednisone, 2
Oral vancomycin, 13
Oropharyngeal candidiasis, 37
Orthopedics consult, 118
Orthostasis, 164
Osteoporosis-related fractures, 45
Overhydration, 74
Oxycodone, 102, 125
P
Packed red blood cells (PRBC), 164
Pain
gabapentin, 137
intrathecal medication, 144145
in nonverbal patients, 141142
palliative sedation therapy, 145
spinal metastasis, 137
Palliative care, 122
Palpable purpura, 3
Pancreatitis
abdominal ultrasound, 103104
anchoring errors, 177
Bedside Index of Severity in Acute Pancreatitis (BISAP) score,
169
CT scan, 104
diagnosis, 56
enteral nutrition by nasojejunal feeding tube, 118
gallstone, 104
hemoconcentration measurements, 157
secondary to hypertriglyceridemia, 13
Index
Paracentesis
patients with cirrhosis and ascites, 164
serum-ascites albumin, 120
transdiaphragmatic lymphatic channels, 120
Parenteral nutrition, 109110
Parkinsons disease, 22, 114
Paroxysmal atrial tachycardia (PAT), 64
Parvovirus B19, 29
Patient Attendant Assessment Tool (PAAT), 185
Patient Protection and Affordable Care Act, 161
Patient satisfaction, 184
Pelvic inflammatory disease (PID)
intramuscular ceftriaxone and oral doxycycline, 146
laparoscopy, 146
management, 146
Pentoxifylline, 3940
Peptic ulcer rebleeding, 174
Percutaneous angioplasty, 75
Percutaneous coronary intervention (PCI), 41
Percutaneous esophageal gastrostomy tubes (PEG), 128
Pericardial friction rub, 7
Pericarditis, 7, 10
Peripartum cardiomyopathy, 114115
Peripheral intravenous access, 177
Peripherally inserted central catheter (PICC), 122, 162163
PESI. See Pulmonary Embolism Severity Index (PESI)
Pharmacologic stress test, 121
Phencyclidine (PCP), 11
Phenytoin toxicity
medications, 59
signs and symptoms, 59
Phlegmasia, 57
Physical restraints, 186
Placebo and antiepileptic therapy, 14
Plan-Do-Study-Act (PDSA) cycle, 168169
Plantar fasciitis, 108
Plasma D-dimer concentrations, 179
Plasma exchange, 3738
Plasma p24 antigen test, 10
Plasmapheresis, 2, 137
Platelet clumping, 104105
Platelet transfusions, 59, 107
Pleural effusions, 190
Pleuritis, 10
Pneumocystis carinii (PcP) pneumonia, 169
Pneumocystis jiroveci pneumonia, 4041, 89
Pneumonia
ceftriaxone and azithromycin therapy, 166
hospitalization, 42
legionella, 15
pleural effusion, 42
pleural effusions, 190
Pneumonia severity index (PSI), 167
Polyarteritis nodosa (PAN), 5960
Polyendocrine failure, 53
Polyethylene glycol, 144, 192
Polymerase chain reaction (PCR) bacterial testing, 156
Polymicrobial bacteremia, 10
Polyserositis, 910
Portal vein patency, 61
Positive antinuclear antibodies, 179
Post-cardiac arrest syndrome (PCAS)
hyperthermia, 136
myocardial dysfunction, 136
Postextubation dysphagia, 143
Post-infectious glomerulonephritis (PIGN), 28, 48
Index
Postobstructive diuresis
defined, 73
management, 74
urea diuresis, 74
Postoperative cognitive dysfunction (POCD), 113, 150
Postoperative confusion, 115
Post-traumatic amnesia, 17
Post-traumatic stress disorder (PTSD)-related symptoms, 143
Post-void residual (PVR) volume, 117
Prednisone, 4
Pregnancy
asthma patients, 139
cholestasis, 133
Preoperative hypertension, 145146
Preoperative malnutrition, 108
Prerenal azotemia, 23
Pressure ulcers
air-fluidized bed and, 167
foam mattress overlay, 167
risk factors for, 166
Primaquine, 4041
Pro-brain natriuretic peptide (proBNP) levels, 14
Procalcitonin (PCT), 172, 192
Prognostic factors for PE (PREP), 14
Progressive neuromuscular disease, 52
Prophylactic proton pump inhibitor therapy, 160
Prostatitis, 85
Prothrombin complex concentrates (PCC), 86
Protocol-driven admission processes, 183
Proton-pump inhibitors (PPI), 45, 92
therapy, 160
Pseudomonas pneumonia
antibiotic treatment, 85
combination therapy, 85
physical examination, 84
Pseudothrombocytopenia, 104105
Psychostimulants, 144
Pulmonary embolism (PE)
anticoagulation for patients, 140
low-molecular-weight heparin (LMWH), 140
onset of symptoms, 187
thrombectomy, 9798
treatment, 140
Pulmonary Embolism Severity Index (PESI), 14
Q
Quality-of-life assessment, 182
Quetiapine, 22, 30
R
Radiation oncology, 14
Raynaud phenomenon, 108
Readmission rates, 163, 172
Rebleeding
rates, 58
risk, 54
Recurrent pulmonary embolism, 184
Reflex sympathetic dystrophy, 138
Refractory itching, 132
Rehabilitation
acute ischemic stroke, 168
beneficial effects, 168
modafinil, 168
prophylactic antibiotics, 168
203
Renal injury
cause, 23
normotensive ischemic acute kidney injury, 23
Renal recovery, 171
Renal replacement therapy, 90
Renal ultrasonography, 124
Replacement therapy, 180
Reporting bias, 162
Repositioning, 127
Revised Cardiac Risk Index (RCRI), 116
Rewarming, 17
Rhabdomyolysis
acute kidney injury (AKI), 139
electrolyte imbalances correction, 139
treatment, 139
tubular necrosis, 91
Rheumatoid arthritis, 108
Risk stratification, 14
Rivaroxaban, 5, 9, 112
Rivastigmine, 27
S
Salicylates, 7
Sarcoid, 62
Satisfied patients, 184
SBP. See Spontaneous bacterial peritonitis (SBP)
Schmidts syndrome, 53
Scleroderma renal crisis, 48
Sclerosing cholangitis, 102
Seizures, 155
alcohol withdrawal, 32
benzodiazepine (BZD), 11
brain tumors patients, 155
eclampsia, 130
juvenile myoclonic epilepsy, 32
Selective serotonin reuptake inhibitors (SSRIs), 142
Self-expandable metal stent (SEMS) placement, 136
Self-induced infection, 10
Self-neglect, 186
Sepsis from pyelonephritis, 61
Sepsis Occurrence in Acutely Ill Patients II (SOAP II) study, 161
Septic shock
nonresponsive to fluid, 5152
and severe sepsis, 137
Serologic testing, 84
Serum
creatine kinase tests, 39
electrolytes, 27
sodium, 63
Shigella infection, 71
Shigella-like toxin, 4748
Short bowel syndrome, 73, 110
Silent pulmonary embolism (PE), 174
Sinus tachycardia, 7
Skin and soft tissue infections (SSTI), 67
Skin antisepsis, 137
Sliding scale, 126
Smoking
marijuana, 22
pharmacotherapy, 47
stop date, 47
varenicline, 47
Sodium and fluid restriction
heart failure, 7778
physical examination, 77
204
Spinal stenosis, 108
Spirometry, 62
Spironolactone, 189
Splenectomy, 59
Split-dose bowel preparation, 144
Spontaneous bacterial peritonitis (SBP), 6, 3233, 48
Staphylococcal toxic shock syndrome, 8, 9
Staphylococcus aureus infection
initial workup and treatment, 5253
toxic shock syndrome, 89
Steroid psychosis, 86
Stevens-Johnson syndrome (SJS)
corticosteroids, 120
intravenous immunoglobulin (IVIG), 119120
skin detachment, 120
Stigmata, 54
Stool culture, for Salmonella infection, 38
Stool osmotic gap, 83
Streptococcal and Staphylococcal infections, 48
Streptococcus pneumonia, 84, 190
Stress ulcer prophylaxis, 193
Stroke
dipyridamole at discharge, 191
physical exam, 133
recurrence reduction, 191
risk, 127
treatment, 134
warfarin, 134
Subarachnoid hemorrhage (SAH), 77
Subendothelial immune complexes, 71
Sudden death, risk, 153
Sulfonylurea-induced hypoglycemia, 70
Supraventricular tachycardia
adenosine treatment, 4849
diltiazem, 49
electrocardioversion, 49
Surgery consultation, 44
Surgical lung biopsy, 49
Surrogate decision-making, 114, 143
Suspected acute intoxication, 182
Symptom-triggered therapy, 41
Synchronized electric cardioversion
diagnosis, 80
management, 81
Synchronous intermittent mandatory ventilation (SIMV), 80
Syncope
isometric counterpressure maneuvers, 26
reassurance and avoidance, 26
reassurance and lifestyle modifications, 18
therapy, 26
vasovagal, 26
Syndrome of inappropriate antidiuretic hormone (SIADH), 1213
Synthetic cathinones, 3132
Systemic corticosteroids, 11
Systemic lupus erythematosus (SLE), 1, 20, 108
Systemic vasculitis, 5960
T
Tachycardia
with fever, 10
management, 6364
Tardive dyskinesia (TD), 191
Therapeutic thoracentesis, 154
Thermal coagulation, 15
Thromboangiitis obliterans, 108
Index
Thrombocytopenic bleeding, 107
Thromboembolic event, 122
Thrombolytics, 75, 9798
Thromboprophylaxis, 12
Thrombosis, 162163. See also Deep vein thrombosis (DVT)
Thrombotic thrombocytopenic purpura (TTP), 8182
Thyroid nodules, 143
Tidal volumes (TV), 80
Time-out, critical component, 154
Todds paralysis, 2829
Total knee replacement (TKR), 147
Total parenteral nutrition (TPN)
home, 150
survival and quality of life, 150
Toxic megacolon (TM)
management, 140
physical examination, 139
Toxic shock syndrome, 8
Tram-track double-layered basement membrane, 7071
Transabdominal ultrasound, 56
Transesophageal echocardiogram (TEE), 115
Transfusion-related acute lung injury (TRALI), 112
Transjugular intrahepatic portosystemic shunt (TIPS), 61
Transthoracic needle aspiration, 94
Trimethoprimsulfamethoxazole combination
(TMP-SMX), 80
Triphasic waves, 19
Triple-phase bone scan, 138
Tropical sprue, 42
U
Upper extremity deep venous thrombosis (UEDVT), 122123
Urea diuresis, 74
Ureterolithiasis, 124
Urinary tract infections (UTIs), 119, 154
Urine antigen assays, 84
Uroepithelial malignancies, 170
US health policy interventions, 161
Utrasound-guided vascular access, 87
V
Vancomycin
ceftriaxone plus, 56
concentrations, 46
skin and soft tissue infections (SSTI), 67
Varenicline, smoking cessation, 47
Variceal bleeding
splenectomy, 92
splenic vein thrombosis (SVT), 92
ultrasonography, 92
Vasopressor
drugs, 5152
therapy, 149150
Vasovagal syncope, 18
VATS. See Video-assisted thoracic surgery (VATS)
Vegetative state, wakefulness without awareness, 2021
Venous thromboembolism (VTE), 2223, 182, 184
Ventilator-associated pneumonia (VAP), 155156
Ventilator withdrawal, 141
Ventriculoperitoneal shunt infections, 71
Vertical nystagmus, 114
Vertigo, 2, 120
Video-assisted thoracic surgery (VATS), 34
Viral encephalitis, 6263
Index
205
Vitamin D
replacement, 180
toxicity, 62
Vitamin deficiency, 112113
Vitamin K, 99
Volume
depletion, 62
replacement, 45
resuscitation, 164
W
Wakefulness without awareness, 2021
Warfarin
anticoagulant therapy, 187188
atrial fibrillation ablation, 165
Z
Zollinger-Ellison syndrome (ZES)
diagnostic evaluation, 65
hypergastrinemia, 65
recurrent peptic ulcers, 65